2. INTRODUCTION
Pharmacodynamics is the study of
biochemical, cellular & phsiological
effects of drugs & their mechanism of
action.
It starts with describing what the
drugs do to the body and goes on to
explain how they do it.
17. Drug Receptor Interaction
Agonist : activates a receptor to produce
an effect in that of the physiological signal
molecule.
Inverse Agonist: activate a receptor to produce
effect in opposite direction.
Antagonist : Agent that prevent action of
agonist on a receptor ,but without of its own
action.
Partial Agonist: Agent that activate receptor to
produce submaximal effect but antagonizes
action of full agonist.
18. Spare Receptor : Spare receptors are receptors
that exist in excess of those required to
produce a full effect.
Allow maximal response without full receptor
occupancy—increases sensitivity of the system.
Silent Receptor : Recptors are sites which bind to
drugs but no pharmacological response is
elicited.
Orphan Receptor: Receptors for which no
endogenous ligands are present.
