SlideShare a Scribd company logo
1 of 9
Download to read offline
Q D m u ın b r * c ł«. . Į e L e e n A Ġ
M H .
o t v u m e r a D Le a m m o gro u p s u s in g a L e L y i
c o e n z y m e A a s th e a c e ty l d o n o T h e N a c e ty l tr a n sfe ra s e s
c o m p ris e th e la rge s t g ro u p o f a m in o gly c o s ide in a c tiv a tin g
e n z y m e s
fo r m th e s m a lle s t gro u p o f a m in o glyc o s id e in a c tiv a tin g
J '
e n z y m e s
O P h o s p h o w g n o f hy d r o x yl g ro u ps w ith
3 ĺ o Į
qS p h o s p h a te d o n o r
a ) acetyt ţ sferases (N A T ) w h ic h a c e ty la te s
b ) Ph os Eh om tra n s fe r e e s ĺ Q P T ) w h ic h p h o s p h o r y Įa te s
Re s is ta n c e (C o n t . )
th e m o s t im p o rta n t c a u s e o f re s ista n c e is
c a ta lyz e d in a c tiv a tio n o f ìnoglicosides M o R in nm iili
aiiiŤriiiglycôsidein a c tiv a tin g e n z ym e s h a v e b e e n re p o r te d ,
J k h o w e v e r a ll c a ta lyz e o n ly th r e e m a jo r typ e s o f re a c tio n s
R e s is ta n c e (C o n t . )
A m in o gly c o s id e in a c tiv a tin g e n z y m e s in c lu d e
C
y
c h n kł4Ï L
)
Re sista nce (Co n t. )
k .
W W -
Ex a m p le s o f a m ìn o gĮyc o sid e s
,
h
,
C H ]
a
T o bra m yd n Dıbeka cin
C om p ıe R
Lhtido m ye in A
L /
= gy
Re sista n c e (Co n t. )
C  げ一 串ダ 刀
b 
W
e n z y m
L
' " jİ j{Xï ï n e u
ŕ
K a n a m yc in A A m ika c in
;
:
È
SA R fo r a m in o gly c o s id e s
SA R fo r a m in o g ly c o s id e s (R in g I)c o n t .

4 .
M e t hyta tio n a t e ith e r « -
c a rbo n o r « ・
a m in o c o n fe rs
V t e si. Ta n c e to e n z ym a tlc a c e tyïa tio n a n d N A T ıo w e r
-
ĺ a n d ba c te ria la c tiv iw (e . g . Ge n ta m w ln C 1)
5 .
R e m o v a lo f 3'
hy d r o x yl o r 4 ı
hyd ro x y l o r b o th
in ka n a m yc in s (e . g .
3'
,
4 d id e o x y k a n a m y c in B ) o r
ge ta m ic in s (e g .
N e tilm lc ln ) c o n fe rs re sis ta n c e to
pho s p h o ry la tïo n a n d d o e s N O T re du c e a n tib a c te r ia l a c tiv ity
L ı
SA R fo r a m in o g [y c o s id e s (R in g II)
R in g lı(d w s tr e p ta m in e ) F e w m o d ific a tio n s fo r
fu n c tio n a ig r o u p s a r e p o s s ib le w ith o u t ıo 5 s o f a c tiv ity fo r
e x a m p le
1 A c e ty ta tio n o f 1 a m in o g ro u p o f ka n a m y c in A to g iv e a m ik a c in )
Ï H g m in o gly c o s id e ,
th e r in g c a n b e r ib o s e ,
r in g ) o r s tre p ta m in e (6 m e m b e r e d r in g )
Amino glycosides 02

More Related Content

What's hot

Top Mobile Trends 2013 - Part 2 (B2B and Enterprise)
Top Mobile Trends 2013 - Part 2 (B2B and Enterprise)Top Mobile Trends 2013 - Part 2 (B2B and Enterprise)
Top Mobile Trends 2013 - Part 2 (B2B and Enterprise)DMI
 
Ejercicio de ligado
Ejercicio de ligadoEjercicio de ligado
Ejercicio de ligadojoansoco
 
Bw nativity-copy
Bw nativity-copyBw nativity-copy
Bw nativity-copySandra Fuso
 
Oddy Fencing portfolio
Oddy Fencing portfolioOddy Fencing portfolio
Oddy Fencing portfoliogarryoddy
 
Firststepskc 090421154931 Phpapp02
Firststepskc 090421154931 Phpapp02Firststepskc 090421154931 Phpapp02
Firststepskc 090421154931 Phpapp02Jewish Agency
 
Certificate HSE Borouge - Scanned by CamScanner
Certificate HSE Borouge - Scanned by CamScannerCertificate HSE Borouge - Scanned by CamScanner
Certificate HSE Borouge - Scanned by CamScannersubhashish sengupta
 
Portfolio Forprøve 2010
Portfolio Forprøve 2010Portfolio Forprøve 2010
Portfolio Forprøve 2010Andreas Brixen
 
WACD hosts Pepperdine GSBM
WACD hosts Pepperdine GSBMWACD hosts Pepperdine GSBM
WACD hosts Pepperdine GSBMRobert Radi
 

What's hot (19)

Duck tutorial
Duck tutorialDuck tutorial
Duck tutorial
 
Pitshanger events
Pitshanger eventsPitshanger events
Pitshanger events
 
Rangkuman bab 2
Rangkuman bab 2Rangkuman bab 2
Rangkuman bab 2
 
Pitshanger events
Pitshanger eventsPitshanger events
Pitshanger events
 
Stage2 slide13
Stage2 slide13Stage2 slide13
Stage2 slide13
 
Top Mobile Trends 2013 - Part 2 (B2B and Enterprise)
Top Mobile Trends 2013 - Part 2 (B2B and Enterprise)Top Mobile Trends 2013 - Part 2 (B2B and Enterprise)
Top Mobile Trends 2013 - Part 2 (B2B and Enterprise)
 
