DMG is a glycine-derivative amino acid classified as a food substance, not a mineral or vitamin. Even though it is found in foods such as beans and organ meat (like liver), it only exists in trace amounts. The human body can synthesize significant amounts of dimethylglycine by metabolizing choline or losing one trimethylglycine methyl group through the homocysteine pathway. However, DMG is broken down so quickly and used in so many different pathways that its levels are spread thin and never get a chance to build up. As such, the most effective way of increasing quantities of dimethylglycine in the human body is through supplementation.

1. Active Ingredient Guide
DMG SUPPLEMENTS

2. Dimethylglycine, also known as DMG, is a powerful methyl
donor with a uniquely fascinating history.
Dimethylglycine was a part of the original vitamin B15 structure
known as pangamic acid. Research over the years gave
evidence that the biological activity ascribed to pangamate
B15, was in fact, due to DMG.
DMG is an active amino acid and intermediate metabolite
in the one-carbon Choline cycle. Its primary function is to
contribute methyl groups for the methylation reactions
and provide other essential building blocks.
Scientists have been aware of DMG’s potential benefits for
over a half-century, and it’s been used to enhance athletic
performance for decades.* Its promise was first put to use
as an addition to equine diets for racehorses in the 1970s
and 1980s. Even though it has been used for decades, this
phenomenal food substance’s benefits have only recently
reached mainstream awareness in the general public.

3. WHAT SEPARATES DMG FROM
OTHER TYPES OF SUPPLEMENTS?
DMG is a glycine-derivative amino acid classified as a food
substance, not a mineral or vitamin.
Even though it is found in foods such as beans and organ meat (like
liver), it only exists in trace amounts. The human body can synthesize
significant amounts of dimethylglycine by metabolizing choline or
losing one trimethylglycine methyl group through the homocysteine
pathway. However, DMG is broken down so quickly and used in so
many different pathways that its levels are spread thin and never get
a chance to build up.
As such, the most effective way of increasing quantities of
dimethylglycine in the human body is through supplementation.

4. Because DMG is such a potent metabolic enhancer, it supports a plethora
of systems in the human body.* It’s similar to the amino acid, glycine,
but with two methyl groups attached. When DMG gives up these methyl
groups to the one-carbon pathway’s methyl pool, they become part of the
molecular building blocks that produce everything from neurotransmitters
and hormones to nucleic acids and mitochondrial function.* Much of the
scientific focus around DMG has been geared towards improved cellular
energy levels, immune function, and advanced glutathione production.*
Because of DMG’s methyl donating properties, it helps recycle SAMe and
Glutathione, the latter of which is a critical aspect of the human body’s
detoxification process of both endogenous and xenobiotic compounds.*
Glutathione is also one of the most impactful free-radical scavengers that
humans, plants, and animals produce.* Although a handful of foods contain
glutathione, historically, it has low bioavailability. Our bodies need the raw
materials for the glutathione synthesis process, and DMG is an efficient
fuel by supplying both a methyl group and glycine for its production.
Supporting glutathione production through the enhanced methylation and
building-blocks provided by DMG is critical to liver health and supporting
natural detoxification and the scavenging of free-radicals.*

5. • DNA replication and repair*
• Immune response as a metabolic enhancer*
• Supports cardiovascular health*
• Supports liver health & detox*
• Supports brain health and cognition*
• Supports respiratory function through improved
circulation and oxygen utilization*
• Stress support*
• Free-radical support through glutathione recycling*
• Supports healthy aging*
•Improves athletic performance*
THE KEY BENEFITS OF DMG
DMG has proven to be a comprehensive cellular metabolite that can boost various
physiological functions to support optimal wellbeing and overall health.* DMG raises
the efficiency and productivity of the methylation metabolic pathway, showing us that
this upstream cellular support may be beneficial in supporting as well as minimizing
several bodily functions.*
DaVinci
Laboratories
has three U.S.
Patents for N,
N-Dimethylglycine’s
value and use in
improving immunity
and benefiting
cellular processes.*

6. DaVinci® utilizes rigorous testing protocols to ensure
that our labels meet or exceed all label claims and are not
misleading. Our products are produced following current
good manufacturing procedures( cGMP) to ensure that
they meet the highest quality control standards. Our DMG
is tested in its raw form by third-parties using top of the
line instrumental analysis, including:
THIRD-PARTY TESTING
FOR DMG
• Infrared analysis
• Nuclear magnetic resonance
• Gas-liquid chromatography/mass spectroscopy

7. Through these processes, we can accurately measure the
quantitative amount and purity of N N-Dimethylglycine.
We also employ third-party testing to verify and ensure
our products meet our standards and FDA standards for
contaminants like heavy metals and microbes.
DaVinci Laboratories looks for other physical aspects as well,
such as particle size, melting-point determination, color, and
taste, to ensure consistency across every batch we produce.

