Overcoming Barriers to Clinical Trial Enrollment (J. Holloway)

1. Overcoming Barriers to
Clinical Trial Enrollment
Jamie Holloway, PhD
Clinical Research Advocate
Science 37
@jamieNholloway

2. Disclosures
Consultant: Science 37
Advisory: Astra Zeneca, Celgene

3. Overcoming Barriers to
Clinical Trial Enrollment
Jamie Holloway, PhD
Clinical Research Advocate
Science 37
@jamieNholloway

4. What are the biggest barriers that prevent you
from participating in a clinical trial?
 Other responses:
 Currently stable
 Waiting for trial to
open
 Discouraged by
oncologist

5. Where would you start looking for a
clinical trial?

6. What costs do you think should be
covered by a clinical trial?
 Parking
 Transportation/tolls
 Housing/hotels if necessary
 Childcare assistance
 Co-pays
 Time

7. Implicit Bias
 A patient can’t consider a clinical trial if the option isn’t presented to them
 Likely based on a doctor’s assumption that a patient will be more successful on
a standard regimen because of the inability to comply with the requirements of
a clinical trial (with the best of intentions)
 Distance from trial site
 Time off work
 Lack of care giver support
 Complicated routine
 Social media or direct patient outreach overcomes implicit bias

8. Decentralized Clinical Trials

10. Remote Clinical Trials
 Early efforts: Pfizer’s REMOTE trial
 Incorporating wearables into larger studies
 Apple Research Kit
 GSK: PARADE
 Novartis: elevateMS

11. Science 37

12. AOBiome Study
 Completely siteless from start to finish
 Recruitment thought social media advertisements (Facebook, Instagram)
 Trial completed in half the time expected by the sponsor
 Increased minority participation (minority enrollment: 41%)

13. Thinking outside the box for fixed site
trials
 Make it easier for additional sites to open
 Reduce barriers when geographic options are limited
 Group procedures to limit visits
 Limit procedures to what is truly necessary
 Consider whether some procedures can be done off site
 Consider compensation
 Targeted social media outreach
 Many patients rely heavily on patient communities
 Build relationships with relevant communities
 Web presence should be easy to find, easy to understand easy to know how to get
involved
 Engage patients throughout and even after trial completion

15. Thank you!
Jamie Holloway, PhD
Clinical Research Advocate
Science 37
@jamieNholloway