zombie-nation , hypertensive nation

1. ZOMBIE-NATIONh y p e r t e n s I v e n a t I o n
By
DR. ABDUL RAB SHAIKH
Consultant Interventional Cardiologist
RED CRESCENT INSTITUTE OF CARDIOLOGY
@
RED CRESCENT INSTITUTE OF CARDIOLOGY
26TH NOVEMBER , MONDAY , 2012

2. A person whose behavior or responses are wooden,
listless, or seemingly rote; automaton.

4. what are the similarities between a zombie and
hypertensives?

8. Who wants to be zombie ????

9. what measures we take to become a
ANGEL!

15. The LIFE Trial
Losartan Intervention For Endpoint reduction in
hypertension study (LIFE)
Presented at the American College of Cardiology
51st Annual Scientific Session
Atlanta, GA

16. Patients with hypertension (blood pressure 160-200/ 95-115 mm Hg)
and left ventricular hypertrophy
Atenolol
Beta-blocker
Dose titrated to BP <140/90 mm Hg
(n=4,588)
Losartan
Angiotensin II antagonist
Dose titrated to BP <140/90 mm Hg
(n=4,605)
Followed for >4 years - Mean follow-up 4.8 years
Cardiovascular death, MI, stroke
LIFE: Study Design

17. 11.0%
12.8%
0%
5%
10%
15%
Losartan Atenolol
P=0.021
Composite of CV Death / MI / Stroke
LIFE: Primary Composite Endpoint
Adjusted
Hazard
Ratio =
0.87
Rate 23.8/1,000
patient yrs
Rate 27.9/1,000
patient yrs
n=508 n=588

18. 4.4%
5.1%
0%
2%
4%
6%
8%
5.0%
6.7%
0%
2%
4%
6%
8%
4.3% 4.1%
0%
2%
4%
6%
8%
P=0.206 P=0.491
Cardiovascular Death Myocardial Infarction
P=0.001
Stroke
LIFE: Individual Endpoint Results
Adjusted
HR 0.89
Adjusted
HR 1.07
Adjusted
HR 0.75
Losartan Atenolol Losartan Atenolol Losartan Atenolol

19. 5.2%
7.0%
0%
2%
4%
6%
8%
10%
Losartan Atenolol
P=0.001
LIFE: New-onset diabetes
Adjusted
Hazard
Ratio =
0.75
Rate 13.0/1,000
patient yrs
Rate 17.4/1,000
patient yrs
n=241 n=319