2018 Nephrology Update - prof. Hussein Sheashaa MNDU 8

1. 2018 Nephrology
Update
Hussein Sheashaa, MD, FACP
Professor of Nephrology, Urology and Nephrology Center and Director of
Medical E-Learning Unit, Mansoura University, and Executive Director of
ESNT- Virtual Academy: http://lms.mans.edu.eg/esnt/
8th
MNDU Conference, March 30th
, 2018

2. 1. Introduction
2. Clinical Nephrology:
A. Diabetes and new trials
B. NS and lupus nephritis
C. Chronic kidney disease
D. CKD-MBD
3. Dialysis
4. Transplantation:
A. Tacrolimus monitoring
B. PTDM and HCV
C. Closing
Focus of The Talk

4. 1436 articles
2018 Nephrology
Publications

6. 1. Introduction
2. Clinical Nephrology:
A. Diabetes and new trials
B. NS and lupus nephritis
C. Chronic kidney disease
D. CKD-MBD
3. Dialysis
4. Transplantation:
A. Tacrolimus monitoring
B. PTDM and HCV
C. Closing
Focus of The Talk

7. J Am Heart Assoc. 2018;7:e007165.
SGLT2 Inhibitors:
CV Safety
>350 000 patients

8. Diabetes Care Volume 41, Supplement 1, January 2018
ADA 2018 Standards:
Cardiovascular Disease
AlogliptinSaxagliptin sitagliptin Lixisenatide Semaglutide
Liraglutide
exenatide

9. SGLT2 Inhibitors:
Mortality and CVS Outcome
Diabetes Obes Metab. 2018 Mar 22.
n 205,160 patients
MI: HR 0.85, 95%CI 0.72-1.00; P=0.05Stroke: HR 0.83, 95%CI 0.71-0.97; P=0.02

10. Kidney International Supplements (2018) 8, 8–17
Kidney International Supplements (2018) 8, 18–
25
Diabetic Kidney
Disease
Natriuresis and kidney
protection?

11. Anaesthesia. 2018 Mar 12
SGLT-2 Inhibitors:
Ketoacidosis

12. Renal Pentad
Indian J Endocrinol Metab. 2018 Jan-Feb;22(1):167-168.

13. DKD:
RAAS System
Nephrol Dial Transplant (2018) 33: 12–22
Nine trials (n 9797 participants with CKD stages 3–
5)

14. A Message from PACD 22

15. 1. Introduction
2. Clinical Nephrology:
A. Diabetes and new trials
B. NS and lupus nephritis
C. Chronic kidney disease
D. CKD-MBD
3. Dialysis
4. Transplantation:
A. Tacrolimus monitoring
B. PTDM and HCV
C. Closing
Focus of The Talk

16. Gut Microbiome and
Kidney

17. Kidney International (April 2018) 93, 789–796
Lupus Nephritis
Diagnosis:
Revision of ISN/RPS

18. 1. Introduction
2. Clinical Nephrology:
A. Diabetes and new trials
B. NS and lupus nephritis
C. Chronic kidney disease
D. CKD-MBD
3. Dialysis
4. Transplantation:
A. Tacrolimus monitoring
B. PTDM and HCV
C. Closing
Focus of The Talk

19. Curr Opin Nephrol Hypertens March 2018, 27:94–101
CKD Progression:
Impact of Metabolic Acidosis

20. Metabolic Acidosis:
Acid Binding (TRC101)
n 135 (DB-RCT)
Clin J Am Soc Nephrol 13: 26–35, Jan 2018
A novel, sodium-free, nonabsorbed
hydrochloric acid binder

21. Curr Opin Nephrol Hypertens March 2018, 27:83–92
Salt-Induced
Hypertension

22. AKI and CKD
Kidney International (2018) 93, 460–469
n 657,840 Patients

23. Kidney International (April 2018) 93,
Unusual Cause of Kidney
Dysfunction

24. 1. Introduction
2. Clinical Nephrology:
A. Diabetes and new trials
B. NS and lupus nephritis
C. Chronic kidney disease
D. CKD-MBD
3. Dialysis
4. Transplantation:
A. Tacrolimus monitoring
B. PTDM and HCV
C. Closing
Focus of The Talk

25. CKD-MBD

26. J Am Soc Nephrol 29: 579–590, 2018
FGF-23 Trajectory and
Mortality

27. Clin J Am Soc Nephrol 2018, in press
Parathyroidectomy

28. 1. Introduction
2. Clinical Nephrology:
A. Diabetes and new trials
B. NS and lupus nephritis
C. Chronic kidney disease
D. CKD-MBD
3. Dialysis
4. Transplantation:
A. Tacrolimus monitoring
B. PTDM and HCV
C. Closing
Focus of The Talk

29. Seminars in Dialysis. 2018; in press
AVF and The Heart

30. Dialysis:
Trace Elements
1278 patients on incident hemodialysis

31. Dialysis:
Trace Elements

32. Seminars in Dialysis. 2018;31:140–148.
Dialysis:
Medical Safety

33. 1. Introduction
2. Clinical Nephrology:
A. Diabetes and new trials
B. NS and lupus nephritis
C. Chronic kidney disease
D. CKD-MBD
3. Dialysis
4. Transplantation:
A. Tacrolimus monitoring
B. PTDM and HCV
C. Closing
Focus of The Talk

34. Journal of Pharmaceutical and Biomedical Analysis 152 (2018) 306–314
Tacrolimus Monitoring:
In Lymphocytes

35. University Hospital Heidelberg
NFAT-Regulated Gene
Expression
(n 55)

36. NFAT-Regulated Gene
Expression

37. 1. Introduction
2. Clinical Nephrology:
A. Diabetes and new trials
B. NS and lupus nephritis
C. Chronic kidney disease
D. CKD-MBD
3. Dialysis
4. Transplantation:
A. Tacrolimus monitoring
B. PTDM and HCV
C. Closing
Focus of The Talk

38. Nephrol Dial Transplant (2018) 33: 177–184
PTDM:
Impact of IS and Virology

39. This article was published at Annals.org on 6 March 2018.
HCV and Kidney
Transplantation
Grazoprevir (GZR), 100 mg, and Elbasvir (EBR), 50 mg
10 HCV D+/R-

40. Transplant International 2018; in press
CNI Level/Dose:
Drug interactions (DAA)
(n 49)

41. 1. Introduction
2. Clinical Nephrology:
A. Diabetes and new trials
B. NS and lupus nephritis
C. Chronic kidney disease
D. CKD-MBD
3. Dialysis
4. Transplantation:
A. Tacrolimus monitoring
B. PTDM and HCV
C. Closing
Focus of The Talk

42. Drug Adherence

43. Fasting Ramadan

44. ESNT Virtual Academy
27323Users

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