The document discusses the anatomy, embryology, histology, relations, blood supply, physiology, regulation of secretion, functions, and benign conditions of the thyroid gland. Some key points:
- The thyroid gland is a butterfly-shaped endocrine gland located in the neck, overlying the trachea. It weighs 20-25g and is larger in females.
- It develops from endodermal cells in the floor of the pharynx and forms as a diverticulum that elongates into the thyro-glossal duct.
- The gland contains follicles composed of epithelial cells and colloid containing thyroglobulin, the precursor of thyroid hormones.
- Benign conditions include non
2. ANATOMY
Thyroid is an endocrine gland overlying the upper part of the trachea and overlies
vertebra C5-T1.
It is made up of two lobes each measuring 5cm X 2.5cm X 2.5cm, weighs 20-25g and
connected by isthmus. It is larger in females than males and tends to increase in size
during pregnancy
Covered by 2 capsules. A true capsule derived from condensation of the connective tissue
of the gland and a false capsule derived from the pretracheal layer of the deep fascia of the
neck.
3.
4. EMBRYOLOGY
It develops from the endodermal cells of the floor of the pharynx( area of tongue
development)
begins as a diverticulum at the dorsum of the tongue between the tuberculum
impar and hypo bronchial eminence.
The thyroid diverticulum elongates to form thyro-glossal duct. The TG duct
elongates distally between hyoid and thyroid cartilage where it divides into two
parts
5. HISTOLOGY
The thyroid gland contains numerous follicles composed of epithelial and colloid.
The major constituent of the colloid is the large glycoprotein thyroglobulin,which
contain the thyroid hormones within its molecules.
Parafolicular or C cells are located between the follicles and produce calcitonin.
14. NON TOXIC GOITER
Enlargement of the thyroid gland that does not result from inflammatory or
neoplastic process and not associated with abnormal thyroid function.
Endemic goiter-occurs in more than 10% of the population and sporadic goiter do not
occur in general population and related to environmental and genetic factors.
ETIOLOGY
IODINE DEFICIENCY- causes goiter when there is less than 50mcg/d (normal children
(100-200) adults (150-250)). Very low intake is associated with hypothyroidism and
cretinism. However ,iodine excess can cause non toxic goiter in setting of autoimmune
thyroid disease.
15. ETIOLOGY CONT…
DYSHORMONOGENESIS- due to inherited defect in the thyroid hormone
biosynthesis pathway.
HEAD AND NECK RADIATION- results in benign or malignant thyroid nodules.
DRUGS- propylthiouracil, lithium ,phenylbutazone etc.
EVIRONMENTALAGENTS- phenolic and phthalate ester derivatives and resorcinol
found in downstream of coal and shale mines.
FOOD- vegetables of genus Brassica e.g. cabbage , turnips, brussels sprouts and
rutabagas. Seaweed, millet, cassava etc.
16. PATHOGENESIS
Persistent growth stimulation by TSH causing diffuse hyperplasia with all follicles
active and uniform uptake of iodine.
A mixed pattern occurs with areas of active colloid lobules and inactive colloid.
lobules Active colloid lobules becomes more hyperplastic and vascularized and
hemorrhage may occur causing central necrosis and leaving a ring of surrounding
ring of active follicles.
17.
18. DIFFUSE HYPERPLASTIC GOITER
The goiter appears in childhood in endemic areas but, in sporadic cases, it usually occurs
at puberty when metabolic demands are high.
The goiter may regress if TSH stimulation ceases, but it tends to recur later at times of
stress such as pregnancy.
The goiter is soft, diffuse and may become large enough to cause discomfort.
A colloid goiter is a late stage of diffuse hyperplasia, when TSH stimulation has ceased
and when there are many inactive follicles full of colloid.
19. NODULAR GOITER
Nodules are usually multiple, forming a multinodular goiter.
Occasionally, only one macroscopic nodule(solitary nodule) is found, but
microscopic changes are present throughout the gland.
Nodules may be colloid or cellular, and cystic degeneration and hemorrhage are
common, as is subsequent calcification.
Nodules appear early in endemic goiter and later (20-30 years) in sporadic goiter,
although the patient may be unaware of the goiter until their late 40s or 50s.
All types of simple goiter are more common in the female than in the male.
20.
21.
