This study evaluated the anxiolytic effects of cannabidiol (CBD) in male rodents using the Elevated Zero Maze test. Rodents were orally administered 20 mg/kg of 99% pure CBD or a sesame oil vehicle daily for 10 days. On day 10, the CBD group traveled less distance and spent less time in the open arms, suggesting sedation rather than anxiolysis. Future studies should test lower CBD doses and consider sex differences to better assess anxiolytic potential while avoiding sedation.
Dr Patrick Treacy on combining therapies for optimal outcomes in treating the...Dr. Patrick J. Treacy
This paper looks at the possibility of combining five
established therapies in an attempt to address
common concerns related to facial ageing. The
therapies included microneedling, low dose
Ultralase laser, (PRP) plasma rich protein growth
factors, Omnilux 633 light and neurotoxins. The technique is
called the DUBLiN face-lift as an acronym of the procedures
involved. D Dermaroller U Ultralase Laser B Blood growth
factors Li Light (near red 633) N Neurotoxin.
The author compared this method to fractionalised laser
skin resurfacing (FLSR) in terms of reduction of photoageing
and overall aesthetic effect. Neurotoxin was used in
both studies.
Simultaneous Determination of Curcumin and Gefitinib in Pure Form by Using UV...Sagar Savale
Plan: Development and Validation of a method for the UV simultaneous determination of curcumin and Gefitinib.
Preface: U.V Spectrophotometric method have been widely employed in determination of individual components in a mixture or fixed dose combination. For the ternary mixture containing Curcumin and Gefitinib, no spectrophotometric method for simultaneous evaluation has been reported so far. Thus our aim is to develop simultaneous equation method for estimation of the ternary mixture using U.V spectrophotometry.
Methodology: The method was validated as per ICH guidelines. The recovery studies confirmed the accuracy and precision of the method.
Outcome: It was successfully applied for the analysis of the drug in bulk and could be effectively used for the routine analysis.
Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. Here in this document, you will everything about CBD and CBD oil benefits.
PUNTOG - HEAD SHOP - VAPE SHOP - HEMP SHOP - GROW SHOP
VENDITA E ASSISTENZA ON LINE SU PRODOTTI NATURALI E AL CBD - (CANAPA)
www.puntog-shop.com
Mobile +39 345 889 3933
Email : info@puntog-shop.com
ORDINI TELEFONICI PER PRODOTTI NATURALI AL CBD
Spediamo la merce in tutta Italia con Consegna in pacco assolutamente robusto. Riceverai la merce entro tre giorni lavorativi dall’ordine. Chiama Ora!
Dr Patrick Treacy on combining therapies for optimal outcomes in treating the...Dr. Patrick J. Treacy
This paper looks at the possibility of combining five
established therapies in an attempt to address
common concerns related to facial ageing. The
therapies included microneedling, low dose
Ultralase laser, (PRP) plasma rich protein growth
factors, Omnilux 633 light and neurotoxins. The technique is
called the DUBLiN face-lift as an acronym of the procedures
involved. D Dermaroller U Ultralase Laser B Blood growth
factors Li Light (near red 633) N Neurotoxin.
The author compared this method to fractionalised laser
skin resurfacing (FLSR) in terms of reduction of photoageing
and overall aesthetic effect. Neurotoxin was used in
both studies.
Simultaneous Determination of Curcumin and Gefitinib in Pure Form by Using UV...Sagar Savale
Plan: Development and Validation of a method for the UV simultaneous determination of curcumin and Gefitinib.
Preface: U.V Spectrophotometric method have been widely employed in determination of individual components in a mixture or fixed dose combination. For the ternary mixture containing Curcumin and Gefitinib, no spectrophotometric method for simultaneous evaluation has been reported so far. Thus our aim is to develop simultaneous equation method for estimation of the ternary mixture using U.V spectrophotometry.
Methodology: The method was validated as per ICH guidelines. The recovery studies confirmed the accuracy and precision of the method.
Outcome: It was successfully applied for the analysis of the drug in bulk and could be effectively used for the routine analysis.
Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. Here in this document, you will everything about CBD and CBD oil benefits.
PUNTOG - HEAD SHOP - VAPE SHOP - HEMP SHOP - GROW SHOP
VENDITA E ASSISTENZA ON LINE SU PRODOTTI NATURALI E AL CBD - (CANAPA)
www.puntog-shop.com
Mobile +39 345 889 3933
Email : info@puntog-shop.com
ORDINI TELEFONICI PER PRODOTTI NATURALI AL CBD
Spediamo la merce in tutta Italia con Consegna in pacco assolutamente robusto. Riceverai la merce entro tre giorni lavorativi dall’ordine. Chiama Ora!
