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9/3/2015 1
Presented by: Mr. Jagtap Lalit R.
Department of Clinical Pharmacy
9/3/2015 2
 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive
lung disease (COLD), and chronic obstructive airway disease (COAD), among
others, is a type of obstructive lung disease characterized by chronically poor
airflow. It typically worsens over time. The main symptoms include shortness of
breath, cough, and sputum production. Most people with chronic bronchitis have
COPD.
9/3/2015 3
 In absence of concomitant presence of emphysema, the underlying condition may be
classified as chronic bronchitis alone, and the exacerbations are then termed "acute
exacerbations of chronic bronchitis" (AECB), and shares many characteristics with that of
acute exacerbation of COPD.As COPD progresses, exacerbations tend to become more
frequent, the average being about three episodes per year.
9/3/2015 4
Name : Mrs. A.B.C.
Address : THALNER , DIST.- DHULE.
Age : 68 year
Sex : Female
Weight : “73” kg
Inpatient no : 1755
Hospital name : Indira Gandhi Memorial Hospital,
Shirpur
D.O.A : 19/01/2014
D.O.D : 26/01/2014
Consultant name : Dr. Pitambar Dighore
 FAMILY HISTORY: Nil
 SOCIAL HISTORY: Non alcoholic,
Non Smoker,
Non Vegetarian .
 OCCUPATION: Farmer
9/3/2015 5
9/3/2015 6
 COPD with exacerbation.
9/3/2015 7
 ASSOCIATED DISEASE:- None
 PAST MEDICATION HISTORY:- Nil
 PAST MEDICAL HISTORY:- Nil
9/3/2015 8

 Cough from last one week
 Chest tightness from last one night
 Wheezing from last one day
 Breathlessness from last one day
 Burning sensation from last one day for 2 hours
 Dysponea
 Restlessness from last one day
9/3/2015 9
DATE 20/09 21/09 22/09 23/09
G.C Fair Fair Fair Fair
PULSE per
min.
83 91 85 80
P/A Soft Soft Soft Soft
B.P. (mmHg) 110/65 130/80 115/72 120/75
9/3/2015 10
Hemogram :-
Normal value
Hemoglobin 9.25gm % 14-16 gm %
Leukocyte count >250 cell/mm3 250 cell/mm3
9/3/2015 11
9/3/2015 12
LUNGS VOLUMES
AND FLOW RATE
MEASUREMENT:
Forced expiratory volume
(FEV1) was decrease
Forced vital capacity (FVC)
was decrease
FEV1/FVC ratio was also
decrease
9/3/2015 13
 ECG REPORT:
The report was found to be normal range.
9/3/2015 14
Chronic Obstructive Pulmonary Disease:-
 Physical examination
 Chest X-ray.
9/3/2015 15
9/3/2015 16
Sr
no Medication
Dose
mg
Std
Dose
mg
Frequency Route Date
1. Nebulizer with
Duolin
(Ipratropium
bromide)
0.20 - 1 1-5 6 hrly inh 20-23
2. Nebulizer with
Budecort
(Budesonide)
0.10 -
0.20
0.20 -
0.40
8 hrly inh. 20-23
3. Inj Oframax forte
(Ceftriaxone sod.)
1500 4000 12 hrly iv 20-23
9/3/2015 17
Sr
no
Medication Dose
mg
Std
Dose
mg
Frequency Route Dat
e
4. Inj Efcorlin
(Hydrocortisone)
100 400 8 hrly iv 20-
21
5. Tab Omnacortil
(Prednisolone)
20-20-
10
05- 60 8 hrly oral 21-
22
6. Syp Grillinctus
BM
(Bromhexine +
Terbutaline)
10 ml 30 ml 12 hrly oral 20-
23
9/3/2015 18
 Tab Omnacortil 20-20-10 mg thrice in a day for three days
 Nebulizer with Duolin 4 times in a day for 5 days
 Nebulizer with Budecort thrice in a day for 5 days
 Inj Oframax fort 1.5 g daily for 7days
 Syp Grillinctus BM 2 t.s.f. for a week
9/3/2015 19
Ceftriaxone with corticosteroids:-
 Effect:– Antibiotics increased pharmacological action of
corticosteroids such as carbohydrate, fat, protein, calcium
metabolism, water excretion, inflammatory, immunologic and
allergic responses.
