Ozone therapy can be an effective supportive treatment for cancer in several ways: 1) It improves oxygenation at the cellular level by increasing red blood cell metabolism and circulation, allowing cancer cells to transition from a hypoxic to normoxic state. 2) It stimulates the immune system and anti-oxidant enzyme production, reducing oxidative stress on cells and enabling the body to better fight cancer. 3) By inducing controlled oxidative stress, ozone therapy can cause apoptosis in cancer cells and act as an autovaccine against tumors. 4) Additional benefits include controlling infections, improving metabolism and quality of life, and reducing side effects from other cancer therapies. Clinical cases demonstrated reductions in tumor size and markers from

1. Ozone Therapy in cancer

2. Ozone
• Ozone is a molecule of Oxygen where
three, instead of two atoms are present.
• Ozone (O3) is a very unstable molecule.
It breaks down into an Oxygen molecule
(O2) and a singlet active Oxygen atom in
about 20 minutes,

3. Cause of cancer is lack of oxygen
• In 1926, Dr.Otto Warburg of the Kaiser
Institute in Berlin announced that the
cause of cancer is lack of oxygen at the
cellular level. He received the Nobel Prize
for Medicine in 1931.

4. Oxygen condition of cells
• Direct effect - Ozone reduces hypoxia.
PO2 = 50mm hg
PO2 = 5mm hg
Normal cell
cancer cell

5. Improved Oxygenation and
metabolism
• The changes observed in RBCs following
Ozone Therapy are increase in 2,3 DPG,
ATP, anti oxidant enzymes and G6PD.
• By continuing Ozone Therapy for several
months (at least 6 months) it may be
possible to profoundly modify functional
activities of RBCs so that Oxygen delivery
increases and tumor passes from hypoxic
to normoxic state.

6. Up regulation of Anti-oxidant
enzyme system
• Persistent oxidative stress is a factor favoring
the progression of invasion and metastasis.
• Ozone Therapy is a procedure that involves
calculated, very transient oxidative stress
capable of inducing cellular response without
adverse effect.
• Ozone paradox is that in spite of being a
powerful oxidant, Ozone is capable of inducing
anti oxidant enzymes and correcting chronic
oxidative stress. Thus checking progression of
invasion and metastasis.

7. Killing cancer cells
• Cancer cells are lacking in anti oxidant
enzymes unlike normal, healthy cells.
• Ozone rapidly oxidizes lipids in their cell
membrane, causing hole in the cell
membrane and ultimately rupture of the
cancer cells.

8. Protecting normal cells by
stimulating anti oxidant enzymes
• Ozone stimulates anti oxidative enzymes in our
normal cells.
• This primes cells to deal effectively with further
oxidative stress, causing preconditioning effect.
• Oxidative stress in the form of free radicals,
generated by radiation or chemotherapy, is more
effectively dealt with these anti oxidative
enzymes.
• Thus side effects of these therapies are largely
prevented by Ozone.

9. Improved circulation
Ozone improves general circulation.
• It directly reacts with endothelial cells and
produces Nitric oxide. This causes
vasodilatation.
• It improves RBC metabolism, makes RBC
membrane more elastic and facilitate smooth
circulation at capillary level.
• It prevents platelet aggregation in therapeutic
doses.
• It leads to new vessel formation inside the
tumor.
• All these translates in better oxygenation at cell
level.

10. Controlling infections
• Ozone is a powerful germicidal agent.
• It is effectively used to treat infections
commonly occurring in cancer patients,
due to decrease immunity.

11. Immune system stimulated
• Ozone induces lymphocytes to produce
lymphokines in a very controlled fashion.
• There is activation of both – helpers as well as
suppressor lymphocytes.
• These activated lymphocytes home in various
lymphoid organs and brings entire immune system
to an alert state.
• Thus Ozone improves immunity and fight against
cancer cells.

12. Autovaccine against cancer cells
• During Ozone Therapy, circulating
neoplastic cells can undergo oxidation and
become a potential auto vaccine.
• Thus producing antibodies against its
tumor cells and help in killing them.

