17. Clinical manifestations Variables Patient number (%) History of the buttock pains and back, no. (%) 755 (93.44) History of peripheral arthritis, no. (%) 518 (64.43) History of uveitis, no. (%) 195 (24.19) History of psoriasis, no. (%) 112 (13.90) History of hematuria no. (%) 55 (6.86) History of oral ulcer, no. (%) (n=805) 94 (11.68) Onset symptom, no. ( peripheral arthristis / enteritis / back pain / uveitis) (%) ( 21.55 /2.96/50.56/2.54) HLA-B27 positive 91.2 % Family history of spondyloarthritis 349 (43.35)
18. HS-CRP Variable HS-CRP- p value HSCRP- r BASDAI 0.0005 0.15117 BASFI 0.0002 * 0.16228 BAS-G 0.0001 * 0.22709
24. SNP of OPG in AS JH Huang, JC Wei. Rheumatology 2010
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26. Arthritis &rheumatism 2009;60(11),3269–79. (J. Gu and JCC Wei and Yu-Ling Wei contributed equally)
27. Identification of RGS1 as a Candidate Biomarker for Undifferentiated Spondylarthritis J. Gu, JCC Wei ,Yu-Ling Wei, D. Yu. Arthritis & rheumatism 2009;60(11),3269–79.
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31. Thank you James Cheng-Chung Wei, M.D., Ph.D. [email_address] +886 975 128095 Chung Shan Medical University Hospital Chinese Medicine Clinical Trial Center
Editor's Notes
Dr Wei, Tsai and Chou published a highly-citated paper showing that HLA-B60 and B61 are strongly associated with B27-negative AS in Taiwan.
Dr Wei and colleagues in Chung Shan medical university had set up an AS databank to investigate the association of AS genotype and clinical phenotype. They had found that MMP-3/ TIMP alleles correlate to disease activity and functional index of AS.
They also collaborated with Prof Brown in Australia and found that IL1 gene complex was associated with AS in Taiwanese Chinese.
Moreover, investigators from Taiwan, China and Prof David Yu in UCLA had close collaboration to discover candidate biomarker for spondyloarthritis by microarray and rt-PCR.
They had found RGS1 as candidate biomarker for USpA, as well as NR4A2, IL-8…etc.
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