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Hospital Felício Rocho
Cirurgia Vascular
Treatment Options for Long
Lesions and Chronic Total
Occlusions
Daniel Mendes Pinto
Vascular Surgery
Hospital Felício Rocho – Belo Horizonte – MG
Agosto - 2016
Hospital Felício Rocho
Cirurgia Vascular
Hospital Felício Rocho
Cirurgia Vascular
JACC 2015:931-41
Lesion length
• Focal: ≤ 1 cm
• Short: > 1 and < 5
• Intermediate: ≥ 5 and < 15 cm
• Long: ≥ 15 cm
Hospital Felício Rocho
Cirurgia Vascular
Bypass surgery: an option for long lesions and CTO
Hospital Felício Rocho
Cirurgia Vascular
Chronic Total Occlusions and Long Lesions
Recent data push to endovascular solution
•Good results of last generation nitinol stents
•Patency rates of DCB
•DES
Hospital Felício Rocho
Cirurgia Vascular
The most difficult step...
Hospital Felício Rocho
Cirurgia Vascular
1. Intraluminal
recanalization
• Technical success: 50 – 62%
• Less colateral damage
• Theoretical risk of embolization
• 0,035” hidrophilic wires
• More recent approach: 0,018” stiff body
• Support catheters (Elitecross, CXI,
Quickcross)
Schmidt JEVT 2012
RCSI-SMJ 2011;4(1):39
Hospital Felício Rocho
Cirurgia Vascular
Intraluminal crossing devices
•Blunt microdissection
• Success rate: 60 – 75%
•Rotational
• Success rate: 70 – 87%
• Distal embolization
Cordis FrontRunner
Liang GZ. Internat J Cardiol 2013;165:423
Hospital Felício Rocho
Cirurgia Vascular
2. Subintimal
recanalization
• High technical sucess rates: 80%
• False lumen free of endothelium and
atheroma: less hiperplasia
• More “suitable space” for stents
• Caution: bifurcation areas (commom
femoral), distal popliteal, trifurcation
• Keep in mind surgical options
RCSI-SMJ 2011;4(1):39
Met R. Cardiovasc Intervent Radiol 2008
Hospital Felício Rocho
Cirurgia Vascular
Re-entry into the true lumen
Small loop
Suport catheter
Angled catheters
New wires
Bern JR4 IM
Hospital Felício Rocho
Cirurgia Vascular
Parallel guidewires
First wire – subintimal
Second wire –
Intraluminal
Hospital Felício Rocho
Cirurgia Vascular
Parallel
antegrade
guidewires
Hospital Felício Rocho
Cirurgia Vascular
3. Re-entry catheters
Outback LTD ®
•Locate
•Tune
•Deploy
Ocke PER. J Res Development 2015
Hospital Felício Rocho
Cirurgia Vascular
Outback LTD ®
Wilkins LR. Tech Vasc Interv Radiol 2016
•Success with re-entry catheters:
• 65 – 100%
•Pooled complication rate: 4%
Kitrou P. J Endovasc Ther 2015;22(4):538
Gandini R. Catheter Cardiovasc Interv 2014;82(3):485
Hospital Felício Rocho
Cirurgia Vascular
4. Retrograde
Access
Distal SFA
Popliteal
Tibials – leg
Tibials - foot
Hospital Felício Rocho
Cirurgia Vascular
Distal SFA / Popliteal
•Supine position
•US guided or fluoro guided
•18G needle
•0,018” or 0,035” wire
•4F, 5F sheath or support with
balloon
Distal SFA
Popliteal
Hospital Felício Rocho
Cirurgia Vascular
Retrograde access – distal SFA
Schmidt JEVT 2012
Hospital Felício Rocho
Cirurgia Vascular
Tibial - lower leg / foot
Tibials – leg
Easy US-guided puncture
Sheathless
Foot: fluoroscopy guided
Hospital Felício Rocho
Cirurgia Vascular
Guidelines of Management of Patients with
Peripheral Arterial Disease
•AHA/ACCF JACC 2005
•TASC II. JVS 2007
•Update Guideline AHA 2011
•AHA/ACCF Circulation 2013
•SVS Guidelines 2015. Practice for
atherosclerotic occlusive disease of the lower
extremities.
Ballon angioplasty
Bail-out stents
Hospital Felício Rocho
Cirurgia Vascular
Review data – femoropopliteal segment
J Vasc Surg 2014;59:1123-33
Hospital Felício Rocho
Cirurgia Vascular
Katsanos et al.
J Vasc Surg 2014: 1123
Hospital Felício Rocho
Cirurgia Vascular
Katsanos et al. J Vasc Surg 2014
Hospital Felício Rocho
Cirurgia Vascular
Long lesions and CTO
Scaffolding is advisable!
