2. 2
Aug 1999 – Aug 2000 Visiting Associate Professor
McMaster University, Hamilton (ON), CA
Nov 1996 – Apr 2012 Senior Researcher
Istituto Dermopatico dellʹImmacolata,
Rome, Italy
Jan 2005 – Dec 2011 Consultant, Centro Cardiologico Monzino, Milan, Italy
Jun 2012 – present
Associate (W2) Professor of Stem Cells Biology
Director, Division of Cardiovascular Epigenetics, Medizinische Klinik III:
Kardiologie, Angiologie/Hämostaseologie, Nephrologie, Göethe‐Universität,
Frankfurt am Main, Germany
Metrics
RG Score 41.71
Publications 120
Total Impact Points 715.15
Views 12k
Downloads 5000
Citations 3424
H index 34
i10 index 63
Awards & Grants
AWARDS
Dec 1986 Award: ʺAnna Villa‐Rusconiʺ fellowship
Jan 1989 Award: Pasteur Cenci‐Bolognetti fellowship
Jan 1990 Award: Fogarty International fellowship (USA)
Jan 1992 Award: Associazione Italiana Ricerca sul Cancro fellowship
Jun 1995 Award: National Cancer Institute Visiting Scientist fellowship (USA)
GRANTS (last three years)
Jun 2012‐Jun 2017 Core Grant from the State of Hessen (DE) in the context of a Research
Excellence Initiative. Project title: “Development of a Cardiovascular
Epigenetics Research Platform”. PI: Prof. Carlo Gaetano. Amount granted :
$ 1.650.000
Jan 2013‐ Jan 2014 Grant from the Cell and Gene Therapy Center (CGT) Frankfurt. Project title
4. 4
2014‐2016: Functional Genomics and Translational Biology Scientific Council‐
American Heart Association Leadership Committee Member‐at‐large.
2014‐present: Member of the European Association for the Study of Diabetes.
2014‐ Member of the “Regenerative Medicine”panel review board, EU
projects, Horizon 2020 research program. Brussels (BE).
2014‐2015‐Project Reviewer for the “Agence Nationale de la Recherche”:
recherche translationnelle en santé. Paris (FR).
2015-Project Reviewer for the “Czech Health Research Council”, Praha (CZ)
2015‐ Chairman of the Italian Ministry of Health Review Board panel for
“Health Research Projects”, Rome (Italy).
Conference organization/ Teaching Experience (last three years)
Oct 2013: Organizer
Goethe‐Universität Frankfurt am Main ∙ Medizinische Klinik III: Kardiologie,
Angiologie/Hämostaseologie, Nephrologie, Frankfurt am Main, Germany
First ʺVilla Vigoniʺ International Conference on ʺCells, genes and molecules for cardiac and
vascular regenerationʺ, Menaggio, Italy
Sep 2014: Organizer
IBSA International Symposium on aging: ʺAging, is it a disease?ʺ, Unklinikum, Frankurt am
Main, Germany.
Goethe‐Universität Frankfurt am Main ∙ Medizinische Klinik III: Kardiologie,
Angiologie/Hämostaseologie, Nephrologie, Frankfurt am Main, Germany
June 2015: Organizer
Cell and Gene Therapy Center (CGT), Frankfurt am Main, Germany. First CGT international
workshop on DNA methylation.
Oct 2015: Organizer
Goethe‐Universität Frankfurt am Main ∙ Medizinische Klinik III: Kardiologie,
Angiologie/Hämostaseologie, Nephrologie, Frankfurt am Main, Germany
Second ʺVilla Vigoniʺ International Conference on ʺCells, genes and molecules for cardiac and
vascular regenerationʺ, Menaggio, Italy
Nov 2014: Teacher
Master in Molecular Medicine Lesson title: Stem cell therapy in cardiovascular diseases.
6. 6
Scientific Research
I have a long standing research interest in cardiovascular epigenetics. Since I am at Goethe University
(May 2012) my main research activity has been focused on human subjects and specifically on the
characterization of epigenetic mechanisms important for the homeostasis of the human vascular and
cardiac districts with special attention paid to pathophysiological conditions that may affect cellular
and organ function including dysmetabolism and diabetes. My laboratory is currently focused on the
understanding of molecular cues at the basis of epigenetic memory and metabolic alterations in
human patients undergoing major cardiac surgery. Special attention is given to the metabolomics
profile of those metabolites important for epigenetic processes including DNA methylation and
subsequent modification of methylated cytosines including formation of hydroxymethyl‐, formyl‐ and
carboxyl‐cytosine. These modifications are currently determined in cardiac biopsis, in isolated cardiac
auricles, in isolated primary cardiac fibroblasts and in peripheral blood samples. In addition, I started
the characterization of a number of new epigenetically active molecules targeting epigenetic enzymes
important for DNA methylation control including DNA methyl transferases and DNA demethylases
alias Ten‐Eleven‐Translocation proteins (TETs). Specific aim of this research activity is to understand
the potential application of novel small molecule pro‐drugs to relevant human cardiovascular diseases
and cardiovascular risk factors including metabolic syndrome and diabetes. In brief, human cardiac
fibroblasts may be considered important to evaluate the effect metabolic alterations potentially
affecting adult cardiac stem cell function. Since, I started my current appointment at Goethe
University (May 2012) a number of human primary cardiac fibroblast preparations (about 50) have
been generated in close collaboration with Prof. Andreas M. Zeiher (Director of the Dept. of
Cardiology at Goethe University Hospital) and Prof. Andres Beiras‐Fernandez of the Thoracic Surgery
Clinic of the Goethe University Hospital. These cells have been used for investigations aimed at
understanding whether an altered metabolism, possible consequence of diabetes, may subsist as a cell
autonomous defect realizing a condition able to permanently alter the intracellular environment,
preventing or reducing the proliferation and differentiation potential of these cells. This research is
still in progress, however, our manuscript published in Diabetes on January 2014, indicates the
presence of horizontally inherited epigenetic defects in human cardiac stromal cells leading to the
accumulation of abnormal DNA methylation in cell obtained from patients with clinical history of
Diabetes. These alterations are detectable ex vivo and in well controlled metabolic conditions. Our
study is now focused on the results of an integrated metabolomic, transcriptomic, genomic approach
in order to understand at which level the alteration is most evident and at what extent. Parallel to this
research, in collaboration with other Institutions in Europe and US we started to characterize new
small molecules targeted to specific epigenetic enzymes deputed at DNA methylation regulation
including DNA methyl‐trasferases (DNMTs) and Ten‐eleven‐translocation (TET) enzymes. This
research recently led to the identification of new lead compounds capable of modulate the content of
methylated DNA in cardiac stromal cells rescuing, at least partially, the intrinsic functional defect. In
addition, in collaboration with Prof. Evelyn Ullrich of the Pediatric Oncology Clinic at KGU, I started a
to evaluate the effect of epigenetically active drugs on the proliferation of human Natural Killer cells
suited for antitumor activity. This activity is currently ongoing.
7. 7
Specific Results:
Identification of the histone acetylase activator SPV106 as a potential activator of cellular
proliferation which has been now reported by us as effective on metabolically compromised
cardiac mesenchymal cell isolated from diabetic patients restoring function (1).
Evaluation of SPV106 effect of human natural killer cells proliferation and request for patent
regarding the use of SPV106 for the activation of primary human cell functions have been
approved by Goethe University. The final patent application is now submitted to the
European Patent Office (Application N. 14 179 989.0).
Characterization of new epigenetically active molecules, targeting DNA methylases and
demethylases (TET proteins). 5 compounds selected for further investigation. One of these
molecules received a first positive evaluation for the patent attorney and it is currently
preparing for a second evaluation by the Goethe University Patenting Committee in 2015 (see
attached document).
Isolation and characterization of 50 cardiac human fibroblast primary cultures obtained from
diabetic and non‐diabetic patients undergoing cardiac surgery.
Identification of altered DNA methylation content in human cardiac cells and peripheral
blood obtained from diabetic donors undergoing cardiac surgery for CABG.
Patents
1. “Use of SPV‐106 for ex‐vivo expansion of immune cells in cellular therapy” PATENT
PENDING APPLICATION AT THE EUROPEAN PATENT OFFICE (NO. 14 179 989.0)
2. “Use of ten‐eleven proteins modulators in Diabetes complications” IN PREPARATION
Top Publications
1. M Fiorilli, M Carbonari, B Scarpati, G Scano, C Gaetano, F Aiuti: Immunoglobulins in the
acquired immunodeficiency syndrome. Annals of Internal Medicine 07/1985; 102(6):862‐3.
2. M Carbonari, M Cherchi, R Paganelli, G Giannini, E Galli, C Gaetano, C Papetti, M Fiorilli:
Relative increase of T cells expressing the gamma/delta rather than the alpha/beta receptor in ataxia‐
telangiectasia. New England Journal of Medicine 02/1990; 322(2):73‐6.
3. C Gaetano, G Scano, M Carbonari, G Giannini, I Mezzaroma, F Aiuti, L Marolla, A M Casadei,
E Carapella: Delayed and defective anti‐HIV IgM response in infants. The Lancet 04/1987;
1(8533):631. DOI:10.1016/S0140‐6736(87)90272‐8
4. C Gaetano, T Matsuo, C J Thiele: Identification and characterization of a retinoic acidregulated
human homologue of the unc‐33‐like phosphoprotein (hUlip) from neuroblastoma cells. Journal of
Biological Chemistry 06/1997; 272(18):12195‐201. DOI:10.1074/jbc.272.18.12195
8. 8
5. B Illi, P Puri, L Morgante, M C Capogrossi, C Gaetano: Nuclear factor‐kappaB and cAMP
response element binding protein mediate opposite transcriptional effects on the flk‐1/KDR gene
promoter. Circulation Research 07/2000; 86(12):E110‐7. DOI:10.1161/01.RES.86.12.e110
6. D DʹArcangelo, F Facchiano, L M Barlucchi, G Melillo, B Illi, L Testolin, C Gaetano, M C
Capogrossi: Acidosis Inhibits Endothelial Cell Apoptosis and Function and Induces Basic Fibroblast
Growth Factor and Vascular Endothelial Growth Factor Expression. Circulation Research 03/2000;
86(3):312‐8. DOI:10.1161/01.RES.86.3.312
7. Carlo Gaetano, Alfonso Catalano, Barbara Illi, Angelina Felici, Saverio Minucci, Roberta
Palumbo, Francesco Facchiano, Antonella Mangoni, Salvatore Mancarella, Judith Mühlhauser,
Maurizio C. Capogrossi: Retinoids Induce Fibroblast Growth Factor‐2 Production in Endothelial
Cells via Retinoic Acid Receptor α Activation and Stimulate Angiogenesis In Vitro and In Vivo.
Circulation Research 04/2001; 88(4):E38‐47. DOI:10.1161/01.RES.88.4.e38
8. Barbara Illi, Simona Nanni, Alessandro Scopece, Antonella Farsetti, Paolo Biglioli, Maurizio C
Capogrossi, Carlo Gaetano: Shear stress‐mediated chromatin remodeling provides molecular basis
for flow‐dependent regulation of gene expression. Circulation Research 08/2003; 93(2):155‐61.