22. CLINICAL PRESENTATION
Tracheal compression-dyspnea and stridor.
Solid food and pill dysphagia if the goiter extends posteriorly
Hoarseness due to vocal cord dysfunction-recurrent laryngeal nerve compression
Change in the pitch of the voice-superior laryngeal nerve compression
Compression of the venous outflow through the thoracic inlet by a mediastinal
goiter-facial plethora, dilated neck and upper thoracic veins.
23. HISTORY AND PHYSICAL EXAMINATION
Obtain a careful diet history for iodine deficiency/iodine excess from medications.
Record any history of head and neck radiation exposure, especially during
childhood.
Family history-inherited forms of dyshormonogenesis in the pediatric patient,
familial papillary carcinoma of the thyroid and familial forms of medullary thyroid
cancer.
Evaluate of the shape, asymmetry, size, and consistency of nontoxic goiters;
lymphadenopathy; and assess thyroid function
24. CONT..
Assess the patient's voice for hoarseness.
Pemberton maneuver?
Facial plethora or engorgement of the neck veins
Examine patients for signs of thyroid dysfunction
Hypothyroidism-sallow complexion, dysarthric speech, mental slowing, weight gain
without change in appetite, cold intolerance, constipation, hypersomnia, and delayed
relaxation of deep tendon reflexes.
Hyperthyroidism-tachycardia, atrial arrhythmias, diaphoresis, weight loss without
change in appetite, heat intolerance, hyperdefecation, palmar erythema, lid lag,
tremor, and brisk reflexes.
25. DIAGNOSIS
Usually through history and examination
The nodules are palpable and often visible; they are smooth, firm not hard, the
goitre is painless and moves freely on swallowing.
Hardness and irregularity, due to calcification, may simulate carcinoma.
A painful nodule, sudden appearance or rapid enlargement of a nodule raises
suspicion of carcinoma but is usually due to hemorrhage into a simple nodule.
Differentiating it from autoimmune thyroiditis may be difficult because the two
conditions frequently coexist.
27. IMAGING
Ultrasonography-gold standard for estimating the number and size of nodules
but is inaccurate in the clinical setting for measuring the volume of large goiters.
FNAC-only required for a nodule within the goiter that demonstrates
ultrasound features of concern. Biopsy should be performed under ultrasound
guidance to ensure the correct nodule is sampled.
CT and MRI-expensive but excellent for assessing tracheal compression and
intrathoracic extension of the goiter.
29. OPERATIVE
Thyroidectomy-total or subtotal- causes rapid relief for obstructive symptoms.
. In case of a multinodular change especially in older patients, total lobectomy on
the more affected side is the appropriate .
Radioactive iodine and thyroid hormone replacement therapy is given post
subtotal thyroidectomy . Prevent recurrence .
30. TOXIC GOITER
Thyrotoxicosis vs Hyperthyroidism? Hyperthyroidism is characterized by increased
thyroid hormone synthesis and secretion from the thyroid gland, whereas
thyrotoxicosis refers to the clinical syndrome of excess circulating thyroid
hormones, irrespective of the source.
Clinical types are:
• diffuse toxic goiter (Graves’ disease);
• toxic nodular goiter;
• toxic nodule;
• hyperthyroidism due to rarer causes.
31. GRAVES DISEASE
Graves disease is an organ-specific autoimmune disorder characterized by a variety
of circulating antibodies, including common autoimmune antibodies, as well as
anti-thyroid peroxidase (anti-TPO) and antithyroglobulin (anti-TG) antibodies.
The most important autoantibody is thyroid-stimulating immunoglobulin (TSI)
which is directed toward epitopes of the thyroid-stimulating hormone (TSH)
receptor and acts as a TSH-receptor agonist.
This results in the characteristic picture of Graves thyrotoxicosis, with a diffusely
enlarged thyroid, very high radioactive iodine uptake, and excessive thyroid
hormone levels compared with a healthy thyroid .
34. GRAVE CONT..
May be associated with other autoimmune diseases, such as pernicious anemia,
myasthenia gravis, vitiligo, adrenal insufficiency, and type 1 diabetes mellitus
35. TOXIC NODULAR GOITER
Complicating simple nodular goiter.
Diffuse and nodular enlargement of the thyroid. Some nodules will show
hyperfunctioning acini while other acini will be inactive.
