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ORAL FLUID AS A CHEMICAL TEST FOR THE DRE PROGRAM : HISTORY, THE FUTURE, AND PRACTICAL CONSIDERATIONS Barry K Logan PhD, DABFT National Director of Forensic Services, NMS Labs Willow Grove PA
Disclaimer ,[object Object]
Current Options in Drug Testing
Drug Testing: Current Approaches  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Testing: Current Approaches  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Testing: Current Approaches  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drugs in Oral Fluid
Oral Fluid ,[object Object],[object Object],[object Object],[object Object]
Cocaine in Oral Fluid  150 mg/70 kg sc cocaine, (N=14 oral fluid) (N=13 plasma) Courtesy, Marilyn Huestis, NIDA
THC in Oral Fluid Courtesy, Marilyn Huestis, NIDA Hours 0.01 0.1 1 10 100 1000 10000 0 1 10 100 Oral Fluid Plasma 3.55%THC GC-MS ng/mL or ng/mg
Methamphetamine in Oral Fluid 0 20 40 60 80 Low Dose High Dose Hours Oral fluid (cutoffs 50 Meth/2.5 Amp) Urine (cutoffs 500Meth/200 Amp) Courtesy, Marilyn Huestis, NIDA
History of OF Drug Testing
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],History of OF Drug Testing
[object Object],[object Object],[object Object],[object Object],[object Object],History of OF Drug Testing
DUID Oral Fluid Use Belgium: saliva screening, blood/saliva confirmation Australia: saliva screening (2x), saliva confirmation Germany: saliva/urine testing, blood confirmation UK: FST, blood sampling; no device being used France: saliva screening, blood confirmation Switzerland: Approved for use
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Drug Testing Around the World
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Drug Testing Around the World
DUID Oral Fluid Use United States: OF Specifically Approved in: Alabama Arizona Colorado Indiana Kansas Louisiana Missouri New York North Carolina North Dakota Ohio Oregon South Dakota Utah Canada: OF Approved in Federal Legislation
Cut-Offs - Amphetamines ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
OF Workplace Testing in the US ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
US National Roadside Survey 2007
2007 US National Roadside Survey ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Sample Collection ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2007 US NRS Scope ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2007 National Roadside Survey ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2007 National Roadside Survey ,[object Object],[object Object],[object Object],Drug Positivity THC 8.65% Cocaine 3.92% Hydrocodone 0.68% Oxycodone 0.82% Alprazolam 0.64% Methamphetamine 0.84% Sertraline 0.50% Propoxyphene 0.52% Tramadol 0.46% Diazepam 0.38% Amphetamine 0.45% Fluoxetine 0.37% Phentermine 0.26% Dextromethorphan 0.22% Methadone 0.19%
2007 NRS - OF Positivity
2007 NRS - Paired Specimens ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2007 NRS - Paired Specimens ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Most common exact matches
Implementing OF Testing
Making OF Testing work for DRE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Making OF Testing work for DRE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Making OF Testing work for DRE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Making OF Testing work for DRE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Summary ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Oral Fluid as a Chemical Test for the DRE Program

  • 1. ORAL FLUID AS A CHEMICAL TEST FOR THE DRE PROGRAM : HISTORY, THE FUTURE, AND PRACTICAL CONSIDERATIONS Barry K Logan PhD, DABFT National Director of Forensic Services, NMS Labs Willow Grove PA
  • 2.
  • 3. Current Options in Drug Testing
  • 4.
  • 5.
  • 6.
  • 8.
  • 9. Cocaine in Oral Fluid 150 mg/70 kg sc cocaine, (N=14 oral fluid) (N=13 plasma) Courtesy, Marilyn Huestis, NIDA
  • 10. THC in Oral Fluid Courtesy, Marilyn Huestis, NIDA Hours 0.01 0.1 1 10 100 1000 10000 0 1 10 100 Oral Fluid Plasma 3.55%THC GC-MS ng/mL or ng/mg
  • 11. Methamphetamine in Oral Fluid 0 20 40 60 80 Low Dose High Dose Hours Oral fluid (cutoffs 50 Meth/2.5 Amp) Urine (cutoffs 500Meth/200 Amp) Courtesy, Marilyn Huestis, NIDA
  • 12. History of OF Drug Testing
  • 13.
  • 14.
  • 15. DUID Oral Fluid Use Belgium: saliva screening, blood/saliva confirmation Australia: saliva screening (2x), saliva confirmation Germany: saliva/urine testing, blood confirmation UK: FST, blood sampling; no device being used France: saliva screening, blood confirmation Switzerland: Approved for use
  • 16.
  • 17.
  • 18. DUID Oral Fluid Use United States: OF Specifically Approved in: Alabama Arizona Colorado Indiana Kansas Louisiana Missouri New York North Carolina North Dakota Ohio Oregon South Dakota Utah Canada: OF Approved in Federal Legislation
  • 19.
  • 20.
  • 21. US National Roadside Survey 2007
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27. 2007 NRS - OF Positivity
  • 28.
  • 29.
  • 30. Most common exact matches
  • 32.
  • 33.
  • 34.
  • 35.
  • 36.

Editor's Notes

  1. Lipophilicity of drug Non-polar analytes (THC) partition into oral fluid more readily than polar metabolites (11-nor-9-carboxy-THC) Usually more parent drug than metabolites pKa of drug Non-ionized basic drugs in blood partition into more acidic oral fluid, become ionized & accumulate, “ion trapping of basic drugs” Molecular size of drug
  2. Median and interquartile ranges presented on log axis. Dasehed lines indicate LOQ (2.5ug/L), SAMHSA (8ug/L) and DRUID (10ug/L) oral fluid cutoffs.
  3. Time To Last Positive Methamphetamine oral fluid positive at 50 ng/mL requires 2.5 ng/mL amphetamine presence Methamphetamine urine positive at 500 ng/mL requires 200 ng/mL amphetamine presence After how many doses? After the last?