Presentation on Summer Training

1. SUMMER TRAINING REPORT
Prepared & Presented BY :
Bhaumik R. Bavishi
15MPH301 Pharmaceutical Analysis
Nirma University

2. INTRODUCTION TO THE SITE
Summer Training Site
• Name: Zydus Cadila Healthcare Ltd.
• Division: Pharmaceutical Technological Centre, Moraiya
• Supervisor: Group Leader: Mr. Hemang Parikh (US-ADL)
Team Leader: Mr. Alpesh Mistry

3. Instruments Used During Summer Training
Karl Fischer titrator.
Dissolution
UV Spectrophotometer
HPLC

4. Karl Fischer Titrator
Model : Metrohm 870 kf titrino plus
Samples Performed: Macitentan, Amitriptylin,
Learning outcome :
-Determination of KF factor
-Determination of moisture content of drug substance

5. Dissolution
Model: TDT-08L – Electrolab
Sample Performed: Macitentan, Amitriptylin
USP Apparatus: 1 (Basket Apparatus) & USP Apparatus: 2 (Paddle Apparatus)
 Learning outcome :
- preparation of dissolution media and buffer,
- sampling and dilution
- In-vitro study of drug release
5

6. UV Visible Spectrophotometer
Model: Shimadzu UV-1700 PharmaSpec
Sample Performed: Macitentan, Amitriptylin
 Learning outcome :
- Checking Absorbance of drug substance

7. HPLC
Model: Waters Corporation - 2690 Alliance
Software: EmpowerTM
Sample Performed: Macitentan, Amitriptylin
 Learning outcome :
Various tests performed by HPLC :-
- Content uniformity
- Blend uniformity
- Assay
- Related substance

8. • It was a good experience to see actual
process and documentation work.