1. Francesca Madiai, PhD
1000 Urlin Ave. ● Columbus, OH 43212● (614) 314-0574 ● Francesca.delfina@gmail.com
❖❖ CLINICAL RESEARCH COORDINATOR ❖❖
SUMMARY: A GCP-certified professional offering 10+ years of experience in clinical
research coordination and extensive scientific knowledge in Immunology/Molecular Biology
with emphasis in Rheumatology.
Demonstrated ability to support the management and coordinate the tasks of multiple
clinical research studies including budget negotiations , regulatory submission and
compliance, and conducting patient visits
Initiated contact and mediated between physicians and medical liaisons in procuring clinical
trials.
AREAS OF EXPERTISE
Project Planning
Clinical Data
Collection
Data Capture
Electronic Medical
Records
HIPPA Compliance
Protocol
Development
Internal/Central IRB
GCP and GLP
Medical Writing
Research Grant
Writing
Study Feasibility
Assessment
KEY ACCOMPLISHMENTS
• Performed a variety of Molecular Biology and Immunology techniques and
experiments for the advancement of basic and pain research.
• Designed, composed and implemented new protocols and procedures;
adapted existing protocols and procedures to meet specific experimental
goals. Published in scientific journals and assisted in writing and obtaining
NIH research grants.
• Trained and supervised junior level lab personnel and students (high school
through PhD/MD).
• Managed lab supplies and equipment, kept precise records of daily lab work,
conducted computer-based data analysis and statistics.
• Served as study coordinator for over 10 years effectively to implement and
facilitate research studies.
EDUCATION

2. 1983 - 1985 Scientific High School Liceo Scientifico Enriquez,
Livorno, Italy
1986 Winder-Barrow High School, Winder, Georgia
High School Diploma
1986 - 1990 Department of Biological Sciences, Honor Tutorial
College, Ohio University, Athens, Ohio
B.S., Summa Cum Laude, Zoology with emphasis in
Microbiology
1991 - 1998 Department of Molecular, Cellular and
Developmental Biology, The Ohio State University,
Columbus, Ohio, Ph.D., Molecular, Cellular and
Developmental Biology
Dissertation:
"Cloning, characterization and expression of the murine fibroblast growth
factor-1 gene".
Committee members: Kevin V. Hackshaw, M.D., Ing-Ming Chiu, Ph.D.,
Ronald L. Whisler, M.D./Ph.D., Lai-Chu Wu, Ph.D.
PROFESSIONAL EXPERIENCE
1989 (Jun - Sept) Laboratory Technician, Department of Chemistry
Ohio University, Athens, Ohio
1991 - 1992 Graduate Teaching Associate, Department of
Molecular, Cellular and Developmental Biology, The
Ohio State University, Columbus, Ohio
1991 - 1998 Graduate Research Associate, Department of
Molecular, Cellular and Developmental Biology, The
Ohio State University, Columbus, Ohio
1998 - 2000 Postdoctoral Researcher, Department of Internal
Medicine, The Ohio State University, Columbus, Ohio
2000 - Present Research Associate, Department of Internal Medicine

3. The Ohio State University, Columbus, Ohio
2005-Present Clinical Research Coordinator, The Ohio State
University Wexner Medical Center, Division of
Rheumatology, Columbus, Ohio
CLINICAL TRIAL EXPERIENCE
• Extensive experience with over fifty clinical trials in Rheumatology
including Fibromyalgia, Osteoarthritis, Rheumatoid Arthritis, Gout, and
Systemic Lupus Erythematosus.
• Assisted with the preparation of IRB applications, including protocol and
informed consents and obtained approval to conduct the study.
• Created Standard Operating Procedures as necessary.
• Developed and maintained source documents and regulatory
documentation of clinical trials.
• Conducted day-to-day execution of clinical research protocols including
obtaining informed consent, completing study procedures, and
dispensing, accounting for study drug, and documenting drug
compliance.
• Responsible for recruiting prospective research subjects for clinical
trials. Responsible for clinical communication with central and local IRBs
and maintaining ethical approval for studies, from initial study approval
through study amendments, annual continuations, and termination.
• Documented and conducted appropriate correspondence regarding
adverse events, including multiple severe adverse events.
• Responsible for clinical tasks including patient assessments,
venipuncture, vital signs, body measurements and ECGs.
• Worked with contracts and budgets with study Sponsors from study
start-up through study close-out.
HONORS AND AWARDS