9. Germana Zaccagnini, Fabio Martelli, Pasquale Fasanaro, Alessandra Magenta, Carlo Gaetano,
Anna Di Carlo, Paolo Biglioli, Marco Giorgio, Ines Martin‐Padura, Pier Giuseppe Pelicci,
Maurizio C Capogrossi: p66(ShcA) modulates tissue response to hindlimb ischemia. Circulation
07/2004; 109(23):2917‐23. DOI:10.1161/01.CIR.0000129309.58874.0F
10. G C Minetti, C Colussi, R Adami, C Serra, C Mozzetta, V Parente, S Fortuni, S Straino, M
Sampaolesi, M Di Padova, B Illi, P Gallinari, C Steinkühler, M C Capogrossi, V Sartorelli, R
Bottinelli, C Gaetano, P L Puri: Functional and morphological recovery of dystrophic muscles in mice
treated with deacetylase inhibitors. Nature Medicine 11/2006; 12(10):1147‐50.
11. Barbara Illi, Claudio Dello Russo, Claudia Colussi, Jessica Rosati, Michele Pallaoro, Francesco
Spallotta, Dante Rotili, Sergio Valente, Gianluca Ragone, Fabio Martelli, Paolo Biglioli,
Christian Steinkuhler, Paola Gallinari, Antonello Mai, Maurizio C Capogrossi, Carlo Gaetano:
Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A
activation and class II histone deacetylases nuclear shuttling. Circulation Research 02/2008;
102(1):51‐8.
12. Claudia Colussi, Chiara Mozzetta, Aymone Gurtner, Barbara Illi, Jessica Rosati, Stefania
Straino, Gianluca Ragone, Mario Pescatori, Germana Zaccagnini, Annalisa Antonini, Giulia
Minetti, Fabio Martelli, Giulia Piaggio, Paola Gallinari, Christian Steinkuhler, Christian
Steinkulher, Emilio Clementi, Carmela DellʹAversana, Lucia Altucci, Antonello Mai, Maurizio
C Capogrossi, Pier Lorenzo Puri, Carlo Gaetano: HDAC2 blockade by nitric oxide and histone
9. 9
deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment..
Proceedings of the National Academy of Sciences 01/2009; 105(49):19183‐7.
13. Simona Nanni, Valentina Benvenuti, Annalisa Grasselli, Carmen Priolo, Aurora Aiello,
Stefania Mattiussi, Claudia Colussi, Vittoria Lirangi, Barbara Illi, Manuela DʹEletto, Anna
Maria Cianciulli, Michele Gallucci, Piero De Carli, Steno Sentinelli, Marcella Mottolese, Paolo
Carlini, Lidia Strigari, Stephen Finn, Elke Mueller, Giorgio Arcangeli, Carlo Gaetano,
Maurizio C Capogrossi, Raffaele Perrone Donnorso, Silvia Bacchetti, Ada Sacchi, Alfredo
Pontecorvi, Massimo Loda, Antonella Farsetti: Endothelial NOS, estrogen receptor β, and HIFs
cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer.
The Journal of Clinical Investigation 05/2009; 119(5):1093‐108. DOI:10.1172/JCI35079
14. Jessica Rosati, Francesco Spallotta, Simona Nanni, Annalisa Grasselli, Annalisa Antonini, Sara
Vincenti, Carlo Presutti, Claudia Colussi, Carmen DʹAngelo, Anna Biroccio, Antonella
Farsetti, Maurizio C Capogrossi, Barbara Illi, Carlo Gaetano: Smad‐interacting protein‐1 and
microRNA 200 family define a nitric oxide‐dependent molecular circuitry involved in embryonic stem
cell mesendoderm differentiation. Arteriosclerosis Thrombosis and Vascular Biology 01/2011;
31(4):898‐907.
15. Claudia Colussi, Jessica Rosati, Stefania Straino, Francesco Spallotta, Roberta Berni, Donatella
Stilli, Stefano Rossi, Ezio Musso, Emilio Macchi, Antonello Mai, Gianluca Sbardella, Sabrina
Castellano, Cristina Chimenti, Andrea Frustaci, Angela Nebbioso, Lucia Altucci, Maurizio C
Capogrossi, Carlo Gaetano: Nε‐lysine acetylation determines dissociation from GAP junctions and
lateralization of connexin 43 in normal and dystrophic heart. Proceedings of the National
Academy of Sciences 02/2011; 108(7):2795‐800.
16. Claudia Colussi, Alessandro Scopece, Serena Vitale, Francesco Spallotta, Stefania Mattiussi,
Jessica Rosati, Barbara Illi, Antonello Mai, Sabrina Castellano, Gianluca Sbardella, Antonella
Farsetti, Maurizio C Capogrossi, Carlo Gaetano: P300/CBP Associated Factor Regulates
Nitroglycerin‐Dependent Arterial Relaxation by N{varepsilon}‐Lysine Acetylation of Contractile
Proteins. Arteriosclerosis Thrombosis and Vascular Biology 08/2012; 32(10):2435‐43.
17. Francesco Spallotta, Chiara Cencioni, Stefania Straino, Simona Nanni, Jessica Rosati, Simona
Artuso, Isabella Manni, Claudia Colussi, Giulia Piaggio, Fabio Martelli, Sergio Valente,
Antonello Mai, Maurizio C Capogrossi, Antonella Farsetti, Carlo Gaetano: A Nitric Oxide‐
dependent Crosstalk Between Class I and III Histone Deacetylases Accelerates Skin Repair. Journal of
Biological Chemistry 03/2013.
18. Matteo Vecellio, Francesco Spallotta, Simona Nanni, Claudia Colussi, Chiara Cencioni, Anja
Derlet, Beatrice Bassetti, Manuela Tilenni, Maria Cristina Carena, Antonella Farsetti, Gianluca
Sbardella, Sabrina Castellano, Antonello Mai, Fabio Martelli, Giulio Pompilio, Maurizio C
Capogrossi, Alessandra Rossini, Stefanie Dimmeler, Andreas M Zeiher, Carlo Gaetano: The
10. 10
Histone Acetylase Activator Pentadecylidenemalonate 1b Rescues Proliferation and Differentiation in
Human Cardiac Mesenchymal Cells of Type 2 Diabetic Patients. Diabetes 01/2014;
Journal covers
1. Barbara Illi, Alessandro Scopece, Simona Nanni, Antonella Farsetti, Liliana Morgante,
Paolo Biglioli, Maurizio C Capogrossi, Carlo Gaetano: Epigenetic histone modification and
cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear
stress. Circulation Research 04/2005; 96(5):501‐8. DOI:10.1161/01.RES.0000159181.06379.63
2. Annalisa Grasselli, Simona Nanni, Claudia Colussi, Aurora Aiello, Valentina Benvenuti,
Gianluca Ragone, Fabiola Moretti, Ada Sacchi, Silvia Bacchetti, Carlo Gaetano, Maurizio
C Capogrossi, Alfredo Pontecorvi, Antonella Farsetti: Estrogen Receptor‐α and Endothelial
Nitric Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase.
Circulation Research 07/2008; 103(1):34‐42. DOI:10.1161/CIRCRESAHA.107.169037.
3. C Colussi, C Banfi, M Brioschi, E Tremoli, S Straino, F Spallotta, A Mai, D Rotili, M C
Capogrossi, C Gaetano: Proteomic profile of differentially expressed plasma proteins from
dystrophic mice and following suberoylanilide hydroxamic acid treatment. Proteomics ‐ Clinical
Applications 01/2010; 4(1):71‐83. DOI:10.1002/prca.200900116.
4. Simona Nanni, Carmen Priolo, Annalisa Grasselli, Manuela DʹEletto, Roberta Merola,
Fabiola Moretti, Michele Gallucci, Piero De Carli, Steno Sentinelli, Anna Maria Cianciulli,
Marcella Mottolese, Paolo Carlini, Diego Arcelli, Mauro Helmer‐Citterich, Carlo Gaetano,
Massimo Loda, Alfredo Pontecorvi, Silvia Bacchetti, Ada Sacchi, Antonella Farsetti:
Epithelial‐Restricted Gene Profile of Primary Cultures from Human Prostate Tumors: A
Molecular Approach to Predict Clinical Behavior of Prostate Cancer. Molecular Cancer
Research 03/2006; 4(2):79‐92. DOI:10.1158/1541‐7786.MCR‐05‐0098.
Invited Reviews/Editorials
1. Barbara Illi, Carlo Gaetano, Maurizio C Capogrossi: How senescent vascular cells lose their Clock
age‐dependent impairment of circadian rhythmicity in smooth muscle cells. Circulation Research
04/2006; 98(4):450‐2. DOI:10.1161/01.RES.0000214331.90904.aa
2. Carlo Gaetano, Claudia Colussi, Maurizio C Capogrossi: PEDF, PPAR‐gamma, p53: Deadly
circuits arise when worlds collide. Cardiovascular Research 12/2007; 76(2):195‐6.
DOI:10.1016/j.cardiores.2007.08.011
3. C Colussi, C Gaetano, MC Capogrossi: AAV‐dependent targeting of myostatin function: follistatin
strikes back at muscular dystrophy. Gene therapy 09/2008; 15(15):1075‐6. DOI:10.1038/gt.2008.95
11. 11
4. Antonella Farsetti, Annalisa Grasselli, Silvia Bacchetti, Carlo Gaetano, Maurizio C Capogrossi:
The telomerase tale in vascular aging: Regulation by estrogens and nitric oxide signaling. Journal of
Applied Physiology 12/2008; 106(1):333‐7. DOI:10.1152/japplphysiol.91360.2008
5. Barbara Illi, Claudia Colussi, Annalisa Grasselli, Antonella Farsetti, Maurizio C Capogrossi,
Carlo Gaetano: NO sparks off chromatin: Tales of a multifaceted epigenetic regulator. Pharmacology
& Therapeutics 09/2009; 123(3):344‐52. DOI:10.1016/j.pharmthera.2009.05.003
6. Claudia Colussi, Barbara Illi, Jessica Rosati, Francesco Spallotta, Antonella Farsetti, Annalisa
Grasselli, Antonello Mai, Maurizio C Capogrossi, Carlo Gaetano: Histone deacetylase inhibitors:
Keeping momentum for neuromuscular and cardiovascular diseases treatment. Pharmacological
Research 03/2010; 62(1):3‐10. DOI:10.1016/j.phrs.2010.02.014
7. Carlo Gaetano, Maurizio C. Capogrossi, Maurizio Fanciulli, Patrizia Filetici, Giulia Piaggio:
Epigenetics in Rome: Breaking news from the Chromatin Remodeling and Human Disease
Workshop. Epigenetics: official journal of the DNA Methylation Society 04/2010; 5(3).
