11. Endometriosis (Cont)
Danazol - 200-800 mg/day 6-9 months
SE- virilizing effects: Decreased br size,
acne, oily skin, hirsutism, weight
gain, deepening of
voice, hot flushes, dry vagina
Medroxyprogesterone acetate 30mg/day
GnRH analogue- maximum 6 months
REFER-if SE severe or symptoms not
relieved
12. Endometriosis (Cont)
Surgical Tm
Conservative by laparotomy or laparoscopy
diathermised or excised, ennucleation
Radical- TAH and BSO + excision of
endometriotic lesions
Combined medical & surgical in severe cases
20. Excessive menstrual loss
too long, too frequent, too heavy, too irregular
Menorrhagia
Def: excessive (80 ml or more) regular loss
Causes-
physiological(normal loss but thinks heavy)
IUD, infection(chronic PID)
Neoplastic fibroids, Ca endometrium,
functioning ov Ts, uterine polyps
Blood dyscrasias, psychological factors
21. Dysfunctional Uterine Bleeding
Not due to organic lesions
Ovulatory or anovulatory
Anovulatory - common in extremes of
life, CHO intolerence, older obese,
endocrine d/s,
- prolonged period of amnorrhoea
followed by heavy persist Bld
23. Management of excessive
menstrual loss
History- as in diagnostic work-up
Examination- anaemia, obesity,
endocrine d/os
Investigations - Bld CP, clotting screen,
TFT & GTT if indicated
Ultrasound, endometrial biopsy if 40 & >
24. Treatment
a. Medical Tm
Anovulatory cycles
adolescent & young, COC few months or
cyclical progestogens (medroxyprogesterone
acetate 10mg daily or norethisterone 5mg bd)
from day 15-25
perimnopausal, cyclical progestogen (regular
withdrawal) if no withdrawal, menopause has
occured, if menopausal sympts +, HRT
containing progestogens
25. Acute Onset of Heavy Bleeding
Control by a high dose of progestogens
& reduce slowly
eg: northisterone
30mg bd x 3 Ds
20mg bd x 3 Ds
10mg bd x 3 Ds
5mg bd x 10 Ds
followed by withdrawal bleeding
26. Ovulatory cycles
more difficult to manage
antifibrinolytic therapy, tranexamic acid
1-3 G/day
prostaglandin synthetase inhibitors
COCs after excluding contraindications
Danazol 200-800 mg daily
Surgical Tm, Hysterectomy or endo:
ablation
27. Fibroids
Commonest Tu: of female GT
History- peak bet 35-45 years nulliparity
or infertility may be symptomless
menorrhagia, IMB if fibroid polyp +
abdominal
swelling, complications (pain)
28. Fibroids
Examination- mass in lower abd
VE- mass arising from the uterus
Diff: Dia: adenomyosis, ova: tumor,
pregnancy
Investigations- bld CP, ultrasound
29. Treatment
Conservative- if small, no symptoms
during
preg, near menopause
Medical Tm- GnRH analogues
contraindications to
surgery
prior to surgery in huge fibroids
Surgery - Myomectomy or
Hysterectomy
30. Intermenstrual Bleeding
Causes- Midcycle bleeding: Reassurance
Premenstrual: due to defective corpus L
Tm- progesterone supplem:
Neoplasia: endom: or cervical polyp,
Cas
Infective: cervicitis, infected polyp
32. Amenorrhoea
Primary- No period up till 14 if no Sdry sex dev:
16 if Sdry sex dev: +
Causes:
Developmental errors of ut, ut atresia
Genital T obstruction: imperforate hymen,
vaginal atresia, transverse vg septum
Chromosomal disorders - eg: Turner`s $
Anorexia nervosa
Management- according to the cause
TIMELY referral
33. Imperforate hymen
CF
Normal growth
Intermittent abdo: pain
Palpable lower abdominal swelling
Difficulty in micturition
Bulging bluish mem: at lower end of vagina
Mn - Incision of mem: under aseptic condition
34. Secondary- Absence of menses for 6
months(who has menstruated before)
Causes - Physiological
before
puberty,adolescence,
during preg:[ commonest],
lactation, after
menopause
36. VAGINAL DISCHARGE
Causes- Physiological [leucorrhoea]
usually mucoid or white,
increased at the time of ovulation,
premenstrual
during sexual excitement and coitus,
during pregnancy, in the female
neonate d/t maternal oestrogen
37. Pathological causes
Premenarchal years
- poor hygiene, foreign bodies,
- thread worms, sexual abuse
Reproductive years
- infections: Candida, Chlamydia, Neisseria,
Trichomonas, Bacterial vaginosis
Herpes, Syphilis,
nonspecific infections
- neoplastic: benign as well as malignant,
usually bld stained
41. - relationship to menstrual cycle. eg
moniliasis worse before menstruation
- hygiene practice : douching, tempons
- risk of STDs, associated UTI
- associated medical conditions. eg diabetes
- history of allergy to rubber, spermicides
- drugs: antibiotics, COCs
- cervical smear result if done
42. Physical Examination
- a complete general and abdominal
examinat:
-VE including urethra, speculum
examination to determine
nature and amount of discharge,
condition of the cervix
43. Investigations
- cervical cytology, vaginal pH.
