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Protein synthesis
 

Protein synthesis

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    Protein synthesis Protein synthesis Presentation Transcript

    • Protein Synthesis
    • tRNAs
    • • tRNAs are interpreters of the genetic code • Length = 73 – 95 bases • Have extensive 2o structure • Acceptor arm – position where amino acid attached • Anticodon – complementary to mRNA • Several covalently modified bases • Gray bases are conserved between tRNAs
    • tRNAs: 2o vs 3o Structure
    • Aminoacyladenylate Formation NH2 N N N N O O O H H OH H P O O O- P O- O O P O- ONH2 H OH O N N O C CH N H N O PPi NH2 O O H H OH H P O- O H OH O C CH NH2 H
    • Aminoacyl-tRNA Synthetase Rxn NH2 NH2 N N N N 5' tRNA N N O O O H H OH H H OH P O- O H H C N O O O N H O H OH H CH H NH2 NH3+ N AMP 5' tRNA N O O H H O H O H OH C CH H NH3+ N N