Usually in the middle-aged or elderly, and very infrequently is associated with eye
signs.
36. OTHER CAUSES OF TOXIC THYROID
Iodide-induced thyrotoxicosis (Jod-Basedow syndrome) esp in patients with areas of
thyroid autonomy, such as a multinodular goiter or autonomous nodule. The
thyrotoxicosis appears to be a result of loss of the normal adaptation of the thyroid to
iodide excess
Struma ovarii-ectopic thyroid tissue associated with dermoid tumors or ovarian
teratomas that can secrete excessive amounts of thyroid hormone .Metastatic
follicular thyroid carcinoma maintains the ability to make thyroid hormone and can
cause thyrotoxicosis in patients with bulky tumors
Patients with molar hydatidiform pregnancy or choriocarcinoma have extremely high
levels of beta human chorionic gonadotropin (βHCG) that can weakly activate the TSH
receptor.
37.
38. MANAGEMENT
Involves use of antithyroid drugs, surgery and radioiodine.
Antithyroid drugs- mostly used are carbimazole and propylthiouracil. They are
used to restore the patient to a euthyroid state and to maintain this for a
prolonged period hoping that a permanent remission will occur.
Advantages-No surgery and no use of radioactive materials.
Disadvantages-Prolonged Tx with a failure rate of at least 50%. Recurrence of the
hyperthyroidism is certain when the drug is discontinued. Antithyroid drugs
cannot cure a toxic nodule.
39. MX CONT..
Radioiodine- destroys thyroid cells reduces the mass of functioning thyroid
tissue.
Disadvantages-Isotope facilities must be available. The patient must be
quarantined while radiation levels are high and avoid pregnancy and close
physical contact, particularly with children. Eye signs may be aggravated.
40. PRE OPERATION PREPARATION
Preoperative preparation includes antithyroid medication, stable (cold) iodine
treatment (to decrease gland vascularity), and beta-blocker therapy
Generally, antithyroid drug therapy should be administered until thyroid functions
normalize (4-8 wk.). Titrate propranolol until the resting pulse rate is less than 80
bpm.
Finally, administer iodide as SSKI (1-2 drops bid for 10-14 d) before surgery.
An additional benefit from stable iodide therapy, besides the reduction in thyroid
hormone excretion, is a demonstrated decrease in thyroid blood flow and
possible reduction in blood loss during surgery
41. SURGERY
AIM
Reducing the mass of overactive tissue.
Subtotal thyroidectomy- patient returns to euthyroid state after transient
hypothyroidism.
Total thyroidectomy- patient requires thyroid hormone replacement.
Advantages-the cure is rapid and the cure rate is high if surgery has been adequate.
Disadvantages-Recurrence of thyrotoxicosis in at least 5% of cases of subtotal
thyroidectomy. Risk of permanent hypoparathyroidism and nerve injury. Poor cosmetic
result from the scar.
42. COMPLICATIONS
Hemorrhage
Recurrent laryngeal nerve paralysis and voice change
Thyroid insufficiency
Parathyroid insufficiency
Thyrotoxic crisis (storm)
Wound infection
Hypertrophic or keloid scar
Stitch granuloma
Cardiac or respiratory events-deep vein thrombosis and pulmonary embolism are uncommon
43. HYPOTHYROIDISM
Hypothyroidism is a common endocrine disorder resulting from deficiency of
thyroid hormones.
It can be primary, in which the thyroid gland produces insufficient amounts of
thyroid hormones or secondary - that is, lack of thyroid hormone secretion due to
inadequate secretion of either thyrotropin from the pituitary gland or TRH from the
hypothalamus-tertiary hypothyroidism.
The patient's presentation may vary from asymptomatic to, rarely, coma with
multisystem organ failure (myxedema coma).
45. THYROIDITIS
Inflammation of the thyroid.
TYPES
• Hashimoto thyroiditis
• Subacute granulomatous thyroiditis/DeQuervain thyroiditis
• Riedel's /fibrous thyroiditis
46. HASHIMOTO THYROIDITIS
Occur in middle aged and elderly patients
Common in female than male 20:1
Causes painless thyroid enlargement
Associated with hypothyroidism.
