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1. C R E A T I V E B I O L A B S
WHAT ARE THE
SIGNALING PATHWAY,
DIAGNOSTICS
MARKER, TARGETED
THERAPY OF LUNG
CANCER?
L E T ' S L E A R N S O M E T H I N G A B O U T I T
Lung cancer (LC) has become the
leading cause of cancer death in many
industrialized countries claiming
more than 160000 and 50000 lives
annually in the United States and
Japan, respectively. The majority of
lung cancers, 85% of non-small-cell
lung cancer and 98% of small cell lung
carcinoma, arise in smokers.
INTRODUCTION
TO LUNG
CANCER
RTK signaling cascade
Integrin-mediated signaling
cascade
Growth inhibitory signaling
cascade
MAIN SIGNALING
PATHWAYS IN
BREAST CANCER
THERAPY
Accurate identification of the histological type of cancer and respective protein
biomarkers is crucial for adequate therapy. Proteins are the most suitable
biomarkers for lung cancer diagnosis because of their involvement in cellular
processes.
PROTEIN MARKERS FOR LUNG
CANCER
Lung cancer therapy for RTK
pathway
Lung cancer therapy for integrin-
mediated pathway
Lung cancer therapy for growth
inhibitory pathway
TARGETED
THERAPY FOR
LUNG CANCER
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