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VARIABILITY OF ENTROPY AS AN INDICATOR FOR STABILITY OF ANAESTHESIA DEPTH DURING IN VITRO FERTILIZATION PROCEDURES
1. PR215VARIABILITY OF ENTROPY AS AN INDICATOR FOR STABILITY OF ANAESTHESIA DEPTH
DURING IN VITRO FERTILIZATION PROCEDURES
I. V. Potievskaya, I. L. Ushakov
Russian Medical Academy for Postgraduate Training
Clinical Hospital “Moscvorechye’, Russia
Introduction. It has been shown that entropy
monitoring allows to assess depth of anaesthesia and
improves anaesthesia awareness [1, 2]. Usually
response entropy (RE) and state entropy (SE) are
measured. We suggested a new calculated parameter
- variability of entropy (VE) to evaluate stability of
anaesthesia. The objective of the study was to
compare stability of intravenous propofol and volatile
sevoflurane anaesthesia during oocytes retrieval by VE
assessment.
Results. There was no significant difference between
sevoflurane and propofol groups in duration of different periods
of anaesthesia (table). In all patients RE and SE values were
below 60 that reflected adequate depth of anaesthesia and did
not significantly differ between groups during induction period
(p=0.52 for RE and p=0.54 for SE) and awakening period
(p=0.18 for RE and p=0.24 for SE (fig.1, 2). At the moment of
oocytes retrieval RE and SE were lower in group 1 comparing
with group 2 (21 [7; 29] vs 36 [10; 56]; p< 0.05 for RE and 20
[7; 27] vs 30 [8; 45]; p< 0.05 for SE). VE was higher in the
group of propofol comparing with sevoflurane during periods of
induction and oocyte retrieval (p<0.05), (fig. 3). This fact may
reflect more stable level of anaesthesia depth in the group of
sevoflurane.
Conclusion. Assessment of variability of entropy in addition to
RE and SE allows not only detect the depth of anaesthesia,
but also more clearly evaluate its stability and balance of
hypnotic and analgesic effects. Use of volatile anaesthetic
sevoflurane during oocytes retrieval demonstrated more stable
anaesthesia level than propofol.
variables
group
Induction
time, s
X±m
Oocytes
retrieval
time, s,
X±m
Total
anesthesia
time, s
X±m
Awakening
time, s
X±m
А (sevoflurane) n=13 125±5 224±33 348±32 395±33
B (propofol) n=13 93±11 353±85 447±87 353±44
Methods. Design: prospective monocentric pilot study. 26
women of ASA physical status I scheduled for oocytes
retrieval were randomized into two groups. In group 1
induction of anaesthesia was performed with sevoflurane.
In group 2 patients received intravenous intermittent
propofol boluses.
VE = RE - SE/SE×100%
Data were presented as mediana, Mann-Whitney test was
applied.
Table. Comparative duration of different anaesthesia
periods in sevoflurane and propofol groups.
1. Bein B. "Entropy". Best practice&research clinical anesthesiology 2006, 20 (1): 101-109.
2. 2. Gao JD, Zhao YJ, Xu CS, Zhao J et al. "Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial". Chin Med J (Engl), 2012,
125 (8): 1389–92.
0,0
50,0
100,0
150,0
1 2 3 4 5
Mean RE at different periods of
anaesthesia
группа 1
группа 2
Group1
Group2
0,0
20,0
40,0
60,0
80,0
100,0
1 2 3 4 5
Mean SE at different periods of
anaesthesia
группа 1
группа 2
Group1
Group2
![PR215VARIABILITY OF ENTROPY AS AN INDICATOR FOR STABILITY OF ANAESTHESIA DEPTH
DURING IN VITRO FERTILIZATION PROCEDURES
I. V. Potievskaya, I. L. Ushakov
Russian Medical Academy for Postgraduate Training
Clinical Hospital “Moscvorechye’, Russia
Introduction. It has been shown that entropy
monitoring allows to assess depth of anaesthesia and
improves anaesthesia awareness [1, 2]. Usually
response entropy (RE) and state entropy (SE) are
measured. We suggested a new calculated parameter
- variability of entropy (VE) to evaluate stability of
anaesthesia. The objective of the study was to
compare stability of intravenous propofol and volatile
sevoflurane anaesthesia during oocytes retrieval by VE
assessment.
Results. There was no significant difference between
sevoflurane and propofol groups in duration of different periods
of anaesthesia (table). In all patients RE and SE values were
below 60 that reflected adequate depth of anaesthesia and did
not significantly differ between groups during induction period
(p=0.52 for RE and p=0.54 for SE) and awakening period
(p=0.18 for RE and p=0.24 for SE (fig.1, 2). At the moment of
oocytes retrieval RE and SE were lower in group 1 comparing
with group 2 (21 [7; 29] vs 36 [10; 56]; p< 0.05 for RE and 20
[7; 27] vs 30 [8; 45]; p< 0.05 for SE). VE was higher in the
group of propofol comparing with sevoflurane during periods of
induction and oocyte retrieval (p<0.05), (fig. 3). This fact may
reflect more stable level of anaesthesia depth in the group of
sevoflurane.
Conclusion. Assessment of variability of entropy in addition to
RE and SE allows not only detect the depth of anaesthesia,
but also more clearly evaluate its stability and balance of
hypnotic and analgesic effects. Use of volatile anaesthetic
sevoflurane during oocytes retrieval demonstrated more stable
anaesthesia level than propofol.
variables
group
Induction
time, s
X±m
Oocytes
retrieval
time, s,
X±m
Total
anesthesia
time, s
X±m
Awakening
time, s
X±m
А (sevoflurane) n=13 125±5 224±33 348±32 395±33
B (propofol) n=13 93±11 353±85 447±87 353±44
Methods. Design: prospective monocentric pilot study. 26
women of ASA physical status I scheduled for oocytes
retrieval were randomized into two groups. In group 1
induction of anaesthesia was performed with sevoflurane.
In group 2 patients received intravenous intermittent
propofol boluses.
VE = RE - SE/SE×100%
Data were presented as mediana, Mann-Whitney test was
applied.
Table. Comparative duration of different anaesthesia
periods in sevoflurane and propofol groups.
1. Bein B. "Entropy". Best practice&research clinical anesthesiology 2006, 20 (1): 101-109.
2. 2. Gao JD, Zhao YJ, Xu CS, Zhao J et al. "Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial". Chin Med J (Engl), 2012,
125 (8): 1389–92.
0,0
50,0
100,0
150,0
1 2 3 4 5
Mean RE at different periods of
anaesthesia
группа 1
группа 2
Group1
Group2
0,0
20,0
40,0
60,0
80,0
100,0
1 2 3 4 5
Mean SE at different periods of
anaesthesia
группа 1
группа 2
Group1
Group2](https://image.slidesharecdn.com/wca2016potievskayaushakov1-160912085431/85/VARIABILITY-OF-ENTROPY-AS-AN-INDICATOR-FOR-STABILITY-OF-ANAESTHESIA-DEPTH-DURING-IN-VITRO-FERTILIZATION-PROCEDURES-1-320.jpg)