13. Inducing apoptosis
• Cancer cells have lost apoptosis.
• Ozone induces apoptosis in cancer cells
causing their death.

14. Inducing liver enzymes
• Liver activation by Ozone therapy helps
induce liver enzymes which have powerful
detoxification action.

15. Decreases cancer fatigue
• Neuroimmunoendocrine system is so
closely related that activation of one leads
to activation of others. Ozone releases
endorphins. This leads to better pain relief
and a generalized feeling of well being.

16. Effects on CNS and endocrine system
Therapy of cancer related fatigue
• There is a strong functional interaction
between the nervous system, the
endocrine glands and the immune cells.
• Ozone Therapy results in energetic feeling
and euphoria. An excellent treatment for
cancer related fatigue.

17. Improves quality of life
• General improvement in metabolism
following Ozone therapy leads to energetic
feeling for the patients. It makes the life of
a cancer patient tolerable.

18. Ozone Therapy in Ca
• eliminate cells which are fermenting sugar
anerobically,
• halt metastasis and restore healthy
aerobic function.
• prevents recurrence of the problem.

19. Improves
Energy
Improves
metabolism
Induces liver
enzymes
Induces
Apoptosis
Autovaccination
against Ca cells
Stimulating
Immune System
Controlling
infections
Anti oxidative
enzymes
stimulation
Improved
circulation
Improved
Oxygenation
Ozone in
Cancer

20. Clinical experience with
Ozone in treatment of cancers

21. Meningioma
• Mr. A, 78 yrs old Male had following
problems:
• Loss of balance while walking, needed
stick for support
• Violent behavior – got into fight with
neighbors and threatened to harm them
physically. Shouts at family members.
• Lethargy, weakness

22. Ozone Therapy
• He was diagnosed to have a frontal lobe meningioma
which was inoperable.
• Ozone therapy was started for the patient in the form of
ear insufflation and ozonated water to drink.
After 7 sessions
• Patient felt energetic.
• Patient had become peaceful and friendly with others.
After 12 sessions,
• Patient could walk without the aid of walking stick.

23. Follow up
• Patient abandoned treatment after a while.
• He started having fits and violent behavior
recurred.
• He again needed stick.
• Patient’s wife pleaded with him as well as the
doctor to restart the treatment.
• After restarting the treatment on a long term
basis (for 3 months) given on twice a week
basis, again his symptoms are controlled.

24. Treatment of liver cell Ca
• Lata, 50 years old female came with the
reports showing liver cell carcinoma with
metastasis in lungs.
• Treatment suggested was Ozonated
Saline twice a week & Major Auto
Haemotherapy once a week for 3 months.
• Later Lata took 5 sessions of Blood Ozone
& 7 sessions of “Steam Ozone”

25. Reports on liver cell Ca

26. Later…
• Patient was taking “IV Ozone & Saline” accompanied
with “Non-Cooked Food”
• Initially, after 3 months’ treatment, the results were
– AFP gone down from 4700 count to 600,
– Bigger Node had reduced by 50% and
– multiple small nodules in lungs had almost disappeared.
• After, 6-7 months’ treatment, the results are not upto the
expectations.
– AFP has gone upto 1700 count from 600.
– Node besides liver has neither increased nor decreased.
– Faint appearance of nodules in lungs are seen.

27. CA vaginal wall
• Mrs. K S, age 47 Muslim lady was a case of post op CA
vaginal wall.
• She had CA cervix in 2004 which was operated in KEM
hospital.
• She had taken 6 chemotherapy following surgery.
Presently she complains of severe pain & discomfort in
lower abdomen, profuse leucorrea, dribbling of urine and
involuntary urination. She was very depressed and
irritated.
• She was given Ozone therapy in the form of rectal
insufflation and vaginal insufflation.