THE ENDOCANNABINOID SYSTEM - Cady Wellness InstituteLouis Cady, MD
This lecture, presented on February 2, 2018 at the Cady Wellness Institute in Newburgh, IN, represented Dr. Cady's review of the current peer-reviewed medical literature current as of that morning. The concepts of "endocannabinoids" vs. "phytocannabinoids" were reviewed. Themes in the medical literature were explored, including the relationship of the endocannabinoid system and CB! and CB2 receptors to modulate hippocampal neurogenesis, cause apoptosis in breast cancer cells, and many other interesting correlations. A careful review of legal vs illegal options for obtaining plant phytocannabinoids in the state of Indiana was emphasized.
Endocannabinoid System - Literature ReviewLouis Cady, MD
In this brief review of the literature, Dr. Louis Cady of the Cady Wellness Institute reviews the endocannabinoid system and the role it plays in bridging the connection between mind and body, modulating anxiety, inflammation, memory and other physiological processes. Nothing in this presentation suggests that any of the products mentioned are appropriate for the treatment, remediation, cure, or prevention of any disease or illness. It does appear, however, that this natural, indwelling, genetically passed down endocannabinoid system may have major implications for holistic physicians and health care practitioners, and for the patients that they serve.
Throughout 2015 the Canadian Cancer Survivor Network (CCSN) will offer a series of webinars designed to provide you with information to help build your knowledge and understanding of medical marijuana use in Canada.
The first webinar in this series features a presentation and Q&A session with Dr. Paul Daeninck , MD, MSc, FRCPC.
Comprehensive Report on The Cannabis Extract MovementTheHempSolution
A comprehensive review of evidence that cannabis extracts can treat many cancers and other diseases. Features information from patients, caregivers, researchers, doctors, dispensaries, and corporations. Includes medical documentation of terminal cancer patients in full remission.
THE ENDOCANNABINOID SYSTEM - Cady Wellness InstituteLouis Cady, MD
This lecture, presented on February 2, 2018 at the Cady Wellness Institute in Newburgh, IN, represented Dr. Cady's review of the current peer-reviewed medical literature current as of that morning. The concepts of "endocannabinoids" vs. "phytocannabinoids" were reviewed. Themes in the medical literature were explored, including the relationship of the endocannabinoid system and CB! and CB2 receptors to modulate hippocampal neurogenesis, cause apoptosis in breast cancer cells, and many other interesting correlations. A careful review of legal vs illegal options for obtaining plant phytocannabinoids in the state of Indiana was emphasized.
Endocannabinoid System - Literature ReviewLouis Cady, MD
In this brief review of the literature, Dr. Louis Cady of the Cady Wellness Institute reviews the endocannabinoid system and the role it plays in bridging the connection between mind and body, modulating anxiety, inflammation, memory and other physiological processes. Nothing in this presentation suggests that any of the products mentioned are appropriate for the treatment, remediation, cure, or prevention of any disease or illness. It does appear, however, that this natural, indwelling, genetically passed down endocannabinoid system may have major implications for holistic physicians and health care practitioners, and for the patients that they serve.
Throughout 2015 the Canadian Cancer Survivor Network (CCSN) will offer a series of webinars designed to provide you with information to help build your knowledge and understanding of medical marijuana use in Canada.
The first webinar in this series features a presentation and Q&A session with Dr. Paul Daeninck , MD, MSc, FRCPC.
Comprehensive Report on The Cannabis Extract MovementTheHempSolution
A comprehensive review of evidence that cannabis extracts can treat many cancers and other diseases. Features information from patients, caregivers, researchers, doctors, dispensaries, and corporations. Includes medical documentation of terminal cancer patients in full remission.
This presentation, created by Syed Faiz ul Hassan, explores the profound influence of media on public perception and behavior. It delves into the evolution of media from oral traditions to modern digital and social media platforms. Key topics include the role of media in information propagation, socialization, crisis awareness, globalization, and education. The presentation also examines media influence through agenda setting, propaganda, and manipulative techniques used by advertisers and marketers. Furthermore, it highlights the impact of surveillance enabled by media technologies on personal behavior and preferences. Through this comprehensive overview, the presentation aims to shed light on how media shapes collective consciousness and public opinion.
Mastering the Concepts Tested in the Databricks Certified Data Engineer Assoc...SkillCertProExams
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Collapsing Narratives: Exploring Non-Linearity • a micro report by Rosie WellsRosie Wells
Insight: In a landscape where traditional narrative structures are giving way to fragmented and non-linear forms of storytelling, there lies immense potential for creativity and exploration.
