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Descriptive study design.19.09.2021.pptx
1. Department of Health and Human Services
Centers for Disease Control and Prevention
Descriptive and Analytic
Studies
Dr. Anjali Upadhye
HOD and Cordinator Department of Research,ADAMC,Ashta
21 September 2021
Descriptive and Analytic
Studies:www.statsanjal.in
2. Learning Objectives
2
Descriptive and Analytic
Studies:www.statsanjal.in
• Understanding Descriptive study
• Types of Descriptive study
• Methods of data collection in Descriptive
study
• Advantages
• Disadvantages
• Cross-sectional study
• Interpret the results of descriptive and analytic
studies.
3. Lesson Overview
3
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Studies:www.statsanjal.in
• Reasons for conducting studies
• Definition, characteristics, and analysis of:
• Descriptive studies
• Analytical studies
4. Why Conduct Studies?
4
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Studies:www.statsanjal.in
To describe burden of disease or prevalence of
risk factors, health behaviors, or other
characteristics of a population that influences risk
of disease
• To determine causes or risk factors for illness
• To determine relative effectiveness of
interventions
6. Descriptive or
Analytic Studies?
Descriptive studies
• Generate hypotheses
• Answer what, who, where, and when
Analytic studies
• Test hypotheses
• Answer why and how
6
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Studies:www.statsanjal.in
8. 8
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What is Descriptive
Research?
Descriptive research is a type of research that
describes a population, situation, or
phenomenon that is being studied. It focuses
on answering the how, what, when, and
where questions If a research problem, rather
than the why.
This is mainly because it is important to have a
proper understanding of what a research
problem is about before investigating why it
exists in the first place.
9. Descriptive Studies
9
Descriptive and Analytic Studies:www.statsanjal.in
Characterize who, where, or when in relation to
what (outcome)
• Person: characteristics (age, sex,
occupation) of the individuals affected by the
outcome
• Place: geography (residence, work, hospital)
of the affected individuals
• Time: when events (diagnosis, reporting;
testing) occurred
10. Types of Descriptive Studies
Individual
10
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Case Report
Case Series
Cross-
sectional
Study
Aggregate
Ecological
Studies
12. Types of Descriptive Studies
Individual
12
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Descriptive-survey
Descriptive survey research uses surveys to gather data about
varying subjects. This data aims to know the extent to which
different conditions can be obtained among these subjects.
For example, a researcher wants to determine the qualification of
employed professionals in Maryland. He uses a survey as his
research instrument, and each item on the survey related to
qualifications is subjected to a Yes/No answer.
This way, the researcher can describe the qualifications possessed
by the employed demographics of this community.
13. Types of Descriptive Studies
Individual
13
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Descriptive-normative survey
This is an extension of the descriptive survey, with the addition
being the normative element. In the descriptive-normative survey,
the results of the study should be compared with the norm.
For example, an organization that wishes to test the skills of its
employees by a team may have them take a skills test. The skills
tests are the evaluation tool in this case, and the result of this test
is compared with the norm of each role.
If the score of the team is one standard deviation above the mean,
it is very satisfactory, if within the mean, satisfactory, and one
standard deviation below the mean is unsatisfactory.
14. Types of Descriptive Studies
Individual
14
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Descriptive-status
This is a quantitative description technique that seeks to answer
questions about real-life situations. For example, a researcher
researching the income of the employees in a company, and the
relationship with their performance.
A survey will be carried out to gather enough data about the
income of the employees, then their performance will be
evaluated and compared to their income. This will help determine
whether a higher income means better performance and low
income means lower performance or vice versa.
15. Types of Descriptive Studies
Individual
15
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Descriptive-analysis
The descriptive-analysis method of research describes a
subject by further analyzing it, which in this case involves
dividing it into 2 parts. For example, the HR personnel of a
company that wishes to analyze the job role of each
employee of the company may divide the employees into the
people that work at the Headquarters in the Maharashtra
and those that work from Mumbai.
A questionnaire is devised to analyze the job role of
employees with similar salaries and who work in similar
positions.
16. Types of Descriptive Studies
Individual
16
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Descriptive classification
This method is employed in biological
sciences for the classification of plants
and animals. A researcher who wishes to
classify the sea animals into different
species will collect samples from various
search stations, then classify them
accordingly.
17. Types of Descriptive Studies
Individual
17
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Descriptive-comparative
In descriptive-comparative research, the researcher considers 2
variables that are not manipulated, and establish a formal
procedure to conclude that one is better than the other. For
example, an examination body wants to determine the better
method of conducting tests between paper-based and computer-
based tests.