DOI:10.4161/epi.5.3.11200
8. Barbara Illi, Claudia Colussi, Jessica Rosati, Francesco Spallotta, Simona Nanni, Antonella
Farsetti, Maurizio C Capogrossi, Carlo Gaetano: NO points to epigenetics in vascular
development. Cardiovascular Research 90: 447‐456. Cardiovascular Research 02/2011; 90(3):447‐
56. DOI:10.1093/cvr/cvr056
9. Alessandra Magenta, Simona Greco, Carlo Gaetano, Fabio Martelli: Oxidative Stress and
MicroRNAs in Vascular Diseases. International Journal of Molecular Sciences 09/2013;
14(9):17319‐46. DOI:10.3390/ijms140917319
10. Chiara Cencioni, Francesco Spallotta, Fabio Martelli, Sergio Valente, Antonello Mai, Andreas
M Zeiher, Carlo Gaetano: Oxidative Stress and Epigenetic Regulation in Ageing and Age‐Related
Diseases. International Journal of Molecular Sciences 09/2013; 14(9):17643‐63.
DOI:10.3390/ijms140917643
11. Simona Greco, Carlo Gaetano, Fabio Martelli: HypoxamiR Regulation and Function in Ischemic
Cardiovascular Diseases. Antioxidants & Redox Signaling 09/2013; 21(8).
DOI:10.1089/ars.2013.5403
12. Alessandra Magenta, Simona Greco, Maurizio C Capogrossi, Carlo Gaetano, Fabio Martelli:
Nitric Oxide, Oxidative Stress, and p66 Shc Interplay in Diabetic Endothelial Dysfunction. Biomed
Res Int. 2014:193095. doi: 10.1155/2014/193095
12. 12
13. Chiara Cencioni, Francesco Spallotta, Simona Greco, Fabio Martelli, Andreas M Zeiher, Carlo
Gaetano: Epigenetic mechanisms of hyperglycemic memory. The International Journal of
Biochemistry & Cell Biology 04/2014; 51(1). DOI:10.1016/j.biocel.2014.04.014
14. Chiara Cencioni, Francesco Spallotta, Antonello Mai, Fabio Martelli, Antonella Farsetti,
Andreas M Zeiher, Carlo Gaetano: Sirtuin function in aging heart and vessels. Journal of
Molecular and Cellular Cardiology 01/2015; 83. DOI:10.1016/j.yjmcc.2014.12.023
Peer Reviewed Journal Publications (full list)
1. M Fiorilli, M Carbonari, B Scarpati, G Scano, C Gaetano, F Aiuti: Immunoglobulins in the
acquired immunodeficiency syndrome. Annals of Internal Medicine 07/1985; 102(6):862‐3.
2. Massimo Fiorilli, Marco Crescenzi, Maurizio Carbonari, Letizia Tedesco, Giandomenico
Russo, Carlo Gaetano, Fernando Aiuti: Phenotypically immature IgG‐bearing B cells in patients
with hypogammaglobulinemia. Journal of Clinical Immunology 12/1985; 6(1):21‐25.
DOI:10.1007/BF00915360
3. P Rossi, M Carbonari, R Bonomo, M Galli, P E Manconi, B Scarpati, G Scano, C Gaetano, B
Ensoli, F Aiuti: Epidemiological aspects of HTLV‐III infection in Italy. European Journal of
Epidemiology 01/1986; 1(4):288‐93. DOI:10.1007/BF00237104
4. C Gaetano, G Scano, M Carbonari, G Giannini, I Mezzaroma, F Aiuti, L Marolla, A M Casadei,
E Carapella: Delayed and defective anti‐HIV IgM response in infants. The Lancet 04/1987;
1(8533):631. DOI:10.1016/S0140‐6736(87)90272‐8
5. M Crescenzi, M Napolitano, M Carbonari, A Antonelli, P Petrinelli, C Gaetano, M Fiorilli:
Establishment of a new Epstein‐Barr virus‐immortalized cell line from chronic lymphocytic leukemia
with trisomy of chromosome 12 that produces monoclonal IgM against a sheep RBC antigen. Blood
02/1988; 71(1):9‐12.
6. Maurizio Carbonari, Michela Cherchi, Roberto Paganelli, Giuseppe Giannini, Elena Galli,
Carlo Gaetano, Claudia Papetti, Massimo Fiorilli: Relative Increase of T Cells Expressing the
Gamma/Delta Rather Than the Alpha/Beta Receptor in Ataxia‐Telangiectasia. New England Journal
of Medicine 02/1990; 322(2):73‐6. DOI:10.1056/NEJM199001113220201
7. A Farsetti, A Pontecorvi, I Antonozzi, M Andreoli, C Gaetano: Cytofluorometric analysis of
lymphocyte subsets in thyroid aspirates from patients with autonomously functioning nodule. Clinical
Endocrinology 06/1990; 32(6):729‐38.
8. C Gaetano, K Matsumoto, C J Thiele: Retinoic acid resistant neuroblastoma cells and the expression
of insulin‐like growth factor‐II. Progress in clinical and biological research 02/1991; 366:165‐72.
13. 13
9. C Gaetano, K Matsumoto, C J Thiele: Retinoic acid negatively regulates p34cdc2 expression during
human neuroblastoma differentiation. Cell growth & differentiation: the molecular biology
journal of the American Association for Cancer Research 11/1991; 2(10):487‐93.
10. K Matsumoto, C Gaetano, W H Daughaday, CJ Thiele: Retinoic acid regulates insulin‐like growth
factor II expression in neuroblastoma cell line. Endocrinology 07/1992; 130(6):3669‐76.
DOI:10.1210/en.130.6.3669
11. C Gaetano, K Matsumoto, C J Thiele: In vitro activation of distinct molecular and cellular
phenotypes after induction of differentiation in a human neuroblastoma cell line. Cancer Research
09/1992; 52(16):4402‐7.
12. CJ Thiele, C Gaetano, K Matsumoto: Coordinate regulation of oncogenes, suppressor genes and cell
cycle genes in human neuroblastoma cell lines sensitive to retinoic acid and its disruption in NB cells
constitutively expressing IGF‐II. Biomedicine & Pharmacotherapy 12/1992; 46(5‐7).
DOI:10.1016/0753‐3322(92)90187‐C
13. Carlo Gaetano, Antonella Melchiori, Adriana Albini, Robetto Benelli, Rita Falcioni, Andrea
Modesti, A. Modica, Susanna Scarpa, Ada Sacchi: Retinoic acid negatively regulates β4 integrin
expression and suppresses the malignant phenotype in a Lewis lung carcinoma cell line. Clinical and
Experimental Metastasis 01/1994; 12(1):63‐72. DOI:10.1007/BF01784335
14. K Matsumoto, E Lucarelli, C Minniti, C Gaetano, CJ Thiele: Signals transduced via insulin‐like
growth factor I receptor (IGF(R)) mediate resistance to retinoic acid‐induced cell growth arrest in a
human neuroblastoma cell line. Cell Death and Differentiation 08/1994; 1(1):49‐58.
15. Pamela Cohen, JJ Letterio, C Gaetano, J Chan, K Matsumoto, MB Sporn, CJ Thiele: Induction of
transforming growth factor beta 1 and its receptors during all‐trans‐retinoic acid (RA) treatment of
RA‐responsive human neuroblastoma cell lines. Cancer Research 1995 Jun 1;55(11):2380‐6. PMID:
7757990.
16. C Gaetano, I Manni, G Bossi, G Piaggio, S Soddu, A Farina, L J Helman, A Sacchi: Retinoic acid
and cAMP differentially regulate human chromogranin A promoter activity during differentiation of
neuroblastoma cells. European Journal of Cancer 02/1995; 31A(4):447‐52. DOI:10.1016/0959‐
8049(95)00038‐K
17. G Piaggio, A Farina, D Perrotti, I Manni, P Fuschi, A Sacchi, C Gaetano: Structure and Growth‐
Dependent Regulation of the Human Cyclin B1 Promoter. Experimental Cell Research 03/1995;
216(2):396‐402. DOI:10.1006/excr.1995.1050
18. A Farina, C Gaetano, M Crescenzi, F Puccini, I Manni, A Sacchi, G Piaggio: The inhibition of
cyclin B1 gene transcription in quiescent NIH3T3 cells is mediated by an E‐box. Oncogene 10/1996;
13(6):1287‐96.
14. 14
19. C Gaetano, Y Kitajima, K. Matsumoto, T Matsuo, CJ Thiele: Identification of a Novel Thyroid
Hormone Receptor Responsive Element in the Human trk‐B Promoter. European Journal of Cancer
01/1997; 33(12). DOI:10.1016/S0959‐8049(97)00415‐2
20. C Gaetano, T Matsuo, C J Thiele: Identification and characterization of a retinoic acidregulated
human homologue of the unc‐33‐like phosphoprotein (hUlip) from neuroblastoma cells. Journal of
Biological Chemistry 06/1997; 272(18):12195‐201. DOI:10.1074/jbc.272.18.12195
21. D DʹArcangelo, F Facchiano, L M Barlucchi, G Melillo, B Illi, L Testolin, C Gaetano, M C
Capogrossi: Acidosis Inhibits Endothelial Cell Apoptosis and Function and Induces Basic Fibroblast
Growth Factor and Vascular Endothelial Growth Factor Expression. Circulation Research 03/2000;
86(3):312‐8. DOI:10.1161/01.RES.86.3.312
22. C Giampietri, M Levrero, A Felici, A DʹAlessio, M C Capogrossi, C Gaetano: E1A stimulates
FGF‐2 release promoting differentiation of primary endothelial cells. Cell Death and Differentiation
04/2000; 7(3):292‐301. DOI:10.1038/sj.cdd.4400654
23. B Illi, P Puri, L Morgante, M C Capogrossi, C Gaetano: Nuclear factor‐kappaB and cAMP
response element binding protein mediate opposite transcriptional effects on the flk‐1/KDR gene
promoter. Circulation Research 07/2000; 86(12):E110‐7. DOI:10.1161/01.RES.86.12.e110
24. Diana Bellavia, Antonio F. Campese, Edoardo Alesse, Alessandra Vacca, Maria Pia Felli, Anna
Balestri, Antonella Stoppacciaro, Cecilia Tiveron, Laura Tatangelo, Mirella Giovarelli, Carlo
Gaetano, Luigi Ruco, Eric S. Hoffman, Adrian C. Hayday, Urban Lendahl, Luigi Frati, Alberto
Gulino, Isabella Screpanti: Constitutive activation of NF‐B and T‐cell leukemia/lymphoma in Notch3
transgenic mice. The EMBO Journal 07/2000; 19(13):3337‐3348. DOI:10.1093/emboj/19.13.3337
25. R Palumbo, C Gaetano, G Melillo, E Toschi, A Remuzzi, M C Capogrossi: Shear Stress
Downregulation of Platelet‐Derived Growth Factor Receptor‐ and Matrix Metalloprotease‐2 Is
Associated With Inhibition of Smooth Muscle Cell Invasion and Migration. Circulation 08/2000;
102(2):225‐30. DOI:10.1161/01.CIR.102.2.225
26. C Gaetano, A Catalano, R Palumbo, B Illi, G Orlando, G Ventoruzzo, F Serino, M C
Capogrossi: Transcriptionally active drugs improve adenovirus vector performance in vitro and in
vivo. Gene Therapy 11/2000; 7(19):1624‐30. DOI:10.1038/sj.gt.3301296
27. Carlo Gaetano, Alfonso Catalano, Barbara Illi, Angelina Felici, Saverio Minucci, Roberta
Palumbo, Francesco Facchiano, Antonella Mangoni, Salvatore Mancarella, Judith Mühlhauser,
Maurizio C. Capogrossi: Retinoids Induce Fibroblast Growth Factor‐2 Production in Endothelial
Cells via Retinoic Acid Receptor α Activation and Stimulate Angiogenesis In Vitro and In Vivo.
