NanoPt2016 Conference Book

Index
Foreword / Organizers Page 5
Sponsors / Committees Page 7
Exhibitors Page 8
Speakers Page 13
Abstracts Page 18
Posters List Page 122

FEI.com | Explore. Discover. Resolve.
Sample: Thermally aged stainless steel. (Left) Helios PFIB, slice thickness 46.6 μm. (Right) Ga PFIB, slice thickness 7.6 μm.
Helios PFIB DualBeam
Large 3D volumes with unprecedented surface resolution
The Helios PFIB DualBeam provides serial sectioning volumes of 97 x 79 x 47 um after cropping,
compared to typical volumes of 19 x 18 x 8 um for Ga FIB. And Helios is optimized for large cross-sections
and high-throughput processing—20 to 100 times faster than traditional FIB—without causing the
mechanical damage typical during polishing.
Obtaining larger, high-resolution volumes faster enables:
• Better statistical accuracy when processing data
• Imaging and analysis of large-grained materials/metals in 3D
• Biopsies or chunking of large regions of interest for further investigation with other techniques while
keeping the bulk sample intact
10 μm

n a n o P T 2 0 1 6 B r a g a ( P o r t u g a l ) | 5
Foreword
On behalf of the Steering, Programme and
Organizing Committees we take great pleasure in
welcoming you to Braga (Portugal) for the nanoPT
International Conference (nanoPT2016), hosted at
INL.
The growing participation in the event (more
than 200 attendees), now in its fourth edition,
confirms the consolidation of nanoPT in the
scientific panorama.
The aim of nanoPT is to bring together the
Portuguese and International Community
(students, researchers, engineers and stakeholders
from academia, national laboratories, industry and
other organisations) to discuss the latest
developments and innovations in the fields of
Nanotechnology and Nanoscience.
nanoPT Conference offers a multitude of
renowned international keynote speakers, invited
and contributed talks, posters and a commercial
exhibition as well as an innovation activity
fostering entrepreneurship and start-up activities.
We are indebted to the following sponsors for
their financial support: International Iberian
Nanotechnology Laboratory (INL), FEI and
Spinograph.
We would also like to thank the following
companies for their participation: Raith GmbH,
PANalytical, micro resist technology GmbH,
SOQUÍMICA/FRITSCH, ScienTec Ibérica, Paralab,
Scienta Omicron, HORIBA Scientific and Dias de
Sousa.
In addition, thanks must be given to the staff
of all the organising institutions whose hard work
has helped planning this conference.
We would like to thank all participants,
speakers, sponsors and exhibitors that joined us
this year.
Hope to see you again in the next edition of
nanoPT (2017).
Organizers

INL - International Iberian
Nanotechnology Laboratory
Av Mestre José Veiga, s/n
4715-330 Braga - Portugal
office@inl.int
www.inl.int
CUTTING EDGE RESEARCH
FOR THE BENEFIT OF SOCIETY
DEPLOYMENT & ARTICULATION
OF NANOTECHNOLOGY
STRATEGIC RESEARCH
Food & Environment
Health
Energy
Nanoelectronics
YOUR WORLDWIDE
SCIENCE & INNOVATION PARTNER

Sponsors
Committees
S t e e r i n g C o m m i t t e e
Antonio Correia Phantoms Foundation (Spain)
Braz Costa CeNTI (Portugal)
António M. Cunha Minho University (Portugal)
Lars Montelius INL (Portugal)
P r o g r a m m e C o m m i t t e e
Higino Correia Minho University (Portugal)
Yolanda De Miguel Tecnalia (Spain)
Joaquín Fernández-Rossier INL (Portugal)
Paulo Freitas INL (Portugal)
João Gomes CeNTI (Portugal)
Rodrigo Martins Universidade Nova (Portugal)
Jose Fernando Mendes Aveiro University (Portugal)
Lars Montelius INL (Portugal)
Rui Reis Minho University (Portugal)
Jose Rivas Santiago de Compostela University (Spain)
Stephan Roche ICN2 (Spain)
Carla Silva CeNTI (Portugal)
Vasco Teixeira University of Minho (Portugal)
O r g a n i z i n g C o m m i t t e e
Andrea Carneiro CeNTI (Portugal)
Viviana Estêvão Phantoms Foundation (Spain)
Paula Galvão INL (Portugal)
Conchi Narros Phantoms Foundation (Spain)
Cristina Padilha INL (Portugal)
Ana Ribeiro CeNTI (Portugal)
Jose Luis Roldán Phantoms Foundation (Spain)

8 | n a n o P T 2 0 1 6 B r a g a ( P o r t u g a l )
Exhibitors
P A N a l y t i c a l
Materials you use every day… PANalytical’s mission is to enable people to get valuable insight
into their materials and processes. Our customers can be found in virtually every industry
segment, from building materials to pharmaceuticals and from metals and mining to
nanomaterials. The combination of our software and instrumentation, based on X-ray diffraction
(XRD), X-ray fluorescence (XRF) and near-infrared (NIR) spectroscopy as well as pulsed fast
thermal neutron activation (PFTNA), provides our customers with highly reliable and robust
elemental and structural information on their materials and is applied in scientific research and
industrial process and quality control.
PANalytical employs over 1,000 people worldwide. The worldwide sales and service network
ensures unrivalled levels of customer support.
The company is certified in accordance with ISO 9001 and ISO 14001. PANalytical is part of
Spectris plc, the productivity-enhancing instrumentation and controls company
www.panalytical.com
Luis.Vital@panalytical.com

R a i t h
Raith offers innovative solutions for sub-10nm focused ion beam (FIB) nanofabrication, SEM-
based electron beam lithography (EBL), large area SEM image capture, gas-assisted
nanolithography, in situ nanomanipluation and nanoprofilometry. Raith’s proprietary FIB
technology offers a wide range of ion species and elevates FIB based nanofabrication to a new
level with highest selectivity and unsurpassed stability for automated wafer-scale patterning.
www.raith.com
sales@raith.com
m i c r o r e s i s t t e c h n o l o g y G m b H , B e r l i n
For 23 years, our company has been developing, manufacturing and selling innovative
photoresists, special polymers and ancillary materials for micro- and nanolithography. Due to
our highly specialized products we are a trusted supplier of global high-tech markets such as
semiconductor industry, MEMS, optoelectronics, nanotechnology and other emerging
technologies. Our distinctive competency is to offer our clients and partners tailor-made
products and technological services and solutions. Furthermore, micro resist technology has
become an esteemed partner for the international research community by developing novel
photoresists and materials for latest lithography developments such as laser-direct writing, NIL
or ink jet printing.
www.microresist.com
info@microresist.de
D i a s d e S o u s a
Dias de Sousa was founded in 1983 and become along 33 years the most important Portuguese
distributor in the area of analytical and scientific instrumentation (sales, applications & services).
We are a company certified according to the latest standards of ISO 9001.
Our mission is be a serious partner, providing genuine solutions in our area in order to ensure full
satisfaction of our customers' needs.
ds@dias-de-sousa.pt
www.dias-de-sousa.pt/sa

P a r a l a b
PARALAB was founded in 1992 with its primary goal set on the distribution of scientific
equipment for laboratory and industry, for measurement and control in the world of
characterization of materials.
Today, Paralab is the reference company in this sector, additionally developing unique expertise
in the area of design and development of projects.
Paralab outstands by:
− Offering the most complete range of laboratory equipment in Portugal;
− Investing heavily in the best after-sales service, supported by a large team of
professionals with deep knowledge of all analytical techniques we distribute;
− Follow-up with customers from pre-sales to the final installation and operation of the
equipment, providing global and integrated solutions.
Our main strength is the technical and scientific background of our human resources. The team
includes graduates and post-graduates in Chemical Engineering, Chemistry, Pharmaceutical
Sciences and Electronic Engineering. This team, allows Paralab to successfully deal with all the
projects in which is involved, and at the same time provide unequal customer training and after
sales support.
www.paralab.pt
info@paralab.pt
S c i e n t a O m i c r o n
Scienta Omicron, brings together the two leading innovators in Surface Science – the former
VG Scienta and Omicron NanoTechnology.
We provide customized solutions and advanced technologies for fundamental research in
surface science and nanotechnology in the fields of
− scanning probe microscopy
− electron spectroscopy,
− thin film deposition and
− tailored system and instrumentation solutions
These capabilities are available in customized solutions from one source with worldwide sales
and service groups. We work with leading researchers around the world and our products are
known for their outstanding performance. Scienta Omicron is part of the Scienta Scientific
Group. For more information please visit www.scientaomicron.com.
www.ScientaOmicron.com
info@ScientaOmicron.com

S O Q U I M I C A
Since 1929, SOQUIMICA commercializes high quality laboratory equipment and provides highly
specialized services to its customers.
We offer our clients the expertise of a qualified and experienced team, which enables support for
the development of tailor-made solutions.
The equipment we sell and the services we provide allow our customers to enjoy the best
solutions for various Applications (Chemical analyzes, Gas and liquid chromatography,
Spectroscopy, Genomics, Life sciences, Laboratory Weighing, Industrial Weighing, Preparation of
samples) and Industries (Environment, Forensics and Toxicology, Energy & Chemicals, Food
Industry and Agriculture, Pharmaceuticals and Biotechnology Industry, Textile Industry,
Inspection of products and materials testing, Clinical research, Refinery & Petrochemicals).
www.soquimica.pt
H O R I B A S c i e n t i f i c
HORIBA Scientific, part of HORIBA Group, provides an extensive array of instruments and
solutions for applications across a broad range of scientific R&D and QC measurements. HORIBA
Scientific is a world leader in elemental analysis, fluorescence, forensics, GD-OES, ICP, particle
characterization, Raman, spectroscopic ellipsometry, sulphur-in-oil, water quality and XRF. Our
instruments are found in universities and industries around the world. Proven quality and trusted
performance have established widespread conﬁdence in the HORIBA Brand.
HORIBA provides service, such as nano-level micro-area analysis to support a wide range of
research activities, from leading-edge scientific research to RD in a variety of industries.
www.horiba.com

S c i e n T e c
ScienTec, specialized in the distribution of rigorously selected scientific equipments (AFM
microscope, Vacuum technology, NanoIndentation systems, Profilometers), has for mission to
serve and assist French, Iberian and Nordic markets.
With more than 15 years experience in Nanotechnology, our sales engineers will help you to
define the right tool and configuration, our application group will teach and help you run the
machines and our after sales team will preventively maintain or repair your systems.
By characterization at ScienTec we mean:
− Atomic Fore Microscopy from CSInstruments
− Vacuum Technology from PREVAC
− NanoIndentation from Nanomechanics
− SNOM and AFM+RAMAN from Nanonics
− Digital Holography Microscopy from Lyncée Tec
− Mechanical Profilometry from KLA Tencor
− Optical profilometry
− Thin Film thickness from Filmetrics
− Accesories and SPM consumables with AppNano
www.scientec.fr
info@scientec.fr
A d v e r t i s i n g

