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Patient Centric Research
Ekta Grewal, M.Sc.
interdisciplinary Consortium on Advanced Motion Performance
(iCAMP)
University of Arizona, Tucson, AZ
Overview
 Phantom pain and sensation
 Phantom limb Syndrome
 Phantom Bladder Syndrome
 Objective outcome evaluation
 Quality of life
 Postural balance
 Gait
 Physical activity
2
Phantom Pain &
Sensations
 Continued sensations following
amputation of a body part
 Common phantom pain/sensations
 Phantom limb syndrome
 Phantom bladder syndrome
3
Management of Phantom
Pain
 Mirror Therapy
 Virtual training
 Not ideal for PBS
 What alternatives do we have ?
4
Alternative Medicine
 Guided imagery
 a therapeutic and stress relaxation
technique
 Endorphins
 Chronic pain conditions, anxiety, cancer
pain, interstitial cystitis
5
https://www.youtube.com/watch?v=W
0i0KvHoSiM
Study Design
 A randomized, double blind, parallel group
controlled trial
 Sample size= 30
 Control- relaxation CD, Intervention- Guided
Imagery twice a day for 8 weeks
 Primary outcome
 Pain (VAS)
 Secondary outcome
Quality of life (SF-36)
6
Skills Acquired
 Conducting comprehensive literature
review
 HES database/ICD-10 and OPCS-4
coding
 Research Design
 IRB protocol
 Patient recruitment
7
Objective Outcome
Evaluation
 Outcome evaluation of an intervention
 Outcomes related to quality of life and day to day
mobility are most evaluated through subjective
measures
 Standard questionnaires
 Self-reports
 No objective measures under most scenarios
8
Why Go Objective
 Example
 Orthopedic surgery
 Knee/Hip joint replacement
 What impact does these interventions have on
everyday living and quality of life
 Postural balance, walking, everyday living activities
 Has the above been improved or at least regained
9
Postural Balance
 Body sway
 Previously assessed subjectively
 Improved technology led to objective
measures
 However, still not feasible for busy
clinics
 Advent of Body-worn sensors
10
ML Sway, cm
APSway,cm
Walking Patterns
 Motion Capture/ Mat Systems
 Tedious
 Confined to in lab measurements
 Body-worn sensors
 Out of lab
 In clinic/home
 Easy
11
Daily Spontaneous
Activities
 Generally
 Pedometers
 Very basic measures (steps, calories,
distance)
 Body worn sensors
 Accurate
 Easy
 Valuable measures (steps, speed,
postural transitions, standing time,
walking time)
12
Stress Assessment
 20 Diabetic patients with active
foot ulcers (57± 12 years)
 Stress assessed during clinical visit
for wound dressing
 Body worn sensor (Zephyr
BioHarness®)
 Stress quantified by HRV
13
18%
35%
47%
Typical example of patient with
low stress (a) and high stress (b)
during would dressing
a
b
Duration of
different
levels of stress
experienced
by patients
during wound
dressing
Skills Acquired
 IRB Protocols: CITI, HIPPA
 Research Design and coordination
 SCM/All scripts
 Patient recruitment
 Data collection
 Body worn sensors
 Grants writing
 SPSS
14
Patient population
 Diabetes/Peripheral neuropathy
 Chronic pancreatitis
 Phantom urinary bladder syndrome
15
Accomplishments
Grants Contributions
 Urostomy Association: Grant awarded during research at
Bournemouth, England
 NIH R21: A Tailored Stress-Management intervention to accelerate
wound healing in diabetes (Submitted)
 Diabetes Research and Wellness Foundation Grant: Multifaceted
Patient Centric Approach to Improve Management of Diabetic Foot
Wounds (Submitted)
 American Diabetes Association: An Innovative Game-Based Exercise to
Accelerate Diabetic Foot Wound Healing (Submitted)
Publications
 Parvaneh S, Grewal GS, Grewal E, Menzies RA. Talal TK, Armstrong DG,
Sternberg E, and Najafi B. 2014 ‘Stressing the Dressing: Assessing Stress
during Wound Care in Real-Time Using Wearable Sensors’. Wound
Medicine, 4: 21-26.
 Parvaneh S, Grewal GS, Grewal E, Talal TK, Armstrong DG and Najafi B.
2014 ‘Heart Rate Variability for assessment of physiological stress
response: validation of a personalized algorithm’. (Submitted).