•Long term patency with 3rd
generation nitinol stents
• > 3 year: 30 – 60%
Zeller, Curr Cardiol Rep 2015
•2-year - 4th generation stents
• 84% freedom from TLR
Walker, NCVH 2015
Hospital Felício Rocho
Cirurgia Vascular
Femoro-popliteal stents
Elgiloy
Nitinol
Helical nitinol
Hospital Felício Rocho
Cirurgia Vascular
Femoro-popliteal stents
Vascular Mimetic Implants
• Fully connected nitinol
• Conform the vessel wall
Smart Flex
Supera
Hospital Felício Rocho
Cirurgia Vascular
Femoro-popliteal lesions
0
10
20
30
40
50
60
70
80
90
100
1 year primary patency
DEFINITIVE-LE
Aterectomia
pp 75%
lesões: 8,1 cm
RESILIENT
Lifestent
pp 81,3%
lesões: 6,2 cm
DURABILITY II
Protegé
pp 77,2%
lesões: 8,9 cm
STRIDES
Drug eluting
stent
pp 68%
lesões: 9,0 cm
STRIDES
Drug eluting
stent
pp 68%
lesões: 9,0 cm
IMPACT
Drug coated
balloon
pp 83,7%
lesões: 8,4 cm
LEVANT I
Drug coated balloon
pp 67%
lesões: 8,1 cm
Vascular Mimetic
Stent
pp 84,1%
lesões: 8 cm
Vascular Mimetic
Stent
pp 81%
Lesões > 15 cm
Atherectomy
Bare nitinol
stents
Drug Eluting
Stents
Drug Coated
Balloons
4th generation
nitinol stents
Hospital Felício Rocho
Cirurgia Vascular
Conclusion
Long lesions / CTO
Femoropopliteal
Non-calcified:
• Intraluminal first
• Subintimal if failed
• Re-entry devices if
avaiable
• Retrograde access
Drug Coated Ballon
Spot stenting
Vascular Mimetic Stents
Severe calcified:
• Subintimal
• Re-entry devices if
avaiable
• Retrograde access
Vascular Mimetic Stents
Bare Nitinol Stents
Hospital Felício Rocho
Cirurgia Vascular
OBRIGADO!
• Disponível em: slideshare.net
• daniel@vascularbh.com.br
• 31 99161.8318

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Treatment of Long Lesions and Femoropopliteal CTO

  • 1. Hospital Felício Rocho Cirurgia Vascular Treatment Options for Long Lesions and Chronic Total Occlusions Daniel Mendes Pinto Vascular Surgery Hospital Felício Rocho – Belo Horizonte – MG Agosto - 2016 Hospital Felício Rocho Cirurgia Vascular
  • 2. Hospital Felício Rocho Cirurgia Vascular JACC 2015:931-41 Lesion length • Focal: ≤ 1 cm • Short: > 1 and < 5 • Intermediate: ≥ 5 and < 15 cm • Long: ≥ 15 cm
  • 3. Hospital Felício Rocho Cirurgia Vascular Bypass surgery: an option for long lesions and CTO
  • 4. Hospital Felício Rocho Cirurgia Vascular Chronic Total Occlusions and Long Lesions Recent data push to endovascular solution •Good results of last generation nitinol stents •Patency rates of DCB •DES
  • 5. Hospital Felício Rocho Cirurgia Vascular The most difficult step...
