Relatively straightforward to demonstrate some of the many critical metabolic roles, the inosine and xanthosine families play in nucleic acid anabolic and catabolic biomolecular reactions. Hopefully, dispelling the misconception of central dogma which classifies the inosine and xanthine families as minor purine intermediate metabolites and reclassify them as a totally new class of atomic molecular structure by nature; the 5 nucleotides (purine=A,G), and pyrmidine families (C,T,U) in the current canonical standard Watson-Crick DNA (ATGC), and RNA (AUGC) genetic codes are omitting the purine inosine (hypoxanthine = base, inosine = nucleoside, IMP,IDP,ITP = nucleotides) and xanthine = base, xanthosine = nucleoside, XMP,XDP,XTP) families. In our Triplex 7 nucleotide Epigenetic Code there are 4 purine families (A,I,X,G) and 3 pyrmidine families (C,T,U). This fully expands the "frozen code" of Crick into its full mature develop while helping explain the recent epigenetic processes where whole genes not just single nucleotide base pairs are remodeled and changed in response to external threatening stimuli and tensors. The purine and pyrmidine metabolic maps are fully displayed and color coded making it easier to see the functional areas of each family. Orange is not a minor color in purine metabolism. Throughout our many presentations we will be featuring different facets of the inosine and xanthine families and the important structure-function roles they play from pluripotent ste m cell development, to nucleic acid crystalline molecular structures, to the atomic element oxygen 8 carrier (i.e. hydrolysis enabling family), to the mRNA transcriptional editing of Adenosine to Inosine by ADAR 1,2,3 enzymes and their enhanced influence in RNAi gene suppression through Dicer and the entire group of small RNA molecules 21-28 mer sequences which control many gene actions including alternative splicing, and removal of toxic ammonia from the CNS and especially the glutamate neurotransmitters which carry ~90% of incoming sensory and outgoing motor neural signals. In sum, we are proposing an updated version 2.0 of the Watson-Crick-Berger? epigenetic primer with 7 not 5 nucleotide families.