'Collapsing Narratives: Exploring Non-Linearity' is a micro report from Rosie Wells.
Rosie Wells is an Arts & Cultural Strategist uniquely positioned at the intersection of grassroots and mainstream storytelling.
Their work is focused on developing meaningful and lasting connections that can drive social change.
Please download this presentation to enjoy the hyperlinks!
Suzanne Lagerweij - Influence Without Power - Why Empathy is Your Best Friend...Suzanne Lagerweij
This is a workshop about communication and collaboration. We will experience how we can analyze the reasons for resistance to change (exercise 1) and practice how to improve our conversation style and be more in control and effective in the way we communicate (exercise 2).
This session will use Dave Gray’s Empathy Mapping, Argyris’ Ladder of Inference and The Four Rs from Agile Conversations (Squirrel and Fredrick).
Abstract:
Let’s talk about powerful conversations! We all know how to lead a constructive conversation, right? Then why is it so difficult to have those conversations with people at work, especially those in powerful positions that show resistance to change?
Learning to control and direct conversations takes understanding and practice.
We can combine our innate empathy with our analytical skills to gain a deeper understanding of complex situations at work. Join this session to learn how to prepare for difficult conversations and how to improve our agile conversations in order to be more influential without power. We will use Dave Gray’s Empathy Mapping, Argyris’ Ladder of Inference and The Four Rs from Agile Conversations (Squirrel and Fredrick).
In the session you will experience how preparing and reflecting on your conversation can help you be more influential at work. You will learn how to communicate more effectively with the people needed to achieve positive change. You will leave with a self-revised version of a difficult conversation and a practical model to use when you get back to work.
Come learn more on how to become a real influencer!
Suzanne Lagerweij - Influence Without Power - Why Empathy is Your Best Friend...
Oral Cannabidiol (CBD) Administration: Assessing Anxiolytic Properties of CBD in a Rodent Model
1. Oral Cannabidiol (CBD) Administration: Assessing Anxiolytic Properties of CBD in a
Rodent Model
INTRODUCTION RESULTS
Usmaan Zunnu Rain*, Nejra Kulaglic*, Jordan Skully, Chela Wallin, Dr. Susanne Brummelte, Dr. Scott E. Bowen
Department of Psychology, Wayne State University. Detroit, Michigan
Cannabidiol (CBD), a constituent in cannabis that is non-
psychoactive, is claimed to be an effective anxiolytic by
activation of the 5HT1a receptor (Crippa et al., 2011, Blessing et
al., 2015). CBD has been popularized due to its therapeutic
properties, yet there is still a need for additional scientific
literature. This study analyzed the anxiolytic properties of a 99%
pure CBD compound, supplied by Ellipse Analytics. Anxiety
responses (distance traveled and time spent within open arm),
after CBD administration, were tested and measured on male
rodents via Elevated Zero Maze.
This study was conducted to evaluate the effectiveness of
CBD’s anxiolytic properties on male rodents in the
Elevated Zero Maze.
Drug and Administration: Pure cannabidiol (CBD), derived
from hemp product, was diluted in sesame oil (vehicle) to create
a 20 mg/kg dosage group. Administration of CBD to rodents via
oral gavage (P.O.) given once daily for 10 days.
*Funding for this project was provided by Ellipse Analytic (Denver, Colorado).
References:
Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825-836.
Crippa, J. A. S., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., ... & Hallak, J. E. C. (2011). Neural basis of anxiolytic effects of cannabidiol (CBD) in
generalized social anxiety disorder: a preliminary report. Journal of psychopharmacology, 25(1), 121-130.
METHODS
Figure 1: Elevated Zero Maze: After
CBD administration, Noldus Ethovision
was used to measure distance traveled and
time spent within the arms of the maze.
Rats were placed on an initial start point
within the open arm of the maze. After 5
minutes, they were taken off.
Administer lower dosage of CBD prior to EZM testing
Address potential sex differences in response to CBD
Assess a potential entourage effect by comparing CBD isolate against other cannabinoids, and CBD in
combination with other cannabinoids
FUTURE DIRECTIONS
ACKNOWLEDGEMENTS & REFERENCES
A special thanks to Alixandria Trombley, Ava Palopoli, Lauren
Richardson, Kristy Tilson, Yusuf Yasarlar, Saadia Taj, and Brandon
Brown for their support in data collection and imputation.