Alphabetical order index
K: Keynote Speakers
I: Invited Speakers
O: Orals (Plenary Session)
OP: Orals (Parallel Sessions)
Speakers
Page
Albuquerque, João (ICETA/UCIBIO/REQUIMTE/FFUP, Portugal)
“Multifunctional Solid Lipid Nanoparticles: a targeted approach for Rheumatoid Arthritis
with theranostic applications” OP 43
Amorim, Bruno (University of Minho, Portugal)
“Vertical current in graphene - insulator/semiconductor - graphene structures” OP 44
Ashokkumar, Anumol (International Iberian Nanotechnology Laboratory, Portugal)
“Advanced Electron Microscopy Study of GdX3@WS2 Nanotubes” O 45
Bjöörn, Patrik (Insplorion AB, Sweden)
“Plasmonic Sensing Technology for Nanomaterial Studies” O 46
Caldeira, F. Jorge (CiiEM ISCSEM, Portugal)
“Inhibitors Design for matrix metalloproteinase’s A molecular view for Dental Restoration” O 47
Capasso, Federico (Harvard Paulson School, USA)
“Metasurfaces: New Frontiers in Structured light and Surface Waves” K 19
Cardoso, Ana R. (BioMark/CINTESIS-ISEP, Portugal)
“Immune response for Malaria detected by novel and a simple biosensing approach” OP 49
Carneiro, Liliana (BioMark/CINTESIS/ISEP, Portugal)
“Functionalization of Single-Walled Carbon Nanohorns for Biosensor Applications” OP 50
Castellanos-Gomez, Andres (IMDEA, Spain)
“2D Semiconductors for Optoelectronics Applications” K 19
Castro, Eduardo (IST, Portugal)
“Phases with non-trivial topology in graphene and transition metal dichalcogenides” I 35
Chen, Yong (Ecole Normale Supérieure, France & Kyoto University, Japan)
“Nanobioengineering of cellular microenvironment: From culture dish to culture patch” K 20
Chiorcea-Paquim, Ana-Maria (University of Coimbra, Portugal)
“Quadruplex formation between a triazole-acridine conjugate and guanine-containing
repeat DNA sequences. Atomic force microscopy and voltammetric characterisation” O 51
Choi, Choon-Gi (Electronics and Telecommunications Research Institute (ETRI), Korea)
“Extraordinary optical properties of visible and terahertz metamaterials” I 36
Costa, Pedro M. F. J. (King Abdullah University of Science and Technology, Saudi Arabia)
“Quantifying impurities in Nanocarbons using ICP-OES” O 53
Costa Lima, Sofia A. (UCIBIO-REQUIMTE, University of Porto, Portugal)
“Nanostructured Lipid Carriers: a new approach for Psoriasis topical therapy” O 54
Cunha, Eunice (University of Minho, Portugal)
“Non-covalent exfoliation of graphite in aqueous suspension for nanocomposite production
with waterborne polyurethane” OP 55
De Beule, Pieter A. A (International Iberian Nanotechnology Laboratory, Portugal)
“Novel imaging devices for optical and mechanical characterization of supported lipid
bilayers at the nanoscale” O 57
Despont, Michel (CSEM SA, Switzerland)
“MEMS are a watch´s best friend” K 20
Falko, Vladimir (National Graphene Institute, the University of Manchester, UK)
“Bright, dark and semi-dark trions in two-dimensional transition metal dichalcogenides” K 22

Page
Ferreira, Ricardo (International Iberian Nanotechnology Laboratory, Portugal)
“Magnetoresistive Sensors aiming room temperature detection of biomagnetic fields” I 37
Ferreira, Nádia S. (BioMark-CINTESIS/ISEP, Portugal)
“Carbon Black modification for polymer anchoring targeting fuel cell powered biosensors” OP 58
Gallo, Juan (International Iberian Nanotechnology Laboratory, Portugal)
“Tuning the relaxation rates of dual mode T1/T2 nanoparticle contrast agents: a study into
the ideal system” O 59
García-Martínez, Noel A. (International Iberian Nanotechnology Laboratory, Portugal)
“Hyperfine interaction in hydrogenated graphene” OP 60
Garcia-Martin, Jose Miguel (IMM / CNM - CSIC, Spain)
“Nanostructured biocompatible coatings to prevent implant infections” O 61
Gerber, Christoph (Basel University, Switzerland)
“Pushing the boundaries in personalized healthcare with AFM technology” K 22
Gimzewski, Jim (California Nanosystems Institute and UCLA, USA)
“Development of a "Brain-like" Computation system using Atomic Switch Networks” K 23
Goldblum, Amiram (The Hebrew University of Jerusalem, Israel)
“Computational Discovery of Liposomal Drugs: From in silico predictions to in vivo validation” O 62
Gomes, João (CeNTI, Portugal)
“Development of fully bioresponsive printed sensors: exploring the electronic tongue
concept for specific analytes” O 63
Grützner, Gabi (micro resist technology GmbH, Germany)
“Material Innovations Enabling Advanced Nanofabrication for Lab to Fab Application” K 23
Guan, Nan (Institut d´Electronique Fondamentale,Université Paris-Saclay, France)
“Flexible White Light-Emitting Diodes Based on Vertical Nitride Nanowires and micro-size
phosphors” OP 64
Guldris, Noelia (International Iberian Nanotechnology Laboratory, Portugal)
“Ultrasmall Doped Iron Oxide Nanoparticles as Dual T1-T2 Contrast Agents for MRI” OP 66
Hora, Carolina (Biomark-CINTESIS/ISEP, Portugal)
“Development of an autonomous electrical biosensing device for a colon-rectal cancer
protein marker” OP 67
Ibarlucea, Bergoi (TU Dresden/Institute for Material Science, Germany)
“Honeycomb-nanowire field-effect transistors for bacterial activity determination in non-
diluted growth media” O 68
Karasulu, Bora (Eindhoven University of Technology (TU/e), The Netherlands)
“Atomic-Scale Simulations of High-κ Dielectrics Deposition on Graphene” O 69
Kavan, Ladislav (J. Heyrovsky Institute of Physical Chemistry, Czech Republic)
“Advanced Nanocarbons (Graphene, Nanodiamond and Beyond) as the Electrode
Materials in Dye-Sensitized Solar Cells” O 70
Korgel, Brian A. (UT Austin, USA)
“Silicon and Germanium Nanowires for Lithium and Sodium Ion Batteries” K 24
Lado, Jose L. (International Iberian Nanotechnology Laboratory, Portugal)
“Large scale calculations of electronic structure of 2D Crystals” OP 72
Laurell, Thomas (Lund University, Sweden)
“Acoustic seed-trapping enables rapid enrichment and purification of nanovesicles
involved extracellular signalling” K 25
Lemma, Enrico Domenico (Istituto Italiano di Tecnologia & Università del Salento, Italy)
“Static and Dynamic Mechanical Characterization of Two-photon Lithography
Photoresists” OP 73

Page
Li, Chen-zhong (Florida International University, USA)
“Nanoparticle Enhanced Electromagnetic Control of Cancer Cell Development for
Nanotheranostics” I 38
Li, Wei (International Iberian Nanotechnology Laboratory, Portugal)
“Cobalt nickel phosphide nanowires on the nickel foam as an highly efficient and
ultrastable bifunctional catalyst for overall water splitting” O 74
Liddle, J. Alexander (NIST, USA)
“Nanofabrication: From DNA-Directed Assembly to Volume Nanomanufacturing” K 26
López Fanarraga, Mónica (Universidad de Cantabria, Spain)
“Anti-tumoral effects of MWCNTs in solid melanoma tumor models” O 76
Loureiro, Joana (UNINOVA, Portugal)
“Thermoelectric properties optimization of nc-Si:H thin films deposited by PECVD” O 77
Machado Jr. , George Luiz (International Iberian Nanotechnology Laboratory, Portugal)
“A comparison of graphene electrochemical sensors and electrolyte-gated field-effect
transistors as label-free immunosensors” OP 78
Madureira, Ana Raquel (Universidade Católica do Porto, Portugal)
“NanoDairy Project: delivery systems of bioactive polyphenolic compounds to dairy
matrices. Evaluation of stability, bioavailability and toxicity” O 80
Makarova, Tatyana (LUT, Finland)
“Tabby graphene: realization of zigzag edge states at the interfaces” I 39
Marques, Catarina B. (Universidade Nova de Lisboa, Portugal)
“V2O5 thin film for high sensitivity flexible and transparent thermal sensors” OP 81
Marques, Juliana (Universy of Minho, Portugal)
“Advanced Photocatalytic Heterostructered Materials for the Controlled Release of Active
Compounds upon Solar Activation” OP 82
Martins, Gabriela V. (Biomark-CINTESIS/ISEP, Portugal)
“Chip-on-Paper for sensoring 8-hydroxy-2'-deoxyguanosine (8-OHdG) oxidative stress biomarker
in point-of-care” OP 83
Miranda, Rodolfo (IMDEA Nanociencia, Spain)
“Tailoring graphene for spintronics” K 26
Moles, Ernest (InstituteforBioengineeringofCatalonia,BarcelonaInstituteforGlobalHealth,Spain)
“Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red
blood cells as a dual therapeutic/prophylactic antimalarial strategy” OP 85
Müllen, Klaus (Max Planck Institute for Polymer Research, Germany)
“How to Make and how to Use Carbon Nanostructures” K 27
Paltiel, Yossi (The Hebrew University of Jerusalem, Israel)
“Chiral-molecules based simple spin devices” O 86
Pang, Stella W.(City University Hong Kong, China)
“Nanofabricated Platforms for Biosensing and Cell Control” K 28
Pascual i Vidal, Lluís (Universitat Politécnica de València - IDM, Spain)
“DNA-gated material as simultaneous drug delivery and radioimaging tool” OP 87
Pastrana, Lorenzo (International Iberian Nanotechnology Laboratory, Portugal)
“Nanostructures for food applications” I 39
Pavlov, Valery (CIC BiomaGUNE, Spain)
“Teaching enzymes to generate and etch semiconductor nanoparticles” O 89
Pellegrin, Eric (CELLS-ALBA / Experiments Division, Spain)
“The ALBA Synchrotron Licht Source: A Tool for Nanoscience” O 91
Peres, Nuno (University of Minho, Portugal)
“Basic Notions in Graphene Plasmonics” K 28

Page
Pérez-Murano, Francesc (IMB-CNM/CSIC, Spain)
“Directed self-assembly of block co-polymers: chemical guiding patterns and advanced
nanometer-scale characterization” K 29
Pernia Leal, Manuel (Andalusian Centre for Nanomedicine and Biotechnology, Spain)
“Optimization of blood circulating times of magnetic nanoparticles based on the effect of
PEG molecular weight coating and nanoparticle size followed by Magnetic Resonance
Imaging” O 92
Petrovykh, Dmitri Y. (International Iberian Nanotechnology Laboratory, Portugal)
“Design and Characterization of DNA and Peptide Biointerfaces” I 40
Pettersson, Carmen (JPK Instruments AG, Germany)
“Easy-to-Use High-Spatial and High-Temporal Atomic Force Microscopy Simultaneous to
Advanced Optical Microscopy” O 93
Pinto, Inês (International Iberian Nanotechnology Laboratory, Portugal)
“Cell Dynamics: nanocharacterization of actomyosin-based force generating systems” I 42
Pinto, Tânia V. (REQUIMTE/LAQV, Universidade do Porto, Portugal)
“Photoswitchable silica nanoparticles for the production of light responsive smart textiles:
from fabrication to coating technology” OP 94
Pires, A. Filipa S. (FCT, Universidade Nova de Lisboa, Portugal)
“Catechins: a powerful weapon against oxidative stress and DNA lesions” OP 96
Pires, Bernardo (INESC-MN, Portugal)
“High Precision Methodology Control for Nano MTJ Fabrication Process up to 150 mm
Wafers” O 97
Prazeres, Duarte Miguel (iBB, Instituto Superior Técnico, Univ. de Lisboa, Portugal)
“Carbohydrate binding modules as a generic tool to anchor biomolecules and metal
nanoparticles on the surface of paper-based biosensors” O 98
Ribeiro, Daniela (ICETA/UCIBIO/REQUIMTE/FFUP, Portugal)
“Biophysical Properties of Model Membranes under the Effect of Daunorubicin” O 100
Ribeiro, Miguel (CeNTI - Centre for Nanotechnology and Smart Materials, Portugal)
“Large area, flexible electrochromic displays based on novel electroactive polymers” O 101
Rivadulla Fernández, Francisco (University of Santiago de Compostela, Spain)
“Fabrication of high-quality epitaxial thin-films of functional oxides by a chemical solution
method” K 30
Rodrigues, Ana Rita O. (University of Minho, Portugal)
“Magnetoliposomes based on manganese ferrite nanoparticles as nanocarriers for
antitumor drugs” OP 101
Rodríguez Méndez, María Luz (Universidad de Valladolid, Spain)
“Antioxidants detection with nanostructured electrochemical sensors” O 103
Sá, Maria H. M. (Biomark-CINTESIS/ISEP, Portugal)
“Carbon Black modification towards electrochemical biosensors” O 104
Sadewasser, Sascha (International Iberian Nanotechnology Laboratory, Portugal)
“Growth of CuInSe2 nanowires by molecular beam epitaxy without external catalyst” O 105
Salomon, Adi (Bar-Ilan University, Israel)
“Strong Coupling in Plasmonic systems and their Interaction with Molecules” O 106
Salonen, Laura M. (International Iberian Nanotechnology Laboratory, Portugal)
“Covalent Organic Frameworks for the Capture of Waterborne Toxins” O 107
Samuelson, Lars (Lund University, Sweden)
“From basic Nanowire research to real-world applications” K 30
San José, Pablo (ICMM-CSIC, Spain)
“Majorana Zero Modes in Graphene” I 41