A random sample of potential participants of the test may be asked
to use the 2 different methods, and factors like failure rates, time
factors, and others will be evaluated to arrive at the best method.
18. Types of Descriptive Studies
Individual
18
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Correlative Survey
Correlative surveys are used to determine
whether the relationship between 2 variables
is positive, negative, or neutral. That is, if 2
variables, say X and Y are directly
proportional, inversely proportional or are not
related to each other.
21. Why Use Descriptive Research Design?
Individual
21
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Define subject characteristics:
It is used to determine the characteristics of the subjects, including their traits, behaviour,
opinion, etc.
Measure Data Trends
It helps to measure the changes in data over some time through statistical methods.
Comparison
Descriptive research is also used to compare how different demographics respond to
certain variables
Validate existing conditions
When you are not sure about the validity of an existing condition, you can use descriptive
research to ascertain the underlying patterns of the research object.
Conducted Overtime
Descriptive research is conducted over some time to ascertain the changes observed at
each point in time.
22. What are the Disadvantages of Descriptive
Research?
Individual
22
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Response and Non-response Bias
Respondents may either decide not to respond to questions or give incorrect
responses if they feel the questions are too confidential. When researchers use
observational methods, respondents may also decide to behave in a particular
manner because they feel they are being watched.
The researcher may decide to influence the result of the research due to
personal opinion or bias towards a particular subject. For example, a
stockbroker who also has a business of his own may try to lure investors into
investing in his own company by manipulating results.
A case-study or sample taken from a large population is not representative of
the whole population.
Limited scope:The scope of descriptive research is limited to the what of
research, with no information on why thereby limiting the scope of the
research.
23. What are the Data Collection Methods in
Descriptive Research?
Individual
23
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1.Observational Method
2.Case Study Method
3.Survey Research
24. Cross-Sectional Study as a
Descriptive Study
Purpose: To learn about the characteristics of a
population at one point in time (like a photo “snap shot”)
Design: No comparison group
Population: All members of a small, defined group or a
sample from a large group
Results: Produces estimates of the prevalence of the
population characteristic of interest
24
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25. When to Conduct a Cross-
Sectional Study
25
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• To estimate prevalence of a health condition or
prevalence of a behavior, risk factor, or potential
for disease
• To learn about characteristics such as
knowledge, attitude and practices of individuals
in a population
• To monitor trends over time with serial cross-
sectional studies
26. Cross-Sectional Study Measures
Prevalence of a condition:
= number of existing cases / size of population
(or population count)
26
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27. Example:
Cross-Sectional Study
27
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Objective
• To estimate the magnitude and patterns of violence
against pregnant women
Study
• Population-based, household, cross-sectional study
in Mbeya and Dar es Salaam, Tanzania, 2001-2002
Result
• Violence experienced by 7% in Dar es Salaam and
12% in Mbeya
Ref: Stöckl H, Watts C, Kilonzo Mbwambo JK. Physical violence by a partner during pregnancy in Tanzania: prevalence
and risk factors. Reprod Health Matters. 2010 Nov;18(36):171-80.
28. Studies to Track Trends in Newly
Recognized Cases
28
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Incidence study
• Newly reported or registered disease cases
compared over time, place, or person
• Population estimates or other population
group totals used as denominators
Ecological study
• Rates are linked to the level of exposure to
some agent for the group as a whole
29. Example:
Incidence Study
29
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Objective
• To estimate the incidence and prevalence of
diabetes in young persons in the United States
Study
• Annual diabetes death rates among youth aged <19
calculated from National Vital Statistics System data
from 1968-2009
Result
• Trends for diabetes death rates varied by age group
Saydah, S, Imperatore, G., Geiss, L., & Gregg, E. (2012). Diabetes death rates among youths aged <19 years—United
States, 1968-2009. MMWR, 61(43), 869-871
30. Example Incidence Study
(continued)
Saydah, S, Imperatore, G., Geiss, L., & Gregg, E. (2012). Diabetes death rates among youths aged <19 years—United
States, 1968-2009. MMWR, 61(43), 869-871.
Descriptive and Analytic Studies:www.statsanjal.in
32. Analytic Studies Definition
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Analytic studies test hypotheses about exposure-
outcome relationships
• Measure the association between exposure and
outcome
• Include a comparison group
33. Developing Hypotheses
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• A hypothesis is an educated guess about an
association that is testable in a scientific
investigation.
• Descriptive data (Who? What? Where? When?)
provide information to develop hypotheses.
• Hypotheses tend to be broad initially and are
then refined to have a narrower focus.
34. Developing Hypotheses
Example
Descriptive and Analytic Studies:www.statsanjal.in
Hypothesis: People who smoke shisha are more
likely to get lung cancer than people who do not
smoke shisha.
