Outline of the Radboud way towards Personalized Health(care)in a great session between health Valley, Topsector LSH, Radboudumc, province Gelderland and others.

1. Health Valley meets Health~Holland
10 September 2015
Personalized health(care)
the Radboud approach
Alain van Gool
Professor Personalized Healthcare
Coordinator Radboudumc Technology Centers
E: alain.vangool@radboudumc.nl

2. Radboud university medical center
• Nijmegen, The Netherlands
• Mission: “To have a significant impact on healthcare”
• Strategic focus on Personalized Healthcare through
“the patient as partner”
• Core activities:
• Patient care
• Research
• Education
• 11.000 colleagues
• 52 departments
• 3.300 students
• 1.000 beds
• First academic centre outside US to fully implement EPIC

3. Strategy Radboudumc – our focus areas
3
www.radboudumc.nl

4. Patient
Radboud
Personalized Healthcare
A significant impact
on healthcare
Molecule
Population
4

5. Personalized Healthcare @ Radboudumc
People are different Stratification by multilevel diagnosis
+Patient’s preference of treatment
Exchange experiences in
care communities Select personalized therapy
Population
Man
Molecule
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6. Example: Personalized healthcare in sepsis
• Sepsis (systemic inflammatory response to infection)
• Major cause of death in hospitals in EU and US, with mortality up to 20-40%
• No specific treatment is available
• Focus on immune-based mechanisms as solution towards therapy
Molecule
• Molecular function of
inflammatory mediators
(cytokines)
• Role in host defense and
organ damage
Man
• Diagnose capacity blood cells
to produce cytokines
• Individualized sepsis therapy
optimally targeting patient’s
immune system
Population
• Cross-patient analysis of
cytokine production and
severity of sepsis
• Design/evaluate personalized
immunotherapies
prof Mihai Netea
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7. Example: Personalized healthcare in Parkinson’s
Patient
Caregiver
Insurer
Self-monitoring
Patient
Caregiver
Insurer
Participatory
research
prof Bas Bloem
dr Marten Munneke

8. Research themes and institutes
www.radboudumc.nl/Research/Themes/Pages/default.aspx
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9. Orientation across the spectrum
from molecule to man to population
Orientationacross
thespectrumofdiseases
PI
Research theme
TechnologyCenters
Research support by Technology Centers
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10. www.radboudumc.nl/research/technologycenters
Genomics
Bioinformatics
Animal
studies
Stem
cells
Translational
neuroscience
Image-guided
treatment
Imaging
Microscopy
Biobank
Health
economics
Mass
Spectrometry
Radboudumc
Technology
Centers
Investigational
products
Clinical
studies
EHR-based
research
Statistics
Human
performance
Data
stewardship
Molecule
Flow
cytometry
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11. About 250 dedicated people working in 18 Technology Centers, ~1600 users (internal, external), ~140 consortia
www.radboudumc.nl/research/technologycenters/
• Proteins
• Metabolites
• Drugs
• PK-PD
• Preclinical
• Clinical
• Behavioural
• Preclinical
• Animal facility
• Systematic review
• Cell analysis
• Sorting
• Pediatric
• Adult
• Phase 1, 2, 3, 4
• Vaccines
• Pharmaceutics
• Radio-isotopes
• Malaria parasites
• Management
• Analysis
• Sharing
• Cloud computing
• DNA
• RNA
• Internal
• External
• Early HTA
• Evidence-based
surgery
• Field lab
• Statistics
• Biological
• Structural
• Preclinical
• Clinical• Economic
viability
• Decision
analysis
• Experimental design
• Biostatistical advice
• Electronic Health Records
• Big Data
• Best practice
• In vivo
• Functional
diagnostics
• iPSC
• Organoids
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12. Working together on the Radboud campus
(Spin-out)
companies
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13. Radboud Research Facilities
Shared facilities network across Radboud campus, also made part of Gelderland facilities
Funding: 6.2M Eur provincie Gelderland + 6.2M Eur Radboud University/Radboudumc)
www.ru.nl/radboudresearchfacilities/
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14. Working with other Technology Networks
Region, nation, Europe, world
14

15. Working through multi-partner projects
Standardisation, harmonisation,
knowledge sharing needed in:
1. Assay development
2. Clinical validation
Example: Biomarker Development Center
Roadmap Molecular Diagnostics (2012) Grant 4.3M Eur (2014)
Move towards EU funding (2016)
Prof Alain van Gool
Prof Ron Wevers
Prof Cees Tack

16. Working through spin-off companies
(LS&H portefeuille Radboud Holding BV)
Pansynt B.V.
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17. Working through spin-off companies
Example: MITeC
www.mitec.nl
Field lab environment for
innovations in image-guided
surgery.
Joined enterprise of several
departments of Radboudumc.
Applied scientific collaboration
with companies for joined
product evaluation and
development.
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18. A self-sustaining technology platform to manufacture radiopharmaceuticals for translational imaging.
Cyclotron, laboratories and GMP-compliant production facility, also accessible for external users.
14M Eur investment, including 8M Eur European Fund for Regional Development (EFRO) subsidy.
www.radboudtranslationalmedicine.nl/
Example: Radboud Translational Medicine
Working through spin-off companies
Contract Manufacture:
A reliable supplier of radiopharmaceuticals
for nuclear diagnostic patient care at
Radboudumc and other hospitals
Research:
Develop new radiotracers for molecular
imaging in preclinical and clinical research
Part of Radboudumc Technology Centers
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19. Working through global innovators
Exponential
technologies
Digital
medicine
Integrated
care
Artifical
intelligence
Robotics Patients
included
Lifestyle
Self
quantification
Global
health
WatsonArtifical
intelligence
Regenerative
medicine
23andme
Robotics
Example: Singularity University’s Faculty
Lucien Engelen, REshape Innovation Center
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20. Takehome message
• Strategic focus on implementing Personalized Healthcare
• Strong technological and methodological infrastructure
• Continuous exploration of functional networks
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