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薬の写真を背景に
脳科学と「ドラッグ」
東京⼤学⼤学院医学系研究科
博⼠課程3年
紺野 ⼤地
⾃⼰紹介
名前:紺野 ⼤地 (Daichi Konno)
所属:東京⼤学⼤学院医学系研究科 博⼠課程3年
経歴:2015年 東京⼤学医学部卒業
3年間 臨床医(専⾨は認知症)
2018年 ⼤学院へ進学
趣味:野球, 旅⾏, 読書, Twitter
https://twitter.com/Daichi__Konno
そもそも「ドラッグ」とは・・・?
ドラッグ 【drug】
①くすり。薬剤。
②違法薬物。⿇薬。
出典:広辞苑(6版)
出典:広辞苑(6版)
ドラッグ 【drug】
①くすり。薬剤。
②違法薬物。⿇薬。
内側前脳束 (MFB)
→「快感を司る神経繊維」
1分で分かる(?)報酬回路
MFBを刺激されたネズミ
→⾷事も忘れて快感に夢中
Routtenberg et al., 1965
出典:広辞苑(6版)
ドラッグ 【drug】
①くすり。薬剤。
②違法薬物。⿇薬。
病院でソフトウェアが処⽅される時代
• CureAppの写真
• ニコチン依存症治療アプリ: 慶應義塾⼤学医学部呼吸器内科と
の共同開発。2019年5⽉、⽇本初となる治療⽤アプリの⼤規模
RCT(ランダム化化⽐較試験)を終了し、現在薬事申請中。
• ⾮アルコール性脂肪肝炎(NASH)治療アプリ: 東京⼤学医学部
附属病院との共同研究。2016年10⽉より臨床研究、2018年4⽉
より多施設での臨床試験を開始。
• ⾼⾎圧治療アプリ:⾃治医科⼤学循環器内科学部⾨との共同開
発。2019年12⽉より治験を開始。
個⼈的に、脳の直接刺激に興味あり
イーロン・マスク率いる「脳に電極を埋め込むベンチャー」
とはいえ、⼈間に電極を埋め込むにはまだまだかかる
DCS/ACS
(電気)
FUS
(超⾳波)
TMS
(磁気)
個⼈的に注⽬している⾮侵襲的な脳刺激⽅法
参考:ニューロテクノロジー
https://www.amazon.co.jp/dp/B07ZSH6569
脳の直接刺激で、こんなことができたらおもしろい...?
“Neuroscience-based のび太“
脳の直接刺激でこんなことができる?その1
・覚醒を司る脳領域の刺激
→朝、苦もなく⽬覚める
・睡眠を司る脳領域の刺激
→夜、瞬間で眠りにつける
注:2020年時点ではまだまだ⼈間ではできません。
“Neuroscience-based ライ○ップ “
脳の直接刺激でこんなことができる?その2
・⾷欲を司る脳領域の刺激
→⾷べてないのに満腹感
→苦痛なく減量?
注:2020年時点ではまだまだ⼈間ではできません。
“Neuroscience-based 冬眠“
脳の直接刺激でこんなことができる?その3
・冬眠を司る脳領域の刺激
→⼈⼯冬眠?
注:2020年時点ではまだまだ⼈間ではできません。
Take home message
• ”治療”としてのドラッグ
• ”⿇薬”としてのドラッグ
• いずれも極めて⼤きなポテンシャル
• ⾮侵襲的な脳刺激に興味あり
(電気, 磁気, 超⾳波, ...)
おまけ
Twitterで脳やAIの最新研究を紹介してます
最近は「科学と理解のあり⽅」的なツイートも...
3
https://twitter.com/Daichi__Konno

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脳科学とドラッグ (20200620 BrainTech勉強会)