• Exposure: smoking shisha
• Outcome: lung cancer
Hypothesis: ?
• Exposure: ?
• Outcome: ?
36. Cohort Studies
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What is a cohort?
A well-defined group of individuals who share a
common characteristic or experience
• Example: Individuals born in the same year
What are other examples of cohorts?
37. Cohort Study
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(longitudinal study, follow-up study)
• Participants classified according to exposure
status and followed-up over time to ascertain
outcome
• Can be used to find multiple outcomes from a
single exposure
• Appropriate for rare exposures or defined
cohorts
• Ensures temporality (exposure occurs before
observed outcome)
38. Cohort Study Design
Study
Population
Exposure is
self-selected
Disease
Exposed
No Disease
Disease
Unexposed
No Disease
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Follow
over time
39. Types of Cohort Studies
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Prospective cohort studies
• Group participants according to past or
current exposure and follow-up into the
future to determine if outcome occurs
Retrospective cohort studies
• At the time that the study is conducted,
potential exposure and outcomes have
already occurred in the past
40. Prospective Cohort Studies
Disease
Exposed
No Disease
Study
Population
Disease
Unexposed
No Disease
Start of
study
(Present)
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(Future)
42. When to Conduct a
Cohort Study
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When the exposure is rare and the outcome is
common
• Agricultural pesticide use and cancer events
To learn about multiple outcomes due to a single
exposure
• Health effects of a nuclear power plant
accident
43. Analysis of Cohort Studies
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Risk:
Quantifies probability of experiencing the outcome of
interest in a given population
• Calculation: Number of new occurrences of
outcome/population at risk
Example:
• 29 new cases of diabetes in a community
• 100,000 people in the community at risk for
diabetes
• What is the risk of diabetes? 29/100,000
44. Analysis of Cohort Studies:
Person-Time, Rate
Quantifies occurrence of outcome in population by time
Calculation:
Example: 1,212 tunnel workers
number of new cases during follow-up period
Sum of time each study participant was
followed and at risk of disease
160 deaths among tunnel workers
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24,035 person-years at risk
Mortality rate = 160 / 24,035
= 6.7 deaths per 1,000 workers per year
R
.
ef: Stern et al. Heart Disease Mortality Among Bridge and Tunnel Officers Exposed to Carbon Monoxide. American
Journal of Epidemiology.1988;128:1276-1288
45. Risk Ratio
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• Can also be called Relative Risk or RR
• Quantifies a population’s risk of disease from a
particular exposure
• Calculation:
Risk in the exposed group /
Risk in the unexposed group
46. Rate Ratio
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Compares the rates of disease in two groups that
differ by demographic characteristics or exposure
history
Calculation:
Rate for group of primary interest
Rate for comparison group
47. RR Strength Scales
RR Strength RR
0.71 – 0.99 Weak 1.01 – 1.50
0.41 – 0.70 Moderate 1.51 – 3.00
0.00 – 0.40 Very strong >3.00
Oleckno WA. Essential epidemiology: principles and applications. Prospect Heights, IL 2002;108.
Descriptive and Analytic Studies:www.statsanjal.in
48. Example: Risk Ratio
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Question: What is the relationship between being
obese and getting type 2 diabetes?
Risk in the exposed group (obese)
Risk in the unexposed group (non-obese)
.00076
.00013
Risk Ratio = 5.8
Interpretation: The risk of diabetes among those
who are obese is 5.8 times the risk among those
who are not obese.
= 5.8
=
49. Example: Person-Time Rate
Ratio
NHANES – Follow-up Study (male diabetics subset)
1971- 1975
1982 – 1984
• Original enrollment
• Follow-up
• Complete follow-up on:
• Mortality Rate Ratio:
• 100/1414.7 ÷ 811/28,029.8 = 70.7/1000 ÷ 28.9/1000= 2.5
Enrolled Died PY of F/U
Diabetics 189 100 1414.7
Non-diabetics 3151 811 28,029.8
Ref: Kleinman J, et al. Am J Epidemiol. 1988; 128:389-401.
