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Goldman Sachs Annual Global
Healthcare Conference

Geno Germano
President – U.S. and General Manager,
Wyeth Pharmaceuticals

June 12, 2007
Forward-Looking Statement

The statements in this presentation that are not historical facts are forward-
looking statements based on current expectations of future events that
involve risks and uncertainties including, without limitation, risks
associated with the inherent uncertainty of pharmaceutical research,
product development, manufacturing, commercialization, economic
conditions including interest and currency exchange rate fluctuations, the
impact of competitive or generic products, product liability and other types
of lawsuits, the impact of legislative and regulatory compliance and
obtaining approvals, and patent, and other risks and uncertainties,
including those detailed from time to time in Wyeth’s periodic reports,
including quarterly reports on Form 10-Q and the annual report on Form 10-
K, filed with the Securities and Exchange Commission. Quarterly results, in
particular, can vary due to issues which include, but are not limited to,
changes in exchange rates, the timing of actions taken by the Company to
ensure long-term improvements to our manufacturing processes, the
timing of regulatory approval of new products and/or facilities and the
timing of promotional programs. Actual results may vary materially from
the forward-looking statements. The Company assumes no obligation to
publicly update any forward-looking statements, whether as a result of new
information, future events or otherwise.
Driving Wyeth’s Growth

    Reliable Safety and Efficacy Profile
n

     4 Over 470,000 Patients Treated Worldwide
     4 Over One Million Patient Years Market Experience

    ~360,000 Incremental Biologic Patients in Top 6 EU Countries
n


    ~60,000 Incremental Biologic Patients in Japan
n

     4 Japanese Post Marketing Surveillance Program Lifted 2Q07

    Significant Growth Opportunities Exist
n

     4 Biologics Market Penetration:
         - RA: U.S. = ~33%; EU = ~20%
         - Psoriasis: U.S. = ~8%; EU = <1%



                    $3 Billion Enbrel Sales in 2010
                            (Outside North America)
Driving Wyeth’s Growth
                 ®




     Launched in 79 Countries; Additional 9 Launches by 2008
 n



      Current and Emerging Market Opportunities             Birth Cohorts

Current National Immunization Programs                     ~ 10 Million
(16 Programs to Date)
Potential National Immunization Programs                   ~ 3 Million
(e.g. Austria, Denmark, Finland, Ireland, Japan)
Private to Potential National Immunization Programs        ~ 8 Million
(e.g. Brazil, Czech Republic, Turkey)
Private Markets                                            ~ 58 Million
(e.g. China, India, Pakistan, Russia)




                      $3 Billion Prevnar Sales in 2010
                                    (Infant Vaccination)
Recent FDA Approvals

    Lybrel ™ - Approved May 2007
n

     4First Low Dose Combination Oral Contraceptive Offering Women the
      Opportunity to Be Period-Free Over Time
     4U.S. Launch Expected in July 2007


    Torisel ™ - Approved May 2007
n

     4Targeted First-in-Class mTOR Inhibitor for the Treatment of Advanced
      Kidney Cancer
     4Proven to Extend Overall Survival for People with Advanced Renal Cell
      Carcinoma
     4U.S. Launch Expected in July 2007
Future Wyeth Growth Drivers
New Pharmaceutical Products Pending FDA Approval



                                       Expected FDA
     Project          Indication
                                           Action

    Pristiq™          Vasomotor        Late July 2007

   Bifeprunox        Schizophrenia      August 2007

    Viviant™        Osteo Prevention   Year End 2007

    Pristiq™          Depression          1Q 2008

 Methylnaltrexone    Opioid Induced
                                       January 2008
      (Sub Q)         Constipation
Pristiq™: A Single Product With Multiple Uses
in a Large Population
                                                  Vasomotor Symptoms
         Depression
    First Line Treatment of                     First FDA-Approved
n                                           n
    Major Depressive Disorder                   Non-Hormonal Treatment of
    Associated With Menopause                   Moderate-to-Severe VMS
    Excellent Results Achieved
n
                                                Submitted Results From Study
                                            n
    With Low Dose Studies
                                                of 100 mg and 150 mg Doses
     4 Demonstrated Efficacy at 50 mg
                                                With Three-day 50 mg Starting
       Dose
                                                Dose
     4 Replicated Efficacy at 100 mg Dose
                                                 4 Markedly Reduced Incidence of
     4 Reduction in Adverse Event Related
                                                   Nausea and Adverse Event Related
       Discontinuation Rates
                                                   Discontinuations
     4 Substantial Improvement in Nausea
       Rates and Overall Tolerability            4 Confirmed Efficacy of the 100 mg
                                                   and 150 mg Doses
    50 mg Dose is Optimal Dose
n

    for Depression
Pristiq™ Market Possibilities
    (U.S.)



