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脳科学とドラッグ (20200620 BrainTech勉強会)
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大地 紺野
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2020年6月20日に行ったBrainTech勉強会で発表したスライドです。 脳科学とドラッグの現状、今後について述べています。
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脳科学とドラッグ (20200620 BrainTech勉強会)
1.
薬の写真を背景に 脳科学と「ドラッグ」 東京⼤学⼤学院医学系研究科 博⼠課程3年 紺野 ⼤地
2.
⾃⼰紹介 名前:紺野 ⼤地 (Daichi
Konno) 所属:東京⼤学⼤学院医学系研究科 博⼠課程3年 経歴:2015年 東京⼤学医学部卒業 3年間 臨床医(専⾨は認知症) 2018年 ⼤学院へ進学 趣味:野球, 旅⾏, 読書, Twitter https://twitter.com/Daichi__Konno
3.
そもそも「ドラッグ」とは・・・?
4.
ドラッグ 【drug】 ①くすり。薬剤。 ②違法薬物。⿇薬。 出典:広辞苑(6版)
5.
出典:広辞苑(6版) ドラッグ 【drug】 ①くすり。薬剤。 ②違法薬物。⿇薬。
6.
内側前脳束 (MFB) →「快感を司る神経繊維」 1分で分かる(?)報酬回路
7.
MFBを刺激されたネズミ →⾷事も忘れて快感に夢中 Routtenberg et al.,
1965
8.
出典:広辞苑(6版) ドラッグ 【drug】 ①くすり。薬剤。 ②違法薬物。⿇薬。
9.
病院でソフトウェアが処⽅される時代
10.
• CureAppの写真 • ニコチン依存症治療アプリ:
慶應義塾⼤学医学部呼吸器内科と の共同開発。2019年5⽉、⽇本初となる治療⽤アプリの⼤規模 RCT(ランダム化化⽐較試験)を終了し、現在薬事申請中。 • ⾮アルコール性脂肪肝炎(NASH)治療アプリ: 東京⼤学医学部 附属病院との共同研究。2016年10⽉より臨床研究、2018年4⽉ より多施設での臨床試験を開始。 • ⾼⾎圧治療アプリ:⾃治医科⼤学循環器内科学部⾨との共同開 発。2019年12⽉より治験を開始。
11.
12.
個⼈的に、脳の直接刺激に興味あり
13.
14.
イーロン・マスク率いる「脳に電極を埋め込むベンチャー」
15.
とはいえ、⼈間に電極を埋め込むにはまだまだかかる
16.
DCS/ACS (電気) FUS (超⾳波) TMS (磁気) 個⼈的に注⽬している⾮侵襲的な脳刺激⽅法 参考:ニューロテクノロジー https://www.amazon.co.jp/dp/B07ZSH6569
17.
脳の直接刺激で、こんなことができたらおもしろい...?
18.
“Neuroscience-based のび太“ 脳の直接刺激でこんなことができる?その1 ・覚醒を司る脳領域の刺激 →朝、苦もなく⽬覚める ・睡眠を司る脳領域の刺激 →夜、瞬間で眠りにつける 注:2020年時点ではまだまだ⼈間ではできません。
19.
“Neuroscience-based ライ○ップ “ 脳の直接刺激でこんなことができる?その2 ・⾷欲を司る脳領域の刺激 →⾷べてないのに満腹感 →苦痛なく減量? 注:2020年時点ではまだまだ⼈間ではできません。
20.
“Neuroscience-based 冬眠“ 脳の直接刺激でこんなことができる?その3 ・冬眠を司る脳領域の刺激 →⼈⼯冬眠? 注:2020年時点ではまだまだ⼈間ではできません。
21.
Take home message •
”治療”としてのドラッグ • ”⿇薬”としてのドラッグ • いずれも極めて⼤きなポテンシャル • ⾮侵襲的な脳刺激に興味あり (電気, 磁気, 超⾳波, ...)
22.
おまけ Twitterで脳やAIの最新研究を紹介してます 最近は「科学と理解のあり⽅」的なツイートも... 3 https://twitter.com/Daichi__Konno
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