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Know your audience. This cardinal rule of both HIV prevention interventions and social media strategies has been a key to the early success of TLBz Sexperts, a growing HIV prevention program based in Chiang Mai, Thailand. TLBz Sexperts is using social media—including Facebook, You Tube, and online chats—to reach transgender people—a population that is at-risk for HIV infection—with important health messages. In this podcast, you will hear from Nada Chaiyajit, a well-known transgender activist from Chiang Mai, who leads the TLBz Sexpert program.