Pharmacology

1. Benzodiazepine
A controlled substance
By: Heidi Palomo

2. Introduction
Very used in the USA.
Numerous Causes this can be
prescribed.
Physicians take extra caution when
prescribing this medications.

3. Pharmacodynamics
Benzodiazepines
bind to GABA
receptors in the
CNS.
One attached they
make a change in
the receptor.

4. Pharmacokinetics
•Onset of Action
•Duration of effect
•Absorption
•Distribution
•Metabolism
•Excretion
•Route of administration
•Medication administer

5. Benzodiazepines
in Clinical
practice
Types
Alprazolam
(Anxiety, Panic
disorder)
Clonazepam
(anticonvulsant
and anxiolytic)
Lorazepam
(anticonvulsant
and anxiolytic)
Midazolam
(preoperatively,
anxiolytic)
Diazepam
(sedation,
anxiety,
relaxation)

6. Toxicity and
altered
states
When drug levels accumulate of benzodiazepines cognitive impairment
is induced in central nervous system.
Amnesia
Sedation
Drowsiness
Ataxia
Inattentiveness
Delirium

7. • Effects occur more often in elderly population.
Risk for falls, fractures
or automobile
accidents
Anterograde amnesia
• Affection of the long-term
memory (episodic or
implicit)

8. Conclusion
• Benzodiazepines should be taken
with responsibility.
• Specially on elderly people
because of their side effects that
can cause amnesia, or even
respiratory depression.

9. Choosing this article
Pub Med
Trustful information
Very complete
Understandable and comprehensive
Well-organized

10. References
• Griffin, C. E., 3rd, Kaye, A. M., Bueno, F. R., & Kaye, A. D. (2013). Benzodiazepine pharmacology and central nervous
system-mediated effects. The Ochsner journal, 13(2), 214–223. Retrieved from
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684331/