Cystic Fibrosis Infections

Bugs, biofilms and resistance in Cystic Fibrosis Davies et al Respiratory Care May 2009 Infectious Disease Journal Club 20 August 2009 Dr Preneshni R Naicker

Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Why the propensity for bacterial infection? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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[object Object],[object Object],[object Object],Break down intercellular tight juctions Slow ciliary beat functions Siderophores Inhibits phagocytosis Suppresses cell-mediated immunity Exotoxin A Cleave Immunoglobulins, complement components and cytokines Elastase Protease

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Infection with other organisms

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Virulence factors of Burkholderia cepacia complex

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Prevention ,[object Object],[object Object],[object Object]

Treatment – basic principles ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Eradication of early Pseudomonas infection in Cystic Fibrosis TWR Lee Chronic Respiratory Disease Journal, May 2009

Introduction ,[object Object],[object Object],[object Object]

How to detect P.aeruginosa in CF pts ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What is the evidence that early eradication is effective? ,[object Object],[object Object],[object Object]

What agents should be used in eradication regimes?

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Any adverse effects of early eradication? ,[object Object],[object Object],[object Object],[object Object]

Practical aspects ,[object Object],[object Object],[object Object],[object Object]

Cystic Fibrosis Infections

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Cystic Fibrosis Infections