4. INTENDED USE OF SOLMAG
®
Magnetic Bead Separation:
Bench-top automated system for quick purification of nucleic acids from bio-
specimens using magnetic bead separation technology.
Liquid Handling System:
Liquid handling automation, using pre-filled reagent cartridges
For research and in vitro diagnosis use
5. FUNCTION PRINCIPLE
Advanced Liquid Handling Magnetic Bead Separation
Sample Material Lysis Step Binding Step
Magnetic Separation Washing Step Elution Step; Purified Nucleic Acid
6. CORE TECHNOLOGIES
The Solis-Charger
®
Technology
The Solis-ChargerR Technology is a novel magnetic bead-based technology
that provides a switchable surface charge dependent on the pH and salt
concentration of the surrounding buffer to facilitate nucleic acid purification.
In low pH conditions, the magnetic beads have a positive charge that binds
the negatively charged nucleic acid backbone (see figure1 below). Proteins
and other contaminants are not bound and are simply washed away in an
aqueous wash buffer. To elute nucleic acids, the charge on the surface of the
bead is neutralized by raising the pH to 8.0 using a low salt elution buffer (see
figure below). Purified nucleic acid elutes instantly into this elution buffer, and
is ready for use in downstream applications.
7. CORE TECHNOLOGIES
The 2D CatcherMag
®
Technology for Sample Preparation
The 2D CatcherMag® technology is a novel magnetic bead-based
modification technology. The 2D CatcherMag® is modified and designed for
different sample types to optimized collection/extraction result. With the
nano-scale modification on the 2D CatcherMag®, we can provide the users a
better solution while collecting the samples for reliable polymerase chain
reaction results and accurate data analysis.
The 2D CatcherMag® adhering to
pathogen in the collection tube
8. SOLMAG
®
12
Automated Nucleic Acid Purification Systems
SolMag
®
12:
Compact Bench-top Instrument
Process 1-12 samples simultaneously
7 inches touch screen
Light: Total weight less than 42 Kg
Fast: Up to 12 results in 35 minutes
Precise liquid volume and temperature control
Extremely easy to operate and maintain
9. SOLMAG
®
12
Front View of Solmag
®
12
Transparent Maintenance Window
The Transparent Window is designed to let the user
have a clean and sharp look inside the system
during operation.
Seven Inches Full-Colored
The full-colored touch-screen will simplified and
guide you through the setup procedure.
Reagent & Plastic Disposable Drawer
Open the drawer to load the ready-to-use
prefilled reagent cartridges and other plastic
consumables required for performing a nucleic
acid purification reaction.
Rubber Hand Holders
Hand Holders are designed to let users move the
instrument with comfort.
10. SOLMAG
®
12
Inside View of Solmag
®
12
Six-linked Prefilled
Reagent Cartridges
Tip Set
Regular Filtered Tip
Small Filtered Tip
Sample Tube
Transferrable Sample Rack
Elution Tube
11. SOLMAG
®
12
Back View of Solmag
®
12
USB Connection Port
RS232 Connection Port
Power Outlet
Power Switch
12. SOLMAG
®
12 SPECIFICATIONS
Light as feather:
SolMag
®
12 weights only
42kgw, which is 50% lighter in
average than other similar
throughputs liquid handling
extractor in the market.
MagNaPure Compact: 60Kg
Qiagen EZ1 Advanced XL: 48Kg
MagCore HF16: 70Kg
SolMag
®
12
Part No. SVP0101
Dimensions (W x D x H) 637mm x 462mm x 540mm
Weight 42kgw
Interface 7” LCD touch-screen
Processing time 20 – 45mins
Throughput 1-12 Samples per run
Temperature
Uniformity
±0.5℃
Liquid Extraction
Volume Error
Less than 5％
Sample Volume 50ul – 3000ul
Elution Volume 30ul – 200ul
Power Input power :
90 ~ 132V&180 ~ 264Vby switch
50/60Hz
Out power :5V60A
Certification CE、IVD、FDA
13. UNIQUE SPECIFICATIONS
7” Touch Screen:
Optimized built-in protocol covers six major applications such as clinical
diagnostic, forensic science, food safety and CFC.
Built-in Template:
Up to three preferable
templates can be set up by
the users for performing the
same routine protocol daily,
which can also reduce the
risk from human operational
error.
14. UV LAMP DECONTAMINATION
• With a built-in UV-lamp, the UV
decontamination guarantee
maximum safety for both samples
and environment
ABOUT INSTRUMENT
SLEEP MODE
SOFTWARE UPDATE
DEVICES TESTS
UV LAMP
15. SOLMAG
®
24
Automated Nucleic Acid Isolation
Systems
SolMag
®
24:
The SolMag®24 provides all the
advantages of the SolMag®12, and
increases the throughput to 24 samples
per run. This new workstation has been
developed to combine the convenience
and reliability of the SolMag® Series with
the need for low-to-medium throughput.
17. WORK STATION
Mid to high throughputs
• >= 24 preps/run
Programmable robot arm controlled
by separated computer
Big instrument dimension / heavy
weight
Complicated setup procedures
/require additional training before
operation
Higher instrument and consumable
cost
• > US$ 80K
Ex:
• Qiasymphony(Qiagne)
• Cobus (Roche)
STANDALONE
Small to mid throughputs
• < 24 preps/run
Built-in micro-processor and protocols,
no PC required
Small Footprint / compact
Easy setup and operation steps
Lower instrument and consumable cost
• <US$10K
Ex:
• SolMag (Solison), EZ1 Advanced
(Qiagen), MagNa Pure Compact
(Roche), iPrep (Invitrogen) … etc
COMPARISON WITH WORK STATION
18. Advantage
• Fully walk away automation:
minimum procedures of set up,
which require three simple steps.
• Enable to handle a wide range
of volumes on starting materials
and elutes
• Better extraction quality
Disadvantage
• Bigger instrument size and
heavier weight
• Higher instrument cost
Ex:
• SolMag (Solison), EZ1 Advanced
(Qiagen), MagNa Pure Compact
(Roche), iPrep (Invitrogen) … etc
MAGNETIC ROD
Advantage
• Lower kit price
Disadvantage
• Easy to have magnetic bead
residues in eluted products
• Limited or fixed sample / elute
volume handling choice
• Semi-Automation: tedious
manual set up procedure
required, kills time and cause
humor errors.
Ex:
• Maxwell (Promega)
• KingFisher (Thermo Fisher)
LIQUID HANDALING
COMPARISON WITH MAGNETIC ROD SYSTEM
