3er Congreso FESNAD. Sevilla, 4 de marzo de 2015.

7. 12-­‐20
weeks
Recruitment
(N=118)
24
weeks
(2nd
trimester)
(N=118)
34
weeks
(3rd
trimester)
(N=118)
Delivery
(N=65)
F
O
L
L
O
W
–
U
P
S
T
U
D
Y

8. Characteris'cs
Normal-­‐weight
pregnant
women
(N
=
118)
Age
(years)1
30.97
±
4.20
Height
(cm)1
1.64
±
0.06
Weight
(kg)1
Before
pregnancy
Second
trimester
(24
weeks)
Third
trimester
(34
weeks)
At
delivery*
58.40
±
5.66
64.78
±
7.13
69.54
±
6.77
70.58
±
6.42
Weight
gain
over
pregnancy
(kg)1*
11.7
±
1.45
Dura9on
of
gesta9on
(weeks)1
39.5
±
2.67
BMI
(kg/m2)1
Before
pregnancy
Second
trimester
(24
weeks)
Third
trimester
(34
weeks)
At
delivery*
21.98
±
1.67
24.29
±
2.40
25.92
±
2.14
26.59
±
2.16
1Data
expressed
as
mean
±
standard
devia9on
(S.D.).
*Data
available
from
a
subsample
(N
=
65)
from
118
pregnant
women.

9.
24
weeks
34
weeks
Delivery
24
weeks
34
weeks
Delivery
*
♯
♯
♯
*
♯
♯
♯
*
:
P24-­‐34
<
0,05
♯:
P24-­‐delivery
and
P34-­‐delivery
<
0,05
Total
leukocytes
Neutrophils
Lymphocytes
Monocytes
Total
leukocytes-­‐C
Neutrophils-­‐C
Lymphocytes-­‐C
Monocytes-­‐C

10.
24
weeks
34
weeks
Delivery
24
weeks
34
weeks
Delivery
*
♯
♯
♯
*
♯
♯
♯
*
:
P24-­‐34
<
0,05
♯:
P24-­‐delivery
and
P34-­‐delivery
<
0,05
125%
62%
40%
48%
17%
Total
leukocytes
Neutrophils
Lymphocytes
Monocytes
Total
leukocytes-­‐C
Neutrophils-­‐C
Lymphocytes-­‐C
Monocytes-­‐C

11.
24
weeks
34
weeks
Delivery
24
weeks
34
weeks
Delivery
*
♯
♯
♯
*
♯
♯
♯
*
:
P24-­‐34
<
0,05
♯:
P24-­‐delivery
and
P34-­‐delivery
<
0,05
125%
62%
40%
48%
17%
Total
leukocytes
Neutrophils
Lymphocytes
Monocytes
Total
leukocytes-­‐C
Neutrophils-­‐C
Lymphocytes-­‐C
Monocytes-­‐C
Pregnancy
was
related
to
an
increase
in
neutrophils
while
trying
to
preserve
the
absolute
numbers
of
lymphocytes
and
monocytes.
Possible
mechanisms
to
explain
our
results:
• To
retain
desirable
levels
of
immune
system
reac9vity.
• To
reserve
energy
for
pregnancy,
as
the
innate
immune
system
is
less
energe9cally
costly
to
maintain
than
the
adap9ve
immune
system.
Miller.
Am
J
Hum
Biol.
2009;21(3):401-­‐3.

12.
24
weeks
34
weeks
Delivery
24
weeks
34
weeks
Delivery
Mature
T-­‐cells
Helper
T-­‐cells
Cytotoxic
T-­‐cells
NK
cells
Lymphocytes
B
Mature
T-­‐cells-­‐C
Helper
T-­‐cells-­‐C
Cytotoxic
T-­‐cells-­‐C
NK
cells-­‐C
Lymphocytes
B-­‐C
*
*
*
*
*
*
♯
♯
♯
♯
♯
♯
♯
♯
*
:
P24-­‐34
<
0,05
♯:
P24-­‐delivery
and
P34-­‐delivery
<
0,05

13.
24
weeks
34
weeks
Delivery
24
weeks
34
weeks
Delivery
Mature
T-­‐cells
Helper
T-­‐cells
Cytotoxic
T-­‐cells
NK
cells
Lymphocytes
B
Mature
T-­‐cells-­‐C
Helper
T-­‐cells-­‐C
Cytotoxic
T-­‐cells-­‐C
NK
cells-­‐C
Lymphocytes
B-­‐C
*
*
*
*
*
*
♯
♯
♯
♯
♯
♯
♯
♯
*
:
P24-­‐34
<
0,05
♯:
P24-­‐delivery
and
P34-­‐delivery
<
0,05
10%
13%
20%
25%
50%
40%

14.
24
weeks
34
weeks
Delivery
24
weeks
34
weeks
Delivery
Mature
T-­‐cells
Helper
T-­‐cells
Cytotoxic
T-­‐cells
NK
cells
Lymphocytes
B
Mature
T-­‐cells-­‐C
Helper
T-­‐cells-­‐C
Cytotoxic
T-­‐cells-­‐C
NK
cells-­‐C
Lymphocytes
B-­‐C
*
*
*
*
*
*
♯
♯
♯
♯
♯
♯
♯
♯
*
:
P24-­‐34
<
0,05
♯:
P24-­‐delivery
and
P34-­‐delivery
<
0,05
10%
13%
20%
25%
50%
40%

15. *Par'al
correla'ons
adjusted
by
maternal
age.
24
weeks:
R
=
0,25,
P
=
0,01
34
weeks:
R
=
0,26,
P
=
0,004
24
weeks:
R
=
0,26,
P
=
0,003
34
weeks:
R
=
0,25,
P
=
0,004
24
weeks:
R
=
0,20,
P
=
0,03
34
weeks:
R
=
0,27,
P
=
0,002

16. • There
are
immunological
changes
during
pregnancy
that
mediate
the
immune
adapta9on
between
mother
and
foetus.
• Pregnancy
was
related
to
an
increase
in
innate
immune
cells
(neutrophils),
and
a
decrease
in
B-­‐cells
and
NK
cells.
• The
correla9ons
observed
between
preconcep9onal
BMI
and
lymphocytes
during
pregnancy
suggest
that
pregnancy
does
not
disrupt
the
habitual
posi9ve
rela9onship
between
nutri9onal
status
and
lymphocyte
numbers.

17. www.proyectopreobe.com
Cris'na
Campoy
Ascensión
Marcos
Esther
Nova
L.
Esperanza
Díaz

18. Cris'na
Campoy
Ascensión
Marcos
Esther
Nova
L.
Esperanza
Díaz
THANK
YOU
FOR
YOUR
KIND
ATTENTION!
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