Page
Sandre, Olivier (LCPO (Univ. Bordeaux / CNRS / Bordeaux-INP), France)
“Iron oxide nanoparticles grafted with thermosensitive polymers and diblock elastin-like
peptides studied by in situ dynamic light backscattering under magnetic hyperthermia” O 108
Schift, Helmut (Paul Scherrer Institut (PSI), Switzerland)
“Patterning of DLC leaky waveguide sensors using nanoimprint lithography” K 31
Shukla, Alok (Indian Institute of Technology, India)
“Theory of Electronic Structure and Optical Properties of Graphene Nanodisks” O 110
Silva, Carla (CeNTI - Centre for Nanotechnology and Smart Materials, Portugal)
“Development of fibers and textiles structures for energy harvesting and storage” O 111
Silva, Cláudia G. (Laboratório Assocado LSRE-LCM, Portugal)
“Au/ZnO nanostructures for photocatalytic applications” O 112
Silva, João Pedro (Center for Biological Engineering, University of Minho, Portugal)
“Antimicrobial peptide delivery from self-assembling Hyaluronic acid Nanoparticles for
tuberculosis treatment” O 114
Teixeira, Bruno M. S. (University of Aveiro, Portugal)
“Effect of spin reorientation transition in NdCo5/Fe bilayers” OP 115
Teixeira, Jennifer P. (I3N, University of Aveiro, Portugal)
“Evaluation of CdS and ZnxSnyOz buffer layers in CIGS solar cells” OP 117
Truta, Liliana A.A.N.A. (BioMark-CINTESIS/ISEP, Portugal)
“The potential of artificial antibodies as biosensing devices for monitoring the Interleukin 2
cancer biomarker” OP 118
van Hulst, Niek (ICFO, Spain)
“NanoPhotonics: ultrafast control of nanoparticles, nanoantennas and single quantum
emitters” K 32
Vieu, Christophe (LAAS-CNRS, France)
“Investigation of cell mechanics using nanodevices and nano-instruments: some examples” K 33
Wang, Xiaoguang (International Iberian Nanotechnology Laboratory, Portugal)
“Facile construction of 3D integrated nickel phosphide composite as wide pH-tolerant
electrode for hydrogen evolution reaction” O 120
Zukalova, Marketa (J. Heyrovsky Institute of Physical Chemistry, ASCR, Czech Republic)
“Li (Na) insertion in TiO2 polymorphs and their composites with graphene for battery
applications” O 121

FedericoCapasso
School of Engineering and Applied Sciences
Harvard University, Cambridge, UK
capasso@seas.harvard.edu
M e t a s u r f a c e s : N e w F r o n t i e r s
i n S t r u c t u r e d l i g h t a n d S u r f a c e
W a v e s
Patterning surfaces with subwavelength
spaced metallo-dielectric features (metasurfaces)
allows one to locally control the amplitude, phase
and polarization of the scattered light, allowing
one to generate complex wavefronts such as
optical vortices of different topological charge and
dislocated wavefronts [1,2]. Recent results on
achromatic metasurfaces will be presented
including lenses and collimators. Metasurfaces
have also become a powerful tool to shape surface
plasmon polaritons (SPPs) and more generally
surface waves. I will present new experiments on
imaging SPP that have revealed the formation of
Cherenkov SPP wakes and demonstrated
polarization sensitive light couplers that control
the directionality of SPP and lenses which
demultiplex focused SPP beams depending on
their wavelength and polarization.
R e f e r e n c e s
[1] N. Yu and F. Capasso Nature Materials 13, 139
(2014)
[2] P. Genevet and F. Capasso Reports on
Progress in Physics 78, 24401 (2015)
Andres Castellanos-Gomez
2D Materials & Devices group. IMDEA Nanoscience.
Madrid, Spain
andres.castellanos@imdea.org
2 D S e m i c o n d u c t o r s f o r
O p t o e l e c t r o n i c s A p p l i c a t i o n s
In this talk I will review the recent progress on
the application of atomically thin crystals different
than graphene on optoelectronic devices. The
current research of 2D semiconducting materials
has already demonstrated the potential of this
family of materials in optoelectronic applications
[1-4]. Nonetheless, it has been almost limited to
the study of molybdenum- and tungsten- based
dichalcogenides (a very small fraction of the 2D
semiconductors family). Single layer molybdenum
and tungsten chalcogenides present large direct
bandgaps (~1.8 eV). Alternative 2D semiconducting
materials with smaller direct bandgap would be
excellent complements to the molybdenum and
tungsten chalcogenides as they could be used for
photodetection applications in the near infrared.
Furthermore, for applications requiring a large
optical absorption it would be desirable to find a
family of semiconducting layered materials with
direct bandgap even in their multilayer form.
Here I will summarize the recent results on the
exploration of novel 2D semiconducting materials
for optoelectronic applications: black phosphorus
[5-7], TiS3 [8, 9]. Recent efforts towards tuning the
optoelectronic properties of 2D semiconductors by
strain engineering will be also discussed [10, 11].
R e f e r e n c e s
[1] Yin Z. et al, Single-layer MoS2 phototransistors,
ACS Nano (2011)
[2] Lopez-Sanchez, O., et al., Ultrasensitive
photodetectors based on monolayer MoS2,
Nature Nanotech. (2013)
[3] Buscema M., et al., Large and tunable photo-
thermoelectric effect in single-layer MoS2,
Nano Letters (2013)
[4] Groenendijk D.J., et al., Photovoltaic and
photothermoelectric effect in a doubly-gated
WSe2 device, Nano Letters (2014)
[5] Castellanos-Gomez, A., et al., Isolation and
Characterization of few-layer black
phosphorus. 2D Materials (2014)
[6] Buscema M., et al., Fast and broadband
photoresponse of few-layer black phosphorus
field-effect transistors. Nano Letters (2014)
[7] Buscema M., et al., Photovoltaic effect in few-
layer black phosphorus PN junctions defined
by local electrostatic gating. Nature
Communications (2014).
K E Y N O T E c o n t r i b u t i o n s

[8] Island J.O., et al., Ultrahigh photoresponse of
atomically thin TiS3 nanoribbon transistors.
Adv. Opt. Mater. (2014)
[9] Island J.O., et al., TiS3 transistors with tailored
morphology and electrical properties. Adv.
Mater. (2015)
[10] Castellanos-Gomez, A., et al., Local strain
engineering in atomically thin MoS2. Nano
Letters (2013)
[11] Quereda, J., et al., Quantum confinement in
black phosphorus through strain-engineered
rippling. arXiv:1509.01182 (2015)
F i g u r e s
Yong Chen
Department of Chemistry, Ecole Normale Supérieure (ENS),
Paris, France
Institute for Integrated Cell-Material Sciences (iCeMS),
Kyoto University, Japan
Centre for Quantitative Biology (CQB), Peking University,
China
yong.chen@ens.fr
N a n o b i o e n g i n e e r i n g o f c e l l u l a r
m i c r o e n v i r o n m e n t : F r o m
c u l t u r e d i s h t o c u l t u r e p a t c h
Nature does nothing uselessly (Aristotle:
I.1253a8). This point of view is particularly helpful
when we develop new tools and methods for cell
biology and biomedical studies. By mimicking the
in vivo cellular microenvironment and tissue
organization, we designed a new patch form
device for off-ground culture and differentiation of
pluripotent stem cells which showed numerous
advantages over conventional culture dish
methods. We will illustrate the high application
potential of such a culture patch method in
regenerative medicine, drug screening and cancer
diagnosis. We will also discuss, among many
others, issues related to the organs on a chip and
body on a chip, taking into account the advantage
of the human induced pluripotent stem cells and
the culture patch methods as well as the
tremendous needs of such an approach in coming
years.
M. Despont
Department of Chemistry, Ecole Normale Supérieure (ENS),
CSEM SA, Neuchâtel, Switzerland
mdespont@csem.ch
M E M S a r e a w a t c h ´ s b e s t
f r i e n d
Besides the breakthrough of MEMS devices in
automotive and consumer markets during the last
decade (pressure sensors, accelerometers,
gyroscopes,..), micro-machining allowed to
develop innovative devices in niche markets like
for example the watch industry. Swiss watch
makers quickly understood the advantages like the
manufacturing accuracy and design freedom
offered by the combination of the micro-
machining techniques and the mechanical
properties of materials like for example silicon.
The mechanical properties of Si make it a
material of choice to realize a spring. It has a high
Young modulus, a low CTE and is a-magnetic. Deep
reactive ion etching (DRIE) was the key enabling
technology that allowed the realization of silicon
watch parts.
One of the first components developed for
watches is the silicon hairspring. This part can be

considered as the hearth of the watch.
Conventional hairsprings are fabricated from a roll-
laminated wire wound in the form of a spiral. Only
a few companies in the world master this
technique. There are extremely stringent
requirements on the alloy used to shape the spring
in order to get a good thermal compensation.
Proper oxidation of the silicon springs allows
getting a fully thermally compensated spring with
properties exceeding the performance of
conventional hairsprings. This material is called the
“Silinvar” (see Fig. 1). These devices are now
manufactured in large volumes by Swiss watch
makers. Since then many components like wheels
and anchors have been realized in silicon.
The design freedom given by the use of
photolithography allowed for the integration of
complex mathematic considerations in order to
improve the performance of the spiral hairsprings.
Another example is the company Girard Perregaux
who developed a totally new escapement
mechanism based on a bi-stable spring element
(figure 2).
Silicon has outstanding mechanical properties.
It is however brittle which makes it more
challenging to integrate in conventional
mechanisms in a watch. It is for example not
possible to press-fit an axis in the center of silicon
part. Recent advances allowed us realizing an
hybridation of metallic parts on silicon either by
bonding or direct electro-deposition (Figs 3 and 4).
This marriage of booth the advanced mechanical
properties of silicon with wafer level metallic parts
(UV LIGA) allowed us to produce complex
assemblies on wafer level. The obtained
components can be worked like traditional parts
by the watch makers, the interfacing with the
other components of the watch being done on the
metallic part.
Future trends in the MEMS developments for
mechanical watches are the use of new materials
like for example Silicon carbide, the development
of innovative surface treatments reducing the
friction (Fig. 5) as well as the fabrication of
complex modules using wafer level assembly
(WLA) techniques.
F i g u r e s
Figure 1: “Silinvar” hairspring. Lateral dimensions are controlled
down to below +/- 200 nm.
Figure 2: Constant escapement spring structure by Girard Perregaux. The
width of the bi-stable spring is 14 microns for a thickness of 120 microns and
a length of 2 cm.
Figure 3: Hybride assembly of a metallic gear on a silicon wheel.
Figure 4: Electrodeposited gold in a Silicon balance wheel in order to get the
required inertia. Courtesy of Patek Philippe SA.