Circulation Research 04/2001; 88(4):E38‐47. DOI:10.1161/01.RES.88.4.e38
15. 15
28. Roberta Palumbo, Carlo Gaetano, Annalisa Antonini, Giulio Pompilio, Enrico Bracco, Lars
Rönnstrand, Carl‐Henrik Heldin, Maurizio C Capogrossi: Different effects of high and low shear
stress on platelet‐derived growth factor isoform release by endothelial cells ‐ Consequences for smooth
muscle cell migration. Arteriosclerosis Thrombosis and Vascular Biology 03/2002; 22(3):405‐11.
DOI:10.1161/hq0302.104528
29. Paolo Turrini, Carlo Gaetano, Alessia Antonelli, Maurizio C Capogrossi, Luigi Aloe: Nerve
growth factor induces angiogenic activity in a mouse model of hindlimb ischemia. Neuroscience
Letters 04/2002; 323(2):109‐12. DOI:10.1016/S0304‐3940(02)00090‐3
30. Irene Massari, Alessia Donnini, Katy Argentati, Stefania Straino, Antonella Mangoni, Carlo
Gaetano, Claudio Viticchi, Maurizio C. Capogrossi, Mauro Provinciali: Age‐dependent effects of
repeated immunization with a first generation adenovirus vector on the immune response and
transgene expression in young and old rats. Experimental Gerontology 06/2002; 37(6):823‐31.
DOI:10.1016/S0531‐5565(02)00011‐6
31. Daniela DʹArcangelo, Carlo Gaetano, Maurizio C Capogrossi: Acidification prevents endothelial
cell apoptosis by Axl activation. Circulation Research 10/2002; 91(7):e4‐12.
DOI:10.1161/01.RES.0000036753.50601.E9
32. Raffaella Cincinelli, Sabrina Dallavalle, Lucio Merlini, Sergio Penco, Claudio Pisano, Paolo
Carminati, Giuseppe Giannini, Loredana Vesci, Carlo Gaetano, Barbara Illi, Valentina Zuco,
Rosanna Supino, Franco Zunino: A Novel Atypical Retinoid Endowed with Proapoptotic and
Antitumor Activity. Journal of Medicinal Chemistry 04/2003; 46(6):909‐12.
DOI:10.1021/jm025593y
33. Barbara Illi, Simona Nanni, Alessandro Scopece, Antonella Farsetti, Paolo Biglioli, Maurizio C
Capogrossi, Carlo Gaetano: Shear stress‐mediated chromatin remodeling provides molecular basis
for flow‐dependent regulation of gene expression. Circulation Research 08/2003; 93(2):155‐61.
DOI:10.1161/01.RES.0000080933.82105.29
34. Corrado Cirielli, Francesco Serino, Stefania Straino, Gabriele Toietta, Damiano Abeni, Giorgio
Ventoruzzo, Giuseppe Orlando, Paola Mazzanti, Guido Melillo, Thomas J Whickham, Imre
Kovesdi, Paolo Biglioli, Carlo Gaetano, Maurizio C Capogrossi: Adenovirus vectors targeting αV
integrin or heparan sulfate receptors display different distribution of transgene activity after
intramuscular injection. The Journal of Gene Medicine 03/2004; 6(3):309‐16.
DOI:10.1002/jgm.521
35. Stefania Mattiussi, Paolo Turrini, Lucia Testolin, Fabio Martelli, Germana Zaccagnini,
Antonella Mangoni, Laura M Barlucchi, Annalisa Antonini, Barbara Illi, Corrado Cirielli, Julio
Padron, Chiara Nicolò, Roberto Testi, Francesco Osculati, Paolo Biglioli, Maurizio C
Capogrossi, Carlo Gaetano: p21(Waf1/Cip1/Sdi1) mediates shear stress‐dependent antiapoptotic
function. Cardiovascular Research 04/2004; 61(4):693‐704. DOI:10.1016/j.cardiores.2003.12.008
16. 16
36. Barbara Illi, Alessandro Scopece, Simona Nanni, Antonella Farsetti, Maurizio C. Capogrossi,
Carlo Gaetano: Shear stress modulates chromatin structure and acts as a vascular phenotype
determinant in mouse embryonic stem cells. Cardiovascular Pathology 05/2004; 13(3):190‐191.
DOI:10.1016/j.carpath.2004.03.573
37. Daniela DʹArcangelo, Valeria Ambrosino, Gianluca Ragone, Maria Giannuzzo, Maurizio C
Capogrossi, Carlo Gaetano: Axl activation mediates laminar shear stress antiapoptotic effects in
human endothelial cells. Cardiovascular Pathology 05/2004; 13(3):194‐194.
DOI:10.1016/j.carpath.2004.03.585
38. Stefania Mattiussi, Fabio Martelli, Maurizio C. Capogrossi, Carlo Gaetano: Impairment of
paxillin function inhibits laminar shear stress sensing in human endothelial cells. Cardiovascular
Pathology 05/2004; 13(3):191‐191. DOI:10.1016/j.carpath.2004.03.575
39. Carlo Gaetano, Germana Zaccagnini, Linda Della Pietra, Simona Nanni, Maurizio C.
Capogrossi, Antonella Farsetti: Activation of telomerase through vegf signaling triggers
angiogenesis in response to hind‐limb ischemia. Cardiovascular Pathology 05/2004; 13(3):179‐180.
DOI:10.1016/j.carpath.2004.03.541
40. Germana Zaccagnini, Fabio Martelli, Pasquale Fasanaro, Alessandra Magenta, Carlo Gaetano,
Anna Di Carlo, Paolo Biglioli, Marco Giorgio, Ines Martin‐Padura, Pier Giuseppe Pelicci,
Maurizio C Capogrossi: p66(ShcA) modulates tissue response to hindlimb ischemia. Circulation
07/2004; 109(23):2917‐23. DOI:10.1161/01.CIR.0000129309.58874.0F
41. Barbara Illi, Alessandro Scopece, Simona Nanni, Antonella Farsetti, Liliana Morgante, Paolo
Biglioli, Maurizio C Capogrossi, Carlo Gaetano: Epigenetic histone modification and
cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress.
Circulation Research 04/2005; 96(5):501‐8. DOI:10.1161/01.RES.0000159181.06379.63
42. Germana Zaccagnini, Carlo Gaetano, Linda Della Pietra, Simona Nanni, Annalisa Grasselli,
Antonella Mangoni, Roberta Benvenuto, Manuela Fabrizi, Silvia Truffa, Antonia Germani,
Fabiola Moretti, Alfredo Pontecorvi, Ada Sacchi, Silvia Bacchetti, Maurizio C Capogrossi,
Antonella Farsetti: Telomerase Mediates Vascular Endothelial Growth Factor‐dependent
Responsiveness in a Rat Model of Hind Limb Ischemia. Journal of Biological Chemistry 05/2005;
280(15):14790‐8. DOI:10.1074/jbc.M414644200
43. Yoon‐La Choi, Chong Jai Kim, Tatsuya Matsuo, Carlo Gaetano, Rita Falconi, Yeon‐Lim Suh,
Seok‐Hyung Kim, Young Kee Shin, Seong Hoe Park, Je Geun Chi, Carol J Thiele: HUlip, a
human homologue of unc‐33‐like phosphoprotein of Caenorhabditis elegans; Immunohistochemical
localization in the developing human brain and patterns of expression in nervous system tumors.
Journal of Neuro‐Oncology 06/2005; 73(1):19‐27. DOI:10.1007/s11060‐004‐3013‐3
44. Simona Nanni, Carmen Priolo, Annalisa Grasselli, Manuela DʹEletto, Roberta Merola, Fabiola
Moretti, Michele Gallucci, Piero De Carli, Steno Sentinelli, Anna Maria Cianciulli, Marcella
17. 17
Mottolese, Paolo Carlini, Diego Arcelli, Mauro Helmer‐Citterich, Carlo Gaetano, Massimo
Loda, Alfredo Pontecorvi, Silvia Bacchetti, Ada Sacchi, Antonella Farsetti: Epithelial‐Restricted
Gene Profile of Primary Cultures from Human Prostate Tumors: A Molecular Approach to Predict
Clinical Behavior of Prostate Cancer. Molecular Cancer Research 03/2006; 4(2):79‐92.
DOI:10.1158/1541‐7786.MCR‐05‐0098
45. Barbara Illi, Carlo Gaetano, Maurizio C Capogrossi: How senescent vascular cells lose their Clock
age‐dependent impairment of circadian rhythmicity in smooth muscle cells. Circulation Research
04/2006; 98(4):450‐2. DOI:10.1161/01.RES.0000214331.90904.aa
46. Stefania Mattiussi, Kazue Matsumoto, Barbara Illi, Fabio Martelli, Maurizio C Capogrossi,
Carlo Gaetano: Papilloma protein E6 abrogates shear stress‐dependent survival in human endothelial
cells: Evidence for specialized functions of paxillin. Cardiovascular Research 07/2006; 70(3):578‐88.
DOI:10.1016/j.cardiores.2006.02.008
47. Daniela DʹArcangelo, Valeria Ambrosino, Maria Giannuzzo, Carlo Gaetano, Maurizio C
Capogrossi: Axl receptor activation mediates laminar shear stress anti‐apoptotic effects in human
endothelial cells. Cardiovascular Research 10/2006; 71(4):754‐63.
DOI:10.1016/j.cardiores.2006.06.002
48. G C Minetti, C Colussi, R Adami, C Serra, C Mozzetta, V Parente, S Fortuni, S Straino, M
Sampaolesi, M Di Padova, B Illi, P Gallinari, C Steinkühler, M C Capogrossi, V Sartorelli, R
Bottinelli, C Gaetano, P L Puri: Functional and morphological recovery of dystrophic muscles in mice
treated with deacetylase inhibitors. Nature Medicine 11/2006; 12(10):1147‐50.
DOI:10.1038/nm1479
49. Carlo Gaetano, Claudia Colussi, Maurizio C Capogrossi: PEDF, PPAR‐gamma, p53: Deadly
circuits arise when worlds collide. Cardiovascular Research 12/2007; 76(2):195‐6.
