2. Case
• 18yrs old Male
• Pain left leg from below the knee joint
• From last one year
• Aggravation on standing
• Relief on taking rest
• No medications were used for pain relief
3. HPOC
• History dates a year back when he got bitten by something while
working in fields.
• There was a little bleeding from the area bitten.
• Pain was bearable.
• First Aid was given by the local quack.
• Area got infected and later turned into a pusy wound.
• Went to see some Hakim who told that you were bitten by a snake.
• The wound took at least a month to heal.
• He didn’t seek help from any medical advice for his problem.
4. • Occupation
• Type of the snake
• Site of the bite
• Marks of bite
• Bleeding
• Swelling / Bruising / bleb formation
• Pain intensity and progression
• Any breathing difficulties
• Non specific signs
• Time of bite and time of presentation
Important Questions to be asked
5. Red flags
• Presence of two bite marks
• Redness and swelling at the site of bite
• Blistering around the bite
• Bleb formation
• Severe tenderness and edema
6. Differential Diagnosis of Pain in Leg
• Musculoskeletal
• Trauma
• DVT
• Varicose Veins
• Ischemia
• Necrotizing fasciitis
• Neuropathy
7. GLOBAL SITUATION OF SNAKE BITE
• An estimated 5.4million people each year are bitten with up to
2.7million envenoming.
• Around 81000 to 138000 people die each year because of snake bite
and around three times as many amputation and other permanent
disabilities are caused by snake bites annually.
• In Asia up to 2 million people are envenomed every year.
8. FACTS
• In June 2017,the WHO added snakebite to the list of neglected
tropical diseases.
• 80% of the total snake species found in the world are non poisonous
and only 10% is poisonous.
• Primarily only 4 species of snakes are dangerous to man, named
Cobra, Krait, Russell’s Viper and Saw scaled Viper.
• India has been recognized as the country with highest snake bite
mortality.
10. ELAPIDAE
• These are extremely venomous snakes.
• These include Cobra, Mumba, krait, and coral snake.
11. Neurotoxic venom
Venoms with Neurotoxic activity produce paralysis and respiratory
distress by binding the nicotinic acetylcholine receptors and preventing
the depolarizing action of acetylcholine
The most important effect of neurotoxins is to prevent the transmission
of nerve impulses on cholinergic synapses which cause muscle paralysis
respiratory failure and death by asphyxiation
12. VIPERIDAE
• These venomous snakes have long hinged fangs.
• They include Adder, rattlesnake, Russel and green viper.
13. HEMOTOXIC VENOM
• The venom of rattlesnakes and other pit vipers damages tissue
around the bite.
• Venom may cause changes in blood cells, prevent blood from
clotting, and damage blood vessels, causing them to leak.
• These changes can lead to internal hemorrhage, respiratory, and
kidney failure.
14. HYDROPHIDAE
• They are the sea snakes and highly venomous
• They an be readily identified by their flattened tails.
15. MYOTOXIC VENOM
• When envenomation occurs in humans, bites are often painless and
minimal swelling occurs. Symptoms include headaches, sweating,
vomiting, body aches, muscle stiffness, and eventually paralysis. As
with the eels that the snakes prey on, the paralysis of any muscles
involved in breathing or swallowing may be fatal.
16. DRY BITE
• About 50% of snakebite cases can be dry bites.
• They are characterized by fang and tooth marks and the absence of
injected venom.
17. ENVENOMATION
• Moderate envenomation is more likely to cause symptoms of severe
pain, swelling of the whole limb, and general feelings of illness, such
as nausea, vomiting, and weakness.
• Severe envenomation symptoms include severe pain, severe swelling,
difficulty breathing, moderate to severe bleeding, and signs of shock.
18. DIAGNOSIS OF SNAKE BITE
• FANG MARKS
Classically two puncture wounds separated by a distance varying
from 8 mm to 4 cm depending on the species involved.