Vladimir Falko
National Graphene Institute, The University of Manchester,
Manchester, UK
Vladimir.Falko@manchester.ac.uk
B r i g h t , d a r k a n d s e m i - d a r k
t r i o n s i n t w o - d i m e n s i o n a l
t r a n s i t i o n m e t a l
d i c h a l c o g e n i d e s
We analyse dark and bright states of charged
and neutral excitons in two-dimensional (2D)
metal dichalcogenides (TMDC) MoX2 and WX2 (X =
S, Se) and analyse their appearance in the optical
spectra affected by the inverted sign of spin-orbit
splitting of conduction band states in MoX2 and
WX2. We use diffusion Monte Carlo approach to
evaluate the trion binding energy and we
determine interpolation formulae for the exciton
and trion binding energies to describe their
dependence on the 2D lattice screening
parameter, the electron/hole band masses, and
electron-hole exchange. Finally, we analyse the
speed of energy relaxation of photoexcited carriers
in TMDCs.
Christoph Gerber
Swiss Nanoscience Institute SNI, Institute of Physics Univ.
of Basel, Basel, Switzerland
christoph.gerber@unibas.ch
P u s h i n g t h e b o u n d a r i e s i n
p e r s o n a l i z e d h e a l t h c a r e w i t h
A F M t e c h n o l o g y
There are more than 200 different types of
cancers, but they all have the same cause: a random
change, or mutation, in a cell's genetic code that
trigger cells in the body to grow and divide
uncontrollably So far some of these mutations are
known and targeted therapies or drugs have been
developed for cancer treatments that made the
difference in survival for many people.
However since the sequencing of the entire
human genome it turns out that we know now what
we are made of but we still don't know to a large
extent how we work that is that epigenetical
changes can eventually alter cancerogenesis and
produce different mutations which means that the
therapy stops working. Including immunotherapie
eliminating cancer by stimulating the immune
system treating the malignant tumors as an
infection and thereby keeping the system from
being 'switched off' could be a powerful
combination in future cancer therapies.
However fast new diagnostic tools are therefore
required. Recently Atomic Force Microscopy (AFM)
technologies have come of age in various biological
applications. Moreover these developments has
started to enter the clinic. From this toolkit we use a
micro-fabricated silicon cantilevers array platform as
a novel biochemical highly sensitive sensor that
offers a label-free approach for point of care fast
diagnostics where ligand-receptor binding
interactions occurring on the sensor generating
nanomechanical signals like bending or a change in
mass which is optically detected in-situ. It enables
the detection of multiple unlabelled biomolecules
simultaneously down to picomolar concentrations
within minutes in differential measurements
including reference cantilevers on an array of eight
sensors. The sequence-specific detection of
unlabelled DNA in specific gene fragments within a
complete genome is shown. In particular the
expression of the inducible gene interferon- a within
total RNA fragments and unspecific back ground.
This gives rise that the method allows monitoring
gene regulation, an intrinsic step in shining light on
disease progression on a genetic level.
Moreover two types of cancer have been
investigated on a genetic level: malignant melanoma
BRAF, the deadliest form of skin cancer as well as
invasive ductal carcinoma HER2 the most common
Breast cancer can be detected with this technology
on a single point mutation without amplification and
labeling in the background of the total RNA.

James K. Gimzewski
Department of Chemistry and Biochemistry, University of
California, Los Angeles, USA
WPI Center for Materials Nanoarchitectonics (MANA),
National Institute for Materials Science (NIMS), Japan;
California Nanosystems Institute, University of California,
Los Angeles, USA
gimzewski@cnsi.ucla.edu
D e v e l o p m e n t o f a " B r a i n - l i k e "
C o m p u t a t i o n s y s t e m u s i n g
A t o m i c S w i t c h N e t w o r k s
The self-organization of dynamical structures in
complex natural systems is associated with an
intrinsic capacity for computation. Based on new
approaches for neuromorphic engineering, we
discuss the construction of purpose-built dynamical
systems based on atomic switch networks (ASN).
These systems consist of highly interconnected,
physically recurrent networks of inorganic synapses
(atomic switches). By combining the advantages of
controlled design with those of self-organization, the
functional topology of ASNs has been shown to
produce emergent system-wide dynamics and a
diverse set of complex behaviors with striking
similarity to those observed in many natural systems
including biological neural networks and assemblies.
Numerical modeling and experimental investigations
of their operational characteristics and intrinsic
dynamical properties have facilitated progress
toward implementation in neuromorphic reservoir
computing. We discuss the utility of ASNs as a
uniquely scalable physical platform capable of
exploring the dynamical interface of complexity,
neuroscience, and engineering.
R e f e r e n c e s
[1] A.Z. Stieg, A.V. Avizienis, H.O. Sillin, C. Martin-
Olmos, M. Aono and J.K Gimzewski. Advanced
Materials 24(2), 286-293 (2012)
[2] H.O. Sillin,H-. H. Hsieh, R. Aguilera, A.V.
Avizienis, M. Aono, A.Z. Stieg and J.K.
Gimzewski, Nanotechnology 38(24), 384004
(2013).
[3] A.V. Avizienis, H.O. Sillin, C. Martin-Olmos, M.
Aono, A.Z. Stieg and J.K Gimzewski. PLoS ONE
7(8): e42772 (2012).
[4] A.Z. Stieg, A.V. Avizienis, H.O. Sillin, H-.H. Shieh,
C. Martin-Olmos, R. Aguilera, E.J. Sandouk, M.
Aono and J.K. Gimzewski. In: Memristor
Networks, Eds. Adamatzky & Chua, Springer-
Verlag (2014).
[5] E.C. Demis, R. Aguilera, H.O Sillin, K.
Scharnhorst, E.J Sandouk1, M. Aono3, A.Z Stieg
& J.K Gimzewski, Nanotechnology, 26 (10)
204003 (2015)
[6] V. Vesna, A.Z. Stieg in Handbook of Science and
Technology Convergence, Eds, W. Bainbridge,
M.C Roco, Springer (2016)
Gabi Grützner
micro resist technology GmbH, Germany
g.gruetzner@microresist.de
M a t e r i a l I n n o v a t i o n s E n a b l i n g
A d v a n c e d N a n o f a b r i c a t i o n f o r
L a b t o F a b A p p l i c a t i o n
For more than 20 years, micro resist technology
GmbH (mrt) has been developing and providing
innovative photoresists, special polymers and
ancillary materials for a variety of micro- and
nanolithography applications. Due to these highly
specialized products, mrt is a trusted supplier of
global high-tech markets such as semiconductor
industry, MEMS, optoelectronics, nanotechnology
and other emerging technologies.
Beside photoresists for UV / DUV-applications
and e-beam lithography mrt has focused on the
development and fabrication of resist materials for
the next generation of lithography applications.
Beside improved versions of positive and negative
tone photoresists the innovation for nanofabrication
is mainly set on nanoimprinting materials and hybrid
polymer materials.
A broad material portfolio for nanoimprint
lithography has been developed including resists for

thermal NIL (T-NIL), in which a thermoplastic
polymer is used, and photo-NIL, in which a liquid
photo-curable formulation is applied. Furthermore,
suitable materials with low viscosity and the fast
photo-curing reaction enable continuous roll-to-roll
NIL processes. The NIL resists are mostly applied as
etch mask for pattern transfer into various
substrates, like Si, SiO2, Al or sapphire. Furthermore,
bilayer approaches for the realization of very high
aspect ratios have been developed.
In addition, mrt offers a broad portfolio of UV-
curable hybrid polymer products for micro- and
nano-optical applications. Their excellent optical
transparency and high thermal stability makes them
perfectly suitable for the production of polymer-
based optical components and waveguides by
means of various micro- and nanofabrication
techniques. Main fields of application are micro
lenses, diffractive optical elements (DOE), gratings,
and single-mode or multi-mode waveguides.
New developments in NIL- and hybrid polymers
will be demonstrated, discussed, and application
results will be given representing different lab and
fab manufacturing schemes.
F i g u r e s
Figure 1: Resist pattern generated by photo-NIL. Figure 2: Microlens array made from OrmoComp®by Ink Jet Printing
Brian A. Korgel
1
, Xiaotang Lu
1
, Aaron
Chockla
1
, Taizhi Jiang1
, Emily Adkins1
,
Chongmin Wang
2
, Meng Gu
2
1
Department of Chemical Engineering, Texas Materials
Institute, Center for Nano- and Molecular Science and
Technology, The University of Texas at Austin, Austin, USA
2
Environmental Molecular Sciences Laboratory, Pacific
Northwestern National Laboratory, Richland, USA
korgel@che.utexas.edu
S i l i c o n a n d G e r m a n i u m
N a n o w i r e s f o r L i t h i u m a n d
S o d i u m I o n B a t t e r i e s
Silicon (Si) and Germanium (Ge) have both been
explored as high storage capacity negative
electrodes (or anodes) in lithium ion batteries as a
replacement for graphite. Si has very high lithium
storage capacity (of about an order of magnitude
greater than graphite); however, Si-based electrodes
usually require the addition of carbon because of
the low electrical conductivity of Si. We have
recently shown that carbon addition can be
minimized by using Si nanowires with a thin layer of
carbon coating [1,2], or completely avoided using Si
nanowires containing high concentrations of tin (Sn,
8-10 mol%) [3]. The Sn-containing Si nanowires can
be cycled in LIBs with very high capacity
(~1,000 mA h g
-1
for more than 100 cycles at a
current density of 2.8 A g
-1
(1 C). Capacities
exceeding graphite (of 373 mA h g
-1
) could be
reached at rates as high as 2 C. Ge nanowire LIB
electrodes have lower charge capacity (1,624
mA h g
-1
) than Si, but perform better than Si at high
cycle rates (without the addition of carbon). One
approach that we have been exploring for achieving
high capacity and high rate capability in batteries is
to combine Si and Ge nanowires into one electrode.
Using this approach, a capacity of 900 mA h g
-1
could
be obtained at extremely fast delithiation rates of

20 C (37.16 A g
-1
). Using in situ TEM, we have been
studying the lithiation/delithiation mechanisms of Si
and Ge nanowires and observe that fast rates lead
to pore formation in both Si and Ge, which should
be considered when designing electrolytes and
electrode formulations [4]. We have also been
studying nanowire materials for energy storage
concepts beyond the lithium ion battery that use
alternatives like Na, Ca or Mg. We have found that
Ge nanowires are a very good electrode material for
Na-ion batteries (NIBs). Crystalline Ge does not
sodiate; however, a pretreatment process of
lithiation to amorphize the nanowires then leads to
very efficient sodiation. We have performed in situ
TEM studies of the sodiation and desodiation of Ge
nanowires and find that sodiation rates are actually
quite fast, similar to the typical rates observed for
lithiation of Ge nanowires. The current state-of-the-
art of Si and Ge nanowire materials for LIB and NIBs
will be discussed.
R e f e r e n c e s
[1] A. M. Chockla, J. T. Harris, V. A. Akhavan, T. D.
Bogart, V. C. Holmberg, C. Steinhagen, C. B.
Mullins, K. J. Stevenson, B. A. Korgel, J. Am.
Chem. Soc. 133 (2011) 20914.
[2] T. D. Bogart, D. Oka, X. Lu, M. Gu, C. Wang, B. A.
Korgel, ACS Nano 8 (2014) 915.
[3] T. D. Bogart, X. Lu, M. Gu, C. Wang, B. A. Korgel,
RSC Adv. 4 (2014) 42022.
[4] X. Lu, T. D. Bogart, M. Gu, C. Wang, B. A. Korgel,
J. Phys. Chem. C 119 (2015) 21889.
F i g u r e s
Figure 1: TEM images of an Si nanowire after several
lithiation/delithiation cycles. The nanowire shrinks in diameter and
develops pores after each delithiation event. Relithiation causes the
nanowire to swell and the pores are filled in.
Thomas Laurell
Dept. Biomedical Engineering, Lund University, Lund,
Sweden
thomas.laurell@bme.lth.se
A c o u s t i c s e e d - t r a p p i n g
e n a b l e s r a p i d e n r i c h m e n t a n d
p u r i f i c a t i o n o f n a n o v e s i c l e s
i n v o l v e d e x t r a c e l l u l a r
s i g n a l l i n g
Extracellular vesicles (EV) encompass several
different cell-derived nanometer scale vesicles,
which all play important roles in intercellular
communication, e.g. through membrane integrated
proteins that target cells and trigger intracellular
signalling pathways or fuses with the target cell
delivering gene-regulating components such as
mRNA or microRNA (miRNA). Exosomes are small
intraluminal vesicles (50-100 nm) secreted via so
called multivesicular endosomes and are recognized
as an important mode of cell-independent
communication and immune system regulation.
Exosomes are present in all biofluids and contain a
wide range of proteins and RNAs that reflect their
tissue of origin. Microvesicles (microparticles) are
larger in size, 100-1000 nm, and are disseminated
from cells by budding from the plasma membrane
into the extracellular space, having similar function
in extracellular communication.
The study of extra cellular vesicles involves
extensive ultracentrifugation protocols to isolate
exosomes and microvesicles. In order for
ultracentrifugation to be functional, sufficient
material must be available to allow the formation of
a visible pellet after the centrifugation. This usually
requires several 2-5 mL of biofluid and is a major
bottle neck in advancing research in this area due to
the limited access to such large sample volumes.
Our group has recently reported that bacteria
as well as nanoparticles (110 nm) can be enriched by
means of capillary based acoustic trapping
configured in the so called seed-trapping mode.
Acoustic seed-trapping utilises inter particle forces,
occurring as ultrasound waves are scattered
between two particles. By seeding the acoustic trap