DOI:10.1016/j.cardiores.2007.08.011
50. Barbara Illi, Claudio Dello Russo, Claudia Colussi, Jessica Rosati, Michele Pallaoro, Francesco
Spallotta, Dante Rotili, Sergio Valente, Gianluca Ragone, Fabio Martelli, Paolo Biglioli,
Christian Steinkuhler, Paola Gallinari, Antonello Mai, Maurizio C Capogrossi, Carlo Gaetano:
Nitric Oxide Modulates Chromatin Folding in Human Endothelial Cells via Protein Phosphatase 2A
Activation and Class II Histone Deacetylases Nuclear Shuttling. Circulation Research 02/2008;
102(1):51‐8. DOI:10.1161/CIRCRESAHA.107.157305
51. Aymone Gurtner, Paola Fuschi, Fiorenza Magi, Claudia Colussi, Carlo Gaetano, Matthias
Dobbelstein, Ada Sacchi, Giulia Piaggio: NF‐Y Dependent Epigenetic Modifications Discriminate
between Proliferating and Postmitotic Tissue. PLoS ONE 02/2008; 3(4):e2047.
DOI:10.1371/journal.pone.0002047
52. Elisa Sala, Luca Mologni, Silvia Truffa, Carlo Gaetano, Gideon E Bollag, Carlo Gambacorti‐
Passerini: BRAF Silencing by Short Hairpin RNA or Chemical Blockade by PLX4032 Leads to
18. 18
Different Responses in Melanoma and Thyroid Carcinoma Cells. Molecular Cancer Research
06/2008; 6(5):751‐9. DOI:10.1158/1541‐7786.MCR‐07‐2001
53. Annalisa Grasselli, Simona Nanni, Claudia Colussi, Aurora Aiello, Valentina Benvenuti,
Gianluca Ragone, Fabiola Moretti, Ada Sacchi, Silvia Bacchetti, Carlo Gaetano, Maurizio C
Capogrossi, Alfredo Pontecorvi, Antonella Farsetti: Estrogen Receptor‐α and Endothelial Nitric
Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase. Circulation
Research 07/2008; 103(1):34‐42. DOI:10.1161/CIRCRESAHA.107.169037
54. C Colussi, C Gaetano, MC Capogrossi: AAV‐dependent targeting of myostatin function: follistatin
strikes back at muscular dystrophy. Gene therapy 09/2008; 15(15):1075‐6. DOI:10.1038/gt.2008.95
55. Antonella Farsetti, Annalisa Grasselli, Silvia Bacchetti, Carlo Gaetano, Maurizio C Capogrossi:
The telomerase tale in vascular aging: Regulation by estrogens and nitric oxide signaling. Journal of
Applied Physiology 12/2008; 106(1):333‐7. DOI:10.1152/japplphysiol.91360.2008
56. Claudia Colussi, Chiara Mozzetta, Aymone Gurtner, Barbara Illi, Jessica Rosati, Stefania
Straino, Gianluca Ragone, Mario Pescatori, Germana Zaccagnini, Annalisa Antonini, Giulia
Minetti, Fabio Martelli, Giulia Piaggio, Paola Gallinari, Christian Steinkuhler, Christian
Steinkulher, Emilio Clementi, Carmela DellʹAversana, Lucia Altucci, Antonello Mai, Maurizio
C Capogrossi, Pier Lorenzo Puri, Carlo Gaetano: HDAC2 blockade by nitric oxide and histone
deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment.
Proceedings of the National Academy of Sciences 01/2009; 105(49):19183‐7.
DOI:10.1073/pnas.0805514105
57. Stefania Mattiussi, Chiara Lazzari, Silvia Truffa, Annalisa Antonini, Silvia Soddu, Maurizio C
Capogrossi, Carlo Gaetano: Homeodomain Interacting Protein Kinase 2 Activation Compromises
Endothelial Cell Response to Laminar Flow: Protective Role of p21. PLoS ONE 02/2009; 4(8):e6603.
DOI:10.1371/journal.pone.0006603
58. Simona Nanni, Valentina Benvenuti, Annalisa Grasselli, Carmen Priolo, Aurora Aiello,
Stefania Mattiussi, Claudia Colussi, Vittoria Lirangi, Barbara Illi, Manuela DʹEletto, Anna
Maria Cianciulli, Michele Gallucci, Piero De Carli, Steno Sentinelli, Marcella Mottolese, Paolo
Carlini, Lidia Strigari, Stephen Finn, Elke Mueller, Giorgio Arcangeli, Carlo Gaetano,
Maurizio C Capogrossi, Raffaele Perrone Donnorso, Silvia Bacchetti, Ada Sacchi, Alfredo
Pontecorvi, Massimo Loda, Antonella Farsetti: Endothelial NOS, estrogen receptor β, and HIFs
cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer.
The Journal of Clinical Investigation 05/2009; 119(5):1093‐108. DOI:10.1172/JCI35079
59. Claudia Colussi, Aymone Gurtner, Jessica Rosati, Barbara Illi, Gianluca Ragone, Giulia
Piaggio, Maurizio Moggio, Costanza Lamperti, Grazia DʹAngelo, Emilio Clementi, Giulia
Minetti, Chiara Mozzetta, Annalisa Antonini, Maurizio C Capogrossi, Pier Lorenzo Puri,
Carlo Gaetano: Nitric oxide deficiency determines global chromatin changes in Duchenne muscular
dystrophy. The FASEB Journal 05/2009; 23(7):2131‐41. DOI:10.1096/fj.08‐115618
19. 19
60. Barbara Illi, Claudia Colussi, Annalisa Grasselli, Antonella Farsetti, Maurizio C Capogrossi,
Carlo Gaetano: NO sparks off chromatin: Tales of a multifaceted epigenetic regulator. Pharmacology
Therapeutics 09/2009; 123(3):344‐52. DOI:10.1016/j.pharmthera.2009.05.003
61. Simona Greco, Marco De Simone, Claudia Colussi, Germana Zaccagnini, Pasquale Fasanaro,
Mario Pescatori, Rosanna Cardani, Riccardo Perbellini, Eleonora Isaia, Patrizio Sale, Giovanni
Meola, Maurizio C Capogrossi, Carlo Gaetano, Fabio Martelli: Common micro‐RNA signature in
skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute
ischemia. The FASEB Journal 07/2009; 23(10):3335‐46. DOI:10.1096/fj.08‐128579
62. Roberta Melchionna, Marta Romani, Valeria Ambrosino, Daniela DʹArcangelo, Chiara
Cencioni, Daniele Porcelli, Gabriele Toietta, Silvia Truffa, Carlo Gaetano, Antonella Mangoni,
Ombretta Pozzoli, Claudia Cappuzzello, Maurizio C Capogrossi, Monica Napolitano: Role of
HIF‐1alpha in proton‐mediated CXCR4 down‐regulation in endothelial cells. Cardiovascular
Research 12/2009; 86(2):293‐301. DOI:10.1093/cvr/cvp393
63. C Colussi, C Banfi, M Brioschi, E Tremoli, S Straino, F Spallotta, A Mai, D Rotili, M C
Capogrossi, C Gaetano: Proteomic profile of differentially expressed plasma proteins from dystrophic
mice and following suberoylanilide hydroxamic acid treatment. Proteomics ‐ Clinical Applications
01/2010; 4(1):71‐83. DOI:10.1002/prca.200900116
64. Claudia Colussi, Roberta Berni, Jessica Rosati, Stefania Straino, Serena Vitale, Francesco
Spallotta, Silvana Baruffi, Leonardo Bocchi, Francesca Delucchi, Stefano Rossi, Monia Savi,
Dante Rotili, Federico Quaini, Emilio Macchi, Donatella Stilli, Ezio Musso, Antonello Mai,
Carlo Gaetano, Maurizio C Capogrossi: The histone deacetylase inhibitor suberoylanilide
hydroxamic acid reduces cardiac arrhythmias in dystrophic mice. Cardiovascular Research 02/2010;
87(1):73‐82. DOI:10.1093/cvr/cvq035
65. Claudia Colussi, Barbara Illi, Jessica Rosati, Francesco Spallotta, Antonella Farsetti, Annalisa
Grasselli, Antonello Mai, Maurizio C Capogrossi, Carlo Gaetano: Histone deacetylase inhibitors:
Keeping momentum for neuromuscular and cardiovascular diseases treatment. Pharmacological
Research 03/2010; 62(1):3‐10. DOI:10.1016/j.phrs.2010.02.014
66. Francesco Spallotta, Jessica Rosati, Stefania Straino, Simona Nanni, Annalisa Grasselli, Valeria
Ambrosino, Dante Rotili, Sergio Valente, Antonella Farsetti, Antonello Mai, Maurizio C
Capogrossi, Carlo Gaetano, Barbara Illi: Nitric Oxide Determines Mesodermic Differentiation of
Mouse Embryonic Stem Cells by Activating Class IIa Histone Deacetylases: Potential Therapeutic
Implications in a Mouse Model of Hindlimb Ischemia. Stem Cells 03/2010; 28(3):431‐42.
DOI:10.1002/stem.300
67. Carlo Gaetano, Maurizio C. Capogrossi, Maurizio Fanciulli, Patrizia Filetici, Giulia Piaggio:
Epigenetics in Rome: Breaking news from the Chromatin Remodeling and Human Disease
20. 20
Workshop. Epigenetics: official journal of the DNA Methylation Society 04/2010; 5(3).
DOI:10.4161/epi.5.3.11200
68. Barbara Illi, Claudia Colussi, Jessica Rosati, Francesco Spallotta, Simona Nanni, Antonella
Farsetti, Maurizio C Capogrossi, Carlo Gaetano: NO points to epigenetics in vascular
development. Cardiovascular Research 90: 447‐456. Cardiovascular Research 02/2011; 90(3):447‐
56. DOI:10.1093/cvr/cvr056
69. Claudia Colussi, Jessica Rosati, Stefania Straino, Francesco Spallotta, Roberta Berni, Donatella
Stilli, Stefano Rossi, Ezio Musso, Emilio Macchi, Antonello Mai, Gianluca Sbardella, Sabrina
Castellano, Cristina Chimenti, Andrea Frustaci, Angela Nebbioso, Lucia Altucci, Maurizio C
Capogrossi, Carlo Gaetano: Nε‐lysine acetylation determines dissociation from GAP junctions and
lateralization of connexin 43 in normal and dystrophic heart. Proceedings of the National
Academy of Sciences 02/2011; 108(7):2795‐800. DOI:10.1073/pnas.1013124108
70. Alessandra Rossini, Caterina Frati, Costanza Lagrasta, Gallia Graiani, Alessandro Scopece,
Stefano Cavalli, Ezio Musso, Marco Baccarin, Marina Di Segni, Francesco Fagnoni, Antonia
Germani, Eugenio Quaini, Manuel Mayr, Qingbo Xu, Andrea Barbuti, Dario DiFrancesco,
Giulio Pompilio, Federico Quaini, Carlo Gaetano, Maurizio C Capogrossi: Human cardiac and
bone marrow stromal cells exhibit distinctive properties related to their origin. Cardiovascular
Research 02/2011; 89(3):650‐60. DOI:10.1093/cvr/cvq290
71. Simona Nanni, Annalisa Grasselli, Valentina Benvenuti, Aurora Aiello, Valentina Pantisano,
Agnese Re, Carlo Gaetano, Maurizio C. Capogrossi, Silvia Bacchetti, Alfredo Pontecorvi,
Antonella Farsetti: The role of nuclear endothelial nitric oxide synthase in the endothelial and prostate
microenvironments. Hormone molecular biology and clinical investigation 03/2011; 5(2).