9/3/2015 20
Prescription outcome:-
 The diagnosis data analysis shows that haemoglobin was found to
be decreased level.
 The physician should be prescribed some blood forming agent
such as haematinics to the patient only orally/ as possible as blood
transfusion.
Ex – Iron and its preparations:-
1) Tb Fersolate 200 mg oral
2) Syp Imferon 10 ml oral
9/3/2015 21
 Smoking should be stopped (or go for nicotine replacement
therapy)
 Eat the iron rich food and blood forming foods.
 Available oxygen therapy for emergency acute exacerbation.
 Tell the patient not to use inhaler more than six times per day.
 Instruct the patient how to use the nasal sprays.
9/3/2015 22
 Instruct patient the
technique for use of
Nebulizer.
9/3/2015 23
 Instruct patient
the technique for
use of Peak flow
meter.
9/3/2015 24
 Some drugs may cause dizziness so use with caution while
driving or performing other task requiring mental alertness
 Patient should notify physician if conditions like dizziness,
palpitation, nausea, cough, weight loss, swelling in feet and
ankles, and sign of infection
 Maintain hygienic condition
 If any type of side effect occur by drug therapy consult
physician immediately
9/3/2015 25
9/3/2015 26
1. Ivan H. Stockley “Drug Interactions”; third edition, Bluckwell
Scientific Publication.
2. www.drugdigest.com
3. IDR, Nov 2006, Page No: 192,273,206.
4. Herfindal T. E. et al, 2006, “Text book of therapeutics” 8th
edition, Lippincott Williams & wilkins, Page No:1348,51.
5. Dipiro J.J. Pharmacotheraphy: “A pathologic
approach”, 6th edition 2001, MacGrow Hill publication, Page
No: 947
9/3/2015 27
7. Satosakar R.S. et al, 2006, “Pharmacology and
p’cotherapeutics”,19th edition, popular prakashan New Delhi.
8 www.wikipedia.org
9. Drug and dosage, a quick glance by mankind
pharmaceuticals.
10. www.netdoctor.com
9/3/2015 28
11. www.emedicine.net
12. Tripathi K.D, 2004 “ Essential of medical pharmacology”, 5th
edition, Jaypee Publication.
9/3/2015 29

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COPD EXACBATION WITH CONSOLIDATION , WITH DIABETESCase presentation lalit jagtap

  • 1. 9/3/2015 1 Presented by: Mr. Jagtap Lalit R. Department of Clinical Pharmacy
  • 3.  Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and chronic obstructive airway disease (COAD), among others, is a type of obstructive lung disease characterized by chronically poor airflow. It typically worsens over time. The main symptoms include shortness of breath, cough, and sputum production. Most people with chronic bronchitis have COPD. 9/3/2015 3  In absence of concomitant presence of emphysema, the underlying condition may be classified as chronic bronchitis alone, and the exacerbations are then termed "acute exacerbations of chronic bronchitis" (AECB), and shares many characteristics with that of acute exacerbation of COPD.As COPD progresses, exacerbations tend to become more frequent, the average being about three episodes per year.
  • 4. 9/3/2015 4 Name : Mrs. A.B.C. Address : THALNER , DIST.- DHULE. Age : 68 year Sex : Female Weight : “73” kg Inpatient no : 1755 Hospital name : Indira Gandhi Memorial Hospital, Shirpur D.O.A : 19/01/2014 D.O.D : 26/01/2014 Consultant name : Dr. Pitambar Dighore
  • 5.  FAMILY HISTORY: Nil  SOCIAL HISTORY: Non alcoholic, Non Smoker, Non Vegetarian .  OCCUPATION: Farmer 9/3/2015 5
  • 6. 9/3/2015 6  COPD with exacerbation.
  • 7. 9/3/2015 7  ASSOCIATED DISEASE:- None  PAST MEDICATION HISTORY:- Nil  PAST MEDICAL HISTORY:- Nil
  • 8. 9/3/2015 8   Cough from last one week  Chest tightness from last one night  Wheezing from last one day  Breathlessness from last one day  Burning sensation from last one day for 2 hours  Dysponea  Restlessness from last one day
  • 9. 9/3/2015 9 DATE 20/09 21/09 22/09 23/09 G.C Fair Fair Fair Fair PULSE per min. 83 91 85 80 P/A Soft Soft Soft Soft B.P. (mmHg) 110/65 130/80 115/72 120/75
  • 10. 9/3/2015 10 Hemogram :- Normal value Hemoglobin 9.25gm % 14-16 gm % Leukocyte count >250 cell/mm3 250 cell/mm3
  • 12. 9/3/2015 12 LUNGS VOLUMES AND FLOW RATE MEASUREMENT: Forced expiratory volume (FEV1) was decrease Forced vital capacity (FVC) was decrease FEV1/FVC ratio was also decrease
  • 13. 9/3/2015 13  ECG REPORT: The report was found to be normal range.
