seminar on spray

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 Introduction
 Components of spray
 Manufacturing of spray
 Advantages
 Disadvantages
 Uses
 Packaging, labeling, storage
 References

3. Spray is an aqueous or oleaginous solution
in the form of coarse droplets to be applied
topically to the nasopharyngeal tract or to
the skin.
Due to its noninvasive nature & quickness
with which spray delivers medication, drug
is delivered directly to the target organ
without any decomposition of drug.
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4. Spray :- It is a medicated liquids prepared for dispersal by atomizer or
nebulizer, usually on external surface or mucous membranes of the
respiratory tract.
Aerosol:- defined as colloidal systems consisting of very finely
subdivided liquid or solid particles disperse in and surrounded by a gas.
It is an Aerosol which is usually used to relieve nasal congestion and
inflammation, that contain antihistamine and antibiotic substances.
In treatment of disease, Spray administration represent a valuable means
by which a therapeutic agent may be delivered. This route posses many
advantage over the route of therapeutic administration.
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5. 1] Propellant:- developed a pressure in
the container.
2] Particular medicaments or drug.
3] Container:- made from metal such as
tin plated steel, aluminium,stainless steel,
glass & plastic.
4] Valves :- delivered the content in the
desired form, then it regulate the flow of
product concentrate.
5] Actuator :- fitted on valve stem &
helps in easy opening & closing of the
valve.
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6. It is mainly done by 2 process :-
PRESSURE FILL PROCESS
 used to fill spray product using hydrocarbon propellant at room temperature
 It is less danger of moisture contamination of product
 Less propellant is loss in the process
COLD FILL PROCESS
 Used to fill spray product using fluorocarbon propellant below room
temperature.
 Aqueous solution cannot be filled by this process(since at low temperature
water will turn into ice)
 No loss of propellant due to cooling of concentrate below 0◦c
Manufacturing of Spray
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7.  Medicaments can be delivered directly to the affected area
to minimizes the discomfort caused by mechanical
application.
 There is no danger of contamination of the product with
foreign materials, since the medication is sealed in a container.
The onset of action is faster compared to other dosage forms
because the medicament is directly applied to the affected
area.
Some examples are:- Beconase, Flonase (nasal spray)
Otomizer (ear spray)
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8.  It is a costly preparation & some of propellants are very toxic.
 Cooling effect of highly volatile propellants may cause discomfort or injured
skin.
 Spray must keep away from high temperature or fire because it may lead to
explosion due to development of high pressure inside.
Uses
 Employed against heat burnt & sunburn, contain local anesthetic & antiseptic.
 Reduce nasal congestion & to treat infection.
 Throat spray contain antiseptic, deodorants that employed to relieve sore throat,
laryngitis
It treat athlete’s foot & other fungal infection .
(Athlete’s Foot also known as TINEA PEDI & RINGWORM is a common skin infection of feet
caused by fungus. It may infect any part of the foot but most often grows between toes)
DISADVANTAGES
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9. PACKAGING :-
 A unique aspect about the spray is that product is actually packaged as part of
manufacturing.
 They have protective cap or cover which fit snugly over the valve and mounting
cup. This protects the valve against contamination with dust and dirt. The cap, which
is generally formed of plastic or metal, also serves a decorative function.
LABELING :-
 Labels are of usually plastic peel away labels.
 Easily removed paper labels.
STORAGE :-
 Not to puncture the pressurized container.
 Not to store or use them near heat or open flame.
 Not to incinerate them.
Should be stored in well filled tight containers. They should be protect from light.
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10. REMINGTON – Essentials of Pharmaceutics , edited by Linda A. Felton
(Page no. 633-639)
 Copper & Gunn’s Dispensing for Pharmaceutical students. 12th edition .
( Page no. 8)
 Pharmaceutics – I , by R.M. Mehta
Vallabh Prakashan (Revised Fifth edition) (page no. 87-90, 15, 28)
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