DOI:10.1515/HMBCI.2011.011
72. Jessica Rosati, Francesco Spallotta, Simona Nanni, Annalisa Grasselli, Annalisa Antonini, Sara
Vincenti, Carlo Presutti, Claudia Colussi, Carmen DʹAngelo, Anna Biroccio, Antonella
Farsetti, Maurizio C Capogrossi, Barbara Illi, Carlo Gaetano: Smad‐Interacting Protein‐1 and
MicroRNA 200 Family Define a Nitric Oxide‐Dependent Molecular Circuitry Involved in Embryonic
Stem Cell Mesendoderm Differentiation. Arteriosclerosis Thrombosis and Vascular Biology
03/2011; 31(4):898‐907. DOI:10.1161/ATVBAHA.110.214478
73. Ilaria Burba, Gualtiero I Colombo, Lidia Irene Staszewsky, Marco De Simone, Paolo Devanna,
Simona Nanni, Daniele Avitabile, Fabiola Molla, Simona Cosentino, Ilaria Russo, Noeleen De
Angelis, Annarita Soldo, Antonella Biondi, Elisa Gambini, Carlo Gaetano, Antonella Farsetti,
Giulio Pompilio, Roberto Latini, Maurizio C Capogrossi, Maurizio Pesce: Histone Deacetylase
Inhibition Enhances Self Renewal and Cardioprotection by Human Cord Blood‐Derived CD34+ Cells.
PLoS ONE 07/2011; 6(7):e22158. DOI:10.1371/journal.pone.0022158
74. Chiara Cencioni, Roberta Melchionna, Stefania Straino, Marta Romani, Claudia Cappuzzello,
Valentina Annese, Joseph C Wu, Giulio Pompilio, Angela Santoni, Carlo Gaetano, Monica
21. 21
Napolitano, Maurizio C Capogrossi: Ex vivo acidic preconditioning enhances bone marrow ckit+ cell
therapeutic potential via increased CXCR4 expression. European Heart Journal 07/2011; 34(26).
DOI:10.1093/eurheartj/ehr219
75. Alessandra Giuliani, Caterina Frati, Alessandra Rossini, Vladimir S Komlev, Costanza
Lagrasta, Monia Savi, Stefano Cavalli, Carlo Gaetano, Federico Quaini, Adrian Manescu,
Franco Rustichelli: High‐resolution X‐ray microtomography for three‐dimensional imaging of cardiac
progenitor cell homing in infarcted rat hearts. Journal of Tissue Engineering and Regenerative
Medicine 08/2011; 5(8):e168‐78. DOI:10.1002/term.409
76. Viviana Meraviglia, Matteo Vecellio, Annalisa Grasselli, Marco Baccarin, Antonella Farsetti,
Maurizio C Capogrossi, Giulio Pompilio, Domenico A Coviello, Carlo Gaetano, Marina Di
Segni, Alessandra Rossini: Human chorionic villus mesenchymal stromal cells reveal strong
endothelial conversion properties. Differentiation 03/2012; 83(5):260‐70.
DOI:10.1016/j.diff.2012.02.006
77. Claudia Colussi, Alessandro Scopece, Serena Vitale, Francesco Spallotta, Stefania Mattiussi,
Jessica Rosati, Barbara Illi, Antonello Mai, Sabrina Castellano, Gianluca Sbardella, Antonella
Farsetti, Maurizio C Capogrossi, Carlo Gaetano: P300/CBP Associated Factor Regulates
Nitroglycerin‐Dependent Arterial Relaxation by N‐epsilon‐Lysine Acetylation of Contractile Proteins.
Arteriosclerosis Thrombosis and Vascular Biology 08/2012; 32(10):2435‐43.
DOI:10.1161/ATVBAHA.112.254011
78. Lucia Cicchillitti, Valeria Di Stefano, Eleonora Isaia, Luca Crimaldi, Pasquale Fasanaro,
Valeria Ambrosino, Annalisa Antonini, Maurizio C Capogrossi, Carlo Gaetano, Giulia
Piaggio, Fabio Martelli: Hypoxia‐inducible Factor 1‐α Induces miR‐210 in Normoxic Differentiating
Myoblasts. Journal of Biological Chemistry 11/2012; 287(53). DOI:10.1074/jbc.M112.421255
79. Matteo Vecellio, Viviana Meraviglia, Simona Nanni, Andrea Barbuti, Angela Scavone, Dario
Difrancesco, Antonella Farsetti, Giulio Pompilio, Gualtiero I Colombo, Maurizio C
Capogrossi, Carlo Gaetano, Alessandra Rossini: In Vitro Epigenetic Reprogramming of Human
Cardiac Mesenchymal Stromal Cells into Functionally Competent Cardiovascular Precursors. PLoS
ONE 12/2012; 7(12):e51694. DOI:10.1371/journal.pone.0051694
80. Francesco Spallotta, Chiara Cencioni, Stefania Straino, Simona Nanni, Jessica Rosati, Simona
Artuso, Isabella Manni, Claudia Colussi, Giulia Piaggio, Fabio Martelli, Sergio Valente,
Antonello Mai, Maurizio C Capogrossi, Antonella Farsetti, Carlo Gaetano: A Nitric Oxide‐
dependent Crosstalk Between Class I and III Histone Deacetylases Accelerates Skin Repair. Journal of
Biological Chemistry 03/2013; 288(16). DOI:10.1074/jbc.M112.441816
81. Simona Nanni, Aurora Aiello, Agnese Re, Alessandro Guffanti, Valentina Benvenuti, Claudia
Colussi, Luis Jaime Castro‐Vega, Armando Felsani, Arturo Londono‐Vallejo, Maurizio C
Capogrossi, Silvia Bacchetti, Carlo Gaetano, Alfredo Pontecorvi, Antonella Farsetti: Estrogen‐
22. 22
Dependent Dynamic Profile of eNOS‐DNA Associations in Prostate Cancer. PLoS ONE 05/2013;
8(5):e62522. DOI:10.1371/journal.pone.0062522
82. Francesco Spallotta, Silvia Tardivo, Simona Nanni, Jessica D Rosati, Stefania Straino,
Antonello Mai, Matteo Vecellio, Sergio Valente, Maurizio C Capogrossi, Antonella Farsetti,
Julie Martone, Irene Bozzoni, Alfredo Pontecorvi, Carlo Gaetano, Claudia Colussi: Detrimental
Effect of Class Selective Histone Deacetylase Inhibitors During Tissue Regeneration Following Hind‐
limb Ischemia. Journal of Biological Chemistry 07/2013; 288(32). DOI:10.1074/jbc.M113.484337
83. Germana Zaccagnini, Biagina Maimone, Valeria Di Stefano, Pasquale Fasanaro, Simona Greco,
Alessandra Perfetti, Maurizio C Capogrossi, Carlo Gaetano, Fabio Martelli: Hypoxia‐Induced
miR‐210 Modulates Tissue Response to Acute Peripheral Ischemia. Antioxidants & Redox
Signaling 08/2013; 21(8). DOI:10.1089/ars.2013.5206
84. Alessandra Magenta, Simona Greco, Carlo Gaetano, Fabio Martelli: Oxidative Stress and
MicroRNAs in Vascular Diseases. International Journal of Molecular Sciences 09/2013;
14(9):17319‐46. DOI:10.3390/ijms140917319
85. Chiara Cencioni, Francesco Spallotta, Fabio Martelli, Sergio Valente, Antonello Mai, Andreas
M Zeiher, Carlo Gaetano: Oxidative Stress and Epigenetic Regulation in Ageing and Age‐Related
Diseases. International Journal of Molecular Sciences 09/2013; 14(9):17643‐63.
DOI:10.3390/ijms140917643
86. Francesco Spallotta, Chiara Cencioni, Stefania Straino, Gianluca Sbardella, Sabrina Castellano,
Maurizio C Capogrossi, Fabio Martelli, Carlo Gaetano: Enhancement of lysine acetylation
accelerates wound repair. Communicative & integrative biology 09/2013; 6(5):e25466.
DOI:10.4161/cib.25466
87. Simona Greco, Carlo Gaetano, Fabio Martelli: HypoxamiR Regulation and Function in Ischemic
Cardiovascular Diseases. Antioxidants & Redox Signaling 09/2013; 21(8).
DOI:10.1089/ars.2013.5403
88. Emily Borretto, Loretta Lazzarato, Francesco Spallotta, Chiara Cencioni, Yuri DʹAlessandra,
Carlo Gaetano, Roberta Fruttero, Alberto Gasco: Synthesis and Biological Evaluation of the First
Example of NO‐Donor Histone Deacetylase Inhibitor. ACS Medicinal Chemistry Letters 10/2013;
4(10):994‐9. DOI:10.1021/ml400289e
89. Matteo Vecellio, Francesco Spallotta, Simona Nanni, Claudia Colussi, Chiara Cencioni, Anja
Derlet, Beatrice Bassetti, Manuela Tilenni, Maria Cristina Carena, Antonella Farsetti, Gianluca
Sbardella, Sabrina Castellano, Antonello Mai, Fabio Martelli, Giulio Pompilio, Maurizio C
Capogrossi, Alessandra Rossini, Stefanie Dimmeler, Andreas M Zeiher, Carlo Gaetano: The
Histone Acetylase Activator Pentadecylidenemalonate 1b Rescues Proliferation and Differentiation in
Human Cardiac Mesenchymal Cells of Type 2 Diabetic Patients. Diabetes 01/2014; 63(6).