8. SUPPORTIVE DMG-BASED
CLINICAL TRIALS
Immunomodulating properties of dimethylglycine in humans: C D Graber, J M
Goust, A D Glassman, R Kendall, C B Loadholt
The results of this 1981 double-blind placebo-controlled study with 20 human
volunteers showed that DMG enhances humoral and cell-mediated immune response
in humans.* The researchers presumed DMG had potential as an immunomodulator
because of studies done on calcium pangamate.* The study proved that the test
group taking DMG had a greater than fourfold increase in antibody response to the
pneumococcal vaccine as compared to the control group.* The DMG group also had a
significantly higher overall response of leukocyte streptokinase-streptodornase, showing
that it enhances the cell-mediated response as well.*
1

9. Dimethylglycine Deficiency and the Development … : Martin Magnusson, Thomas
J. Wang, Clary Clish, Gunnar Engström, Peter Nilsson, Robert E. Gerszten, and Olle
Melander Researchers conducted a study in 2015 to investigate N, N Dimethylglycine,
and its association with insulin resistance and metabolic traits using mass spectrometry-
based metabolic approaches.* Results showed consistent data points to the possibility of
DMG deficiency playing a causal role in insulin resistance development. This study sparks
the need for further studies to examine the inhibition of DMG-dehydrogenase (possible
protective effects of DMG on glucose metabolism DMGDH-catalyzed reaction) and
points to possibilities that DMG supplementation may be useful to maintain a normal
insulin response.*
2
Stimulation of the Immune Response by Dimethylglycine, a Non-toxic Metabolite,:
Reap,E and Lawson J In 1990, researchers studied the impact of DMG on the immune
response in New Zealand white rabbits. A group of rabbits were fed DMG for 14 days
leading up to being exposed to immunocompromising factors. The animals given DMG
demonstrated a fourfold increase in mean antibody titer compared to controls.* Animals
that were given DMG showed a tenfold increase in mean lymphocyte proliferative
response (p = 0.0024) and a fourfold increase of lymphocyte production ( p = 0.0180).*
This trial confirmed the results of the Grabor study that DMG can enhance both the
humoral and cell-mediated response. No adverse effects or toxicity was observed at any
time during the trial.
3

10. N, N-Dimethylglycine Decreases Oxidative Stress and Improves In Vitro
Development of Bovine Embryos: Toshikiyo T and et al In 2016, researchers tested
the cellular protective capabilities of DMG using early-development stage bovine
embryos produced in vitro, which are known to be sensitive to reactive oxygen species.
After in vitro fertilization, presumptive zygotes were cultured with or without 0.1 μM
DMG under different oxygen tensions. Findings proved that DMG enhanced the in vitro
development of IVP bovine embryos by acting as a free-radical fighter.*
4
Assessment of Free Radical Scavenging Activity of Dimethylglycine Sodium Salt and
Its Role in Providing Protection against Lipopolysaccharide-Induced Oxidative Stress
in Mice: Kaiwen Bai, Wen Xu, Jingfei Zhang, Tao Kou, Yu Niu, Xiaoli Wan, Lili Zhang,
Chao Wang, Tian Wang In this 2016 study, researchers compared the free-radical
fighting abilities of DMG-Na and commonly used antioxidants, Trolox (6-hydroxy-2, 5, 7,
8-tetramethylchroman-2-carboxylic acid) against ABTS, DPPH, and H2O2.* The goal was
to test to see if lipid peroxidation’s contribution to the development of oxygen radical-
related cell membrane damage could be reduced through enhanced antioxidant efforts.
The free-radical scavenging activities of DMG proved to be the highest at 40mg/ml.*
5

11. Effect of a Nutritional Supplement Containing N, N –dimethylglycine (DMG) on
Racing Standardbred. Equine Practice: Levine, S, and et al This study demonstrated
that when DMG is made part of an equine’s diet, it can effectively reduce the build-up of
lactic acid in the horses showing how DMG can improve their racing performance.* The
horses on DMG were more aggressive, have better appetites and attitudes, and recover
faster from racing and training than the control group of horses that did not receive the
DMG.*
6
5 Continued Gastric intubation in mice with 12 mg DMG-Na/0.3 ml sterile saline solution
significantly increased (P < 0.05) the body weight (BW) (28 d), organ proportion (liver and
spleen), and antioxidant capacity in serum and the liver (Superoxide dismutase (SOD),
Hydrogen peroxidase (CAT), Glutathione peroxidase (GPx), and Total antioxidant capacity
(T-AOC).* These results indicate that DMG-Na could protect against the LPS-induced
oxidative stress by enhancing the free radical scavenging capacity and increasing the
activity of antioxidant defense systems.*
5

