The document discusses the organs of the immune system. It describes primary lymphoid organs like the thymus, where T cells mature, and bursa of Fabricius, where B cells mature in birds. Secondary lymphoid organs include lymph nodes and Peyer's patches in the intestines, which contain follicles where B and T cells interact with antigens and activate an immune response. Lymphocytes then circulate through the blood and lymph, migrating between secondary lymphoid organs to survey for pathogens and launch adaptive immune responses.
12. The functional thymus consists of two cell populations; the stromal cells and the thymocytes. The stromal cells include (1) the subcapsular epithelial cells; (2) the cortical epithelial cells; (3) the medullary epithelial cells; (4) macrophages; and (5) dendritic cells of bone marrow origin. (From Kierszenbaum AL: Histology and cell biology: an introduction to pathology, St Louis, 2002, Mosby.)
17. BURSA OF FABRICIUS (B cell maturation) follicle lumen Cortex (lymphocytes, M Ø, plasma cells) medulla
18. PEYER’S PATCHES Group I (90% Ileum ) Ruminants, Pigs, Horses, Dogs, Humans. Group II Illeum/Jejunum) Rabbits, Rodents.
19. When stimulated by antigen, immunoglobulin A (IgA)-producing B cells are produced in inductive sites, such as the Peyer’s patches.
20. The role of M cells as antigen-processing cells in the intestinal wall. Antigen that enters enterocytes is usually rapidly degraded in lysosomes. Antigen that enters M cells is not degraded. It may be presented directly to intraepithelial lymphocytes within the M. Yersinia, M. tuberculosis, Listeria, reovirus , Salmonella.
21. Structure of the two different types of Peyer’s patch (PP) in sheep. A, An ileal PP at age 8 weeks. B, A PP from the jejunum, also at 8 weeks. Original magnification ×32. (From Reynolds JD, Morris B: Eur J Immunol 13:631, 1983.)