1. Risk Factors for Recurrence of Group B Streptococcus Colonization in a Subsequent Pregnancy ○ ● ● ● ○ ● Shang-Yu Huang, MD, Po-Jen Cheng, MD Linko Chang-Gung Memorial Hospital Taiwan

2. Introduction

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6. Materials and Methods

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12. Results

13. Table I – Univariable associations between recurrent GBS colonization and factors from the index and subsequent pregnancy. 70 181 29 222 24 89 121 17 Maternal age: index pregnancy (years) -- 1.00 5 (29.4) ＜ 20 (0.98~1.87) 1.38 49 (40.5) 20-29 (0.81~1.76) 1.22 32 (36.0) 30-39 (0.96~1.93) 1.42 10 (41.7) ≧ 40 Marital status: index pregnancy -- 1.00 84 (37.8) Married (0.79~1.63) 1.10 12 (41.4) Single Ethnicity: -- 1.00 67 (37.0) Taiwanese (0.77~1.81) 1.12 29 (41.4) Foreign-born N 95% CI RR ‡ (unadjusted) Recurrence of GBS: n (%) † Variable *

14. Table I – Univariable associations between recurrent GBS colonization and factors from the index and subsequent pregnancy. –cont. N 95% CI RR ‡ (unadjusted) Recurrence of GBS: n (%) † Variable * (0.82~1.39) 0.98 16 (40.0) 40 ≧ 60 kg (0.71~1.27) 0.91 28 (37.3) 75 50-59 kg (0.65~1.23) 0.90 32 (36.8) 87 40-49 kg -- 1.00 20 (40.8) 49 ＜ 40 kg Pre-pregnancy weight: index pregnancy (1.03~1.83) 1.47 20 (52.6) 38 Yes -- 1.00 76 (35.7) 213 No Smoking: subsequent pregnancy

15. Table I – Univariable associations between recurrent GBS colonization and factors from the index and subsequent pregnancy. –cont. N 95% CI RR ‡ (unadjusted) Recurrence of GBS: n (%) † Variable * 51 73 92 35 Pre-pregnancy weight: subsequent pregnancy -- 1.00 14 (40.0) ＜ 40 kg (0.77~1.42) 0.98 36 (39.1) 40-49 kg (0.83~1.39) 0.93 27 (37.0) 50-59 kg (0.79~1.44) 0.93 19 (37.3) ≧ 60 kg (0.87~1.46) 1.11 11 (42.3) 26 ≧ 4000 kg (0.59~1.61) 0.99 77 (37.7) 204 2500-3999 kg -- 1.00 8 (38.1) 21 ＜ 2500 kg Birth weight: index pregnancy

16. Table I – Univariable associations between recurrent GBS colonization and factors from the index and subsequent pregnancy. –cont. N 95% CI RR ‡ (unadjusted) Recurrence of GBS: n (%) † Variable * 30 79 118 24 Weight gain during pregnancy: index pregnancy -- 1.00 9 (37.5) ＜ 5 kg (0.72~1.46) 1.09 48 (40.7) 5-9 kg (0.65~1.28) 0.94 28 (35.4) 10-14 kg (0.69~1.38) 0.98 11 (36.7) ≧ 15 kg (0.58~1.60) 0.94 30 (36.6) 82 No -- 1.00 66 (39.1) 169 Yes Breast-feeding: index pregnancy

17. Table I – Univariable associations between recurrent GBS colonization and factors from the index and subsequent pregnancy. –cont. N 95% CI RR ‡ (unadjusted) Recurrence of GBS: n (%) † Variable * 16 62 69 104 Time interval between index and subsequent pregnancies (months) -- 1.00 32 (30.8) ≧ 36 (0.79~1.68) 1.27 27 (39.1) 24-35 (1.01~1.99) 1.47 28 (45.2) 12-23 (1.20~2.71) 1.83 9 (56.3) ＜ 12 (1.04~1.98) 1.42 16 (51.6) 31 Positive -- 1.00 80 (36.4) 220 Negative GDM screening: index pregnancy

18. Table I – Univariable associations between recurrent GBS colonization and factors from the index and subsequent pregnancy. –cont. 154 N 95% CI RR ‡ (unadjusted) Recurrence of GBS: n (%) † Variable * 52 40 211 GDM screening: subsequent pregnancy -- 1.00 75 (35.5) Negative (1.09~2.11) 1.48 21 (52.5) Positive Intensity of GBS colonization: index pregnancy -- 1.00 15 (28.8) Light (1.21~2.89) 1.85 24 (53.3) 45 Heavy (0.85~1.79) 1.28 57 (37.0) Moderate

20. Table II –Predictive factors for recurrence of GBS colonization (multivariable model). (1.2~2.6) 1.7 25 (53.3) Heavy (0.8~1.9) 1.2 57 (37.0) Moderate 1.0 15 (28.8) Light Intensity of GBS colonization: index pregnancy (1.1~2.4) 1.6 9 (56.3) ＜ 12 (0.9~2.1) 1.3 28 (45.2) 12-23 (0.7~1.9) 1.2 27 (39.1) 24-35 1.0 32 (30.8) ≧ 36 Time interval between index and subsequent pregnancies (months) Adjusted RR † (95% CI) Recurrence of GBS: n (%) * Variable

21. Discussion

24. Thanks for your attention