with larger particles (≈10 um) that can easily be
retained against flow by the primary acoustic
radiation force, when exciting a capillary with a local
ultrasonic vibration, nanometer sized particles in a
sample that is exposed to the larger seed particles in
the acoustic trap will be attracted to the seed
particles, aggregate and be retained against flow.
This mechanism enables rapid enrichment of
nanometersized solid particles as well as biological
nanoparticles, i.e. bacteria, exosomes and
microvesicles. The basics of acoustic trapping will be
discussed and the application of acoustic seed-
trapping to realise a rapid microfluidic system for
detection of bacteria in blood will be described and
the first tests of this in a clinical setting on 57 patient
samples will be discussed. The seed-trapping
platform has also been investigated for the
enrichment and enumeration of platelet derived
microvesicles in blood plasma from patients with
myocardial infarction, demonstrating analogous
data to what was obtained by ultracentrifugation
based sample preparation. Initial data on exosome
and micro vesicle enrichment from cell cultures,
cerebrospinal fluid and blood plasma will also be
presented, showing our first data on protein content
in these vesicles using LC MS/MS analysis and
detection of short RNA and microRNA by qRT-PCR.
The development of acoustic seed-trapping for
nanoparticle preparation now opens up a Holy Grail
for biomarker research and diagnostics in small
sample volumes (50-200 uL) which are not
accessible for ultra centrifugation and hence
extensive studies of extracellular vesicles in
cryopreserved biobank samples based on large
population-based cohorts may now be possible.
J. Alexander Liddle
Center for Nanoscale Science and Technology, National
Institute of Standards and Technology, Gaithersburg,
Maryland, USA
james.liddle@nist.gov
N a n o f a b r i c a t i o n : F r o m D N A -
D i r e c t e d A s s e m b l y t o V o l u m e
N a n o m a n u f a c t u r i n g
The term “nanofabrication” encompasses the
myriad of techniques that can be used to make
nanostructures, but only a small subset can make
the transition to economic viability that defines
“nanomanufacturing”. I will discuss some of the
process-related criteria, such as speed, yield,
precision, defectivity, and flexibility, as well as
economic criteria, such as market size and cost
margin, which must be considered when
determining whether or not a fabrication process
might be suited to manufacturing. I will illustrate
these concepts through examples taken from the
semiconductor industry and our own work on DNA-
directed assembly [1 – 4].
R e f e r e n c e s
[1] S. H. Ko, et al., Adv. Func. Mater., 22 1015
(2012)
[2] S. H. Ko, et al., Angew. Chemie, 52, 1193 (2013)
[3] K. Du, et al., Chem. Commun., 49, 907 (2013)
[4] S. H. Ko, et al., Soft Matter, 10, 7370 (2014)
R. Miranda
Instituto Madrileño de Estudios Avanzados en Nanociencia
(IMDEA-Nanociencia), Madrid, Spain
Dep. Física de la Materia Condensada, Universidad
Autónoma de Madrid, Madrid, Spain.
rodolfo.miranda@imdea.org
T a i l o r i n g G r a p h e n e f o r
S p i n t r o n i c s
The development of graphene spintronic
devices requires that, in addition to its capability to
passively transmit spins over long distances, new
magnetic functionalities are incorporated to
graphene. By growing epitaxially graphene on single
crystal metal surfaces under UHV conditions [1] and
either adsorbing molecules on it or intercalating
heavy atoms below it, long range magnetic order or
giant spin-orbit coupling, respectively, can be added
to graphene.

i) Achieving long range magnetic order by a
monolayer of electron acceptor molecules adsorbed
on graphene /Ru(0001). Epitaxial graphene is
spontaneously nanostructured forming an
hexagonal array of 100 pm high nanodomes with a
periodicity of 3 nm [2]. Cryogenic Scanning
Tunnelling Microscopy (STM) and Spectroscopy and
DFT simulations show that TCNQ molecules
deposited on gr/Ru(0001) acquire charge from the
(doped) substrate and develop a sizeable magnetic
moment revealed by a prominent Kondo resonance.
The molecular monolayer self-assembled on
graphene develops spatially-extended spin-split
electronic bands. The predicted spin alignment in
the ground state is visualized by spin-polarized STM
at 4.6 K [3]. The system shows promising
perspectives to become an effective graphene-
based spin filter device.
ii) Introducing a giant spin-orbit interaction on
graphene/Ir(111) by intercalation of Pb. The
intercalation of an ordered array of Pb atoms below
graphene results in a series of sharp pseudo-Landau
levels in the differential conductance revealed by
STS at 4.6 K. The vicinity of Pb enhances by four
orders of magnitude the, usually negligible, spin-
orbit interaction of graphene. The spatial variation
of the spin-orbit coupling creates a pseudo-magnetic
field that originates the observed pseudo-Landau
levels [4]. This may allow the processing and
controlled manipulation of spins in graphene.
R e f e r e n c e s
[1] A.L. Vázquez de Parga et al, Phys. Rev. Lett. 100,
056807 (2008)
[2] B. Borca et al, Phys. Rev. Lett. 105, 036804
(2010)
[3] M. Garnica et al, Nature Physics 9, 368 (2013)
[4] F. Calleja et al, Nature Physics 11, 43 (2015)
F i g u r e s
Figure 1: Differential conductance for Pb-intercalated graphene.
Klaus Müllen
MaxPlanckInstituteforPolymerResearch,Mainz,Germany
muellen@mpip-mainz.mpg.de
H o w t o M a k e a n d h o w t o U s e
C a r b o n N a n o s t r u c t u r e s
Graphene is praised as multifunctional wonder
material and rich playground for physics. Above all,
it is a two-dimensional polymer and thus a true
challenge for materials synthesis. Herein I present,
both, “bottom-up” precision synthesis and “top-
down” fabrication protocols toward graphene. The
resulting materials properties cover an enormous
breadth ranging from batteries, supercapacitors,
oxygen reduction catalysts, photodetectors and
sensors to semiconductors. Another question is
whether graphene holds promise for robust
technologies. An attempt will be made at providing
answers.
R e f e r e n c e s
Nature 2010, 466, 470; Nature Chem. 2011, 3, 61;
Nature Nanotech. 2011, 6, 226; Nature Chem. 2012,
4, 699; Angew. Chem. Int. Ed. 2012, 51, 7640;
Nature Commun. 2013, DOI: 10.1038/ncomms3646;
Adv. Polym. Sci. 2013, 262, 61; Angew. Chem. Int.
Ed. 2014, 53, 1570; J. Am. Chem. Soc. 2014, 136,
6083; Angew. Chem. Int. Ed. 2014, 53, 1538; Nature
Nanotech. 2014, 9, 182; Nature Nanotech. 2014, 9,
131; Nature Chem. 2014, 6, 126; Nature Commun.
2014, DOI:10.1038/ncomms5973; Nature Nanotech.
2014, 9, 896; Nature Commun. 2014,
DOI:10.1038/ncomms5253; Adv. Mater. 2015, 27,
669; ACS Nano 2015, 9, 1360; Angew. Chem. Int. Ed.
2015, 54, 2927; J. Am. Chem. Soc. 2015, 137, 6097;
Nature Commun. 2015, DOI: 10.1038/ncomms8655.

Stella W. Pang
DepartmentofElectronicEngineering,CenterforBiosystems,
Neuroscience,andNanotechnology,CityUniversityofHong
Kong,Kowloon,HongKong
pang@cityu.edu.hk
N a n o f a b r i c a t e d P l a t f o r m s f o r
B i o s e n s i n g a n d C e l l C o n t r o l
Biosensing using neural probes and cell
migration control using patterned topography will
be reviewed. Neural probes are used in vivo to study
neural activities of the central nervous system and
retinal responses. We have developed low
impedance neural probes with integrated
temperature sensors to monitor neural activities in
the brain and retina. By controlling the dimension,
distribution, and morphology of the electrode sites
on the probes, neural signals with high signal to
noise ratio were obtained. Improved neural activity
detection was achieved by lowering the electrode
impedance using plasma treatment of the electrode
surface. Position of the implanted neural probes
could be monitored using the integrated
temperature sensors. These temperature sensors
were useful to detect the temperature rise during
neural stimulation at different current levels.
Controlling cell movement and cell screening
are crucial for biosystems. Cell switches based on
patterned topography with different bending angles,
segment lengths, and pattern densities have been
designed to control unidirectional cell migration
with better than 85% probability of passing the
switches. To improve the unidirectional passing
probability, sealed channels with guidance
topography, a height of 15 μm, and a width of 10
μm were used to confine the cells and move them
through the channels in the designated direction
without external force, chemical gradient, or fluidic
flow. This will be the basis for “smart” platform,
which is capable of sorting adherent cells to the
predesigned locations.
Natural killer (NK) cells serve an important role
in immune system by recognizing and killing
potentially malign cells without antigen
sensitization, and could be important in cancer
therapy. We have designed and fabricated microwell
arrays with microchannel connections to study the
interaction dynamics of NK-92MI cells with MCF7
breast cancer cells using time-lapse imaging. NK cell
cytotoxicity was found to be stronger in larger
microwells with shorter triggering time of first target
lysis. Microchannel connection between adjacent
microwell of the same size increased the overall
target death ratio by >10%, while connection
between microwells of different sizes led to
significantly increased target death ratio and
delayed first target lysis in smaller microwells. Our
findings reveal unique cell interaction dynamics such
as initiation and stimulation of NK cell cytotoxicity in
a confined microenvironment.
N. M. R. Peres
UniversityofMinho,DepartmentandCenterofPhysics,
Braga,Portugal
peres@fisica.uminho.pt
B a s i c N o t i o n s i n G r a p h e n e
P l a s m o n i c s
In this talk we discuss basic notions of graphene
plasmonics in the mid- and far-infrared spectral
regions. We first compare some elementary
properties of metal plasmonics versus graphene
plasmonics in those spectral regions. We then move
to the physics of surface plasmon-polaritons in a
continuous graphene sheet. It follows a discussion of
the methods for exciting SPP's in graphene.
Subsequently, the properties of a periodic micro-
ribbons grid and its potential application in
biosensing is discussed. The case of graphene nano-
structures is also briefly considered. The coupling of
SPP's to phonons is analysed.
R e f e r e n c e s
[1] P. A. D. Gonçalves and N. M. R. Peres, An
Introduction to Graphene Plasmonics, (World
Scientific, 2016)