Figure 2. Timelines of CBD administration and
corresponding cohort assessments. Anxiety and stress testing
were assessed together (anxiety tested on the 1st and 10th day
and stress tested on the 5th day). CBD dosing for behavioral
testing included vehicle (n= 16), and 20 mg/kg (n= 16).
0 and 20 mg/kg Distance Traveled by Day
OBJECTIVE
DISCUSSION
There was a significant difference between dose groups on Day 10, where the 20mg/kg dose group traveled less
and spent less time within the open arms of the EZM. This signifies a potential sedation effect due to the lack of
movement within the dosage group. Anxiolytic potential of CBD is difficult to assess due to possible sedation.
Figure 3. Means displayed represent distance traveled (cm) in the entirety
of the Elevated Zero Maze by dose group by day. Dose groups evaluated
are control (sesame oil, n=16) and 20mg/kg (n=16). There was no
significant effect of dose groups related to the total distance traveled on
Day 1. On Day 10, there was a significant difference between the dose
groups [P=.017]. Error bars shown are mean ± SEM.
Figure 4. Means displayed represent the cumulative time (s) spent in the
open arm of the EZM by dose by day. Dose groups evaluated are control
(sesame oil, (n=16) and 20mg/kg (n=16). There was no significant effect
of dose group on Day 1. There was a significant difference between dose
groups on Day 10 [P=.043]. Error bars shown are mean ± SEM.
0 and 20 mg/kg Open Arm Duration (s) by Day
2. Oral Cannabidiol (CBD) Administration: Assessing Anxiolytic Properties of CBD in a Rodent Model
Usmann Zunnu Rain*, Nejra Kulaglic*, Jordan Skully, Chela Wallin, Dr. Susanne Brummelte, Dr. Scott E. Bowen
Department of Psychology, Wayne State University. Detroit, Michigan
• Cannabidiol (CBD) is a non-psychoactive constituent in cannabis
• Anxiolytic and panicolytic properties
• Lack of extensive scientific literature
• 99% pure compound of CBD provided by Ellipse Analytics (Denver, CO)
Evaluate the effectiveness of CBD’s anxiolytic properties on male rodents in
the Elevated Zero Maze.
CBD could provide a safer alternative to a variety of current therapeutic
drugs
INTRODUCTION
OBJECTIVE
WHY?
3. Oral Cannabidiol (CBD) Administration: Assessing Anxiolytic Properties of CBD in a Rodent Model
Usmann Zunnu Rain*, Nejra Kulaglic*, Jordan Skully, Chela Wallin, Dr. Susanne Brummelte, Dr. Scott E. Bowen
Department of Psychology, Wayne State University. Detroit, Michigan
METHODS
Figure 2: Timelines of CBD administration and corresponding cohort
assessments.
Figure 1: EZM Training Apparatus
4. Oral Cannabidiol (CBD) Administration: Assessing Anxiolytic Properties of CBD in a Rodent Model
Usmann Zunnu Rain*, Nejra Kulaglic*, Jordan Skully, Chela Wallin, Dr. Susanne Brummelte, Dr. Scott E. Bowen
Department of Psychology, Wayne State University. Detroit, Michigan
RESULTS
Figure 3. Means displayed represent the distance traveled
(cm) in the entirety of the Elevated Zero Maze by dose group
by day. Beta weights show that the 20mg/kg CBD dosage
group traveled 283.261 cm less than the vehicle on Day 10.
Figure 4. Means displayed represent the cumulative time (s)
spent in the open arm of the EZM by dose by day. Based on
beta weights, the 20mg/kg CBD dosage group spent 16.4
seconds less in the open arms of EZM compared to the
vehicle on Day 10.
5. There was a significant difference between dose groups on Day 10, where the 20mg/kg
dose group traveled less and spent less time within the open arms of the EZM. This
signifies a potential sedation effect due to the lack of movement within the dosage group.
Anxiolytic potential of CBD is difficult to assess due to possible sedation.
Administer lower dosages of CBD before EZM testing
Address potential sex differences in response to CBD
Assess a potential entourage effect by comparing CBD isolate against other cannabinoids, and
CBD in combination with other cannabinoids
DISCUSSION
Oral Cannabidiol (CBD) Administration: Assessing Anxiolytic Properties of CBD in a Rodent Model
Usmaan Zunnu Rain*, Nejra Kulaglic*, Jordan Skully, Chela Wallin, Dr. Susanne Brummelte, Dr. Scott E. Bowen
Department of Psychology, Wayne State University. Detroit, Michigan
FUTURE DIRECTIONS