Protein Biomarker Discovery: Reflection Wilmarie Morales Soto During the seminar, Lysandra Santiago, emphasized that the need for biomarkers toidentify several diseases is increasing because they can help detect them at an earlier state andtherefore allow patients to get better treatment. Unfortunately the identification of biomarkersis very difficult. Several techniques have been developed for biomarker detection such as, massspectrometry, liquid chromatography, and shotgun proteomics, amongst others. Thesetechniques, though very accurate, have an outstanding amount of variable which are difficult tocontrol. The problem with these results is that, when examining the data, it is very challengingto determine what potential biomarkers have any value. To eliminate a few of these variables, scientists began developing new ways to identifythese proteins. They began experimenting with and combining several methods together.These experiments were successful in that they were able to eliminate a significant amount ofthe variables that presented a problem, but on the other hand they discarded so manyvariables that they might be eliminating essential information. Biomarker detection technology is one that must continue to advance, for it is far fromperfect. “It is time to evaluate the entire process right from sample accusation to bioinformicanalysis with the aim to implement and develop innovative strategies that will lead us to theultimate goal of routine biomarker discovery”(Santiago 2011). We cannot deny the importanceof biomarkers for the advancement in all medical sciences. Using biomarkers to detect certain
diseases early on, like cancer for example, can help improve treatments and, evidently, savemany lives.