  • 6. Hospital Felício Rocho Cirurgia Vascular 1. Intraluminal recanalization • Technical success: 50 – 62% • Less colateral damage • Theoretical risk of embolization • 0,035” hidrophilic wires • More recent approach: 0,018” stiff body • Support catheters (Elitecross, CXI, Quickcross) Schmidt JEVT 2012 RCSI-SMJ 2011;4(1):39
  • 7. Hospital Felício Rocho Cirurgia Vascular Intraluminal crossing devices •Blunt microdissection • Success rate: 60 – 75% •Rotational • Success rate: 70 – 87% • Distal embolization Cordis FrontRunner Liang GZ. Internat J Cardiol 2013;165:423
  • 8. Hospital Felício Rocho Cirurgia Vascular 2. Subintimal recanalization • High technical sucess rates: 80% • False lumen free of endothelium and atheroma: less hiperplasia • More “suitable space” for stents • Caution: bifurcation areas (commom femoral), distal popliteal, trifurcation • Keep in mind surgical options RCSI-SMJ 2011;4(1):39 Met R. Cardiovasc Intervent Radiol 2008
  • 9. Hospital Felício Rocho Cirurgia Vascular Re-entry into the true lumen Small loop Suport catheter Angled catheters New wires Bern JR4 IM
  • 10. Hospital Felício Rocho Cirurgia Vascular Parallel guidewires First wire – subintimal Second wire – Intraluminal
  • 11. Hospital Felício Rocho Cirurgia Vascular Parallel antegrade guidewires
  • 12. Hospital Felício Rocho Cirurgia Vascular 3. Re-entry catheters Outback LTD ® •Locate •Tune •Deploy Ocke PER. J Res Development 2015
  • 13. Hospital Felício Rocho Cirurgia Vascular Outback LTD ® Wilkins LR. Tech Vasc Interv Radiol 2016 •Success with re-entry catheters: • 65 – 100% •Pooled complication rate: 4% Kitrou P. J Endovasc Ther 2015;22(4):538 Gandini R. Catheter Cardiovasc Interv 2014;82(3):485
  • 14. Hospital Felício Rocho Cirurgia Vascular 4. Retrograde Access Distal SFA Popliteal Tibials – leg Tibials - foot
  • 15. Hospital Felício Rocho Cirurgia Vascular Distal SFA / Popliteal •Supine position •US guided or fluoro guided •18G needle •0,018” or 0,035” wire •4F, 5F sheath or support with balloon Distal SFA Popliteal
  • 16. Hospital Felício Rocho Cirurgia Vascular Retrograde access – distal SFA Schmidt JEVT 2012
  • 17. Hospital Felício Rocho Cirurgia Vascular Tibial - lower leg / foot Tibials – leg Easy US-guided puncture Sheathless Foot: fluoroscopy guided
  • 18. Hospital Felício Rocho Cirurgia Vascular Guidelines of Management of Patients with Peripheral Arterial Disease •AHA/ACCF JACC 2005 •TASC II. JVS 2007 •Update Guideline AHA 2011 •AHA/ACCF Circulation 2013 •SVS Guidelines 2015. Practice for atherosclerotic occlusive disease of the lower extremities. Ballon angioplasty Bail-out stents
  • 19. Hospital Felício Rocho Cirurgia Vascular Review data – femoropopliteal segment J Vasc Surg 2014;59:1123-33
  • 20. Hospital Felício Rocho Cirurgia Vascular Katsanos et al. J Vasc Surg 2014: 1123
  • 21. Hospital Felício Rocho Cirurgia Vascular Katsanos et al. J Vasc Surg 2014
  • 22. Hospital Felício Rocho Cirurgia Vascular Long lesions and CTO Scaffolding is advisable! •Long term patency with 3rd generation nitinol stents • > 3 year: 30 – 60% Zeller, Curr Cardiol Rep 2015 •2-year - 4th generation stents • 84% freedom from TLR Walker, NCVH 2015
  • 23. Hospital Felício Rocho Cirurgia Vascular Femoro-popliteal stents Elgiloy Nitinol Helical nitinol
  • 24. Hospital Felício Rocho Cirurgia Vascular Femoro-popliteal stents Vascular Mimetic Implants • Fully connected nitinol • Conform the vessel wall Smart Flex Supera
  • 25. Hospital Felício Rocho Cirurgia Vascular Femoro-popliteal lesions 0 10 20 30 40 50 60 70 80 90 100 1 year primary patency DEFINITIVE-LE Aterectomia pp 75% lesões: 8,1 cm RESILIENT Lifestent pp 81,3% lesões: 6,2 cm DURABILITY II Protegé pp 77,2% lesões: 8,9 cm STRIDES Drug eluting stent pp 68% lesões: 9,0 cm STRIDES Drug eluting stent pp 68% lesões: 9,0 cm IMPACT Drug coated balloon pp 83,7% lesões: 8,4 cm LEVANT I Drug coated balloon pp 67% lesões: 8,1 cm Vascular Mimetic Stent pp 84,1% lesões: 8 cm Vascular Mimetic Stent pp 81% Lesões > 15 cm Atherectomy Bare nitinol stents Drug Eluting Stents Drug Coated Balloons 4th generation nitinol stents
  • 26. Hospital Felício Rocho Cirurgia Vascular Conclusion Long lesions / CTO Femoropopliteal Non-calcified: • Intraluminal first • Subintimal if failed • Re-entry devices if avaiable • Retrograde access Drug Coated Ballon Spot stenting Vascular Mimetic Stents Severe calcified: • Subintimal • Re-entry devices if avaiable • Retrograde access Vascular Mimetic Stents Bare Nitinol Stents
  • 27. Hospital Felício Rocho Cirurgia Vascular OBRIGADO! • Disponível em: slideshare.net • daniel@vascularbh.com.br • 31 99161.8318