4. 2001Columbus Medical Foundation Research Award
2003 Columbus Medical Foundation Research Award
PUBLICATIONS
1. Madiai F, Hackshaw KV, Chiu I-M. Cloning and characterization of the
mouse FGF-1 gene. Gene, 179: 231 - 236, 1996.
2. Madiai F, Hackshaw KV, Chiu I-M. Characterization of the entire
transcriptional unit of the mouse FGF-1 Gene: Tissue specific expression of
the FGF-1.A mRNA . J Biol Chem, 274: 11937 - 11944, 1999.
3. Madiai F, Hackshaw KV. Lack of FGF-1 overexpression during
autoimmune nephritis in the kidneys of MRL lpr/lpr mice. Res Commun
Mol Path Pharm, 103: 37 - 44, 1999.
4. Zhang Ying-xue, Madiai F, , Hackshaw KV. Cloning and Differential
Expression of a Novel Form of Mouse Acidic Fibroblast Growth Factor
(Afgf) mRNA. Biochem Biophys Acta, 1521, 45 - 58, 2001.
5. Madiai F, Hackshaw KV. Expression of the mouse FGF1.A during
embryonic development and in the aging heart. Res Commun Mol Path
Pharm., 112: 139 – 144, 2002.
6. Madiai F, Hussain S-R, Goettl VM, Burry R, Stephens RL, Hackshaw KV.
Upregulation of FGF-2 in reactive spinal cord astrocytes following
unilateral lumbar spinal nerve ligation. Exp Brain Res., 148: 366 – 376,
2003.
7. Madiai F, Goettl VM, Stephens RL, Hackshaw KV. Ciliary Neurotrophic
Factor immunoreactivity is not associated with reactive astrocytes in the
rat spinal cord following unilateral spinal nerve ligation Neuroscience Res
Comm. 34:122-129, 2004
8. Alzate O, Hussain SR, Goettl VM, Tewari AK, Madiai F, Stephens RL Jr,
Hackshaw KV. Proteomic identification of brainstem cytosolic proteins in
a neuropathic pain model. Brain Res Mol Brain Res. 128:193-200,
2004.
9. Madiai F, Goettl VM, Hussain SR, Clairmont AR, Stephens RL Jr,
Hackshaw KV. Anti-fibroblast growth factor-2 antibodies attenuate
mechanical allodynia in a rat model of neuropathic pain. J Mol
Neurosci. 27:315-324, 2005.
10. Wu LC, Goettl VM, Madiai F, Hackshaw KV, Hussain SR. Reciprocal
regulation of nuclear factor kappa B and its inhibitor ZAS3 after
peripheral nerve injury. BMC Neurosci. 12:7-14, 2006.
11. Liu S, Madiai F, Hackshaw KV, Allen CE, Carl J, Huschart E, Karanfilov
C, Litsky A, Hickey CJ, Marcucci G, Huja S, Agarwal S, Yu J, Caligiuri
MA, Wu LC. The large zinc finger protein ZAS3 is a critical modulator of
osteoclastogenesis. PLoS One. 6(3):e17161, 2011.
12. Wu LC, Pfeiffer DR, Calhoon EA, Madiai F, Marcucci G, Liu S, Jurkowitz
MS. Purification, identification, and cloning of lysoplasmalogenase, the

5. enzyme that catalyzes hydrolysis of the vinyl ether bond of
lysoplasmalogen. J Biol Chem. 286(28):24916-30, 2011

6. enzyme that catalyzes hydrolysis of the vinyl ether bond of
lysoplasmalogen. J Biol Chem. 286(28):24916-30, 2011