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50. Case-Control Study
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Purpose:
• To study rare diseases
• To study multiple exposures that may be
related to a single outcome
Study Subjects
Participants selected based on outcome status:
• Case-subjects have outcome of interest
• Control-subjects do not have outcome of
interest
52. When to Conduct a
Case-Control Study
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• The outcome of interest is rare
• Multiple exposures may be associated with a
single outcome
• Funding or time is limited
53. Exposure odds ratio (OR) ≈ RR when disease is rare
Odds of being exposed among the cases = a/c
Odds of being exposed among the controls = b/d
Exposure odds ratio = (a/c)/(b/d) = (a*d)/(b*c)
(Cross-product ratio)
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Case-Control Study:
Analysis Format
Exposure Cases Controls
Yes a b
No c d
54. Example
Odds Ratio
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Lead Poisoning
Odds Ratio = 17/83 ÷ 13/87 = 17x87 / 13x83= 1.37
Work in mine? Cases Controls
Yes 17 13
No 83 87
55. Prevalence Ratio and Prevalence
Odds Ratio
• Chronic disease – date of onset is unknown
• Measure prevalence rather than incidence
RR
OR
PR (prevalence ratio)
POR (prevalence odds ratio)
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56. Prevalence Ratio
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• Usually from a cross-sectional study
• Similar to risk ratio from cohort study
• PR= Prevalence of disease in exposed group/ Prevalence of
disease in unexposed group
OR
• PR= a/(a+b) / c/(c+d)
Exposure With disease Without disease Total
Exposed a b a+b
Unexposed c d c+d
Total a+c b+d
57. Prevalence Odds Ratio
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• Usually from a cross-sectional study
• Similar to odds ratio from case control study
• Calculated same way as odds ratio:
POR = a*d
c*b
With disease Without disease
Exposed a b a+b
Unexposed c d c+d
a+c b+d
58. Example: Prevalence Ratio and
Prevalence Odds Ratio
Prevalence of Breast Cysts
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Prevalence of breast cysts among ever users = 124/3247 = .038
Prevalence of breast cysts among never-users = 77/2644 = .029
Prevalence ratio = .038/.029 = 1.3
Prevalence odds ratio = 124 * 2557
3123 * 77
= 1.3
Lifetime use of oral
contraceptives
Yes
Cyst
No
Cyst
Total
Ever Used 124 3123 3247
Never Used 77 2557 2644
Total 201 5690 5891
59. Practice Exercise #1
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Background:
• NCDs such as type 2 diabetes are poorly understood and
under-prioritized in many low-to-middle income countries.
• You want to determine the risk of type 2 diabetes associated
with cardiovascular risk factors such as obesity and
abdominal fat mass in your country.
Questions:
1. What type of study would you conduct and why?
2. What is the measure of association to calculate for this
study?
60. Practice Exercise #2
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Background:
• The prevalence of prostate cancer has increased in your
country over the last 5 years.
• You want to examine the association between calcium intake
and prostate cancer risk.
• You have limited time and funding to conduct this study.
Questions:
1. What type of study would you conduct and why?
2. What is the measure of association to calculate for this
study?
61. Practice Exercise #3
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Background:
• Cardiovascular disease (CVD) is of growing concern;
however your country has no recent data on the burden of
this disease.
• You want to estimate the burden of cardiovascular disease in
the two main cities in your country.
Questions:
1. What type of study would you conduct and why?
2. What is the measure of association to calculate for this
study?
63. Types of Descriptive and
Analytic Studies
Descriptive and Analytic Studies:www.statsanjal.in 63
Types of descriptive studies
• Aggregate: Ecological study
• Individual: Case report, case series, cross-
sectional study
Types of analytic studies
• Experimental: Randomized control trial
• Observational: Cohort, case-control, cross-
sectional
64. Cohort vs. Case-Control Studies
Descriptive and Analytic Studies:www.statsanjal.in 64
Study Comparison Cohort Study Case-Control Study
Preferred Study
Design When…
Members are easily
identifiable
Members are easily
accessible
Exposure is rare
There may be multiple
diseases involved
Identifying entire cohort
would be too costly or time
consuming
Accessing entire cohort
would be too costly or time
consuming
Illness is rare
There may be multiple
exposures involved
Study Group Exposed persons Persons with illness (cases)
Comparison Group Unexposed persons Persons without illness
(controls)
65. Sampling Advantages and
Disadvantages
Descriptive and Analytic Studies:www.statsanjal.in 65
Advantages
• Results are generalizable
• Representative
Disadvantages
• Expensive
• Logistically difficult
• Time-intensive
Probability Sampling Non-Probability Sampling
Advantages
• Easy
• Quick access to certain
groups
Disadvantages
• Not representative
• Results are not
generalizable
66. Skill Assessment
Descriptive and Analytic Studies:www.statsanjal.in 66
• You will work in small groups to complete two parts of a
skill assessment:
1. Identify the type of study to conduct and sampling
method
2. Interpret the results
• Materials and questions can be found in your
Participant Guide.
• Spend approximately 1 hour completing the
assessment.
• Be prepared to share the group’s work.