Ejercicio de ligado
Ejercicio de ligadoEjercicio de ligado
Ejercicio de ligado
 
Design and layout of major work areas
Design and layout of major work areasDesign and layout of major work areas
Design and layout of major work areas
 
Bw nativity-copy
Bw nativity-copyBw nativity-copy
Bw nativity-copy
 
1908-09: Direct Cause of 1914...
1908-09: Direct Cause of 1914...1908-09: Direct Cause of 1914...
1908-09: Direct Cause of 1914...
 
Oddy Fencing portfolio
Oddy Fencing portfolioOddy Fencing portfolio
Oddy Fencing portfolio
 
Jeugdaffiche
JeugdafficheJeugdaffiche
Jeugdaffiche
 
Page 9
Page 9Page 9
Page 9
 
Boost your business!
Boost your business!Boost your business!
Boost your business!
 
Firststepskc 090421154931 Phpapp02
Firststepskc 090421154931 Phpapp02Firststepskc 090421154931 Phpapp02
Firststepskc 090421154931 Phpapp02
 
Certificate HSE Borouge - Scanned by CamScanner
Certificate HSE Borouge - Scanned by CamScannerCertificate HSE Borouge - Scanned by CamScanner
Certificate HSE Borouge - Scanned by CamScanner
 
Aap-Noot-Nier
Aap-Noot-NierAap-Noot-Nier
Aap-Noot-Nier
 
Portfolio Forprøve 2010
Portfolio Forprøve 2010Portfolio Forprøve 2010
Portfolio Forprøve 2010
 
WACD hosts Pepperdine GSBM
WACD hosts Pepperdine GSBMWACD hosts Pepperdine GSBM
WACD hosts Pepperdine GSBM
 

Amino glycosides 02

  • 1. Q D m u ın b r * c ł«. . Į e L e e n A Ġ M H .
  • 2.
  • 3. o t v u m e r a D Le a m m o gro u p s u s in g a L e L y i c o e n z y m e A a s th e a c e ty l d o n o T h e N a c e ty l tr a n sfe ra s e s c o m p ris e th e la rge s t g ro u p o f a m in o gly c o s ide in a c tiv a tin g e n z y m e s fo r m th e s m a lle s t gro u p o f a m in o glyc o s id e in a c tiv a tin g J ' e n z y m e s O P h o s p h o w g n o f hy d r o x yl g ro u ps w ith 3 ĺ o Į qS p h o s p h a te d o n o r a ) acetyt ţ sferases (N A T ) w h ic h a c e ty la te s b ) Ph os Eh om tra n s fe r e e s ĺ Q P T ) w h ic h p h o s p h o r y Įa te s Re s is ta n c e (C o n t . ) th e m o s t im p o rta n t c a u s e o f re s ista n c e is c a ta lyz e d in a c tiv a tio n o f ìnoglicosides M o R in nm iili aiiiŤriiiglycôsidein a c tiv a tin g e n z ym e s h a v e b e e n re p o r te d , J k h o w e v e r a ll c a ta lyz e o n ly th r e e m a jo r typ e s o f re a c tio n s R e s is ta n c e (C o n t . ) A m in o gly c o s id e in a c tiv a tin g e n z y m e s in c lu d e
  • 4. C y c h n kł4Ï L ) Re sista nce (Co n t. )
  • 5. k . W W - Ex a m p le s o f a m ìn o gĮyc o sid e s , h , C H ] a T o bra m yd n Dıbeka cin C om p ıe R Lhtido m ye in A L / = gy Re sista n c e (Co n t. ) C げ一 串ダ 刀 b W
  • 6. e n z y m L ' " jİ j{Xï ï n e u ŕ K a n a m yc in A A m ika c in
  • 7. ; : È SA R fo r a m in o gly c o s id e s
  • 8. SA R fo r a m in o g ly c o s id e s (R in g I)c o n t . 4 . M e t hyta tio n a t e ith e r « - c a rbo n o r « ・ a m in o c o n fe rs V t e si. Ta n c e to e n z ym a tlc a c e tyïa tio n a n d N A T ıo w e r - ĺ a n d ba c te ria la c tiv iw (e . g . Ge n ta m w ln C 1) 5 . R e m o v a lo f 3' hy d r o x yl o r 4 ı hyd ro x y l o r b o th in ka n a m yc in s (e . g . 3' , 4 d id e o x y k a n a m y c in B ) o r ge ta m ic in s (e g . N e tilm lc ln ) c o n fe rs re sis ta n c e to pho s p h o ry la tïo n a n d d o e s N O T re du c e a n tib a c te r ia l a c tiv ity L ı SA R fo r a m in o g [y c o s id e s (R in g II) R in g lı(d w s tr e p ta m in e ) F e w m o d ific a tio n s fo r fu n c tio n a ig r o u p s a r e p o s s ib le w ith o u t ıo 5 s o f a c tiv ity fo r e x a m p le 1 A c e ty ta tio n o f 1 a m in o g ro u p o f ka n a m y c in A to g iv e a m ik a c in ) Ï H g m in o gly c o s id e , th e r in g c a n b e r ib o s e , r in g ) o r s tre p ta m in e (6 m e m b e r e d r in g )