However a side swipe may produce only a single puncture while
multiple bites could result in numerous fang marks
19. SNAKE VENOM
• Combination of enzymatic and non enzymatic polypeptides
• Acidic
• On drying ….. fine needle like crystals
• Water soluble
• Lethal dose for
• Cobra 0.12gms
• Krait 0.06gms
• Russell snake 0.15
Healthy angered and hungry snake unload more venom than a recently satiated
snake.
21. CLINICAL FEATURES
When venom has not been injected
Out of fear
• Vasovagal attack
• Collapse Slowing of heart rate
22. CLINICAL SYMPTOMS
• Severe local pain with burning ,bursting and throbbing, at the site of
the bite.
• Local swelling
• Painful enlarged regional lymph nodes
• Bites by sea snakes my virtually be painless and may cause negligible
local swelling.
23. ASSESS SIGNS OF ENVENOMING
• Fang marks
• Local Swelling
• Bruising
• Lymphangitis
• Blistering
• Necrosis
24. SYSTEMIC FEATURES
Nausea, vomiting, malaise, abdominal pain, weakness, drowsiness,
prostration
Cardiovascular symptoms
Dizziness, faintness, collapse, shock, hypotension, cardiac arrhythmias,
pulmonary edema and cardiac arrest
Bleeding and clotting disorders
Bleeding from gums, epistaxis, hemoptysis, hematemesis, melena,
hematuria, petechia, purpura, ecchymosis etc.
25. Neurological symptoms
Drowsiness, paresthesia, abnormalities of taste and smell, heavy
eyelids, ptosis, facial palsy, aphonia, generalized and respiratory
paralysis
Skeletal muscle breakdown
Generalized pain, stiffness and tenderness of muscles, trismus,
myoglobinuria, hyperkalemia, cardiac arrest
26. SNAKE BITE MANAGEMENT
Do it RIGHT
• R……Reassure the patient.
• I…….Immobilize basically Pressure Immobilization
• G. H ..….. Go to Hospital immediately.
• Tell the doctor of any specific symptoms such as ptosis that manifest
on the way to hospital.
27. DONTS IN FIRST AID
• Do not apply the tourniquet.
• Do not wash the bite site with soap or any other solution to remove
the venom.
• Do not make cuts or incisions on or near the bitten area.
• Do not freeze or apply extreme cold to the area of bite.
• Do not apply any kind of potentially harmful herbal or household
remedy.
28. • Do not attempt to suck out venom.
• Do not give the victim anything to drink if semi unconscious.
• Do not take the patient to any quack.
29. TREATMENT PROTOCOL IN HOSPITAL
• Deal with airway, breathing and treatment of shock.
• IV access should be established in unaffected extremity.
• CBC, coagulation profile and fibrinogen concentration should be assessed.
• All the patients should be kept under observation for a minimum of 24
hours.
• Many species particularly the krait and the hump nosed pit viper are
known for delayed appearance of symptoms which can develop after 6 to
12 hours.
31. ASV
• Anti-Snake venom serum is a sterile preparation containing purified
and concentrated immunoglobulins (Polyvalent Equine
Immunoglobulins) obtained from the serum of healthy horses,
donkey or sheep which are immunized against the venoms of one or
more species.
32. NIH
• Biological Production Division National Institute of Health Islamabad,
PAKISTAN FOR THE REGISTERED MEDICAL PRACTITIONER ANTI-SNAKE
VENOM SERUM (Polyvalent Equine Immunoglobulins)
33. SPECIFIC SERUM TREATMENT
• At first the dose of 10-30 ml of the serum will be injected
intravenously very slowly.
• The second dose can be repeated two hours after the first dose or
even earlier depending on the condition of the patient and severity of
symptoms.
34. • Further doses can be repeated after six hours interval until the
symptoms disappear completely.
• One third of first dose of anti-snake venom serum can be
administered locally to prevent gangrene development.