DOI:10.2337/db13‐0731
23. 23
90. Armando Felsani, Bjarki Gudmundsson, Simona Nanni, Elena Brini, Anna Moles, Hans
Guttormur Thormar, Peter Estibeiro, Carlo Gaetano, Maurizio Capogrossi, Antonella Farsetti,
Jon Johannes Jonsson, Alessandro Guffanti: Impact of different ChIP‐Seq protocols on DNA
integrity and quality of bioinformatics analysis results. Briefings in Functional Genomics 02/2014;
14(2). DOI:10.1093/bfgp/elu001
91. Alessandra Magenta, Simona Greco, Maurizio C Capogrossi, Carlo Gaetano, Fabio Martelli:
Nitric Oxide, Oxidative Stress, and p66 Shc Interplay in Diabetic Endothelial Dysfunction. Biomed
Res Int. 2014:193095. doi: 10.1155/2014/193095
92. Chiara Cencioni, Francesco Spallotta, Simona Greco, Fabio Martelli, Andreas M Zeiher, Carlo
Gaetano: Epigenetic mechanisms of hyperglycemic memory. The International Journal of
Biochemistry & Cell Biology 04/2014; 51(1). DOI:10.1016/j.biocel.2014.04.014
93. Alessandra Perfetti, Simona Greco, Enrico Bugiardini, Rosanna Cardani, Paola Gaia, Carlo
Gaetano, Giovanni Meola, Fabio Martelli: Plasma microRNAs as biomarkers for myotonic
dystrophy type 1. Neuromuscular Disorders 06/2014; 24(6). DOI:10.1016/j.nmd.2014.02.005
94. Mario Baumgart, Marco Groth, Steffen Priebe, Aurora Savino, Giovanna Testa, Andreas Dix,
Roberto Ripa, Francesco Spallotta, Carlo Gaetano, Michela Ori, Eva Terzibasi Tozzini,
Reinhard Guthke, Matthias Platzer, Alessandro Cellerino: RNA‐seq of the aging brain in the
short‐lived fish N. furzeri – conserved pathways and novel genes associated with neurogenesis. Aging
cell 07/2014; DOI:10.1111/acel.12257
95. Zhihui Liu, Wenling Li, Xuefei Ma, Nancy Ding, Francesco Spallotta, Eileen Southon, Lino
Tessarollo, Carlo Gaetano, Yoh‐Suke Mukoyama, Carol J Thiele: Essential Role of the Zinc
Finger Transcription Factor Casz1 for Mammalian Cardiac Morphogenesis and Development. Journal
of Biological Chemistry 09/2014; 289(43). DOI:10.1074/jbc.M114.570416
96. Viviana Meraviglia, Valerio Azzimato, Luca Piacentini, Mattia Chiesa, Rupesh K Kesharwani,
Caterina Frati, Maurizio C Capogrossi, Carlo Gaetano, Giulio Pompilio, Gualtiero I Colombo,
Alessandra Rossini: Syngeneic Cardiac and Bone Marrow Stromal Cells Display Tissue‐Specific
microRNA Signatures and microRNA Subsets Restricted to Diverse Differentiation Processes. PLoS
ONE 09/2014; 9(9):e107269. DOI:10.1371/journal.pone.0107269
97. Chiara Cencioni, Francesco Spallotta, Antonello Mai, Fabio Martelli, Antonella Farsetti,
Andreas M Zeiher, Carlo Gaetano: Sirtuin function in aging heart and vessels. Journal of
Molecular and Cellular Cardiology 01/2015; 83. DOI:10.1016/j.yjmcc.2014.12.023
98. Francesca Prandi, Marco Piola, Monica Soncini, Claudia Colussi, Yuri D’Alessandra, Eleonora
Penza, Marco Agrifoglio, Maria Cristina Vinci, Gianluca Polvani, Carlo Gaetano, Gianfranco
Beniamino Fiore, Maurizio Pesce: Adventitial Vessel Growth and Progenitor Cells Activation in an
24. 24
Ex Vivo Culture System Mimicking Human Saphenous Vein Wall Strain after Coronary Artery
Bypass Grafting. PLoS ONE 02/2015; DOI:10.1371/journal.pone.0117409
99. Viviana Meraviglia, Valerio Azzimato, Claudia Colussi, Maria Cristina Florio, Anna Binda,
Alice Panariti, Khaled Qanud, Silvia Suffredini, Laura Gennaccaro, Michele Miragoli, Andrea
Barbuti, Paul D Lampe, Carlo Gaetano, Peter P Pramstaller, Maurizio C Capogrossi, Fabio A
Recchia, Giulio Pompilio, Ilaria Rivolta, Alessandra Rossini: Acetylation mediates Cx43 reduction
caused by electrical stimulation. Journal of Molecular and Cellular Cardiology 08/2015;
DOI:10.1016/j.yjmcc.2015.08.001
100. A Re, S Nanni, A Aiello, S Granata, C Colussi, G Campostrini, S Mattiussi, C D’Angelo, A
Biroccio, A Rossini, A Barbuti, D Di Francesco, F Trimarchi, A Pontecorvi, C Gaetano, and A
Farsetti: Anacardic acid and thyroid hormone enhance cardiomyocytes production from
undifferentiated mouse ES cells along functionally distinct pathways. Endocrine 2015, (in press).
101. Germana Zaccagnini, Anna Palmisano, Tamara Canu, Biagina Maimone, Francesco M. Lo
Russo, Federico Ambrogi, Carlo Gaetano, Francesco De Cobelli, Alessandro Del Maschio,
Antonio Esposito, Fabio Martelli: Magnetic resonance imaging allows the evaluation of tissue
damage and regeneration in a mouse model of critical limb ischemia. Plos One 2015 (in press).
102. Viviana Meraviglia, Jianyan Wen, Luca Piacentini, Giulia Campostrini, Cheng Wang, Maria
Cristina Florio, Valerio Azzimato, Lorenzo Fassina, Martin Langes, Johnson Wong, Michele
Miragoli, Carlo Gaetano, Giulio Pompilio, Andrea Barbuti, Dario DiFrancesco, Deborah
Mascalzoni, Peter P. Pramstaller, Gualtiero I. Colombo, Huei‐Sheng Vincent Chen, Alessandra
Rossini: Higher cardiogenic potential of iPSCs derived from cardiac versus skin stromal cells.
Frontiers in Biosciences 2015 ( in press).
Manuscripts submitted
1. Valente Sergio, Mellini Paolo, Spallotta Francesco, Carafa Vincenzo, Nebbioso Angela, Polletta
Lucia, Carnevale Ilaria, Saladini Serena, Trisciuoglio Daniela, Gabellini Chiara, Tardugno
Maria, Zwergel Clemens, Cencioni Chiara, Atlante Sandra, Moniot Sébastien, Steegborn
Clemens, Budriesi Roberta, Tafani Marco, Del Bufalo Donatella, Altucci Lucia, Gaetano Carlo,
Mai Antonello: 1,4‐Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair
and Mitochondrial Function, and Exhibit Inhibition of Proliferation in Cancer Cells. Submitted,
2015.
2. Davide Garella, Sandra Atlante, Emily Borretto, Mattia Cocco, Marta Giorgis, Annalisa
Costale, Antonella Di Stilo, Gianluca Miglio, Chiara Cencioni, Eli Fernández‐de Gortari, José L.
25. 25
Medina‐Franco, Francesco Spallotta, Carlo Gaetano, Massimo Bertinaria: Chemical modulation
of NSC137546 scaffold toward improved inhibitors of DNA methylation. Submitted, 2015.
Invited Lectures (Selected)
1. 1995 Invited Speaker, UCSF, Host: Prof. Mark Israel, San Francisco, Ca, USA.
2. 1996 Invited Speaker, European Institute of Oncology (IEO), Host: Prof. PierPaolo Di Fiore,
Milan, Italy
3. 1999 Invited Speaker, Favaloro University, Host: Prof. René G. Favaloro, Buenos Aires,
Argentina.
4. 2005 Invited Speaker, The British Society for Cardiovascular Research Conference, Host: Prof.
Qingbo Xu, Oxford, UK
5. 2007 Invited Speaker, King´s College London, Host: Prof. Qingbo Xu, London, UK
6. 2008 Invited Speaker, Seminari Biologici Series, Catholic University, Host: Prof. Tommaso
Galeotti, Rome, Italy
7. 2009 Invited Speaker, Medical Research Council‐University College London, Host: Dr.
Antonella Riccio, London, UK
8. 2009 Organizer & Lecturer, National Cancer Institute Regina Elena, Workshop “Epigenetics
in Rome: Breaking news from the Chromatin Remodeling and Human Disease”, Rome, Italy
9. 2010 Invited Speaker, Burnham Institute, Host: Prof. Vincent Chen, S. Diego, Ca, USA
10. 2010 Invited Speaker, Royal Bristol Infirmary, Bristol University, Bristol, UK
11. 2011 Invited Speaker FASEB Meeting Histone Deacetylases & Reversible Acetylation in
Signaling & Disease, Steamboat Springs, Colorado USA
12. 2011 Invited Speaker, European Society of Cardiology (ESC) Congress 2011,Paris, France
13. 2012 Invited Speaker, University of Fribourg, “Vascular Progenitors in Biology and Medicine
Meeting”, Fribourg, Switzerland
14. 2013 Invited Speaker, San Donato Hospital IRCCS, Host: Dr. Fabio Martelli, Milan, Italy
26. 26
15. 2013 Invited Speaker, Leiden University, Host: Prof. Paul Quax, Leiden, The Netherland
16. 2014 Invited Speaker, NIH/National Cancer Institute, Host: Prof. Carol J. Thiele, Bethesda,
USA
17. 2014 Chairman, German Centre for Cardiovascular Research (DZHK), Symposium on
Epigenetics, Host: Prof. Andreas Zeiher, Berlin, Germany
18. 2015 Invited Speaker, German Heart Center at the TU Munich, Symposium on ʺRedox stress
and epigenetics in cardiovascular diseasesʺ, Host: Prof. Agnes Görlach, Munich, Germany
19. 2015 Invited Speaker, IFOM‐IEO Campus, Host: Prof. PierPaolo Di Fiore, Milan, Italy
20. 2015 Invited Speaker Euro Global Diabetes Summit and Medicare Expo, Host: Prof. Massimo
Collino, Valencia, Spain
Contribution to American Heart Scientific Sessions (Accepted abstracts)
(1‐31)
1. Palumbo, R., Gaetano, C., Melillo, G., Toschi, E., Remuzzi, A., and Capogrossi, M. C. (2000)
Shear Stress Downregulation of Platelet-Derived Growth Factor Receptor-β and Matrix
Metalloprotease-2 Is Associated With Inhibition of Smooth Muscle Cell Invasion and
Migration. Circulation 102, 225-230
2. Zaccagnini, G., Martelli, F., Fasanaro, P., Magenta, A., Gaetano, C., Di Carlo, A., Biglioli, P.,
Giorgio, M., Martin-Padura, I., Pelicci, P. G., and Capogrossi, M. C. (2004) p66ShcA Modulates
Tissue Response to Hindlimb Ischemia. Circulation 109, 2917-2923
3. Colussi, C., Illi, B., Straino, S., Capogrossi, M. C., and Gaetano, C. (2007) Abstract 1274:
Altered Chromatin Landscape Provides Molecular Basis for Endothelial Dysfunction in
Duchenne Muscle Dystrophy. Circulation 114, II_240
4. Grasselli, A., Nanni, S., Colussi, C., Sacchi, A., Gaetano, C., Pontecorvi, A., Capogrossi, M. C.,
and Farsetti, A. (2007) Abstract 1396: Nitric Oxide is Required for Estrogen Regulation of
hTERT Expression and Telomerase Activity in Human Endothelial Cells. Circulation 114,
II_266-II_267
5. Illi, B., Colussi, C., Martelli, F., Capogrossi, M. C., and Gaetano, C. (2007) Abstract 354: Nitric
Oxide Regulates Chromatin Folding in Human Endothelial Cells via PP2A activation and
HDAC-4 Nuclear Shuttling. Circulation 114, II_45-II_46
27. 27
6. Illi, B., Spallotta, F., Mattiussi, S., Capogrossi, M. C., and Gaetano, C. (2007) Abstract 301:
Epigenetic Reprogramming during SS-dependent Differentiation of Mouse Embryonic Stem
Cells: Role of Nitric Oxide and Histone Deacetylases. Circulation 114, II_32
7. Illi, B., Spallotta, F., Rosati, J., Mattiussi, S., Nanni, S., Rotili, D., Valente, S., Mai, A., Farsetti,
A., Capogrossi, M. C., and Gaetano, C. (2007) Abstract 692: Class II HDACs Are Required
During Early Stage Mouse Embryonic Stem Cell Differentiation in Response to Nitric Oxide.