28. Ca vaginal wall
• Patient improved within first 4 sessions.
• Her vaginal discharge had completely
disappeared!
• She started passing proper stools.
• She started gaining control on her micturation,
• Her appetite improved.
• Above all, she improved psychologically. She
became better, happy & cheerful.
• Her zeal for life returned.

29. Ca breast
• Ms. S S 50 yrs old unmarried female
• She had a large lump in left side of the
breast with tenderness for 6 months.
• She also suffered from loss of appetite
and weight for 6 months.
• It was 4” in size to begin with.
• She wa sonly on naturopathy treatment.
• Ozone therapy was started as funneling
and rectal insufflation.

30. Ca breast
• After 5th session lump became soft,
tenderness gone and size reduced
approx. by ½ inch.
• After 20th session it became almost half
of its original size

31. Radiation proctitis
• B P, 67 yrs old male had Ca rectum. He was
operated and local radiation was given following
which he started passing mucous in stool with
pain.
• All types of conventional treatment were tried
including steroid enemas but rectal discharge
did not stop.
• He had to wear diaper round the clock. His work
and social life was zero. He lost hope that he
would ever be working again!
• As a last resort, he was suggested rectal
insufflation.

32. Ca rectum
• After 2nd session pain was gone.
• After 10th session, volume of mucous was reduced. He
had to wear diaper only at night.
• He continued ozone therapy for 4 months thrice a week.
• After stoppage of treatment again mucous came in large
volume with stool.
• He was started on rectal insufflation again as twice a
week maintenance. After 8 months, he stopped ozone as
there is no mucous in stool and no pain.
• Lastly he was given the machine todo treatment at
home. He is back to work, travels globe and enjoys his
life!

33. Ca left maxillary sinus
• Mr. M.R. age 22 yrs is a known case of Ca
left nasopharynx. His CT SCAN confirmed
Angiofibroma of Maxillary sinus.
• Patient complained of occasional bleeding
from nose, swelling on the cheek, Pain in
the ear.
• Patient was on Radiation therapy and
Ozone therapy in the form of ear
insufflation.

34. Ca left maxillary sinus
• Patient showed improvement from 3rd
sitting onwards; his swelling reduced; no
pain in the ear. Bleeding from nose had
not occurred since over 1 month. He took
12 sessions.

35. Ca colon
• Mr N.S. age 45 having a long history of diarrhoea
alternating with constipation, was steadily losing weight
and advised CT abdomen
• CT revealed a big mass in large intestine and was
advised colectomy. About 10-12 cm intestine was
removed including lymph nodes around intestines
• He took 6 chemotherapy cycles before starting ozone
therapy
• Chief complaints after chemotherapy: Profound
weakness, Lack of appetite, Loose motions &
constipation alternately, His Hb had reduced to 10.2.

36. Ca colon
• Therapy advised: Rectal Insufflation for 2 times a week
• Dosage: 20 mcg/ml x 3 min x 150ml; slowly increased to
30 mcg
• Improvement was remarkable; his energy level started
increasing in first 2 sittings
• Appetite improved, stools were normal
• His Hb checked after 10 sittings was 11.7. Totally 30
rectal insufflation and 10 major auto haemotherapy
administered.
• Follow up treatment reduced to once a week. His latest
biopsy at colectomy site was normal. No metastasis
revealed in follow up CT scan.

37. Observations
• Ozone therapy works wonderfully on
alimentary carcinomas and Genito urinary
tract carcinomas eg. CA Colon, CA
Rectum and CA Cervix
• Cancer which are habit related take a little
longer for improvement eg. CA:Cheek,
CA:Larynx, CA:Tongue. These are all
related to tobacco chewing, smoking, pan
and/or gutka eating. In these cases the
toxin build up is very high and it takes
longer to control

38. My Observations (Contd)
• Ozone Therapy works best as supportive
therapy with ongoing conventional therapies
particularly for Cancer
• It reduces the side effects of Chemo Therapy
and Radiation Therapy
• The aim is to lengthen or maintain the effects of
classical therapy and to improve the patients
well-being, life style and life quality

39. Thank you