• Antiserum can be diluted with isotonic solution.
37. FACTS
• Rabies is a vaccine-preventable viral disease.
• Dogs are the main source of human rabies deaths, contributing up to 99% of all
rabies transmissions to humans.
• Interrupting transmission is feasible through vaccination of dogs and prevention
of dog bites.
• 40% of people bitten by suspect rabid animals are children under 15 years of age.
• Immediate, thorough wound washing with soap and water after contact with a
suspect rabid animal is crucial and can save lives.
38. MORTALITY / MORBIDITY
• WOUND INFECETION AND CELLULITIS
• Puncture wounds have a higher rate of infection than lacerations.
• Lacerations cause more damage to tissues than puncture wounds.
• Septic arthritis from wounds in joint spaces.
• OSTEIOMYELITIS FROM DEEP WOUNDS
• MENINGISTI FROM PENETRATING SKULL WOUNDS
39. SYMPTOMS
INCUBATION PERIOD
• Typically 2 to 3 months
• May vary from 1 week to 1 month
INITIAL SYMPTOMS
• Pain with Fever
• Unexplained tingling, pricking or burning sensation
• Progressive inflammation of brain and Spinal cord
40. FORMS OF RABIES
• FURIOUS RABIES
• Hyperactivity
• Excitable behaviors
• Hydrophobia
• Aerophobia
• Death
• PARALYTIC RABIES
• Muscles gradually become paralyzed
• Coma develops slowly
• Death
41. POST EXPOSURE PROPHYLAXIS (PEP)
• Extensive washing and local treatment of the bite wound or scratch as
soon as possible after a suspected exposure
• Stat dose of ATT
• A course of potent and effective rabies vaccine
• Administration of rabies immunoglobulin (RIG), if indicated.
42. EXPOSURE RISK AND INDICATION FOR PEP
• CATEGORY I WASHING OF EXPOSED SKIN AND NO PEP
• Bite while feeding the suspect animal where skin is intact
• CATEGORY II PEP
• Minor scratches without bleeding from contact or licks on broken skin
• CATEGORY III PEP AND RIG
• One or more bites, scratches.
• Licks on broken skin.
43. PROTOCOL OF RABIES SHOT
• A regimen of four 1-mL vaccines should be administered
intramuscularly to previously unvaccinated persons. The first dose of
the four-dose course should be administered as soon as possible after
exposure. Additional doses should be administered on days 3, 7, and
14 after the first vaccination.
44. TYPES OF THE RABIES VACCINE PEP
1. RABIES IMMUNOGLOBULINS RIG
HRIG
ERIG
2. ANTI RABIES VACCINE
HDCV
PCECV
• HRIG
• ERIG
• 2. Anti Rabies Vaccine
• Human diploid cell vaccine HDCV
45. RABIES IMMUNOGLOBULINS
• Rabies immunoglobulins are special neutralizinf antibodies that
immediately neutralize virus on contqct.
• Tabies iimunoglobukins gives a coating to the virus so that it cannot
enter the nerveending resulting in reduction or total obliteration of
inoculated virus
46. RABIES IMMUNOGLOBULINS
• There are two types of specific Rabies Immunoglobulins:
• 1. Human Rabies Immunoglobulin (HRIG)
• 2. Equine Rabies imuunoglibulin (ERIG)
47. HUMAN RABIES IMMUNOGLOBULINS
• It is a liquid of freeze dried preparation containing immunoglobulins
mailny IgG obtained from plasma or serum of donors immunized
gainst rabies and ontains specific antibiotics that neutralie the rabies
virus
• It is prepared from palsm of more than 1000 donors
• IT provies passive prtection whrn given immedicately to individuals
exposed to rabies virus
48. Equine Rabies Immunoglobulin
• Advantages
• Massice yield
• Much afforable than human rabies immunoglobulin low cost
• Widely avaialble
• Modern purification and ultra filtration technologies has made it
safer.
