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Financing early-stage
biomedical startups
A master thesis research at the University of Warwick UK
Sabin C. Carme
Background
PhD
Paris LyonTrondheim LondonDijon
MBA
Industry R&D Technology transfer
8 years 4 years
Training
Preliminaries
Only my opinion
European overview
Mostly for early stage
3
2
1
How finance works ?
Who are the actors ?
Goals / Question to answer
What do they want?
What you need to prepare ?
4
CASE
STUDIES
How to maximize
your opportunities?
50min - Coffee 20 min pause – 50 min
Venture Capital Specifics
« Finance » diversified risks for investment
Seed VC is the most risky
Pure players
Niche experts
Corporate
Bank subsidiaries
Public funded
Venture Capitalist
10 % 20 % 30 %40 %
Evaluate
BP
Conduct
Due Dilligence
Maximise investment by
advising company board
and prepare exit
Raise fund money from
limited partners
*EVCA 2007
Reward
5 years
Invest
Re-Invest
5 years
Divest
Risk balanced Portfolio
IRR = 50%
Funds management
2 M€ 2 M€ 2 M€ 2 M€
5 M€ 5 M€
2 M€
5 M€
5 M€ 10 M€
Why 50 M€ is only 5 investments (1 per year)
Serie A
Serie B
Serie C
Bootstrap PE IPOEnded M&A
Syndicates Mapping
…
Performance
Nasdaq
IPO Boom
New investment funds
400%
Stock Market
*NEXTVIEW 2015
Investor
Rationality in
Decision making
*NEXTVIEW 2015
Entrepreneur
Behind the deal
http://osagepartners.com/
Advices
You need to do it !
But you can ask for help
http://osagepartners.com/ www.partechventures.com/team/boris-golden
Investment Process
Project Stage
Booth 2011 LifeSci VC
Project
=
Asset
(product)
X
Company
(rest)
Project Stage
http://www2.lbl.gov/tt/researchers/resourcespubs/raising_money_whitepaper.pdf
Company
Fundamentals
Redis J. (2010) ICT start-ups venture capital and funding. Problems and Perspectives in Management, Volume 8.
Company
VC example of choice
In which of those 4 companies
should I invest ?
Each one has the
most advanced
science in its area
targeting Billion €
markets
Dataroom
Investigator Brochure
Pharmacological data reports
CMC Product
Patent / FTO
Business Plan
Business model analysis
Key suppliers relashionships
Expenses prevision
Target Product Profile
Clinical dv plan
Preclinical dev plan
Risk analysis
Health economy / Regulatory
Science Book
Research publications
Conference poster and presentation
Investigator Brochure
Pharmacological data reports
CMC Product
Patent / FTO
Business Plan
Business model analysis
Key suppliers relashionships
Expenses prevision
Target Product Profile
Clinical dv plan
Preclinical dev plan
Risk analysis
Health economy / Regulatory
Science Book
Research publications
Conference poster and presentation
Raw data archive
Incubator
Accounting expert
Hospital R&D office
Reg expert
Parma industry share of practices
Drug dev expert
Just Do It
Dataroom
Process
3 months
Roadshow
+
3-6 months
Due dill
http://www2.lbl.gov/tt/researchers/resourcespubs/raising_money_whitepaper.pdf
Fundraise simulation
Inspired from http://osagepartners.com/
Fundraise simulation
Inspired from http://osagepartners.com/
Fundraise simulation
Inspired from http://osagepartners.com/
Fundraise simulation : liquidation preference+participation
Inspired from
https://biostrategyanalytics.wordpress.com/2013/07/22/a-simple-vc-investment-model-what-every-biotech-entrepreneur-should-know/
Fundraise simulation : liquidation preference+participation
Inspired from
https://biostrategyanalytics.wordpress.com/2013/07/22/a-simple-vc-investment-model-what-every-biotech-entrepreneur-should-know/
Maximise your opportunities
Master your ecosystem
Isenberg et al https://hbr.org/2015/07/the-real-guide-to-innovation-tourism
Pharma Industry specifics
http://www.rsc.org/chemistryworld/Issues/2009/January/PharmaRefocusesOnThePatentCliff.asp
The pharma industry sees over $63 billion of annual
income washed away due to patent erosion by 2014
Pharma Industry specifics
Pharma Industry specifics
Pharma Industry specifics
http://www.roche.com/
Pharma Industry - White Papers
Value Chain Analysis
Operating model & Business steering
Environment
Nutopya* Benchmark
www.nutopya.com
* A think tank
Not incorporated yet
Start-up
company
Investor
Entrepreneur
MICRO
Environnement
MACRO
Environnment
Macro
Micro
Venture
Investor
Entrepreneur
Micro
Micro
Micro
Macro
Macro
Macro Go
NoGo
Go
NoGo
Go
NoGo
Refine venture project
Refine investor target
Refine team roles and
leadership
Due
Dilligence
Rational Decision
Case studies
Why raise 1M€
Raise 1M€ for 18 months
9 months to structure the company
+ 9 months to raise 5-10M€ in serie A
- Recruit Research engineer
- Prepare technical dossier
- Conduct technical projects and milestones
- Recruit COO/BD
- Consolidate Dataroom
- Conduct the investor roadshow
50%
50%
Before to raise 1M€
InoVizi
RDI
33k€
BPI FrenchTech
Emergence
40k€
Capital
100k€ (prêts)
Love
Money
34k€
Réseau
Entreprendre
33k€
SATT / CLARA
INCUBATEUR
140+20k€
Surveys Market/IP R&D
200k€ (subventions)
Starting point
Before to raise 1M€
InoVizi
RDI
33k€
BPI FrenchTech
Emergence
40k€
Capital
100k€ (prêts)
Love
Money
34k€
Réseau
Entreprendre
33k€
SATT / CLARA
INCUBATEUR
140+20k€
Surveys Market/IP R&D
200k€ (subventions)
Starting point
How to raise 1M€
BA
50k€
Crowdfunding
250k€
VC-FNA
200k€
BPI
500k€
Leverage and traction effect
Contest
5k€
How to raise 1M€
Contest
Prize
5k€
Great
incentive
for team
motivation
Increase “business” peers recognition
How to raise 1M€
R&D
Increase “business” peers recognition
Phase2
PHRC - PRT
Market
access
How to raise 1M€
Business Angels - SIBA
How to raise 1M€
VC FNA - Fonds National Amorçage
How to raise 1M€
Fonds Accélération Biotechnologies Santé
How to raise 1M€
Crowfunding
https://mypharmacompany.com/fr/knowmore/mypharmacademy/show/2/Les-4-types-de-Financement-participatif
How to raise 1M€ BPI (Feb 2014)
Cas 1
Cas 2
Cas 3 Neolys
sabin.carme@qwest-science.com https:www.nutopya.com
Sabin C. Carme
w
sabin.carme@qwest-science.com https:www.nutopya.com
Sabin C. Carme
w
sabin.carme@qwest-science.com https:www.nutopya.com
Sabin C. Carme
w

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