Pathogenesis
Autoimmune disease
47. GROSS PICTURE
Symmetrically enlarged thyroid gland
Firm consistency
Intact non adherent capsule
Cut surface pale, homogenous and sometimes nodular
48. MICROSCOPY
Dense inflammatory infiltrate consisting of ; lymphocytes, macrophages and
plasma cells
Some acini are atrophied while others show regenerative changes( lined with
deeply eosinophilic granular cytoplasm termed as HURTHLE CELLS( Hurtle cell
metaplasia)
Fibrosis
50. SUBACUTE GRANULOMATOUS
THYROIDITIS/DEQUERVAIN THYROIDITIS
Occurs between 30-50yrs
More common in females than male 5:1
Cause painful thyroid enlargement
Associated with transient hyperthyroidism
Pathogenesis
Associated with viral infection e.g cocksackie, mumps and adenoviruses.
51. GROSS PICTURE
Unilateral or bilateral enlargement
Intact/slightly adherent capsule
Cut areas show scattered firm yellowish areas
MICROSCOPIC
Aggregation of neutrophils
Pool of colloid surrounded by multinucleated giant cells, histiocytes and
lymphocytes
Fibrosis
53. RIEDEL’S THYROIDITIS
Rare, unknown cause, affect both sexes equally.
GROSS PICTURE
Hard in consistency and adherent to surrounding structures
MICROSCOPIC PICTURE
Dense fibrous tissue replacing normal thyroid gland and penetrating the capsule
to surround neck structures.
54. CENTRAL HYPOTHYROIDISM
Results when the hypothalamic-pituitary axis is damaged by:
Pituitary adenoma
Tumors impinging on the hypothalamus
History of brain irradiation
Drugs (e.g. dopamine, lithium)
Sheehan syndrome
55. MYXEDEMA
Myxedema is the hypothyroidism in adults, characterized by generalized
edematous appearance-Swelling of the face, bagginess under the eyes, non-
pitting edema and atherosclerosis.
Other features include: Anemia, fatigue and muscular sluggishness, extreme
somnolence, menorrhagia and decreased cardiovascular functions such as
reduced rate and force of contraction of the heart, cardiac output and blood
volume; increase in body weight, constipation, mental sluggishness, depressed
hair growth, scaliness of the skin, frog-like husky voice and cold intolerance.
56. CRETINISM
Cretinism is the hypothyroidism in children, characterized by stunted growth.
Cretinism occurs due to congenital absence of thyroid gland, genetic disorder or lack
of iodine in the diet.
A newborn baby with thyroid deficiency may appear normal at the time of birth but a
few weeks after birth, the baby starts developing signs like sluggish movements and
croaking sound while crying.
There is stunted growth with bloated body. The tongue becomes so big that it hangs
down with drooling. The big tongue obstructs swallowing and breathing. The tongue
may sometimes choke the baby.
57. MANAGEMENT
The treatment goals for hypothyroidism are the reversal of clinical progression
and the corrections of metabolic derangements
Levothyroxine is considered the treatment of choice.
Surgery is indicated for large goiters that compromise tracheoesophageal
function; surgery is rarely needed in patients with hypothyroidism and is more
common in the treatment of hyperthyroidism.
60. CONT…
Papillofollicular carcinoma behaves like papillary carcinoma of thyroid.
Hurthle cell carcinoma behaves like follicular carcinoma.
b. Undifferentiated-Anaplastic carcinoma (13%).
c. Medullary carcinoma (6%).
d. Malignant lymphoma (4%)
e. Secondary(rare) – From colon, kidney, melanoma.
61. ETHIOPATHOGENESIS
• Radiation either external or radioiodine can cause papillary carcinoma thyroid-
Chernobyl nuclear disaster in Ukraine in 1986.
• Pre-existing multinodular goiter-can turn into follicular carcinoma.
• Family history-Medullary carcinoma thyroid is often familial.
• Hashimoto’s thyroiditis may predispose to papillary carcinoma of thyroid.
62.
63. PAPILLARY CARCINOMA
• Most common(60%)- slowly progressive and less aggressive tumour.
• Common in females and younger age group.
• Etiology-Radiation either external or radioactive iodine therapy.
• TSH levels in the blood of these patients are high and so it is called as hormone
dependent tumor.
• Grossly-It can be soft, firm, hard, cystic. It can be solitary or multinodular. It contains
brownish black fluid.
