ACTREC ONCOTHERAPEUTICS FELLOWSHIP few questions from the MCQ exam for PharmD MD Pharmacology

1. Justify the following statement
Therapeutic Drug Monitoring of
diuretics is not practiced:
There are no available sensitive
methods for measuring blood
diuretic levels
Response can be assessed without
blood diuretic levels
Alldiuretics are prodrugs
There is no exposure-response
relationship
In the presence and absence of a
selective beta-1 agonist, pindolol
behaves the following way
Agonist in the presence of a
selective beta-1 agonist
Agonist in both situations
Antagonist in both situations

2. Choose the false statement in the
context of renal elimination
Polar drugs or their metabolites get
filtered in the kidneys and typicaly
do not undergo reabsorption
Measurement of creatinine
clearance can be used for
assessment of renal function
Alkalinization of urine will enhance
elimination of certain acidic drugs
eGFR estimation using Cystatin C
method is affected by muscle mass
Which of the following is true about
pharmaceutical equivalence
between drugs?
Two or more drug products are
identical in quality, purity,
uniformity, disintegration and
dissolution
Two or more drug products contain
the same labeled chemical
substance, but give different
therapeutic effects

3. elimination of certain acidic drugs
eGFR estimation using Cystatin C
method is affected by muscle mass
Which of the following is true about
pharmaceutical equivalence
between drugs?
Twoor more drug products are
identical in quality, purity,
uniformity,disintegration and
dissolution
Two or more drug products contain
the same labeled chemical
substance, but give different
therapeutic effects
Two or more drug products give the
same therapeutic effect, but
contain different labeled chemical
substances
Twoor more drug products contain
the same labeled chemical
substance in the same amount

4. 1)Find the false statement
A) mureceptor antagonists must be used
promptly in the treatment of opioid-induced
respiratory depression
B) ideal agents for neurolept analgesia are
fentanyl and droperidol
2)Extra advice after administration of
Dronabinol for nausea and vomiting in
cancer patient
3) Voricanazole and posaconazole.find the
false statement from its pharmacology,
indication,kinetics andTDM.
4) Which one of the following processes is
best suited for permeationof very large
protein molecules into cells? Endocytosis
5) which of the following can lead to drug
tolerance and drug resistance?

5. 6)Tick the false statement:
A)rituximab causes common infusion
reaction
B)rituximab chimeric monoclonal antibodies
against cd 20 bcell antigen
C)rituximab has dose independent
pharmacokinetics
D) first fdaapproved for a subset of
relapsed/refractory non-hodgkin's
lymphoma
7) which statement was true
A)is valsartan contraindicated with diabetes
medicines
B)isvalsartan used in heart failure patients
with ejection fraction only
C) used in heart failure patients in any kind
of disease.
8)in the presence or absence of selective
beta 1
agonist how does pindolol act
A) antagonist in presence of beta 1agonist
B)agonist in both situation
C) antagonist in both situation
D)agonist in presence of beta 1agonist

6. 9) response curve is useful in
determining the therapeutic index of the
drug
A)quantal
B)exposure
C)dose
10)case control study-find the wrong
statement from the options
A) it selects the participants based on
presence or absence of disease or event of
interest
B)used for rare exposure
C)
11)type 2error
12)state the false sentence
A)leucovorin is used for methotrexate
toxicity
B) leucovorin is a folate analogue
C) leucovorin increases 5 fu-efficacy
13) medicine not good for fetus
A)albuterol
B)valproicacid
C)acetaminophen
D)sumatriptan

7. 14)40 yr old diabetic patient suddenly
experienced tremors, unexplained
fatigue, sweating and difficulty in
concentrating. Investigation revealed a
plasma blood glucose level of 50 mgidl.
Which of the following drugs is unlikely to
cause this condition?
A)metformin
B)glinizide
C)capaglifazon
D)levofloxacin
15)A 40-year-old man presents with
numbness and pain in finger pads. It is
provoked while washing the clothes in cold
water. Drugs which can be related to this
condition except
A)cisplatin
B)pembrolizumab
C) hydroxyurea

8. TATAACTREC ONCOTHERAPEUTICS FELLOWSHIP
2023
Questions