F i g u r e s
Figure 1: Spectrum of surface phonon-plasmon-polaritons of
graphene on SiO2
Francesc Pérez-Murano
MicroelectronicsInstituteofBarcelona(IMB-CNM,CSIC)
Bellaterra,Spain
Francesc.Perez@csic.es
D i r e c t e d s e l f - a s s e m b l y o f
b l o c k c o - p o l y m e r s : c h e m i c a l
g u i d i n g p a t t e r n s a n d a d v a n c e d
n a n o m e t e r - s c a l e
c h a r a c t e r i z a t i o n
Directed self-assembly (DSA) of block co-
polymers allows the generation of high-resolution
patterns at wafer scale level [1]. The characteristic
feature size of the final pattern is dictated by the
molecular weight of the block co-polymer, while its
orientation is prompted by the predefinition of
guiding patterns on the surface. DSA is considered
by the semiconductor industry as one of the best
candidates as lithography method for the next
technological nodes, as it combines high resolution
(< 10 nm half pitch) and high throughput, together
with more simplicity and lower cost in comparison
with extreme UV optical lithography.
In chemical epitaxy DSA, the guiding patterns
that fix the orientation and position of the block co-
polymer self-assembled features are defined as
areas of the surface of varied chemical strength
(affinity) with the blocks forming the co-polymer. In
the first part of the talk, we will show different
examples of creating high resolution chemical
guiding patterns for chemical epitaxy DSA:
functionalization by selective oxygen plasma
exposure [2], direct chemical modification by atomic
force nanolithography [3]; and electron beam
exposure [4]. By properly tuning of the interface
energies, it is possible to generate patterns of dense
arrays of line/spaces using wide guiding stripes,
relaxing the requirements of the lithography
method for the guiding pattern generation.
In addition, we will show our recent advances in
the characterization of thin polymer layers of self-
assembled block co-polymers by Atomic Force
Microscopy (AFM). There is an increasing need for
new metrology approaches when the critical
dimension of the patterns approaches or it is below
10 nm. We use peak force tapping to probe the
nanomechanical properties of the block co-
polymers, including the change in elasticity of the
block copolymer phases, allowing to determine the
optimal conditions for their imaging [5].
The work has been developed in the framework
of several EU-funded collaborative projects: SNM
FP7-ICT-2011-8-318804 , CoLiSa FP7-ICT-2011-8-
318804, PLACYD (FP7-ICT-2011-8-318804 and PCIN-
2013-033 MINECO.
R e f e r e n c e s
[1] R. Ruiz et al. Density multiplication and improved
lithography by directed block copolymer
assembly. Science 321 (2008) 936-939
[2] L. Oria et al. Polystyrene as a Brush Layer for
Directed Self-Assembly of Block Co-Polymers.
Microelectron.Eng. 110 (2013) 234-240
[3] M. Fernández-Regúlez et al. Sub-10 Nm
Resistless Nanolithography for Directed Self-
Assembly of Block Copolymers.
Appl.Matter.Interfaces 6 (2014) 21596-21602
[4] L. Evangelio et al. Creation of guiding patterns
for directed self-assembly of block copolymers
by resistless direct e-beam exposure. J.
Micro/Nanolith. MEMS MOEMS. 14 (2015)
033511

[5] M. Lorenzoni et al. Nanomechanical Properties
of Solvent Cast PS and PMMA Polymer Blends
and Block Co-Polymers. J. Micro/Nanolith.
MEMS MOEMS. 14 (2015) 033509
Francisco Rivadulla
CIQUS-CentrodeInvestigaciónenQuímicaBiológicay
MaterialesMoleculares,UniversidaddeSantiagode
Compostela,SantiagodeCompostela,Spain
f.rivadulla@usc.es
F a b r i c a t i o n o f h i g h - q u a l i t y
e p i t a x i a l t h i n - f i l m s o f
f u n c t i o n a l o x i d e s b y a
c h e m i c a l s o l u t i o n m e t h o d
In this talk I will review our most important
results about the physical properties of high-quality
epitaxial oxide thin-films prepared by a chemical
solution method.
In the first part of the talk I will describe our
efforts for identifying the most relevant chemical
aspects of the synthesis, and the strategies we
followed for optimizing them.
After that, I will discuss several examples to
demonstrate that an excellent control over the
thickness, chemical, structural, electronic and
magnetic homogeneity can be achieved on
multicationic oxides, over areas of several cm
2
by
this simple method.
I will show that epitaxial oxide-heterostructures
can be also prepared in this way, which constitutes
an important step forward in the competitiveness of
the chemical solution methods, compared with
traditional physical deposition techniques.
Finally, I will describe our attempts to combine
this chemical solution technique with physical
deposition methods (in this case MBE) for the
synthesis of complex heterostructures on Silicon.
Particularly, I will show how a large piezoelectric
response can be obtained in relatively thick layers of
BaTiO3, deposited over porous chemically-
synthesized layers of LSMO, on STO/Si.
R e f e r e n c e s
[1] Quanxi Jia et al. Nature Materials 3, 529 - 532
(2004)
[2] F. Rivadulla et al. Chem. Mat. 25, 55 (2013)
[3] Lucas et al. ACS Appl. Mat. Interf. 6, 21279
(2014)
[4] J. M. Vila-Fungueiriño et al.Chem. Mater. 26,
1480 (2014).
[5] J. M. Vila-Fungueiriño et al., ACS Appl. Mat.
Interf. (2015)
[6] B. Rivas-Murias et al. Scientific Reports 5,
11889 (2015)
[7] J. M. Vila-Fungueiriño et al. Frontiers in physics.
3, 38 (2015)
Lars Samuelson
LundUniversity,NanoLund/SolidStatePhysics,Lund,Sweden
lars.samuelson@ftf.lth.se
F r o m b a s i c N a n o w i r e r e s e a r c h
t o r e a l - w o r l d a p p l i c a t i o n s
Semiconductor nanowires are ‘needle’-like
structures with unique materials, electronic and
optical properties that renders them promising for
next-generation applications in fields like
opto/electronics, energy systems and life sciences.
An intensive and world-wide research effort in the
field of nanowires was launched in the late 1990s,
about ten years after the pioneering work by Dr.
Hiruma at Hitachi, Japan. In my research group we
spent the first five years on fundamental studies of
the materials growth and the materials physics of
nanowires, especially heterostructure systems [1],
while in parallel also developing novel methods that
combined top-down patterning with bottom-up self-
assembly, to enable the reproducible fabrication of
perfectly ordered nanowire arrays [2], [3].
From around 2005 it became evident that this
blue-sky materials research [4], [5] offered
significant advantages and opportunities for various
applications, primarily in enabling high-speed [6]
and optoelectronics devices by monolithic
integration of III-V nanowires with silicon [7]. We
have also explored ways in which these
nanostructures can be used for energy scavenging
[8] and in applications that enable energy
conservation [9].

In this talk I will also present my perspective of
broader materials research considerations related to
semiconductor nanowires, what the state-of-the-art
is, what the key challenges are and focus particularly
on the opportunities that these nanostructures
present in terms of realizing the next-generation of
high-performance optoelectronics devices such as
solar cells and light-emitting diodes, at a low cost
and with low materials consumption [10].
R e f e r e n c e s
[1] M.T. Björk et al., “One-dimensional steeple-chase
for electrons…”, Nano Lett 2 (2002) 87.
[2] T. Mårtensson et al., “Fabrication of individually
seeded NW…”, Nanotechn. 14 (2003) 1255.
[3] T. Mårtensson et al., “Nanowire arrays defined by
nanoimprint litho..”, Nano Lett 4 (2004) 699.
[4] A.I. Persson et al., “Solid-phase diffusion
mechanisms for…”, Nature Materials 3 (2004)
677.
[5] K.A. Dick et al., “Synthesis of branched
‘nanotrees’ by…”, Nature Materials 3 (2004) 380.
[6] C. Thelander et al., “Nanowire-based one-dim.
electronics”, Materials Today 9 (2006) 28.
[7] T. Mårtensson et al., “Epitaxial III-V nanowires on
silicon”, Nano Lett 4 (2004) 1987
[8] J. Wallentin et al., “InP nanowire array solar cells
achieving 13.8%...”, Science 339 (2013) 1057.
[9] B. Monemar et al., “NW-based visible LEDs..”,
Semicond. & Semimet Acad. Press/Elsevier
(2015).
[10] M. Heurlin et al., “Continuous gas-phase
synthesis of nanowires…”, Nature 492 (2012) 90.
H. Schift, D. Virganavicius, V.J. Cadarso
PaulScherrerInstitut(PSI),LaboratoryforMicro-and
Nanotechnology,VilligenPSI,Switzerland
helmut.schift@psi.ch
P a t t e r n i n g o f D L C l e a k y
w a v e g u i d e s e n s o r s u s i n g
n a n o i m p r i n t l i t h o g r a p h y
Patterning of materials such as diamond is of
interest for a number of application, such as stamps
in NIL or hard X-rays optics, due to their unique
properties (i.e. high hardness, chemical inertness).
Particularly diamond-like carbon (DLC) films have
become attractive because of their cost-efficient
fabrication and room temperature deposition.
During the growth of the DLC film it is possible to
dope it with nanometer scale clusters of metals (i.e.
silver, copper, etc.). This is an additional advantage
since it further broadens their application spectrum
[1]. In this work we present a method capable of
pattern DLC films in a straightforward way by using
thermal nanoimprint lithography (T-NIL) and a
simplified process for pattern transfer using hard
masks [2].
We used the SiPol resist (micro resist
technology GmbH), a thermoplastic resist with a
10% content of covalently bonded silicon that makes
it highly resistant to oxygen plasma [3]. Initially Sipol
was developed to be used in bilayer system with an
organic transfer layer like (UL1) (Fig. a, b, e). Here,
SiPol is used directly on DLC (c+d). An “incomplete
filling” strategy was employed by using stamps with
250 nm deep patterns. T-NIL was optimized at low
temperature (90°C) to avoid other issues such as
lack of adhesion, capillary effects or dewetting. This
allowed “zero” residual layer imprint and etching
the DLC films (f).
We develop periodic structures based on DLC
which enables to manufacture leaky waveguide
sensors. As a result, it is possible to obtain a sensor
based on a grating structure that is highly sensitive
to the change of the refractive index of surrounding
media.
R e f e r e n c e s
[1] T. Tamulevičius, A. Tamulevičiene, D.
Virganavičius et al., Nucl. Instrum. Meth. B 341
(2014) 1-6.
[2] H. Schift, J. Vac. Sci. Technol. B 26(2), (2008)
458-480.
[3] M. Messerschmidt et al., Microelectron. Eng. 98
(2012) 107-111.

