1. AJINOMOTO
FOUNDATION
AJINOMOTO 99
AJINOMOTO
Science & Technology Newsletter 2548
FOUNDATION
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( ) . . 1974 . . 1991
Faurion A. F (Umami
Taste Receptor) F F F
F . . 1996 Chaudhari N. F
1
molecular cloning F mGluRs
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F F mGluR4 F F F F (Taste buds)
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( F ) F L-AP4 F F F F F
F F F F F mGluR4
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F F F mGluR4 (
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F F F mGluR4
F N-terminal F
F (glutamate
affinity) F F F F F
F F F mGluR4 F
F F F ( 0.1 mM)
F F mGluR4 F Brain (Neurotransmitter) mGluR4
taste mGluR4 F F (Umami receptor)
FF F F F F receptor mGluR4 F
F F F
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1. Kurihara K, Kashiwayanagi M. Physiological studies on umami taste. J Nutr. 2000 Apr;130(4S Suppl):931S-4S. Review.
2. Chaudhari N, Yang H, Lamp C, Delay E, Cartford C, Than T, Roper S. The taste of monosodium glutamate: membrane
receptors in taste buds. J Neurosci. 1996 Jun 15;16(12):3817-26.
3. Chaudhari N, Landin AM, Roper SD. A metabotropic glutamate receptor variant functions as a taste receptor.
Nat Neurosci. 2000 Feb;3(2):113-9.
1. mGluRs F metabotropic glutamate receptors F receptor G protein F F F F (G protein-
coupled receptors; GPCRs) receptor F F F metabolism F
2. L-AP4 F L-2-amino-4-phosphonobutyrate agonist mGluR4 F F receptor
F F F