• Disadvantages
• Presence of forign protien
• Chances of immudiate hypersensitvity
49. TEST DOSE OF RIG
• 0.1ML OF 1:10 DILUTED RIG wih t normak saline is given intradermally
on the left forearm.
• Observation the patient is observed for 15 minutes for any local or
reactions
50. MECHANISM OF ACTION OF RIG
• Following intramuscular administration – Rabies immunoglobulin
provides immediate passive antibodies for a short period of time. This
protects the patient until the patient can produce antibodies from the
rabies vaccine.An adequate titre of passive antibody is present 24
hours after RIG administration.Duration of Protective Effect:Short:
Rabies immunoglobulin has a half-life of approximately 21 days.Cross
sensitivity and/or related problems:Patients sensitive to other human
immune globulin products may be sensitive to Rabies
Immunoglobulin also.
51. WHO STANCE ON ADMINSTRQTION OF RIG
• RIG hould be administered nly once, preferably at, or as soon as
possible after, the infilitration of PEP.
• RIG is infiltereated into and around the wound
• For optimal effectiveness the maximum dose calculation for RIG is
40IU/Kg body weight for equine derived RIG (eRIG).
52. RECOMMENDED TIMELINES FOR RABIES
VACCINE
• If a dog, cat, bat, or other mammal you might suspect has rabies has
bitten you, get to the doctor. The first dose of the vaccine should be
administered within the first 24 hours after exposure.
53. COURSE OF RABIES VACCINE
• The first dose of the 4-dose course should be administered as soon as
possible after exposure (day 0). Additional doses then should be
administered on days 3, 7, and 14 after the first vaccination.
Editor's Notes
Todays presentatipn is based on a case who presented almost two amonths ago
Leg pain turned a constant feature after that incident
So the imporatn questions to be asked were about his occupation as high risk groups include rural agricultural workers, herders, fishermen etc
Its also important to ask if the patinet has happened to see the snake himself
Site is imporatnt as Usually such bites are more on extremities
Do inquire about twi disticnt bite marks and bleeding
Do ask if there was any swelling bruising and even some bleb formation
Pain intensity is imporatnat as it progresses with time
Its important to ask if there was any breathing difficulty and other non specific signs like nausea vomiting fever vertigo etc
Time of bite and time of presentation is also very important
These red flags should make you think what should be the immediate course of action
DD for pain in leg is that the paijn might be muscular or may have occurred due to any trauma.
Such persistent pain migh tbe due to DVT, varicose viens ichemia necrotizing fasciitis or some neuropathy as well
So lets talk about global situation of snake bite
ACCORDING TO WHO
SNAKE VENOMS ARE USUALLY CLASSIFIED AS
Note
Krait and russel viper is much more toxic that that of cobra
These venoms consist primarily of neurotoxins that generally cause death by muscle paralysis, RESPIRSTORY DISTRESS AND DEATHH BY ASPHYXIATION
Hemotoxins form the rattle snake and pit vipers destroy red blood cells, disrupt blood clotting, and/ can cause organ degeneration
These changes can lead to internal hemorrhage, respiratory, and kidney failure and can ultimately lead to death
... Venoms of this kind have a proteolytic action.
They produce swelling cardiovascular damage and eventual necrosis.
They also disrupt blood clothing and in the process of destroying the bloods functionality severely damage internal organs and other body tissues which can be extremely painful. The intermediate cause of death in such cases is usually hypovolemic shock
Envenomation increases capillary permeability that results in blood and plasma loss form the intravascular to the extracellular space creating edema which in case of being sufficiently important nay cause circulatory compromise and hypovolemic shock
The venom is very potent and toxic.
MYOTOXINS IN THE VENOM DAMAGE THE SKELETAL MUSCLES AND CARDIAC TISSUE A
A dry bite is a bite by a venomous SNAKE in which no venom is released. ...
