Clarithromycin (Impurities at Pharmaffiliates) is a semi-synthetic antibiotic belongs to the group of macrolide antibiotics. It is used to treat infections caused by bacteria. It also acts as a novel chiral selector for the enantiomeric separation of basic drugs in capillary electrophoresis.

1. Clarithromycin Impurities
At Pharmaffiliates

2. Macrolides are a group of antibiotics produced by various
strains of Streptomyces (spore-forming bacteria that grow
slowly in soil or water as a branching filamentous mycelium
similar to that of fungi) and have a complex chemical
(macrocyclic) structure.
Macrolides act by inhibiting protein synthesis, specifically by
blocking the 50S ribosomal subunit. They are broad-spectrum
antibiotics. Azithromycin, Clarithromycin, and Erythromycin
are drugs that belong to the Macrolides class.

3. Clarithromycin, a semi-synthetic antibiotic belongs to
the group of macrolide antibiotics. It is used to treat
infections caused by bacteria. It also acts as a novel chiral
selector for the enantiomeric separation of basic drugs in
capillary electrophoresis.
Clarithromycin is metabolized to eight metabolites in the
human body, but only one, the 14-hydroxy metabolite, has
been shown to have antibacterial activity.
High-performance liquid chromatography is used to identify
and estimate the manufacturing and degradation impurities
of Clarithromycin.

4. Product Code Chemical Name Product Name CAS No.
PA 03 60000 Clarithromycin Clarithromycin - API 81103-11-9
PA 03 60010 Clarithromycin F
Clarithromycin -
Impurity A
124412-58-4
PA 03 60020
6-O-Methyl-15-
norerythromycin A
Clarithromycin -
Impurity B
299409-85-1
PA 03 60030
6-O-Methylerythromycin 9-
Oxime
Clarithromycin -
Impurity C
127253-06-9
PA 03 60040 N-Desmethyl Clarithromycin
Clarithromycin -
Impurity D
101666-68-6
PA 03 60050
6,11-Di-O-methyl
Erythromycin
Clarithromycin -
Impurity E
81103-14-2
PA 03 60060 12-O-Methyl Clarithromycin
Clarithromycin -
Impurity F
128940-83-0
Pharmaffiliates Analytics and Synthetics Pvt. Ltd, is a manufacturer/supplier and exporter of
Clarithromycin Process Impurity, Clarithromycin Degradation Impurity, Clarithromycin Related
Compound, and Clarithromycin Potential Impurity. Details are tabulated below :

5. Product Code Chemical Name Product Name CAS No.
PA 03 60070 Clarithromycin (9E)-O-Methyloxime Clarithromycin - Impurity G 127182-44-9
PA 03 60080 N-Demethyl-N-formyl Clarithromycin Clarithromycin - Impurity H 127140-69-6
PA 03 60090 De(cladinosyl) Clarithromycin Clarithromycin - Impurity I 118058-74-5
PA 03 60100 Erythromycin A Oxime Clarithromycin - Impurity J 13127-18-9
PA 03 60110
3-O-De(cladinosyl)-8,9,10,11-
tetradehydro-9-deoxo-11,12-dideoxy-
9,12-epoxy Clarithromycin
Clarithromycin - Impurity K 127157-35-1
PA 03 60120 Clarithromycin (9Z)-Oxime Clarithromycin - Impurity L 127253-05-8
PA 03 60130
3''-N-Demethyl-6-O-
methylerythromycin A (E)-9-oxime
Clarithromycin - Impurity M 127182-43-8
PA 03 60140
(10E)-10,11-Didehydro-11-deoxy-6-O-
methylerythromycin A
Clarithromycin - Impurity N 144604-03-5
PA 03 60150 Clarithromycin (9Z)-O-Methyloxime Clarithromycin - Impurity O 127252-80-6
PA 03 60160 4′,6-Di-O-methylerythromycin A Clarithromycin - Impurity P 123967-58-8

6. These impurities are provided with a certificate of
analysis along with the characterization data like NMR
MASS, IR and HPLC Purity. We also provide additional
data like 13C NMR, CHN, TGA RF on request.
Pharmaffiliates are also the supplier of all
Clarithromycin USP, EP, BP, JP pharmacopeia
impurities, any unknown impurity, APIs, stable
isotopes and intermediates with structure elucidation
with help of 13C NMR, 1H NMR, MASS, CHN, HPLC
data.

7. Pharmaffiliates is a worldwide manufacturer and
supplierof reference material which includes
intermediates, chiral standards, glucuronides, stable
isotopes, metabolites, etc. which are acceptable to
all regulatory agencies in the world like US-FDA,
MHRA, MCC, WHO, Brazil and Japan.
Pharmaffiliates provides high quality and cost-
effective organic synthesis services worldwide.
Pharmaffiliates has emerged as a global name of
leading manufacturer and supplier of impurity
reference standards.

8. Pharmaffiliates
Plot Number 225 ,Industrial Area,
Phase II, Panchkula, Haryana- 134109,
India
https://www.pharmaffiliates.com/
Marketing@pharmaffiliates.com
mktg@pharmaffiliates.com
+91- 9216178188
+91-9216119588
+91-172-5066494-45

9. THANK YOU