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Cystic Fibrosis....Cassie

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Cystic Fibrosis....Cassie

  1. 1. By: Cassandra Petrilla
  2. 2. It is an inherited disease of your secretory glands, including the glands that make mucus and sweat.
  3. 3.  Cystic fibrosis of the Pancreas  Fibrocystic Disease of the Pancreas  Mucoviscidosis  Mucoviscidosis of the Pancreas  Pancreas Fibrocystic Disease  Pancreatic Cystic Fibrosis
  4. 4. What causes CF?  When a mutation called delta-F508 occurs in a single gene on chromosome 7.  The gene that is infected contains instructions for building a protein called cystic fibrosis transmembrane (CFTR).  The gene will there forth produce CFTR that does not work and chloride ions can not pass through the membrane.  In 70-80% of the cases in the US the gene is completely missing from the membrane.  If CFTR is missing, chloride ions are not reabsorbed.
  5. 5. How is CF inherited?  A person gets CF when they inherit 2 mutated CFTR genes , one from each parent.  The parents might not have the disease because they have a normal copy of the gene on their other chromosome.  CF is a recessive disorder.
  6. 6. 1. Your sweat is saltier than most people. 2. The doctors then use the “sweat test”. 3. During the test, the doctors use a sweat-inducing chemical called pilocarpine. 4. If the reading comes back that your chloride ion is above 60 mmol/liters, then you have CF.
  7. 7. Intestines  The digestive enzyme that your pancreas makes (breaks down your food so you can eat) cannot reach your small intestines.  Without this enzyme you cannot fully absorb fats and proteins.  This can then lead to vitamin deficiency and malnutrition because nutrients leave your body unused. Lungs Your mucus becomes thick and sticky.  The mucus will eventually build up in your lungs and block the airways.  This buildup makes it easy for bacteria to grow.  This leads to serious lung infections and over time can severely damage your lungs.
  8. 8. • CF causes your sweat to leave your body 5 times saltier. • This leads to abnormal heart rhythms. • Your balance of minerals in your blood becomes upset and can cause health problems. • Have increased risk for diabetes or osteoporosis. • Causes infertility in men and makes it harder for women to get pregnant. • Most common death of people with CF is respiratory failure.
  9. 9. NO CURE FOR CF!!!  You can take supplements containing enzymes to help digestion.  You can take replacement enzymes such as pancreatin.  You can reduce chest infections with frequent physiotherapy and either occasional or continuous antibiotics.  You can take physiotherapy which involves vigorous massage to help loosen the sticky mucus.  In severe cases a lung or heart and lung transplant operation is necessary.
  10. 10. Prevalance Rate of CF-1 in 31,000 in U.S. get it
  11. 11.  Cystic Fibrosis Worldwide  Canadian Cystic Fibrosis  Cystic Fibrosis Research, Inc.  Karen’s Climb Foundation Pennsylvania Cystic Fibrosis, Inc.  Reaching Out Foundation  St. Louis Second Wind Transplant Association
  12. 12.  http://www.nhlbi.nih.gov/health/dci/Diseases/cf/cf_what.html  http://www.yourgenesyourhealth.org/cf/have.htm http://www.ask.com/bar?q=how+do+you+treat+cystic+fibrosis&page=1&qs rc=0&ab=2&u=http%3A%2F%2Fhcd2.bupa.co.uk%2Ffact_sheets%2FMosb y_factsheets%2FCystic_fibrosis.html  http://www.nhlbi.nih.gov/health/dci/Diseases/cf/cf_what.html http://www.lpch.org/clinicalSpecialtiesServices/COE/PulmonaryCareCF/ov erview.html

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