50 % of the bites by venomous snakes are dry bites that result in negligible envenomation.
This is characterized by fang and tooth marks but no injected venom.
In moderate envenomation there could be severe pain, some swelling of the whole limb and general feeling of illlness.
But in severe cases three could be signs of breathing difficulty and shock
To confirm snake bite one should look for fang marks separated by some distance depending uponth especies involved
Briefly about snake venom
It’s a combination of enymatic and non enzymatic polypeptides
ENVENOMATION HAS LOCAL AND SYSTEMIC EFFECTS BOTH
After a dry snake bite due to fear there might be misleading symptoms like vasovagal shock and collapse
Following the bite there is increasing local pain with burning ,bursting and throbbing, at the site of t
Local swelling that gradually extends proximally up the bitten limb with extreme tenderness and paInful enlarged regional lymph nodes draining the site of the bite.
Bites by sea snakes my virtually be painless and may cause negligible local swelling. Someone who is sleeping may not even wake up when bitten by krait and there may be no detectable fang marks or signs of local envenoming.
APART FROM FANG MARKS THERE COULD BE Local swelling AND bruising and THERE MAY BE inflammation OF MORE THAN HALF OF THE LIMB.
AND THAT TOO WITHIN FEW HOURS AFTER THE BITE
LOOK FOR THE Enlarged tender lymph nodes draining the bitten limb.
Any Blister or bullae.
Also check Necrosis of part of limb
Generalized or systemic symptoms INCLUDE Nausea, vomiting, malaise, abdominal pain, weakness, drowsiness, prostration
cardiovascular symptoms
Dizziness, faintness, collapse, shock, hypotension, cardiac arrhythmias, pulmonary edema and cardiac arrest
Bleeding and clotting disorders
Apart from the bleeding from the wound there might be bleeding from gums, epistaxis, hemoptysis, hematemesis, melena, hematuria, petechia, purpura, ecchymosis etc.
First Aid is based primarily around this mnemonic RIGHT
R is to reassure the patient as 70% of all the snakebites are form non venomous species and Only 50% of bites by venomous species actually envenomate the patient.
Second we need to Immobilize the same way as fractured limb.
Its purpose is to retard the movement of venom from bite into the circulation , thus buying time for the patient to reach medical care.
Since Traditional remedies have no proven benefit in treating snakebite so patient should be immediately taken to any government hospital where antivenom is available
Tell the doctor of any specific symptoms such as ptosis that might manifest on the way to hospital.
These donts are recommended by WHO
Initial management is to deal with airway, breathing and treatment of Shock
Also give tetanus toxiid
IV access should be establised in unaffected extremity
Coagluation profile and fibrinogen concentration should also be assessed .
All the patinets should be kept under observation for a minimum of 24 hours
Because some species are known for delayed appearance of symptoms which can develop after 6 to 12 hours.
anitvenom is immunoglobulin usually pepsin refined fragments of whole IgG purified form the plasma of hrse, mule or donkey or sheep that hs been immunized with venoms of one or nore species of snakes
Anti-Snake venom serum is a sterile preparation containing purified and concentrated immunoglobulins obtained from the serum of healthy horses immunized against the vBiological Production Division National Institute of Health Islamabad, PAKISTAN FOR THE REGISTERED MEDICAL PRACTITIONER ANTI-SNAKE VENOM SERUM (Polyvalent Equine Immunoglobulins)enoms of all the four poisonous snakes of Pakistan
We need to have a little info about what ASV is.
anitvenom is immunoglobulin usually pepsin refined fragments of whole IgG purified form the plasma of hrse, mule or donkey or sheep that hs been immunized with venoms of one or nore species of snakes
Anti-Snake venom serum is a sterile preparation containing purified and concentrated immunoglobulins obtained from the serum of healthy horses immunized against the vBiological Production Division National Institute of Health Islamabad, PAKISTAN FOR THE REGISTERED MEDICAL PRACTITIONER ANTI-SNAKE VENOM SERUM (Polyvalent Equine Immunoglobulins)enoms of all the four poisonous snakes of Pakistan
And this ASV is produced in biological production division of NIS Islamabad.