Circulation 116, II_129
8. Rossini, A., Scopece, A., Pozzoli, O., Pompilio, G., Gaetano, C., Capogrossi, M. C., and
Germani, A. (2007) Abstract 1015: Human Heart Contains A Stem Cell Population With
Mesenchymal Properties. Circulation 116, II_202
9. Colussi, C., Berni, R., Bocchi, L., Savi, M., Delucchi, F., Stilli, D., Quaini, F., Musso, E.,
Capogrossi, M. C., and Gaetano, C. (2008) Abstract 3861: Histone Deacetylase Inhibitors
Ameliorate Cardiac Electrical Competence In Dystrophic Mice. Circulation 118, S_494
10. Colussi, C., Straino, S., Illi, B., Rosati, J., Vitale, S., Capogrossi, M. C., and Gaetano, C. (2008)
Abstract 1822: Epigenetic Parallelism Between Hindlimb Ischemia And Duchenne Muscular
Dystrophy Revealed By Global Histone Modification Profiling. Circulation 118, S_392
11. Rosati, J., Spallotta, F., Vincenti, S., Arcelli, D., Presutti, C., Capogrossi, M. C., Gaetano, C.,
and Illi, B. (2008) Abstract 3832: Mir429 Regulates NO-dependent Differentiation Of Mouse
Embryonic Stem Cells. Circulation 118, S_493
12. Rossini, A., Scopece, A., Pompilio, G., Gaetano, C., and Capogrossi, M. C. (2008) Abstract 302:
Cardiac Stromal Cells Response to Lineage-Specific Differentiation Signals Reveals
Commitment to a Cardiovascular Differentiation Default Program. Circulation 118, S_280-
S_281
13. Gaetano, C., Colussi, F. C., Scopece, M. A., Mattiussi, S., Vitale, S., Rosati, J., Illi, B., and
Capogrossi, M. C. (2009) Abstract 5648: Epigenetic Basis of Nitrate Tolerance: Fundamental
Role of Protein Acetylation. Circulation 120, S1133-S1134
14. Rosati, J., Spallotta, F., Vincenti, S., Presutti, C., Capogrossi, M. C., Gaetano, C., and Illi, B.
(2009) Abstract 2111: SIP1/ZEB2 Targeting by the Nitric Oxide-dependent miR200 Family is
28. 28
Important for Early Mesodermic/Cardiovascular Commitment of Mouse Embryonic Stem
Cells. Circulation 120, S595
15. Rossini, A., Frati, C., Lagrasta, C., Graiani, G., Scopece, A., Cavalli, S., Pompilio, G., Quaini, F.,
Gaetano, C., and Capogrossi, M. C. (2009) Abstract 3230: Cardiac Stromal-derived Cells
Reveal Higher Proficiency to Myocardial Regeneration Than Bone Marrow Mesenchymal
Cells With Identical Genetic Background. Circulation 120, S766
16. Rossini, A., Vecellio, M., Scopece, A., Di Rocco, G., Pompilio, G., Capogrossi, M. C., and
Gaetano, C. (2009) Abstract 3224: MicroRNA Profiling of Cardiac and Bone Marrow Stromal
Cells With Identical Genetic Background Reveals Distinctive Signatures Unmodulated by
Differentiation Stimuli. Circulation 120, S764
17. Spallotta, F., Rosati, J., Straino, S., Ambrosino, V., Rotili, D., Valente, S., Mai, A., Capogrossi,
M. C., Gaetano, C., and Illi, B. (2009) Abstract 5852: Nitric Oxide Determines Mesodermic
Differentiation of Mouse Embryonic Stem Cells Activating Class II Histone Deacetylases:
Consequences for Post-ischemia Hindlimb Regeneration. Circulation 120, S1162
18. Burba, I., Colombo, G. I., Staszewsky, L. I., Devanna, P., De Simone, M., Avitabile, D., Molla,
F., Russo, I., De Angelis, N., Gambini, E., Spada, D., Biondi, A., Gaetano, C., Pompilio, G.,
Latini, R., C. Capogrossi, M., and Pesce, M. (2010) Abstract 14311: Enhanced Cardioprotection
by Histone Deacetylase Inhibitor Valproic Acid-preconditioned Human Cord Blood (UCB)-
Derived CD34+ Cells. Circulation 122, A14311
19. Colussi, C., Rosati, J. D., Straino, S., Spallotta, F., Berni, R., Stilli, D., Rossi, S., Musso, E.,
Macchi, E., Mai, A., Altucci, L., Quaini, F., Tremoli, E., Capogrossi, M. C., and Gaetano, C.
(2010) Abstract 10140: Lysine Acetylation Determines Dissociation From GAP-Junctions and
Lateralization of Connexin 43 in Normal and Dystrophic Heart. Circulation 122, A10140
20. Vecellio, M., Pompilio, G., Di Rocco, G., Capogrossi, M. C., Gaetano, C., and Rossini, A. (2010)
Abstract 12218: In Vitro Production of Niche-like Precursors by Epigenetic Reprogramming of
Stroma-Derived Cardiac Cells. Circulation 122, A12218
21. Colussi, C., Rosati, J., Tardivo, S., Mai, A., Capogrossi, M. C., and Gaetano, C. (2011) Abstract
10655: Fundamental Role for Class IIa Histone Deacetylases in the Regulation of Myo-miRs
Expression Following Hind-Limb Ischemia and Muscle Regeneration. Circulation 124, A10655
29. 29
22. Nanni, S., Re, A., Benvenuti, V., Aiello, A., Rosati, J., Colussi, C., Gaetano, C., Bacchetti, S.,
Pontecorvi, A., Capogrossi, M. C., and Farsetti, A. (2011) Abstract 12662: A Genome-Wide
Analysis of eNOS-Binding DNA Regions Reveals Unprecedented Regulatory Elements
Important for Estrogen Transcriptional Response in Human Endothelial Cells. Circulation 124,
A12662
23. Vecellio, M., Florio, M. C., Nanni, S., Farsetti, A., Pompilio, G., Di Francesco, D., Barbuti, A.,
Capogrossi, M. C., Rossini, A., and Gaetano, C. (2011) Abstract 11827: Cardiac Stromal Cell
Reprogramming to Functional Cardiovascular Precursors via Epigenetic Intervention.
Circulation 124, A11827
24. Vecellio, M., Pompilio, G., Spallotta, F., Colussi, C., Sbardella, G., Castellano, S., Mai, A.,
Capogrossi, M. C., Rossini, A., and Gaetano, C. (2011) Abstract 11858: Epigenetic Reversion of
Metabolic Memory Alterations in Human Cardiac Stromal Cells Isolated from Type-2 Diabetic
Patients. Circulation 124, A11858
25. Colussi, C., Spallotta, F., Nanni, S., Rosati, J. D., Tardivo, S., Straino, S., Mai, A., Capogrossi, M.
C., Farsetti, A., and Gaetano, C. (2012) Abstract 12479: Class I and II Histone Deacetylases
Orchestrate Muscle Regeneration Program Following Hind-limb Ischemia. Circulation 126,
A12479
26. Meraviglia, V., Azzimato, V., Kesharwani, R. K., Capogrossi, M. C., Gaetano, C., Pompilio, G.,
Colombo, G. I., and Rossini, A. (2013) Abstract 14715: Syngeneic Cardiac and Bone Marrow
Stromal Cells Display Tissue-Specific microRNA Signatures and microRNA Subsets Restricted
to Diverse Differentiation Processes. Circulation 128, A14715
27. Prandi, F., Piola, M., Soncini, M., Colussi, C., Penza, E., Agrifoglio, M., Polvani, G. L., Gaetano,
C., Fiore, G. B., and Pesce, M. (2013) Abstract 11456: Pressure-Driven Remodeling in Human
Saphenous Veins: Evidences of Mechano-Epigenetic Effects in Intima Hyperplasia Associated
to Coronary Artery By-Pass Grafting. Circulation 128, A11456
28. Azzimato, V., Meraviglia, V., Colussi, C., Florio, M. C., Panariti, A., Qanud, K., Gaetano, C.,
Pramstaller, P. P., Capogrossi, M. C., Pompilio, G., Recchia, F. A., Rivolta, I., and Rossini, A.
(2014) Abstract 13799: Electrical Pacing Inhibits Gap Junction-Mediated Cardiac Cell -Cell
Communication by Promoting Cx43-Acetylation. Circulation 130, A13799
30. 30
29. Cencioni, C., Savoia, M., Spallotta, F., Kuenne, C., Guenther, S., Zeiher, A. M., and Gaetano,
C. (2014) Abstract 13123: Noncoding RNAs in Early Mouse Embryonic Stem Cell Commitment
to Cardiovascular Precursors. Circulation 130, A13123
30. Meraviglia, V., Wen, J., Piacentini, L., Campostrini, G., Wang, C., Azzimato, V., Wong, J.,
Gaetano, C., Pompilio, G., Barbuti, A., DiFrancesco, D., Pramstaller, P. P., Colombo, G. I.,
Chen, V. H., and Rossini, A. (2014) Abstract 12965: Higher Cardiac Differentiation Properties
are Evident in Long Term Cultured Induced Pluripotent Stem Cells Obtained From Atrial
Mesenchymal Cells Compared to Skin Mesenchymal Cells. Circulation 130, A12965
31. Spallotta, F., Cencioni, C., Farsetti, A., Zeiher, A. M., and Gaetano, C. (2014) Abstract 18405:
Epidrug Treatment Rescues Proliferation and Differentiation in Human Cardiac Mesenchymal
Cells of Type 2 Diabetic Patients: A Case of Epimetabolic Memory. Circulation 130, A18405
Contribution to American Heart Scientific Sessions
(Sessionorganizer/Moderator/Invited presenter)
2008‐ Session Organizer & presenter: Epigenetics and Cardiovascular System
2009‐ Session Moderator: Genetics, Genomics and Congenital CV Disorders
2010‐ Invited presenter: Genetic and Epigenetic Specification of Cardiovascular Diseases