Workshop presentation on conducting literature and data research on biomaterials and biologicals.

1. Biomaterials &
Biologicals:
Research Sources
Amanda Werhane
Wendt Library
February 2007

2. Agenda
• Introduction
• Materials & biologicals
• Properties
• Library & campus resources
• Online resources

3. Introduction
• Amanda Werhane
– BS in Biological Aspects of
Conservation
– MA in Library & Information
Studies
– Liaison to BME, CBE, MSE
– Rm.315 Wendt Library
– (608) 262-9455
– awerhane@engr.wisc.edu
– IM: AmandaAtWendt

4. Workshop goals
#1 – introduce you to at least one tool, or
part of a tool, that you hadn’t used
before
#2 – introduce you to the libraries and
librarians who can help you throughout
the years
http://tinyurl.com/ytgqgg

5. Biomaterials & biologicals
• Biological and synthetic materials used in
biomedical engineering. Ex:
– skin grafts
– prostheses
– dental materials
• Viral/bacterial cultures and products used in
industry. Ex:
– biofuels
– food technology
– medicine
– pesticides

6. Materials & biologicals
• Categories of materials:
– Metals
– Ceramics
– Polymers
– Biologicals (sometimes included as polymers)
– Composites

7. Molecular formulae
• Variant alphabetization
– Ex: KBr  BrK
• Truncation and wildcard symbols for
unknown or variable elements:
– * ? # x
• Organic [Hill]: Carbon + Hydrogen +
others in alphabetical order
• Polymer: Try monomer first

8. Names
• Chemical Abstracts, IUPAC, scientific names,
common names, trade names
• Direct or inverted
– Direct: 2,4-dimethylpyridine
– Inverted: Pyridine, 2,4-dimethyl-
• International variations
• Abbreviations:
– Clostridium butyricum
– C. butyricum

9. Registry numbers
• Unique identifiers, assigned by different
sources
• Most common = CAS Registry Number

10. Properties & applications
• Properties:
– Chemical: elemental make-up of the material
– Structural: how the atoms are arranged (on different size scales) - x-ray
diffraction, electrical, magnetic, thermal, optical
– Physical: how a material interacts with different forms of energy: color,
density, phase diagrams (melting/boiling points)
– Mechanical: reaction of a material when a force is applied to it: strength,
ductility, rigidity, failure
– Safety, toxicity, health: biocompatibility (inert, bioactive, biodegradable)
• Applications:
– Medicine, health
– Agriculture
– Food
– Fuel

11. Difficulties
• Specific property information can be
difficult to find
• Might exist only in the journal literature
• Might not exist in table form
• Might not yet exist at all

12. Property names
• Synonyms
• International variations
• Abbreviations
• Ex: Dissociation constant = pKa, ionisation
constant, ionization constant

13. Property units
• Know the units and symbols for the
property
• Greek and Cyrillic alphabets
• Latin words

14. “Webbing” for search terms
• Create a web of possible terms:
– Synonyms
– Broader terms
– Narrower terms
– Related terms
• Sources:
– Engineering Index Thesaurus
– Medical Subject Headings (MESH) -
http://www.nlm.nih.gov/mesh
– Library of Congress Subject Headings (LCSH) –
http://digital.library.wisc.edu/1711.web/worldcat

15. Sample keywords and
subjects
• Absorbable implants
• Animal cell biotechnology
• Artificial organs
• Bioactivity/bioactive(s)
• Bioceramic
• Biocompatible materials
• Biological products
• Biologicals
• Biomaterials
• Biomed* and sensor*
• biomedical engineering
• Biomedical materials
• Biomolecules
• Biotechnology
• Bone and cartilage
• Cell culture
• Cells, Cultured
• Human cell culture
• Interface/interfacial
• Optical sensors
• Polymeric composites
• Prosthes(is/es) and implants
• Tissue engineering
• Vaccines
• Veterinary biologicals

16. Library resources
• Librarians are ready to help you by phone, by email, by
IM/chat, and in person
• Wendt Library
– http://wendt.library.wisc.edu > Help with Research > Resources
by Subject
– MadCat: many titles have scanned table of contents and/or
index
• Chemistry Library
– http://chemistry.library.wisc.edu
• Steenbock Library (agriculture & life sciences)
– http://steenbock.library.wisc.edu
• Ebling Library (health & medical sciences)
– http://ebling.library.wisc.edu

17. Campus resources
• Engineering campus - http://www.engr.wisc.edu/lists
• Biochemistry research facilities - http://
www.biochem.wisc.edu/research/facilities.html
• BioComp research computing service -
http://www-biocomp.doit.wisc.edu
• Biological & Biomaterials Preparation, Imaging, and
Characterization facility -
http://www.ansci.wisc.edu/facstaff/Faculty/pages/albrecht/albrecht_• UW Biotechnology Center - http://www.biotech.wisc.edu
• Waisman Clinical BioManufacturing Facility - http://
www.waisman.wisc.edu/wcbf

18. http://library.wisc.edu >
Find by Name
• ASM Handbook – material properties
• Beilstein/Gmelin CrossFire [must talk to Chemistry librarians for instructions] –
chemical data
• CCINFOWeb – health and safety
• ChemFinder.com – material properties
• CRC Handbook of Chemistry and Physics – chemical data
• Encyclopedia of Agricultural, Food, and Biological Engineering – general overviews
• EngNetBase – full-text books
• Entrez – search all PubMed/NCBI health and medicine databases
• Espacenet – patents
• ILI Standards Infobase – standards
• Kirk-Othmer – general encyclopedia for materials and processes
• Knovel – full-text books and productivity tools
• MatWeb.com – material properties and sources
• Merck Index – pharmaceuticals and chemical properties
• NIST Webbook – material properties
• Physical and Chemical Properties Data – guide
• SciFinder Scholar [click on (i) for link to download page] – chemical data, literature,
sources
• Technology Research Database Collection – multiple material literature databases

19. SciFinder Scholar
• Computers:
– Public computers, 2nd floor Infolab computers,
and Rm.108 computers: Already installed
– CAE labs: Must add to applications from Start
menu
– All others: Must be downloaded and installed,
if allowed -
http://www.library.wisc.edu/databases/launch/uw/scifinder

20. Beilstein/Gmelin CrossFire
• Large, powerful database
• Must be downloaded and installed on
computer
• Ask a Chemistry librarian for passwords
and instructions
– http://minerva.library.wisc.edu

21. Online resources –
direct access
• Biomat.net – Biomaterials Network - resources
• Biomaterials Properties Database - http://
www.lib.umich.edu/dentlib/Dental_tables/toc.html
• Biopharmaceutical Products in the U.S. and European Markets - http://
www.biopharma.com
• Biophysical Chemistry Subject Guide -http://
chemistry.library.wisc.edu/biophysics/databases.htm
• Center for Biologics Evaluation and Research - http://www.fda.gov/cber
• FDA Center for Devices and Radiological Health - http://www.fda.gov/cdrh
• iHOP – http://www.ihop-net.org – Information Hyperlinked over Proteins
• MatData.net – Material Data Network – material properties and sources
• Materials for Medical Devices Database -
http://ndgo.net/asm/mmdd/cardiovascular - [UW does not yet have a
subscription]
• Metabolomics Toolbox - http://www.hmdb.ca – human metabolites database
• SigmaAldrich.com – chemical and biologicals data and sources
• UW Scientific Contracts/Vendors -
http://www.bussvc.wisc.edu/purch/contract/scsummry.html