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Pulmonary Vein, Arrhythmogenic Coupling
1. Arrhythmogenic Coupling between
Na+-Ca2+ Exchanger and IP3 Receptor in
Rat Pulmonary Vein Cardiomyocyte
Yosuke Okamoto1,
Makoto Takano2,
Kouiti Kawamura3,
Takayoshi Ohba1,
Kyoichi Ono1.
Department of Cell Physiology, Akita University Graduate School of Medicine
1
2
Department of Physiology, Kurume University School of Medicine, Kurume
3
Department of Cellular and Organ Pathology, Akita University Graduate School of Medicine
28. “Ca release via the IP3R is activated by α1 stimulant, and the Ca2+ in
2+
turn spin up the NCX, which is co-localized with the IP3R, producing
transient depolarization. β1-adrenergic action of NE reinforce CICR,
resulting in Ca2+ overload. The accumulated Ca2+ would be released
again via the IP3R. ”
Okamoto Y et al. J Mol Cell Cardiol. 2012 (in press)
Editor's Notes
There waw little change on the membane resistance (n = 3)