• Microscopy-It shows cystic spaces, papillary projections with psammoma bodies,
malignant cells with intranuclear cytoplasmic inclusions.
64.
65. FOLLICULAR CARCINOMA
It accounts for about 15% of thyroid cancers and is more common in the elderly
and in females.
It is a well-differentiated tumor of thyroid epithelium, second in incidence to
papillary thyroid cancer.
It can occur either de novo or in a pre-existing multinodular goitre.
It can be invasive-blood spread common or non-invasive—blood spread not
common.
Typical features: Capsular invasion and angioinvasion- spreading into the bones,
lungs, liver and occasionally lymph nodes.
66.
67. CONT..
• Occasionally associated with a history of radiation exposure.
• It is more malignant than papillary carcinoma, spreading hematogenous with
distant metastases.
• These tumors are more typically uninodular when compared to papillary thyroid
carcinoma.
• While vascular invasion is frequent with follicular carcinoma, spread to lymph
nodes is uncommon, occurring in only 8 to 13 percent of cases
68.
69. CLINICAL FEATURES
PAPILLARY CARCINOMA
Soft or hard or firm, solid or cystic, solitary or
multinodular thyroid swelling.
Compression features are uncommon.
Palpable discrete lymph nodes in the neck (40%) .
May present with metastasis to neck lymph nodes only
FOLLICULAR CARCINOMA
Swelling in the neck-firm or hard and nodular.
Tracheal compression and stridor.
Dyspnoea, haemoptysis, chest pain when there are
metastases to the lungs.
Recurrent laryngeal nerve involvement causes hoarseness
of voice, +ve ‘Berry’s sign’ signifies advanced malignancy
(infiltration into the carotid sheath and so absence of
carotid pulsation).
Pulsatile secondary malignancies in the skull and long
bones.
70. INVESTIGATIONS
PAPILLARY CARCINOMA
FNAC of thyroid nodule and lymph node.
Radioisotope scan-cold nodule.
High TSH levels
Plain X-ray neck shows fine calcification.
Nodular goitre shows coarse – ring/rim
calcification.
U/S neck or CT scan neck to identify
nonpalpable nodes in neck.
FOLLICULAR CARCINOMA
FNAC inconclusive-because capsular- and
angioinvasion, which are the main features in
follicular carcinoma, cannot be detected by
FNAC.
Frozen section biopsy -If unavailable, then
hemithyroidectomy is done.
U/S abdomen, chest X-ray, X-ray bones to r/o
metastases
Tru cut biopsy gives tissue diagnosis, but
danger of hemorrhage and injury to vital
structures like trachea, recurrent laryngeal
nerve.
71. MANAGEMENT
PAPILLARY CARCINOMA
Total or near total thyroidectomy.
Suppressive dose of L-Thyroxine 0.3 mg OD life long. TSH level should be < 0.1 m
U/L.
MRND (modified radical neck dissection) type III-if lymph nodes are involved.
Prognosis-Excellent with 90% survival at 10yrs
72.
73. FOLLICULAR CARCINOMA
Total thyroidectomy is done, along with block dissection whenever lymph nodes
are enlarged.
Maintenance dose of L-Thyroxine 0.1 mg O.D or T3 80 μg/day is given lifelong.
On table frozen section biopsy is useful in negative FNAC but doubtful cases.
If secondaries are detected therapeutic dose radioactive iodine is given orally.
Secondaries in bone are treated by external radiotherapy.
Internal fixation should be done whenever there is pathological fracture.
74. HURTHLE CELL CARCINOMA
Is a variant of follicular carcinoma of thyroid which contains abundant oxyphill cells. It spreads
more commonly to regional lymph nodes than follicular carcinoma of thyroid.
Note:
Hurthle cell carcinoma does not take up radioactive iodine
It secretes thyroglobulin
Poorer prognosis than follicular cell carcinoma
Regional nodes are commonly involved than follicular carcinoma
Abundant oxyphill cells are specific
Total thyroidectomy, MRND and TSH suppression is the treatment
75.
76. ANAPLASTIC CARCINOMA
One of the least common thyroid carcinomas-1.6% of all thyroid cancers.