F i g u r e s
Niek F. van Hulst
ICFO–theInstituteofPhotonicSciences,theBarcelonaInst.
ofScience&Technology,Barcelona,Spain
ICREA–InstitucióCatalanadeRecercaiEstudisAvançats,
Barcelona,Spain
Niek.vanHulst@ICFO.eu
N a n o P h o t o n i c s : U l t r a f a s t
C o n t r o l o f N a n o p a r t i c l e s ,
N a n o a n t e n n a s a n d S i n g l e
Q u a n t u m E m i t t e r s
In my group, we aim to squeeze light down to
the smallest nanoscale and fastest femtosecond
scale; with these nano-femto-tools we can talk to
individual molecules, Q-dots, proteins & plasmonic
antennas. Here I will focus on the concepts to
control interactions with quantum emitters both in
space and time, specifically using optical
nanoantennas and phase shaped fs pulses.
For spatial control, single photon emitters are
brought in the near field of optical resonant
antennas for nanoscale excitation and enhancement
of the emission into multipolar radiation patterns,
with full command of symmetry, multipole parity,
rates and polarization. With state-of-the-art antenna
fabrication the excitation can be confined to 10 nm
scale, while the emission can be enhanced up to
1000 times, reaching towards strong coupling in the
weak cavity limit.
For temporal control, phase shaped fs pulses
are exploited to drive single quantum systems and
resonant antennas to dynamically control both their
fs response and nanoscale fields. As examples we
tackle vibrational response and Rabi-oscillations in
individual molecules at ambient conditions; and
closed loop control of two-photon excitation of
single quantum dots.
Finally, as an application of the spatio-temporal
control, I will address the role of quantum effects in
photosynthesis. Surprisingly within individual
antenna complexes (LH2) of a purple bacterium it is
observed that ultrafast quantum coherent energy
transfer occurs under physiological conditions.
Quantum coherences between electronically
coupled energy eigen-states persist at least 400 fs,
and distinct, time-varying energy transfer pathways
can be identified in each complex. Interestingly the
single molecule approach allows tracking coherent
phase jumps between different pathways, which
suggest that long-lived quantum coherence renders
energy transfer robust in the presence of disorder.
In conclusion I hope to apprise the NanoPT2016
audience as to the potential of nano-femto tools
This work is supported by ERC-Advanced Grant
247330; FP7-NanoVista 288263; Marie-Curie
International COFUND Fellowships; MICINN Grants
CSD2007-046 NanoLight, FIS2009-08203; MINECO
Grant FIS2012-35527; Catalan AGAUR 2014
SGR01540; Severo Ochoa grant SEV2015-0522;
Fundació CELLEX Barcelona.
R e f e r e n c e s
[1] Lukasz Piatkowski, Esther Gellings, Niek van
Hulst, Nature Commun. 7 (2016).
[2] K.J.Tielrooij, L.Piatkowski, M.Massicotte,
A.Woessner, Q.Ma, Y.Lee, C.N.Lau, P.Jarillo-
Herrero, N.F. van Hulst, F.H.L.Koppens, Nature
NanoTechnology 10 (5), 437-443 (2015)
[3] Emilie Wientjes, Jan Renger, Alberto G. Curto,
Richard Cogdell, Niek F. van Hulst, Nature
Commun. 5: 4236 (2014)
e)
f)

[4] Anshuman Singh, Gaëtan Calbris, Niek F. van
Hulst. NanoLett. 14, 4715-4723 (2014)
[5] Nicolò Accanto, Lukasz Piatkowski, Jan Renger,
Niek F. van Hulst, NanoLett. 14, 4078-4082
(2014)
[6] Nicolò Accanto, Jana B Nieder, Lukasz
Piatkowski, Marta Castro, Francesco Pastorelli,
Daan Brinks, Niek F van Hulst, Light: Science &
Applications 3, e143 (2014)
[7] Ion Hancu, Alberto Curto, Marta Castro-López,
Martin Kuttge, Niek F. van Hulst, NanoLett. 14,
166-171 (2014)
[8] Richard Hildner, Daan Brinks, Jana B Nieder,
Richard Cogdell, Niek F. van Hulst, Science 340,
1448-1451 (2013)
[9] Daan Brinks, Marta Castro-Lopez, Richard
Hildner, Niek F. van Hulst, PNAS 110, 18386–
18390 (2013)
[10] Alberto Curto, Tim Taminiau, G. Volpe, M.
Kreuzer, Romain Quidant, Niek F. van Hulst,
Nature Commun. 4: 1750 (2013)
[11] Lukas Novotny and Niek F. van Hulst, Nature
Photonics. 5, 83-90 (2011)
F i g u r e s
Figure 1: Nano-femto-
photonics, combining
optical nanoantennas
with phase controlled
femtosecond pulses
C. Vieu
CNRS,LAAS,7avenueducolonelRoche,Toulouse,France,
UnivdeToulouse,INSA,LAAS,Toulouse,France
cvieu@laas.fr
I n v e s t i g a t i o n o f c e l l
m e c h a n i c s u s i n g N a n o d e v i c e s
a n d N a n o - i n s t r u m e n t s : s o m e
e x a m p l e s
It is now well established that to perform their
various functions, cells undergo a large range of
intra and extracellular events, which involve
mechanical phenomena at both the micro and
nanoscale. Cells are able to sense forces and
stiffness (mechanosensing) and to transduce them
into a cascade of biochemical signals leading to a
context specific cell response (mechanotransduction).
At the core of the mechanical activity of cells are the
components of their cytoskeleton acting as
contractile cables actuated by proteic nanomotors.
The nanoscale is thus the appropriate one for
investigating the organisation of the active
mechanical components and also for the
measurement of the exerted forces at a subcellular
level. On the other hand the microscale is adapted
for upscaling these investigations to cell aggregates
and tissues. The nanomechanics of cells is today a
flourishing domain of activity in which new methods
derived from micro/nanotechnologies have been
developed for shedding some light and quantitative
values in the mechanosensing properties of cells.
This fundamental activity in cell biology meets some
medical perspectives as mechanical properties of
cancer cells and tumours turned out to differ
significantly from normal cells or tissues.
After a short presentation of the biological
knowledge related to cell mechanics, I will present
some elegant methods coming form the micro/nano
community that starts to become standard
methods. In particular at the nanoscale, the use of
Atomic Force Microscopy (AFM) to sense the rigidity
of cells [1] or to measure the force exerted by living
cells [2] will be exemplified through the investigation
of human macrophages. At the microscale, I will
show how the forces generated by adherent cells
can be investigated using flexible micrometric pillars
of polydimethylsiloxane (PDMS) and how this
method can be upscaled to measure the forces
generated by growing aggregates of cells in the
context of tumor growth and metastasis nucleation
[3].
R e f e r e n c e s
[1] Dynamics of podosome stiffness revealed by
atomic force microscopy, A. Labernadie, C.
Thibault, C. Vieu, I. Maridonneau-Parini, GM
Charrière, Proceedings of the National
Academic of Sciences 107 (49), 21016-21021
(2010)
[2] Protusion force Microscopy reveals oscillatory
force generation and mechanosensing activity

of human macrophage podosomes, A.
Labernadie, A. Bouissou, P. Delobelle, S. Balor,
R. Voituriez, A. Proag, I ; Fourquaux, C. Thibault,
C. Vieu, R. Poincloux, GM Charrière and I.
Maridonneau-Parini, Nat. Comm. (5) 2014
[3] Microdevice arrays of high aspect ratio
polydimethylsiloxane pillars for the
investigation of multicellular tumour spheroid
mechanical properties, L. Aoun, P. Weiss, B ;
Ducommun, V. Lobjois and C. Vieu, Lab on Chip
14(3) 2344-2353 (2014)
F i g u r e s
c)
Figure 1: a,b) AFM images of the adhesive structures of living human macrophages (podosomes) and extraction of the quantitative measurment of
the time oscillating force of an individual podosome. c) A Micro-device of high aspect ratio PDMS pillars for sensing the force of a growing tumoral
spheroid
30 nm
0 nm
0 s 36 s 72 s
108 s 144 s 180 s
ba c
e
Height(nm)
d
0 50 100 150 200 250 300
0
20
40
60
80
100
120
Force(nN)
Time (s)

EduardoV.Castro1,2
,JoãoH.Braz1
,AiresFerreira3
,
MaríaP.López-Sancho4
andMaríaA.H.
Vozmediano
4
1
CeFEMA, Instituto Superior Técnico, Universidade de
Lisboa, Lisboa, Portugal
2
Beijing Computational Science Research Center, Beijing,
China
3
Department of Physics, University of York, UK
4
Instituto de Ciencia de Materiales de Madrid, CSIC,
Madrid, Spain
eduardo.castro@tecnico.ulisboa.pt
P h a s e s w i t h n o n - t r i v i a l
t o p o l o g y i n g r a p h e n e a n d
t r a n s i t i o n m e t a l
d i c h a l c o g e n i d e s
Topological phases of matter are new
quantum states which do not fit into Landau's
paradigm of spontaneous symmetry breaking. A
topological insulator may have exactly the same
symmetries of a non-topological insulator or
semiconductor, yet we cannot adiabatically
transform one into the other. While both have a
finite energy gap in the bulk, only the topological
insulator is metallic at the edge/surface due to the
presence of a protected edge/surface states.
Two dimensional materials have many
attributes, but experimental evidence for
topological phases has not been reported yet.
Curiously enough, one of the first proposals for a
two-dimensional topological insulator was made
for graphene. The key ingredient is the intrinsic
spin-orbit coupling which, unfortunately, is
extremely low in graphene, making this phase
undetectable. It has been suggested that randomly
depositing certain heavy adatoms can amplify the
effect by many orders, and that a dilute
concentration should be enough to open a
detectable topological gap. Here we analyze this
problem taken into account the random position
of the adatoms, which makes the problem
intrinsically disordered, using a realistic adatom
parametrization. We show that: (i) for the widely
used model where adatoms locally enhance
graphene's intrinsic spin-orbit interaction, and
additionally induce a local shift of the chemical
potential, a low adatom density (coverage <<1% )
makes the system topologically non-trivial; (ii) for a
realistic model where, apart from intrinsic spin
orbit, extra terms are also induced, the critical
adatom density is larger by at least one order of
magnitude (coverage >>1%). Using realistic
parameter values we show that recent
experiments are still deep in the topologically
trivial side of the transition.
Fortunately, nature provides other two-
dimensional materials where the subject of
topology is pertinent. In particular, transition
metal dichalcogenides are semiconducting
materials which, contrary to graphene, have non-
negligible spin-orbit coupling. Even though the
system is topologically trivial, the sizable spin-orbit
coupling induces an appreciable spin-splitting of
the valence band, where a finite anomalous spin-
valley-Hall response develops due to the non-
trivial topology of the Fermi surface. Taking into
account the moderate to high local electron-
electron interactions due to the presence of
transition metal atoms, we show that the system is
unstable to an itinerant ferromagnetic phase
where all charge carriers are spin and valley
polarized. The spontaneous breaking of time
reversal symmetry originates an anomalous charge
Hall response which should be detected
experimentally.
I N V I T E D c o n t r i b u t i o n s

Choon-Gi Choi, Yoonsik Yi, Chi-Young Hwang
Creative Research Center for Graphene Electronics,
Electronics and Telecommunications Research Institute
(ETRI), Daejeon, Korea
cgchoi@etri.re.kr
E x t r a o r d i n a r y o p t i c a l
p r o p e r t i e s o f v i s i b l e a n d
t e r a h e r t z m e t a m a t e r i a l s
Metamaterials and metasurfaces are
artificially fabricated materials and surfaces with
periodic wavelength structures that exhibit exotic
properties such as negative refraction, superlens
imaging, invisibility cloaking, extraordinary
transmission and near-perfect absorption.
In this work, we report a flexible and
freestanding fishnet structured negative refractive
index media working at visible wavelength. The
metamaterial has basically a multilayer fishnet
structure with circular hole instead of the
rectangular one to reduce the pitch size of the
metamaterial. The metamaterial shows negative
refractive index in optical regime between 570nm
and 615nm.
In addition, we introduce a flexible multi-
layered THz metamaterial designed by using the
Babinet’s principle with functionality of narrow
band-pass filter. The metamaterial give us
systematic ways to design frequency selective
surfaces (FSSs) working on the intended frequency
and band (width). It shows an extraordinary
transmission at the THz working frequency due to
the strong coupling of the two layers of
metamaterial complementary to each other
Finally, we propose a design of metamaterial
absorber structures and its numerical analysis for
the use of reflection type spatial light modulation
in the visible regime. Since the size of each
metamaterial element is subwavelength scale,
neighboring metamaterial elements of the same
type can be grouped into a single pixel of a
hologram or a spatial light modulator. The
modification of the structure allows the control of
each pixel's reflectivity from near-zero to a pre-
designed level. Each metamaterial hologram pixel
consists of 20×20 absorbers of the same structure
(pixel size of 4×4μm
2
, 500×500 pixels).
F i g u r e s
Figure 1: (a) Negative index media flexible metamaterial. The lengths of a unit cell
along the incident electric field (l1) and magnetic field (l1) are set to 160nm and 224
respectively, the thicknesses of both metal (t) and polyimide layer (s) are 50 nm, and
the hole diameter (d) is 100nm. (b) Top-view of the SEM image of the fabricated
metamaterial. (c) The image the metamaterial on the flexible substrate.
Figure 2: Thin square-fishnet-square flexible terahertz
metamaterial. Unit cell period is 40 um and gap is 5 um.
Figure 3: Simulations for metamaterial hologram generation and reconstruction.
Accommodation effect can be observed from the reconstruction results (d:
reconstruction distance)