                                                                12 Million         4 Million
                                               23 Million                    +
                                                            +    Women             Women        >35 Million Women
                                                Women
                                                                                                   U.S. Prevalence1)

                                              Vasomotor
                                              Vasomotor                          Fibromyalgia
                                                                 MDD             Fibromyalgia
                                                                 MDD
                                              Symptoms
                                              Symptoms


                                                                  GAD
                                                                  GAD


                                                                  SAD
                                                                  SAD


                                                                 Panic
                                                                 Panic


                                                                                     2006
                                                                                                  ~2 to 3 Million
                                                                                                     Patients


1) 2006 Syndicated Depression Omnibus shows VMS and
depression overlap of ~3M women, 2005 Depression
Consumer; Landscape Study shows fibromyalgia and
depression overlap of ~1M women
Future Wyeth Growth Drivers
               Near Term FDA Submissions



    Project           Indication      Proposed Filing

  ReFacto® AF          Hemophilia      Submitted 2Q07

    Tygacil®           CAP/HAP             Mid 2007
                      Menopausal
   Aprela™             Symptoms/           Late 2007
                      Osteoporosis
Methylnaltrexone     Post Operative
                                           Early 2008
      (I.V.)               Ileus
Aprela™: Optimal Targeted Response of
Tissue Selective Estrogens Complex (TSEC)

          Product Profile
      n

           4Relieves Vasomotor Symptoms
           4Prevents Osteoporosis
           4Improves Vulvovaginal Atrophy (VVA)
           4Excellent Amenorrhea
           4Less Breast Tenderness
           4Provides Endometrial Protection Without Progestin

          NDA Filing: Late 2007
      n




     The Most Comprehensive Medicine
              for Menopause
Aprela™ Market Possibilities

 Premarin Family in 2001
     ~13 Million Women Worldwide
 n
                                    Global Revenue = $2 Billion
     Less Than $1.00 Per Day
 n




 Premarin Family Today
     ~3 Million Women Worldwide
 n
                                    Global Revenue = $1 Billion
     About $1.00 Per Day
 n




 Aprela’s Possibilities
     Capture a % of Lost Patients
 n

                                    Global Revenueð$2 Billion +
     Modern Day Pricing
 n
Positioning Wyeth To Be A Stronger
Company
    Build Breadth and Diversity Into Every Aspect of the
n

    Company So Wyeth Will Never Be Dependent on One
    Product or Any One Research Program


    Continue to Improve Profitability by Enhancing Productivity
n




    Achieve Solid Top Line Growth, Effectively Manage Costs,
n

    and Grow the Bottom Line at a Meaningfully Faster Rate
    Than the Growth in Revenues

 Position Wyeth to Be a Stronger Company at the End of the
 Decade Then We Are Today and Enter the Next Decade With
                     Great Momentum
wyeth 		Goldman Sachs 28th Annual Global Healthcare Conference

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wyeth Goldman Sachs 28th Annual Global Healthcare Conference

