0
Monsanto Corn Breeding:
                Providing Improved Products to Multiple
                         Commercial Channe...
Regional Breeding Teams
             Based on Adaptation Areas

                                              North

     ...
State of the Art Field Plot Equipment
                                          Enables Optimal Farming Practices
        ...
Monsanto Tests Future Products in
   Hundreds of Environments




                                    4
Global Germplasm Resources
            Enable Deployment of
      Differentiated Product Portfolios
    12 countries and 3...
Utilization of our Global Germplasm Pool is Creating
            Products with Unique Genetics

                          ...
New Products with Ex-US Genetics Have Improved Grain
        Yield Compared With Other Products




                      ...
New Products with Ex-US Genetics Have Improved Stalk
 Strength and Stability Compared With Other Products

               ...
Getting the “Best” Genetic
Combination Is a “Numbers Game”
                                              •   Lottery
     ...
Monsanto is Changing the
    “Numbers Game” in Plant Breeding
                                                    With a F...
Monsanto Built New IT Systems
                              to Handle All of the Information
3500000
                     ...
Marker Assisted Breeding Methods are Starting
 to Deliver Improved Products to the Market



                             ...
Key Points of Monsanto’s Corn
      Breeding Program
• Expanded the scale of the breeding engine
     • Improvements in eq...
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monsanto 07-31-06a

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Transcript of "monsanto 07-31-06a"