R. Ferreira, E. Paz, J. Crocco and P. P. Freitas
INL – International Iberian Nanotechnology Laboratory,
Portugal
ricardo.ferreira@inl.int
M a g n e t o r e s i s t i v e S e n s o r s
a i m i n g r o o m t e m p e r a t u r e
d e t e c t i o n o f b i o m a g n e t i c
f i e l d s
Magnetoresistive devices and magnetic
nanostructures are key building blocks in a large
number of commercial electronic products across
a wide range of applications [1-4] covering
industrial positioning sensors, automotive sensors,
hard disk drive read heads and embedded
memories.
This presentation will focus on the key
developments carried out at INL during the last 4
years concerning the development of state-of-the-
art magnetoresistive devices using
CoFeB/MgO/CoFeB Magnetic Tunnel Junctions.
Key challenges include the development of a high
yield process able to provide sensors with well
controlled dispersion of key specifications and
linear transfer curves [5,6].
Despite the large sensitivities of MgO based
sensors, the detection of low frequency weak
magnetic fields at room temperature remains
challenging due to the large 1/f noise noise
present in the devices. This capability is required
to address applications such as Magneto-
Cardiography (MCG), a non-invasive and non-
contact technique used to monitor the transient
activity of the human heart which generates
magnetic fields in the range of 1pT-100pT at
frequencies in the range of 1Hz. MCG is currently
performed with SQUID magnetometers requiring
cryogenic setups and with limited spatial
resolution.
The solution developed at INL to address MCG
applications with MTJ sensors is described,
including the device stack, geometry and
acquisition setup used to minimize the 1/f noise in
MTJ sensors down to levels of 30pT/Hz @ 4 Hz.
The current low frequency detection limits [7-10]
are already small enough to pick up the magnetic
field of the heart but still require an improvement
of about one order of magnitude in order to
resolve the field in the time domain.
R e f e r e n c e s
[1] "2-axis Magnetometers Based on Full Wheatstone
Bridges Incorporating Magnetic Tunnel Junctions
Connected in Series”, R. Ferreira, E. Paz, P. P.
Freitas, J. Ribeiro, J. Germano and L. Sousa, IEEE
Trans. Magn., 48(11), p 4107 (2012)
[2] "Electrical Characterization of a Magnetic Tunnel
Junction Current Sensor for Industrial
Applications”, J. Sanchez, D. Ramirez, S. Ravelo, A.
Lopes, S. Cardoso, R. Ferreira and P. P. Freitas, IEEE
Trans. Magn., 48(11), p2823 (2012)
[3] "Improved Magnetic Tunnel Junctions Design for
the Detection of Superficial Defects by Eddy
Currents Testing", F. A. Cardoso, L. S. Rosado, F.
Franco, R. Ferreira, E. Paz, S. Cardoso, P. M. Ramos,
M. Piedade and P. P. Freitas, IEEE Trans. Magn.,
50(11), p6201304, (2014)
[4] "Integration of TMR Sensors in Silicon
Microneedles for Magnetic Measurements of
Neurons", J. Amaral, V. Pinto, T. Costa, J. Gaspar, R.
Ferreira, E. Paz, S. Cardoso and P. P. Freitas, IEEE
Trans. Magn., 49(7), p3512-3515, (2013)
[5] "Large Area and Low Aspect Ratio Linear Magnetic
Tunnel Junctions with a Soft-Pinned Sensing Layer”,
R. Ferreira, E. Paz, P. P. Freitas, J. Wang and S. Xue,
IEEE Trans. Magn., vol 48, issue 11, p 3719 (2012)
[6] "Linearization of Magnetic Sensors with a Weakly
Pinned Free Layer MTJ Stack Using a Three-Step
Annealing Process”, R. Ferreira, E. Paz and P. P.
Freitas, in press (2016)
[7] "Strategies for pTesla Field Detection Using
Magnetoresistive Sensors With a Soft Pinned
Sensing Layer", J. Valadeiro, J. Amaral, D. C. Leitao,
R. Ferreira, S. Cardoso and P. P. Freitas, IEEE Trans.
Magn., 51(1), p4400204, (2015)
[8] "Magnetic tunnel junction sensors with pTesla
sensitivity", S. Cardoso, D. C. Leitao, L. Gameiro, F.
Cardoso, R. Ferreira, E. Paz and P. P. Freitas,
Microsyst. Technol., 20, p793-802, (2014)
[9] "Room temperature direct detection of low
frequency magnetic fields in the 100 pT/Hz(0.5)
range using large arrays of magnetic tunnel
junctions", E. Paz, S. Serrano-Guisan, R. Ferreira
and P. P. Freitas, J. App. Phys., 115(17), p17E501,
(2014)
[10] "Magnetic tunnel junction sensors with pTesla
sensitivity for biomedical imaging", S. Cardoso, L.
Gameiro, D. C. Leitao, F. Cardoso, R. Ferreira, E.
Paz, P. P. Freitas, U. Schmid, J. Aldavero and M.
LeesterSchaedel, Smart Sensors, Actuators, and
Mems, 8763, (2013)

Chen-zhong Li1,2
, Evangelia Hondroulis2
,
Ming Hong
1
, Xia Li
1
1
College of Chemistry and Chemical Engineering, Liaocheng
University, Shandong, China
2
Nanobioengineering/Bioelectronics lab, Department of
Biomedical Engineering, Florida International University,
Florida, USA
licz@fiu.edu
N a n o p a r t i c l e E n h a n c e d
E l e c t r o m a g n e t i c C o n t r o l o f
C a n c e r C e l l D e v e l o p m e n t f o r
N a n o t h e r a n o s t i c s
Nanomaterials are being considered in the
development of new drugs and new therapies and
have been used in tissue engineering and medical
imaging, leading to improved diagnostics and new
therapeutic treatments. Nanotheranostics is
referred to as a treatment strategy that integrates
nanotechnology and therapeutics to diagnostics,
aiming to monitor the response to treatment, which
would be a key part of personalized medicine and
require considerable advances in predictive
medicine. A major limitation in the current
treatments such as chemotherapy, radio therapy for
cancer is the negative side effects that occur.
Recently non-invasive therapy including electrical
therapy and magnetic therapy recently has made
significant progress based on the deep
understanding of biophysical and bioelectrical
properties of biomolecules and the development of
nanotechnology and fabrication technology.
Recently we demonstrated a whole cell-based
array-formatted electrical impedance sensing
system to monitor the effects of external alternating
electric fields on the behavior of ovarian cancer cells
HTB-77™ (SKOV3) compared to normal human
umbilical vascular endothelial cells CRL-1730™
(HUVEC). The biosensor employed will measure in
real-time the electrode surface impedance changes
[2] produced by growing cell monolayers over the
electrodes and detecting any changes in resistance
associated with changes in the cell layer after
electric field exposure [3]. A significant effect on
slowing down proliferation rate was observed in the
cancer cells through the lower resistance curves of
the electrical impedance sensing system in real-time
as the external field was applied compared to a
control with no applied field. Upon further
investigation of this technique, our group has found
that the therapeutic effects of the electric therapy
technique can be significantly increased by
functionalizing the surface of cancer cell membranes
with gold nanoparticles, this is specifically true for
breast cancer tissue [2]. The binding of charged
nanoparticles to the cell surface plasma membrane
will change the zeta potential value of the cells, a
feature of the cell that has been used in cell biology
to study cell adhesion, activation, and agglutination
based on cell-surface-charge properties. We
determined that an enhanced electric field strength
can be induced via the application of nanoparticles,
consequently leading to the killing of the cancerous
cells limited effects on non-cancerous cells. This
discovery will be helpful for developing an electronic
therapeutic platform for non-invasive cancer
treatment without limited harmful side effects.
R e f e r e n c e s
[1] E. Hondroulis, S. J. Melnick, X. Zhang, Z-Z. Wu,
C.-Z. Li, Electrical Field Manipulation of Cancer
Cell Behavior Monitored by Whole Cell
Biosensing Device, Biomedical Microdevices,
2013. 15(4), 657-663.
[2] E. Hondroulis, C.Z Li. Whole cell impedance
biosensoring devices. Methods Mol. Biol.
2012;926:177-87
[3] E. Hondroulis, C. Chen, C. Zhang, K. Ino, T.
Matsue, C.-Z. Li, “Immuno Nanoparticles
Integrated Electrical Control of Targeted Cancer
Cell Development Using Whole Cell
Bioelectronic Device”, Theranostics, 2014;
4(9):919-930.

Tatiana Makarova
Lappeenranta University of Technology, Lappeenranta,
Finland
Tatyana.Makarova@lut.fi
T a b b y g r a p h e n e : r e a l i z a t i o n o f
z i g z a g e d g e s t a t e s a t t h e
i n t e r f a c e s
Tabby is a pattern of kitty's coat featuring
distinctive stripes, dots, or swirling patterns. Ideally,
the stripes are non-broken lines; evenly spaced.
Decoration of the graphene basal plane with the
stripes of attached atoms along the zigzag
crystallographic directions creates the edge states at
the sp
2
/sp
3
interfaces.
“Zigzag" is a magic word in the graphene world:
it is expected that zigzag edges qualitatively change
the electronic properties, including spin magnetism.
Theories predict an extended spin polarization along
the graphene edges in the ground state, with
opposite spin directions at opposite edges.
We have recently synthesized a novel graphene
derivative decorated by monoatomic fluorine chains
running in the crystallographic directions and
measured strong one-dimensional magnetism in this
two- dimensional material [1].
Tabbies have been realized on bilayer graphenes
where the bipartite lattice creates a discriminating
mechanism leading to the formation of regular
stripy patterns whereas crossing and branching are
suppressed.
R e f e r e n c e s
[1] Makarova, T. L. et al., Scientific Reports 5,
13382 (2015).
Lorenzo Pastrana
INL – International Iberian Nanotechnology Laboratory,
Portugal
lorenzo.pastrana@inl.int
N a n o s t r u c t u r e s f o r f o o d
a p p l i c a t i o n s
There are three primary structures at nanoscale
suitable to be used in foods, namely:
nanoparticles/nanocapsules, nanolaminates and
nanofibres /nanotubes. All these structures can be
obtained using food grade biopolymers such as
carbohydrates, lipids or proteins. As the
consequence of their properties, each structure can
be used for different applications. Thus,
nanoparticles/nanocapsules are useful for controlled
delivery of bioactive and functional compounds or
to protect against degradation during processing or
storage of labile food components. The main
application for nanolaminates is to develop edible
coatings for active packaging of fresh and perishable
foods. Finally, nanofibres and self-assembling
nanotubes can be used for nanoencapsulation but
also to modify or create new macroscopic
rheological properties. Several examples of these
applications will be discussed: On demand and
smart delivery of encapsulated antimicrobials on
temperature and pH sensitive pNIPA nanohydrogels
will be showed [1]. In the same way, casein
nanocapsules are suitable for calcium and iron
fortification of biscuits without modification of their
organoleptic properties. Nanoemulsions of candelilla
wax incorporating a polyphenol extract can be used
to obtain an edible nanocoating able to prevent
apple spoilage and extend their shelf life [2]. Finally,
self-assembling nanotubes can be used to
encapsulate caffeine and also to modify the
rheological properties of α-lactoglobulin solutions
[3].
R e f e r e n c e s
[1] Clara Fuciños, Miguel Cerqueira, Maria J. Costa,
António Vicente, María Luisa Rúa, Lorenzo M.
Pastrana. (2015) Functional Characterisation
and Antimicrobial Efficiency Assessment of
Smart Nanohydrogels Containing Natamycin
Incorporated into Polysaccharide-Based Films.
Food and Bioprocess Technology 8: 1430-1441.
[2] Miguel A. De León-Zapata, Lorenzo Pastrana-
Castro, María Luisa Rua-Rodríguez, Olga
Berenice Alvarez-Pérez, Raul Rodríguez-Herrera,
Cristóbal N. Aguilar. (2015) Experimental

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