  • 14. 9/3/2015 14 Chronic Obstructive Pulmonary Disease:-  Physical examination  Chest X-ray.
  • 16. 9/3/2015 16 Sr no Medication Dose mg Std Dose mg Frequency Route Date 1. Nebulizer with Duolin (Ipratropium bromide) 0.20 - 1 1-5 6 hrly inh 20-23 2. Nebulizer with Budecort (Budesonide) 0.10 - 0.20 0.20 - 0.40 8 hrly inh. 20-23 3. Inj Oframax forte (Ceftriaxone sod.) 1500 4000 12 hrly iv 20-23
  • 17. 9/3/2015 17 Sr no Medication Dose mg Std Dose mg Frequency Route Dat e 4. Inj Efcorlin (Hydrocortisone) 100 400 8 hrly iv 20- 21 5. Tab Omnacortil (Prednisolone) 20-20- 10 05- 60 8 hrly oral 21- 22 6. Syp Grillinctus BM (Bromhexine + Terbutaline) 10 ml 30 ml 12 hrly oral 20- 23
  • 18. 9/3/2015 18  Tab Omnacortil 20-20-10 mg thrice in a day for three days  Nebulizer with Duolin 4 times in a day for 5 days  Nebulizer with Budecort thrice in a day for 5 days  Inj Oframax fort 1.5 g daily for 7days  Syp Grillinctus BM 2 t.s.f. for a week
  • 19. 9/3/2015 19 Ceftriaxone with corticosteroids:-  Effect:– Antibiotics increased pharmacological action of corticosteroids such as carbohydrate, fat, protein, calcium metabolism, water excretion, inflammatory, immunologic and allergic responses.
  • 20. 9/3/2015 20 Prescription outcome:-  The diagnosis data analysis shows that haemoglobin was found to be decreased level.  The physician should be prescribed some blood forming agent such as haematinics to the patient only orally/ as possible as blood transfusion. Ex – Iron and its preparations:- 1) Tb Fersolate 200 mg oral 2) Syp Imferon 10 ml oral
  • 21. 9/3/2015 21  Smoking should be stopped (or go for nicotine replacement therapy)  Eat the iron rich food and blood forming foods.  Available oxygen therapy for emergency acute exacerbation.  Tell the patient not to use inhaler more than six times per day.  Instruct the patient how to use the nasal sprays.
  • 22. 9/3/2015 22  Instruct patient the technique for use of Nebulizer.
  • 23. 9/3/2015 23  Instruct patient the technique for use of Peak flow meter.
  • 24. 9/3/2015 24  Some drugs may cause dizziness so use with caution while driving or performing other task requiring mental alertness  Patient should notify physician if conditions like dizziness, palpitation, nausea, cough, weight loss, swelling in feet and ankles, and sign of infection  Maintain hygienic condition  If any type of side effect occur by drug therapy consult physician immediately
  • 26. 9/3/2015 26 1. Ivan H. Stockley “Drug Interactions”; third edition, Bluckwell Scientific Publication. 2. www.drugdigest.com 3. IDR, Nov 2006, Page No: 192,273,206. 4. Herfindal T. E. et al, 2006, “Text book of therapeutics” 8th edition, Lippincott Williams & wilkins, Page No:1348,51. 5. Dipiro J.J. Pharmacotheraphy: “A pathologic approach”, 6th edition 2001, MacGrow Hill publication, Page No: 947
  • 27. 9/3/2015 27 7. Satosakar R.S. et al, 2006, “Pharmacology and p’cotherapeutics”,19th edition, popular prakashan New Delhi. 8 www.wikipedia.org 9. Drug and dosage, a quick glance by mankind pharmaceuticals. 10. www.netdoctor.com
  • 28. 9/3/2015 28 11. www.emedicine.net 12. Tripathi K.D, 2004 “ Essential of medical pharmacology”, 5th edition, Jaypee Publication.