Lung Cancer

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Avtansh Gupta

Lung Cancer

Health & Medicine

SCC:
Centrally located
Produces Cavitary lesions
Causes obstruction
Association with- Para-
Neoplastic syndrome:
Hypercalemia due to PTH
H/E- Desmoses and
Pearls seen

ADCL:
Non-smokers
Women
Peripherally located
Paraneoplastic Syn-
Migratory Thrombophlebitis
Tumor cells grow along the
intertubular lining
Filigree pattern
H/E Glands lined by
epithelium

LCLC:
Sheets of highly
pleomorphic
cells
Centrally
Diagnosis of
exclusion

SCLC
Males> Females
Centrally located
Produces Maximum Para
Neoplastic Syndrome
H/E:
Small cells, scanty
cytoplasm
Nuclear molding
Necrosis

Azzopardi effect
Granular Chromatin :
Salt and Pepper
Chromatin
Fragile cells break
and releases DNA
which deposits in the
blood vessel wall
producing basophillic
staining

MC - Cough
Dyspnoea and hemoptisis
Horner’s Syn-Caused by
lung carcinoma at the Apex.
(Pancoast Tumor)
Ptosis
Miosis
Enophthalmus
Anhidrosis
Loss of cilio spinal reflex.

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