Once the venom is into the circulation, it is then the ASV that can neutralize it.
Anti-Tetanus Serum or any other supportive therapy can be given as needed
Rabies is a vaccine-preventable, zoonotic, viral disease. Once clinical symptoms appear, rabies is virtually 100% fatal. In up to 99% of cases, domestic dogs are responsible for rabies virus transmission to humans.
It is spread to people and animals through bites or scratches, usually via saliva.
AGE GROUP IS USUALLY LES THAN 15 YRS AS Provoked bites are significantly more frequent than unprovoked bites
THIS POINT IS VERY CRUCIAL THAT IMMEDIATE THOROUGH WOUND WASHING WITH SOAP AND RUNNING WATER CAN SAVE MANY LIVES .
THAT WHY ITS IMPORTANT TO KEEP SOOFI OR GAI SOAPS AT HOME THAT IF ANY SUCH SITUATUION ARISES YOU ARE TO TAKE PROPER TIMELY ACTION.
ONE CAN END UP INTO WOUND INFECTION CELLLULITIS OSTEOMYLITIS FROM DEEP WOUNDS
EVEN MENINGITIS FROM PENETERATING SKULL WOUNDS
The incubation period for rabies is typically 2–3 months but may vary from 1 week to 1 MONTH, depending upon factors such as the location of virus entry and viral load. Initial symptoms of rabies include a fever with pain and unusual or unexplained tingling, pricking, or burning sensation (paraesthesia) at the wound site. As the virus spreads to the central nervous system, progressive and fatal inflammation of the brain and spinal cord develops.
There are two forms of the disease:
Furious rabies results in signs of hyperactivity, excitable behaviour, hydrophobia (fear of water) and sometimes aerophobia (fear of drafts or of fresh air). Death occurs after a few days due to cardio-respiratory arrest.
Paralytic rabies accounts for about 20% of the total number of human cases. This form IS less dramatic BUT HAS A longer course than the furious form. Muscles gradually become paralysed, starting at the site of the bite or scratch. A coma slowly develops, and eventually death occurs.
ITS IMORTANTT TO MENTION HERE THAT The paralytic form of rabies is often misdiagnosed, contributing to the under-reporting of the disease.
Diagnosis
Post-exposure prophylaxis (PEP)
Post-exposure prophylaxis (PEP) is the immediate treatment of a bite victim after rabies exposure. This prevents virus entry into the central nervous system, which results in imminent death. PEP consists of:
Extensive washing and local treatment of the bite wound or scratch as soon as possible after a suspected exposure;
a course of potent and effective rabies vaccine that meets WHO standards; and
the administration of rabies immunoglobulin (RIG), if indicated.
Starting the treatment soon after an exposure to rabies virus can effectively prevent the onset of symptoms and death.
DOG BITE IS TREATED ACCORDING TO CATEGORY OF EXPOSURE
HRIG
ERIG
2. Anti Rabies Vaccine
Human diploid cell vaccine HDCV
Prified Chick Embbryo cell culture vaccine
SINCE RIG IS EQUINE RABIES IMMUNOGLOBULINS, IT IS MANDATORY TO CARRY OUT AN INTRADERMAL TEST TO KNOW THE SENSITIVITY OF THE INDIVIDUAL.
If a dog, cat, bat, or other mammal you might suspect has rabies has bitten you, get to the doctor. The first dose of the vaccine should be administered within the first 24 hours after exposure.
The vaccine should be given at recommended intervals for best results. Talk to your doctor or state or local public health officials if you will not be able to have your shots at the recommended interval. Rabies prevention is a serious matter and changes should not be made in the schedule of doses