- saline wet mount, wet mount on 10%
KOH solution
- Gram stain, C & S: HVS, endocervical
- colposcopy if indicated
44. Treatment
- Treat the underlying cause
- lucorrhoea- Explanation and Reassurance
Failure of cure of vaginal discharge
- incorrect diagnosis, use of incorrect drugs
- Tm course too short or incorrect dosage
- underlying cause untreated
- lack of pretreatment explanation
- poor compliance, SE of drugs
- aesthetically not acceptable
45. Possible causes of relapse
[ reappearance of same condition]
- failure to deal with predisposing
factors
- lack of attention to hygiene
measure
- other local underlying pathology,
46. Reinfection
- sexual transmission,
failure to treat sex partner
- change of sex partner,
failure of long term prophylaxis
Referral
- suspicious cx or vg lesions
- chronic discharge not responding to
Tm
- Dx unclear, very anxious patient
47. PRURIUS VULVAE
Causes- with discharge
- without discharge
Pruritus with discharge
Trichomonas vaginalis and
Candida albicans account 80%
48. Pruritus without
discharge
Generalised pruritus ( jaundice,
uraemia,allergy,lymphadenoma)
Skin diseases [scabies, psoriasis]
Parasitic infections: thread worm,
pediculosis pubis
Discharge from anus & rectum: fissure
in ano, piles,fecal incontinence
50. History : onset, duration, predisposing factors
systemic illnesses, previous treatm:
Physical examination
General: evidence of DM, uraemia, liver failure
deficiency states
Pelvic/E: color of vulval skin, dystrophies,
if d/c +, amount, color, odour, condition
of cervix and vaginal walls
51. Investigations
For systemic diseases if necessary
If vg d/c +, tests for Trichomonas &
Candida
Biopsy if skin changes +
52. Management
Treat underlying cause:eg DM, Candida
If no cause found:
loose fitting cotton underwear
to keep the vulva well aerated
personal hygiene
sedatives at night, antihistamines
ointments containing corticosteroids anfungicides
local anaesthetics s/b avoided
fungicides orally if perineal pruritus +
53. Management of infection by Candida
albicans
Commonest cause of vg d/c
Dx by C/F and investigations
History- intense pruritus and soreness, > at night
VE - erythema of labia, perineum & vagina
scanty, thick, white curd-like discharge
not sexually transmitted
54. Predisposing factors
-Pregnancy, premenstrual period
- Medical diseases: dm, iron DA
- Drugs: COCs, A/B, corticosteroids,
immunosuppresive drugs
- Adhesive tights
56. Treatment ( fungicides)
- Clotrimazole( canestin) 200mg vg pessaries hs X 3
Resistant cases: ( oral ketoconazole or
itraconazole)
hepetic damage must be excluded
-Genital hygiene:daily washing with bland soap &
water
Avoid close-fitting tights,washing of
underwear at 80*C,>
- Treatment of underlying causes: eg DM
57. Trichomonas infection
C/F- itching or burning sensation, dyspareunia
- profuse, offensive, frothy, white , green or
brownish vg discharge
- oedema and congestion of vulva
- vg stuck with reddish-purple or dark-red spots
(strawberry spots)
- associated gonococcal infection common
- usually sexually transmitted
58. Diagnosis
- from C/F, vg pH is increased
- vg d/g in N saline +ce of motile flgellated
protozoa
- culture of swabs
Treatment
- Metronidazole 200 t.d.s X 7 Ds both
partners
(should avoid alcohol during Tm)
59. Bacterial vaginosis
C/F
- foul smelling profuse offensive fishy vg d/c
-VE- unusual looking (green or yellow or
foamy)- no sign of inflammation
irritation uncommon, not STI
Tm - Metronidazole as for Trichomoniasis
60. LUMPS and SWELLINGS of the VULVA
Tum- From any structure of the skin (keratinized sq
ep)
Causes- trauma: haematoma
- infections: Condylomata accuminata (viral
warts), syphilitic condylomas, boils
- retention cysts: sebaceous, epidermoid,
Bartholin, remnants of Wolffian ducts
- vascular changes: haemangioma, varicose
veins
61. - urethral and paraurethral conditions: urethral
prolapse, caruncle, paraurethral gland cysts
- inguinal hernia, hydrocele of canal of Nuck
- genital prolapse
- benign tumors: lipoma, fibroma, papilloma,
hydradinoma,(tumor
of sweat gld)
- malignant tumors- sq cell Cas, melenoma,
sarcoma, basal cell Ca
62. Enlargement of Bartholin`s gland
Bartholin`s adenitis
- The gland is acutely painful and swollen
- usually due to Gonococcus
- may be due to Staphyllococcus or G -ve bacilli
- an abscess may be formed
- if the main duct is blocked= Bartholin`s cyst
Tm- Marsupialisation for both cyst and abscess
63. Urethral caruncle
- is a reddened area involving the
posterior margin of the urethral orifice
- usually symptom-less and found in
postmenopausal O+
- occasionally can cause bleeding and
dyspareunia
- Tm: topical oestrogens or excision or
cautery
64. Malignancies
- progressively enlarging lumps and ulcers
associated with chronic pruritus and foul
smelling discharge
- mass is irregular, fragile ulcer with
irregular rolling edges
- enlarged inguinal lymph nodes may be
present
- biopsy is necessary to confirm the Dx
- needs REFERRAL for radical surgery