In Plant Training at Kumudini Pharma Limited and Presented to R. P. Shaha University. By Md Faiazul Haque Lamem , Student Of Pharmacy . All Rights Reserved.

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Presentedby
Supervisedby
Md Faiazule Haque Lamem
Id No – 19200006
DEPARTMENT OF PHARMACY
R. P. SHAHA UNIVERSITY
Muaj Ibne Sahid
Assistant Professor
DEPARTMENT OF PHARMACY
R. P. SHAHA UNIVERSITY
Presentation on
“In-plant training”

2. Training Reflection ;-
Introduction
• Debasish Kumar Nath, General Manager, Kumudini Pharma Limited.
• S.M Harun-Ur-Rashid, DGM (Production), Kumudini Pharma Limited.
• Md. Aminul Islam,AGM (QualityAssurance), Kumudini Pharma Limited.
• Shukla Sarkar, Deputy Manager, QA, Kumudini Pharma Limited.
• Nihar Ranjan, Deputy Manager, Quality Control, Kumudini Pharma Limited.
• Ahsanul Kabir, Production Manager, Kumudini Pharma Limited.
• Md. Sohag Uddin, Senior Officer, Production, Kumudini Pharma Limited.
Acknowledgement

3. Systematic Safe storage of related goods
Efficient distribution of pharmaceutical products, and Quality medications
Areas of warehouse
 Quarantine room
 Cold and cool room
 Passed materials area
 Rejected materials room
 Loading / unloading area
Figure – Layout of Ware House in KPL 3
Warehouse

4. FIFO
FEFO
Store Area
 Materials of storage:
I. Excipients
II. Active ingredients
III.Packaging materials.
COOL= 15℃ - 20℃
COLD= 2℃ - 8℃
 Temperature
 Method  Color Tags Used in Warehouse
- Quarantine
- Under Test
- Passed(Accepted)

5. Production
 The production department in Kumudini Pharma Limited is responsible for
Manufacturing drugs in accordance with established standards and regulations.
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Production Department
Solid dosage form Liquid dosage form Semi-solid dosage form
Tablet Capsule PFS Syrup Suspension Cream, Ointment

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Tablet
 A tablet is a solid dosage form for oral use, that consists of suitable
pharmaceutical excipients and active ingredients prepared by compression
Active
Ingredient
Excipient
Granulation
 Dry Granulation
 Wet Granulation
Compression
Coating
Packing
16 ,45 station
Enteric, Film coating
Blistering Alu-Alu, Alu-PVC, Alu-PVDC
Primary, Secondary ,Tertiary Packing
a b c d
a) Vigotrum Gold
Multivitamin Mineral
b) Esomiloc 20 mg Tablet
Esomeprazole
c) Rubee 20 mg Tablet
Rabeprazole Sodium
d) Orgy 10 mg Tablet
Cetirizine Dihydrochloride
Observed product:
Tablet Manufacturing Process-

7. Granulation
Process of converting powders into granules to form tablets by using a binder
solution/solvent or by application of pressure on powders.

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Tablet Compression
 After the preparation of granules or sized slugs or mixing of ingredients, they are
compressed to get final product.
16 station 45 station ( with two outlet)
Put materials into hopper
Filling of dies
Compression between
the rotating area
of punch and dies
Ejection

9. Tablet Coating
 Tablet coating is the application of a coating material to the exterior part of a tablet.
Defects of tablets
 Capping
 Cracking
 Chipping
Coating solution making
Coating Machine

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Capsules
 Capsules are oral dosage forms containing medication in a shell, typically made of
gelatin, for easy administration.
“Hard Gelatin Capsules”
Consist of two parts, the Body, and the Cap,
Observed product:  Omiloc 20mg
Omeprazole
Inserter
Manual Capsule filler

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Semi-solid Products
 Semi- solids are neither solid nor liquid , products when applied to the skin treat a
pathological condition and protects from another harmful environment.
Semi- solid products like:  Cream  Ointment
 Naftifun cream
Naftifine Hydrochloride
 Curex Cream
Crotamiton 10% topical
Observed product:
Figure- Product filling machine
Manufacturing Process-
Water
Phase
OIL
Phase
Milky Appearance > Cooling
Mixing

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Liquid Products
 Liquid dosage forms are medications , containing a mixture of active drug components
and excipients dissolved in a suitable mixtures of solvents.
 Urilizer 200 ml
Potassium Citrate + Citric Acid.
 Ambroxol Syrup 100ml
Ambroxol HCL BP 15mg
Observed product:
Liquid
Preparation
Bottle
Washing
Labeling

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Packaging
 Final stage in production, Ensures secure packaging, accurate labeling, and maintaining
quality standards for final product distribution.

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Blister packaging machine
 Jornen blister machine

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Product Development
 New product formulation.
 Development of existing product.
 Refers to all of the stages involved in bringing a product from concept or idea
through market release and beyond.
Figure – Different stability chambers of Kumudini Pharma Limited
Stability Test
Real time
stability test Accelerated
stability test

16.  Developing Quality control plans and Documentation Protocol
Quality Assurance
Pharmaceutical Quality Assurance (QA) involves implements-
SOP,
BMR,BPR
Developmen
Monitorin
g
Auditin
g
Trainin
g
Fig – QA Dept Room of KPL

17. Quality control
Pharmaceutical Quality Control (QC) involves ensuring –
 Sampling and Testing Products during Production.
 Ensure and manage quality standards of products.
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Quality control test:-

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QC Machineries in KPL
Conductometer
pH Meter Viscometer Friability tester Disintegration Tester Dissolution Tester
Electronic balance Atomic absorption
spectrometry
UV- visible spectroscopy
High Performance Liquid
Chromatography
Karl - Fisher
Titrator

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