It occurs in elderly and is a very aggressive tumour of short duration, presents with
a swelling in thyroid region which is rapidly progressive causing—
i. Stridor and hoarseness of voice due to tracheal obstruction.
ii. Dysphagia.
iii. Fixity to the skin.
iv. Positive Berry’s sign—involvement of carotid sheath leads to absence of carotid
pulsation.
77.
78. CONT..
Swelling is hard, with involvement of isthmus and lateral lobes.
FNAC is diagnostic.
Tracheostomy and isthmectomy has got a role to relieve respiratory obstruction
temporarily.
Treatment is external radiotherapy, as usually thyroidectomy is not possible.
Adriamycin as chemotherapy.
Poorest prognosis of all thyroid malignancies and one of the worst survival rates
of all malignancies in general.
79. MEDULLARY CARCINOMA OF THYROID (MCT)
Uncommon (5%) type of thyroid malignancy.
Arises from the parafollicular ‘C’ cells derived from the neural crest and located mostly at the
upper pole of the thyroid gland.
It contains characteristic ‘amyloid stroma’ wherein malignant cells are dispersed.
Immunohistochemistry reveals calcitonin in amyloid.
In these patients blood levels of calcitonin both basal as well as that following calcium or
pentagastrin stimulation is high, a very useful tumour marker.
Tumour also secretes serotonin, prostaglandins, ACTH and VIP(PARANEOPLASTIC SYNDROME)
It spreads mainly to lymph nodes (60%).
80.
81. CONT..
• It can be:
• Sporadic-usually solitary(70%)
• Associated with MEN II syndrome and pheochromocytoma with hypertension.
When associated with MEN type II B plus pheochromocytoma (Sipple’s
disease) it is most aggressive.
• Familial MCT (20%)-commonly multicentric, AD mutations on chromosome
10.
• There may be mucosal neuromas in lips, oral cavity, tongue, eyelids with marfanoid
features.
• MCT is not TSH dependent and does not take up radioactive iodine.
83. CLINICAL FEATURES
A slight female preponderance is observed.
Thyroid swelling often with enlargement of neck lymph nodes.
Diarrhoea, flushing (30%).
Hypertension, pheochromocytomas and mucosal neuromas when associated with
MEN II syndrome.
Sporadic and familial types occur in adulthood whereas cases associated with
MEN syndrome II occur in younger age groups
84. INVESTIGATIONS
FNAC: shows amyloid deposition with dispersed malignant cells and “C” cell
hyperplasia.
Tumour marker: Calcitonin level will be higher.
U/S abdomen.
U/S neck to see neck nodes. CT neck and chest to identify neck and mediastinal
nodes.
Urinary VMA, urinary catecholamines, urinary metanephrine, serum calcium,
serum parathormone estimation.
111 Indium octreotide scanning-useful in detecting MCT(70% sensitivity). Also
used for postop follow up to find out residual/metastatic disease.
85.
86. TREATMENT
Surgery is the main therapeutic modality. Total thyroidectomy with central node
dissection (level 6) in all patients even if there are no nodes in the neck plus
maintenance dose of L-thyroxine.
Neck lymph nodes block dissection if lymph nodes are involved. Later regular U/S
neck is done to detect early neck nodes.
No role of suppressive hormone therapy or radioactive iodine therapy.
External beam radiotherapy for residual tumour disease.
If there is associated pheochromocytoma it should be treated surgically by
adrenalectomy, followed later by thyroidectomy.
87. MALIGNANT LYMPHOMA
It is Non-HL type.
Associated with pre-existing Hashimoto’s thyroiditis
CLINICAL FEATURES
The most common clinical presentation is an enlarging thyroid mass.
Patients may have evidence of hypothyroidism.
Local extension into the aerodigestive tract or surrounding tissues may cause
dysphagia, dyspnea, or symptoms of pressure in the neck.
Vocal fold paralysis and hoarseness suggest involvement of the recurrent laryngeal
nerve.
88. CONT..
Regional and distant lymphadenopathy is common
FNAC is useful to diagnose the condition (Often trucut biopsy).
Chemotherapy is the mainstay of treatment. Doxorubicin or CHOP (i.e.
cyclophosphamide, hydroxydaunomycin, Oncovin [vincristine], prednisone) is the
commonly used chemotherapeutic regimen.
Rarely, total thyroidectomy is done to enhance the results.