 Grewal E et al. Phantom Urinary Bladder Syndrome: A Systematic
Review (Drafting)
16

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Ekta Grewal

  • 1. Patient Centric Research Ekta Grewal, M.Sc. interdisciplinary Consortium on Advanced Motion Performance (iCAMP) University of Arizona, Tucson, AZ
  • 2. Overview  Phantom pain and sensation  Phantom limb Syndrome  Phantom Bladder Syndrome  Objective outcome evaluation  Quality of life  Postural balance  Gait  Physical activity 2
  • 3. Phantom Pain & Sensations  Continued sensations following amputation of a body part  Common phantom pain/sensations  Phantom limb syndrome  Phantom bladder syndrome 3
  • 4. Management of Phantom Pain  Mirror Therapy  Virtual training  Not ideal for PBS  What alternatives do we have ? 4
  • 5. Alternative Medicine  Guided imagery  a therapeutic and stress relaxation technique  Endorphins  Chronic pain conditions, anxiety, cancer pain, interstitial cystitis 5 https://www.youtube.com/watch?v=W 0i0KvHoSiM
  • 6. Study Design  A randomized, double blind, parallel group controlled trial  Sample size= 30  Control- relaxation CD, Intervention- Guided Imagery twice a day for 8 weeks  Primary outcome  Pain (VAS)  Secondary outcome Quality of life (SF-36) 6
  • 7. Skills Acquired  Conducting comprehensive literature review  HES database/ICD-10 and OPCS-4 coding  Research Design  IRB protocol  Patient recruitment 7
  • 8. Objective Outcome Evaluation  Outcome evaluation of an intervention  Outcomes related to quality of life and day to day mobility are most evaluated through subjective measures  Standard questionnaires  Self-reports  No objective measures under most scenarios 8
  • 9. Why Go Objective  Example  Orthopedic surgery  Knee/Hip joint replacement  What impact does these interventions have on everyday living and quality of life  Postural balance, walking, everyday living activities  Has the above been improved or at least regained 9
  • 10. Postural Balance  Body sway  Previously assessed subjectively  Improved technology led to objective measures  However, still not feasible for busy clinics  Advent of Body-worn sensors 10 ML Sway, cm APSway,cm
  • 11. Walking Patterns  Motion Capture/ Mat Systems  Tedious  Confined to in lab measurements  Body-worn sensors  Out of lab  In clinic/home  Easy 11
  • 12. Daily Spontaneous Activities  Generally  Pedometers  Very basic measures (steps, calories, distance)  Body worn sensors  Accurate  Easy  Valuable measures (steps, speed, postural transitions, standing time, walking time) 12
  • 13. Stress Assessment  20 Diabetic patients with active foot ulcers (57± 12 years)  Stress assessed during clinical visit for wound dressing  Body worn sensor (Zephyr BioHarness®)  Stress quantified by HRV 13 18% 35% 47% Typical example of patient with low stress (a) and high stress (b) during would dressing a b Duration of different levels of stress experienced by patients during wound dressing
  • 14. Skills Acquired  IRB Protocols: CITI, HIPPA  Research Design and coordination  SCM/All scripts  Patient recruitment  Data collection  Body worn sensors  Grants writing  SPSS 14
  • 15. Patient population  Diabetes/Peripheral neuropathy  Chronic pancreatitis  Phantom urinary bladder syndrome 15
  • 16. Accomplishments Grants Contributions  Urostomy Association: Grant awarded during research at Bournemouth, England  NIH R21: A Tailored Stress-Management intervention to accelerate wound healing in diabetes (Submitted)  Diabetes Research and Wellness Foundation Grant: Multifaceted Patient Centric Approach to Improve Management of Diabetic Foot Wounds (Submitted)  American Diabetes Association: An Innovative Game-Based Exercise to Accelerate Diabetic Foot Wound Healing (Submitted) Publications  Parvaneh S, Grewal GS, Grewal E, Menzies RA. Talal TK, Armstrong DG, Sternberg E, and Najafi B. 2014 ‘Stressing the Dressing: Assessing Stress during Wound Care in Real-Time Using Wearable Sensors’. Wound Medicine, 4: 21-26.  Parvaneh S, Grewal GS, Grewal E, Talal TK, Armstrong DG and Najafi B. 2014 ‘Heart Rate Variability for assessment of physiological stress response: validation of a personalized algorithm’. (Submitted).  Grewal E et al. Phantom Urinary Bladder Syndrome: A Systematic Review (Drafting) 16