  • 1. Goldman Sachs Annual Global Healthcare Conference Geno Germano President – U.S. and General Manager, Wyeth Pharmaceuticals June 12, 2007
  • 2. Forward-Looking Statement The statements in this presentation that are not historical facts are forward- looking statements based on current expectations of future events that involve risks and uncertainties including, without limitation, risks associated with the inherent uncertainty of pharmaceutical research, product development, manufacturing, commercialization, economic conditions including interest and currency exchange rate fluctuations, the impact of competitive or generic products, product liability and other types of lawsuits, the impact of legislative and regulatory compliance and obtaining approvals, and patent, and other risks and uncertainties, including those detailed from time to time in Wyeth’s periodic reports, including quarterly reports on Form 10-Q and the annual report on Form 10- K, filed with the Securities and Exchange Commission. Quarterly results, in particular, can vary due to issues which include, but are not limited to, changes in exchange rates, the timing of actions taken by the Company to ensure long-term improvements to our manufacturing processes, the timing of regulatory approval of new products and/or facilities and the timing of promotional programs. Actual results may vary materially from the forward-looking statements. The Company assumes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise.
  • 3. Driving Wyeth’s Growth Reliable Safety and Efficacy Profile n 4 Over 470,000 Patients Treated Worldwide 4 Over One Million Patient Years Market Experience ~360,000 Incremental Biologic Patients in Top 6 EU Countries n ~60,000 Incremental Biologic Patients in Japan n 4 Japanese Post Marketing Surveillance Program Lifted 2Q07 Significant Growth Opportunities Exist n 4 Biologics Market Penetration: - RA: U.S. = ~33%; EU = ~20% - Psoriasis: U.S. = ~8%; EU = <1% $3 Billion Enbrel Sales in 2010 (Outside North America)
  • 4. Driving Wyeth’s Growth ® Launched in 79 Countries; Additional 9 Launches by 2008 n Current and Emerging Market Opportunities Birth Cohorts Current National Immunization Programs ~ 10 Million (16 Programs to Date) Potential National Immunization Programs ~ 3 Million (e.g. Austria, Denmark, Finland, Ireland, Japan) Private to Potential National Immunization Programs ~ 8 Million (e.g. Brazil, Czech Republic, Turkey) Private Markets ~ 58 Million (e.g. China, India, Pakistan, Russia) $3 Billion Prevnar Sales in 2010 (Infant Vaccination)
  • 5. Recent FDA Approvals Lybrel ™ - Approved May 2007 n 4First Low Dose Combination Oral Contraceptive Offering Women the Opportunity to Be Period-Free Over Time 4U.S. Launch Expected in July 2007 Torisel ™ - Approved May 2007 n 4Targeted First-in-Class mTOR Inhibitor for the Treatment of Advanced Kidney Cancer 4Proven to Extend Overall Survival for People with Advanced Renal Cell Carcinoma 4U.S. Launch Expected in July 2007
  • 6. Future Wyeth Growth Drivers New Pharmaceutical Products Pending FDA Approval Expected FDA Project Indication Action Pristiq™ Vasomotor Late July 2007 Bifeprunox Schizophrenia August 2007 Viviant™ Osteo Prevention Year End 2007 Pristiq™ Depression 1Q 2008 Methylnaltrexone Opioid Induced January 2008 (Sub Q) Constipation
  • 7. Pristiq™: A Single Product With Multiple Uses in a Large Population Vasomotor Symptoms Depression First Line Treatment of First FDA-Approved n n Major Depressive Disorder Non-Hormonal Treatment of Associated With Menopause Moderate-to-Severe VMS Excellent Results Achieved n Submitted Results From Study n With Low Dose Studies of 100 mg and 150 mg Doses 4 Demonstrated Efficacy at 50 mg With Three-day 50 mg Starting Dose Dose 4 Replicated Efficacy at 100 mg Dose 4 Markedly Reduced Incidence of 4 Reduction in Adverse Event Related Nausea and Adverse Event Related Discontinuation Rates Discontinuations 4 Substantial Improvement in Nausea Rates and Overall Tolerability 4 Confirmed Efficacy of the 100 mg and 150 mg Doses 50 mg Dose is Optimal Dose n for Depression
  • 8. Pristiq™ Market Possibilities (U.S.) 12 Million 4 Million 23 Million + + Women Women >35 Million Women Women U.S. Prevalence1) Vasomotor Vasomotor Fibromyalgia MDD Fibromyalgia MDD Symptoms Symptoms GAD GAD SAD SAD Panic Panic 2006 ~2 to 3 Million Patients 1) 2006 Syndicated Depression Omnibus shows VMS and depression overlap of ~3M women, 2005 Depression Consumer; Landscape Study shows fibromyalgia and depression overlap of ~1M women
  • 9. Future Wyeth Growth Drivers Near Term FDA Submissions Project Indication Proposed Filing ReFacto® AF Hemophilia Submitted 2Q07 Tygacil® CAP/HAP Mid 2007 Menopausal Aprela™ Symptoms/ Late 2007 Osteoporosis Methylnaltrexone Post Operative Early 2008 (I.V.) Ileus
  • 10. Aprela™: Optimal Targeted Response of Tissue Selective Estrogens Complex (TSEC) Product Profile n 4Relieves Vasomotor Symptoms 4Prevents Osteoporosis 4Improves Vulvovaginal Atrophy (VVA) 4Excellent Amenorrhea 4Less Breast Tenderness 4Provides Endometrial Protection Without Progestin NDA Filing: Late 2007 n The Most Comprehensive Medicine for Menopause
  • 11. Aprela™ Market Possibilities Premarin Family in 2001 ~13 Million Women Worldwide n Global Revenue = $2 Billion Less Than $1.00 Per Day n Premarin Family Today ~3 Million Women Worldwide n Global Revenue = $1 Billion About $1.00 Per Day n Aprela’s Possibilities Capture a % of Lost Patients n Global Revenueð$2 Billion + Modern Day Pricing n
  • 12. Positioning Wyeth To Be A Stronger Company Build Breadth and Diversity Into Every Aspect of the n Company So Wyeth Will Never Be Dependent on One Product or Any One Research Program Continue to Improve Profitability by Enhancing Productivity n Achieve Solid Top Line Growth, Effectively Manage Costs, n and Grow the Bottom Line at a Meaningfully Faster Rate Than the Growth in Revenues Position Wyeth to Be a Stronger Company at the End of the Decade Then We Are Today and Enter the Next Decade With Great Momentum