2. Introduction
Cerebral infarction in the territory of the anterior cerebral artery (ACA) is
often found accompanying middle cerebral artery (MCA) infarctions
Isolated ACA stroke accounts for only up to 3–5% of strokes
Pericallosal artery infactions are even rarer
Mostly caused by emboli
MRI (DWI) is highly sensitive for diagnosis
Kazui S, Sawada T, Naritomi H, Kuriyama Y, Yamaguchi T (1993) Angiographic evaluation of brain infarction limited to the anterior cerebral artery territory. Stroke 24:549–553
Kumral E, Bayulkem G, Evyapan D, Yunten N (2002) Spectrum of anterior cerebral artery territory infarction: clinical and MRI findings. Eur J Neurol 9:615–624
Suwanwela NC, Leelacheavasit N (2002) Isolated corpus callosal infarction secondary to pericallosal artery disease presenting as alien hand syndrome. J Neurol Neurosurg Psychiatry 72:533–536
Gass A, Ay H, Szabo K, Koroshetz WJ (2004) Diffusionweighted MRI for the ‘‘small stuff’’: the details of acute cerebral ischaemia. Lancet Neurol 3:39–45
4. Radiology
Alonso A, Gass A, Rossmanith C, Kern R, Griebe M, Binder J, Hennerici MG, Szabo K. Clinical and MRI patterns of pericallosal artery infarctions: the significance of supplementary motor area lesions. Journal of neurology. 2012 May
1;259(5):944-51.
5. Clinical Presentation
Etiology: Embolism either from cardiac origin or due to arterioarterial
propagation of thrombotic material
Contralateral hemiparesis with lower limb predominance to be a core
symptom
Motor hemineglect
Decreased verbal fluency and mutism
Acute confusional state
Apraxia
“Alien Hand Syndrome”
Alonso A, Gass A, Rossmanith C, Kern R, Griebe M, Binder J, Hennerici MG, Szabo K. Clinical and MRI patterns of pericallosal artery infarctions: the significance of supplementary motor area lesions. Journal of neurology. 2012 May
1;259(5):944-51.
6.
7. Introduction
A higher-order, motor control disorder featuring involuntary, yet purposeful,
movements
The affected limb is typically the hand, although leg (alien limb phenomena)
involvement has been reported
A complex sense of limb foreignness, including misidentifying the limb as the
examiner's. Sometimes the limb is personified
AHS arise from the disruption of interhemispheric connections, and/or of the
connections between the frontal areas and the parietal lobes
Park YW, Kim CH, Kim MO, Jeong HJ, Jung HY. Alien hand syndrome in stroke - case report & neurophysiologic study. Ann Rehabil Med. 2012;36:556–560.
Chan JL, Chen RS, Ng KK. Leg manifestation in alien hand syndrome. J Formos Med Assoc.1996;95:342–346.
Carrilho PE, Caramelli P, Cardoso F, Barbosa ER, Buchpiguel CA, Nitrini R. Involuntary hand levitation associated with parietal damage: Another alien hand syndrome. Arq Neuropsiquiatr. 2001;59:521–525. Doody RS, Jankovic J. The alien hand and related
signs. J Neurol Neurosurg Psychiatry. 1992;55:806–810.
8. Associated Symptoms
Decreased motor spontaneity
Speech hesitation
Apraxia
Tactile dysnomia
Behaviors associated with frontal lobe dysfunction
Brainin M, Seiser A, Matz K. The mirror world of motor inhibition: The alien hand syndrome in chronic stroke. J Neurol Neurosurg Psychiatry. 2008;79:246–252.
9. Etiology
Anterior cerebral artery strokes
Midline tumors
Nurodegenerative illnesses
Rarer causes include spontaneous pneumocephalus, migraine
aura, seizure, and Parry–Romberg Syndrome, a presumed autoimmune
disorder with progressive facial hemiatrophy
Sarva H, Deik A, Severt WL. Pathophysiology and treatment of alien hand syndrome. Tremor and Other Hyperkinetic Movements. 2014;4.
10. Kumral E. Compulsive grasping hand syndrome: A variant of anarchic hand. Neurology. 2001;57:2143–2144.
11. Treatment
Sarva H, Deik A, Severt WL. Pathophysiology and treatment of alien hand syndrome. Tremor and Other Hyperkinetic Movements. 2014;4.
12. Summary
Pericallosal artery infarction is a rare condition
Mostly due to emboli
Diagnosed by MRI
One of the clinical presentation is the “Alien Hand Syndrome”
AHS is a higher-order, motor control disorder featuring involuntary, yet
purposeful, movements
AHS arise from the disruption of interhemispheric connections, and/or of the
connections between the frontal areas and the parietal lobes
No approved or recommended therapies for AHS
Functional imaging might help to study further about this entity