12. DAILY SYSTEM-SPECIFIC
RECOMMENDED DMG
AMOUNTS
Support for Overall Health and Healthy Aging* | 125-500 mg
Support for Blood Sugar & Normal Insulin Response* | 375-1000 mg
Support for Sports Practice & Fitness* | 375-1000 mg
Support for Endurance Sports* | 1000-2500 mg
Healthy Immune Support* | 375-750 mg
Cardiovascular & Circulatory Support* | 375-1000 mg
Neurological & Behavioral Support* | 375-1000 mg
Stress Support* | 250-750 mg
Support for Respiratory Function* | 750-1000 mg
Support for Liver Function & Detox* | 750-1000
Daily Energy Support* | 1000-1500 mg

13. ALLER-DMG™
Aller-DMG™ is an advanced supplement that supports
healthy histamine levels and immune system function.* With
DMG, Grape Seed Extract, Quercetin, Bromelain, N-Acetyl
Cysteine, Vitamin C, no other formula on the market
contains all of these well-researched nutrients combined
into one great formula to help support proper immune &
respiratory function and comfort*.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.
DAVINCI SUPPLEMENTS
CONTAINING DMG

14. GLUCONIC® DMG
GLUCONIC® DMG is a dietary supplement to support the
immune system, circulatory, cardiovascular, neurological
functions, muscle recovery, and endurance.* Gluconic® DMG
is an adaptogen that can be used to maintain good health
and benefit performance and productivity.* As a metabolic
enhancer, DMG supports the body in times of stress,
throughout the aging process, and during immune system
challenges.*
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.
GLUCONIC® DMG LIQUID
This is a dietary supplement to support the immune system,
circulatory, cardiovascular and neurological functions, as well
as muscle recovery and endurance.* DMG supports lactic acid
metabolism during workouts, thereby supporting recovery
and endurance.*

15. BEHAVIOR BALANCE-DMG
Behavior Balance-DMG™ is an advanced
nutritional supplement that combines our
patented N, N-Dimethylglycine (DMG) with
betaine, folic acid, vitamins E, B6 and B12,
l-carnosine, zinc, and magnesium in an easy
to swallow enteric-coated capsule.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

16. BEHAVIOR BALANCE-DMG™ LIQUID
Behavior Balance-DMG™ Liquid is an advanced,
Phenol free, nutritional supplement that combines
our patented N, N-Dimethylglycine (DMG) with
Betaine, Folic Acid, Vitamins B6 and B12, Zinc, and
Magnesium in a great tasting, natural black cherry-
flavored liquid. These nutrients work synergistically
to support stress coping mechanisms and immune
system function.*
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

17. IMMUNO-DMG™ CHEWABLE
Immuno-DMG™ Chewable with Elderberry and
Vitamin D3 is an advanced nutritional supplement
combining Gluconic® DMG, Maitake PD-Fraction®
(Maitake Mushroom Extract), and Larch Tree
Arabinogalactan Powder with Beta 1,3 Glucans.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

18. COQ10 - DMG
A dietary supplement to support heart health and
energy function.* Ingredients include 300 mg of
DMG, 300 mg of COQ10, and 5 IU of Vitamin E.
Other ingredients include: mannitol powder, xylitol,
stearic acid, silicon dioxide, vegetable stearate, and
citric acid.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

19. NEURO-DMG™
A dietary supplement to support brain and
neurological functions.* This formula was
designed for individuals who have difficulty
with memory or recall, thought focus, and
following information or conversations.*
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

20. MULTIPHASE DETOX™*
MultiPhase Detox™* combines various
minerals, herbs, antioxidants, glutathione
precursors, amino acids, DMG, and three
patented ingredients that are known to
support bioavailability and liver health.*
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

21. PERNA® PLUS
A dietary supplement to support proper
joint and connective tissue functions.* The
effectiveness of Perna® Plus is due to the
unique biological activity of the many identified
nutrients in the Perna mussel combined with
Glucosamine, Methylsulfonylmethane (MSM),
Dimethylglycine (DMG), and Manganese
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.