  1. 1. Monsanto Corn Breeding: Providing Improved Products to Multiple Commercial Channels Keys to Success • Breeding programs are structured to support commercial strategy Line Review Worksheet • Automation of the breeding process has 08_01DKD2*2/7640:@>0003.1001. Show selected lines only Export Add Filter? Lines Nursery notes YLD % of Check Mean Keep Plot Lineage Select Pedigree Trait 1 Trait 2 Trait 3 Comments increased the breeding through-put, which x 08_01DKD2*2/7640:@>0003.1001. 110 14011 :@>0003.1001.4001. 7 5 22 nice 08_01DKD2*2/7640:@>0102.1001. 95 X 14012 :@>0003.1001.4002. 6 6 24 better Breeder Comments 08_01DKD2*2/7640:@>0126.1001. 85 Advance this line into PCM1 on 6 testers x 08_01DKD2*2/7640:@>0160.1002. 120 08_01DKD2*2/7640:@>0171.1003. 101 x enables intense selection pressure to 08_01DKD2*2/7640:@>0175.1002. 105 08_01DKD2*2/7640:@>0179.1003. 87 Data GCA SCA Checks Check mean Select Below and update above? Line Data Double click entry to show Set data sheet Select Set Entry Tester Gen # Loc SELIN YLD MST TWT YM RTLP STLP PHT EHT CZ INT FSP DRP ERM GCA All 39 120 120 105 97 120 220 105 100 75 75 100 114 identify the very best products X C7201 5 19HGZ1 F4 13 140 250 18.5 56.3 14 15 115 53 1 99 113 C8202 4 80IDM2 F4 13 103 229 19.1 56.7 12 2 116 44 3 4 100 114 X C8207 12 LH283 F4 13 113 226 19 57 12 1 118 42 5 4 100 115 C8101 26 :@>0003+ F3 7 132 241 18 56 13 6 112 51 2 99 113 Rank Data Ranks Data • Expanding germplasm diversity by utilizing Set Entry Tester Overall Loc 1 Loc 2 Loc 3 Loc 4 Loc 5 Loc 6 Loc 7 Loc 8 Loc 9 Loc 10 Loc 11 Loc 12 Loc 13 Loc 14 Loc 15 Sort by Yield Levels Mean Yield 140 150 160 165 170 175 180 185 190 200 210 215 300 C7201 5 19HGZ1 1 45 55 66 33 20 5 4 4 3 2 2 1 2 Green - Hybrid above chk m C8202 4 80IDM2 18 50 66 33 21 30 40 5 6 7 8 2 1 3 Red - Hybrid below chk mea C8207 12 LH283 16 60 12 20 30 8 8 5 4 10 12 2 8 4 C7201 5 19HGZ1 2 1 5 8 25 47 36 22 1 1 5 4 3 8 our pool of global germplasm C8202 4 80IDM2 4 2 5 22 44 56 12 11 5 8 22 14 16 55 C8207 12 LH283 16 14 22 11 10 1 17 27 26 5 4 9 8 7 • Utilize molecular markers to enhance the probability of success • Rapidly integrate biotech traits into elite products • Expanded our pipeline depth to provide more improved products 1
  2. 2. Regional Breeding Teams Based on Adaptation Areas North W. Central E. Central South Regional Breeding Team Objectives: 1. Focus on most elite germplasm 2. Maintain important germplasm types 3. Enhance product diversity 4. Enhance breeder germplasm knowledge and info exchange 5. Breeder synergy to identify and 2 support customer needs
  3. 3. State of the Art Field Plot Equipment Enables Optimal Farming Practices 1.8x Growth Optimal Planting Date Optimal Plant Spacing From Texas - Canada 2.75 2.50 Plots (Millions) 180000 2.25 Plots Planter / Day 160000 140000 2.00 120000 1.75 100000 80000 1.50 60000 40000 1.25 20000 1.00 0 '03 '04 '05 '06 '07E 12 15 18 21 24 27 30 11 14 17 20 23 26 29 11 14 17 20 23 2 5 8 2 5 8 4/ 4/ 4/ 5/ 5/ 5/ 3/ 3/ 3/ 3/ 3/ 3/ 3/ 4/ 4/ 4/ 4/ 4/ 4/ 4/ 5/ 5/ 5/ 5/ 5/ 3
  4. 4. Monsanto Tests Future Products in Hundreds of Environments 4
  5. 5. Global Germplasm Resources Enable Deployment of Differentiated Product Portfolios 12 countries and 3 companies/country = 36 major germplasm acquisitions Asgrow DEKALB Int’l Int’l Asgrow USA DEKALB USA Inter-company Crosses Cargill Int’l Holden’s Agroceres Sensako “Inter-company” breeding crosses are a routine part of our program Starting 2nd Breeding Generation of an integrated germplasm pool
  6. 6. Utilization of our Global Germplasm Pool is Creating Products with Unique Genetics 23% of 50-60% of Our Pre-Commercial Pipeline Commercial For RM 110-120 Products New Germplasm with Ex-US Genetics
  7. 7. New Products with Ex-US Genetics Have Improved Grain Yield Compared With Other Products Monsanto Product Competitor Product Monsanto Product Competitor Product Monsanto Product Competitor Product Higher Grain Yield
  8. 8. New Products with Ex-US Genetics Have Improved Stalk Strength and Stability Compared With Other Products Better Stalks in Environments with More Stalk Lodging Monsanto Product Competitor Product Monsanto Product Competitor Product Competitor Product Monsanto Product Better Stalks
  9. 9. Getting the “Best” Genetic Combination Is a “Numbers Game” • Lottery – 5 White balls selected from a set of white balls numbered 1-55 – 1 Red ball selected from a set of red balls numbered 1-42 9 10 1 2 3 4 56 7 8 – Probability of matching the 6 numbers is ~1 in 146 million • Genetic Combinations – Slots (picked white and red balls = 6) equal genes – The different numbers on the balls are different alleles (variant) at each gene 55 alleles – Probability of getting the “best” (match) 6 at this gene (slot) numbers is ~1 in 146 million • Getting the “best” plant product is much 10 Chromosomes of Corn harder – Corn as tens of thousands of genes (slots) – Monsanto’s elite global germplasm pool has lots of genetic variation (alleles) – With just 20 genes and only 2 alleles the probability is ~1 in 1 trillion of getting the “best” plant 1
  10. 10. Monsanto is Changing the “Numbers Game” in Plant Breeding With a Few Cycles of Selection Use Molecular Markers to Identify We Can Quickly Improve our Which “Ball” We Want to Pick Probability of Success 1 2 3 4 5 6 7 8 9 10 Cycle Freq. of Best Genotype 0 1 per trillion 1 5 per billion 2 1 per 5,000 3 1 in 5 Grain Yield Grain Yield from Parent 1 from Parent 2 2
  11. 11. Monsanto Built New IT Systems to Handle All of the Information 3500000 Conv Select Traits Data points (millions) 3000000 MAB 2500000 Quality metrics Predicted Model Response 2000000 Parental Contribution 1500000 1000000 500000 Identify and Select QTLs 0 Phenotypic Genotypic QC Analysis • Breeder’s have 1-2 weeks to process • Decision support systems integrated and make decisions on millions of dps with phenotypic and genotypic information systems • 700% increase in information and analysis with the inclusion of molecular marker information 3
  12. 12. Marker Assisted Breeding Methods are Starting to Deliver Improved Products to the Market Monsanto Product Competitor Product Monsanto Product Competitor Product Monsanto Product Competitor Product Higher Grain Yield 4
  13. 13. Key Points of Monsanto’s Corn Breeding Program • Expanded the scale of the breeding engine • Improvements in equipment and automation has driven growth in the program size and yield testing capability (plots). • Integrated and utilized our global elite germplasm pools to deliver improved product performance and product diversity – We continue to deliver the biotech trait package with the very best germplasm • Utilizing new technologies (molecular markers) to improve the rate of genetic gain in our breeding programs 1
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