Pain Pathophysiology: Peripheral Sensitization

1. PAIN PATHOPHYSIOLOGY:
PERIPHERAL SENSITIZATION
Ade Wijaya, MD – May
2019

3. PERIPHERAL SENSITIZATION
Tissue
irritation
Release
inflammator
y mediators

Nociceptor
threshold
Allodinia
Hyperalgeusia
Recruitment of so-called silent nociceptors, which are not usually sensitive to painful stimuli or
inflammatory substrates such as prostaglandins or bradykinin.

4. BRADYKININ
Sensitize C and Aδ fibers to prostaglandins, protons, serotonin, heat,
and mechanical stimuli
Facilitate the production of prostaglandins

7. SUMMARY
 Multiple mechanisms modulate the functioning of primary afferent
nerve terminals
 The final common pathway appears to involve the increase in
intracellular Ca and protein kinase levels
 Both Ca and protein kinases exert a profound influence on the
control of gene
transcription