Artigo sobre a depressão e aspectos ligados a neurogenese. Várias são as causas da depressão, e muitas delas podem estar ligados a fatos de neurogÊnesse
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
Neurogenese e depressão
1. Neurogênese e depressão: etiologia ou nova ilusão?
Neurogenesis and depression: etiology or new ilusion?
5555HHHHVVVVXXXXPPPPRRRR
1RYRVQHXU{QLRVFRQWLQXDPVHQGRJHUDGRVQRFpUHEURDGXOWRGHGLYHUVDVHVSpFLHVDQLPDLV0XLWRVHVWXGRVWrPGHPRQVWUDGRTXH
GLYHUVRV IDWRUHV DPELHQWDLV LQFOXVLYH R HVWUHVVH LQIOXHQFLDP D SUROLIHUDomR GH FpOXODV KLSRFDPSDLV 1HVVH VHQWLGR D GLPLQXLomR
GD QHXURJrQHVH LQGX]LGD SHOR HVWUHVVH SDUHFH VHU XP LPSRUWDQWH IDWRU QD HWLRORJLD GD GHSUHVVmR 1HVVD UHYLVmR D UHODomR HQWUH
QHXURJrQHVH H GHSUHVVmR p HQIDWL]DGD
'''''HHHHHVVVVVFFFFFUUUUULLLLLWWWWWRRRRRUUUUUHHHHHVVVVV1HXU{QLRVFLWRORJLD'HSUHVVmRHWLRORJLD (QYHOKHFLPHQWR FHOXODU+LSRFDPSRFUHVFLPHQWR GHVHQYROYLPHQWR $PtJ
GDODSDWRORJLD
$$$$EEEEVVVVWWWWUUUUDDDDFFFFWWWW
1HZKLSSRFDPSDOQHXURQVDUHFRQWLQXRXVOJHQHUDWHGLQWKHDGXOWEUDLQRIVHYHUDODQLPDOVSHFLHV6HYHUDOVWXGLHVKDYHGHPRQVWUDWHG
WKDW D YDULHW RI HQYLURPHQWDO IDFWRUV LQFOXGLQJ VWUHVV LQIOXHQFH WKH SUROLIHUDWLRQ RI KLSSRFDPSDO FHOOV 7KXV VWUHVV LQGXFHG
GHFUHDVHRIKLSSRFDPSDOQHXURJHQHVLVVHHPWREHDQLPSRUWDQWIDFWRULQWKHHWLRORJRIGHSUHVVLRQ,QWKLVUHYLHZWKHUHODWLRQVKLS
EHWZHHQ QHXURJHQHVLV DQG GHSUHVVLRQ KDV EHHQ HPSKDVL]HG
.....HHHHHZZZZZRRRRRUUUUUGGGGGVVVVV1HXURQVFWRORJ'HSUHVVLRQHWLRORJ HOO DJLQJ+LSSRFDPSXVJURZWK GHYHORSPHQW $PJGDODSDWKRORJ
1 Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brasil
2 Núcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes (UMC), Mogi das Cruzes (SP), Brasil
3 Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brasil
Rev Bras Psiquiatr. 2005;27(3):249-53
Financiamento: FAEP, FAPESP, CNPq, CAPES
Conflito de interesses: Inexistente
Recebido: 4 de Novembro de 2004
Aceito: 11 de Março de 2005
Correspondência
Fulvio Alexandre Scorza
Neurologia Experimental - Ed. Leal Prado
Rua Botucatu, 862
04023-900 São Paulo, SP, Brasil
E-mail: scorza.nexp@epm.br
$77778888$/,=$d®2
249
Fulvio Alexandre Scorza,1,2
Alexandro de Borja Gonçalves Guerra,3
Esper Abrão Cavalheiro,1 Helena Maria Calil3
2. 250 Scorza FA et al
Rev Bras Psiquiatr. 2005;27(3):249-53
(QWUH DV SULQFLSDLV SRSXODo}HV GH QHXU{QLRV KLSRFDPSDLV
DV FpOXODV JUDQXODUHV GR JLUR GHQWDGR VmR DV TXH DSUHVHQWDP
D SURSULHGDGH GH QHXURJrQHVH SyVQDWDO $ PDLRULD GDV
FpOXODV JUDQXODUHV GR JLUR GHQWDGR p JHUDGD QR SHUtRGR SyV
QDWDOQRHQWDQWRRGHVHQYROYLPHQWRFRPSOHWRGDFDPDGDGH
FpOXODV JUDQXODUHV RFRUUH DSUR[LPDGDPHQWH HQWUH R R H R
RGLDVGHYLGD$VFpOXODVJUDQXODUHVVmRRULJLQiULDVGHFp
OXODVSURJHQLWRUDVORFDOL]DGDVQRKLORGRJLURGHQWDGR,QLFLDO
PHQWH HVWmR GLVSHUVDV HP WRGR R KLOR H QD VHJXQGD VHPDQD
SyVQDWDO VH ORFDOL]DP QD =6* GR JLUR GHQWDGR SHUPDQHFHQ
GRPLWRWLFDPHQWHDWLYDVDSURGXomRGHQRYDVFpOXODVIRLHVWL
PDGD HP QHXU{QLR FpOXODV JUDQXODUHV H[LVWHQWHV RX
VHMD HP XP FDPXQGRQJR GH PHVHV VmR SURGX]LGDV FHQWH
QDV GH FpOXODV SRU GLD
3. 1D JUDQGH PDLRULD GRV RUJDQLVPRV
HVWH SURFHVVR SRGH SHUVLVWLU SRU SHUtRGRV EDVWDQWH SURORQJD
GRV SURYDYHOPHQWH DWp D VHQHVFrQFLD 1R UDWR DGXOWR DV
FpOXODV SURJHQLWRUDV VH HQFRQWUDP QD =6* GR JLUR GHQWDGR
SUROLIHUDQGR H PLJUDQGR FRQWLQXDPHQWH SDUD D FDPDGD GH
FpOXODV JUDQXODUHV 1HVVD UHJLmR HVVDV FpOXODV GHVHQYRO
YHP PRUIRORJLD WtSLFD GDV FpOXODV JUDQXODUHV H[SUHVVDP
PDUFDGRUHV GH GLIHUHQFLDomR QHXURQDO H HVWHQGHP VHXV
D[{QLRV SDUD D YLD GH ILEUDV PXVJRVDV TXH VH SURMHWD SDUD D
UHJLmR $ GR KLSRFDPSR
))))DDDDDWWWWWRRRRRUUUUUHHHHHVVVVV TTTTTXXXXXHHHHH DDDDDOOOOOWWWWWHHHHHUUUUUDDDDDPPPPP DDDDD QQQQQHHHHHXXXXXUUUUURRRRRJJJJJrrrrrQQQQQHHHHHVVVVVHHHHH
3DUDOHODPHQWHWHPVLGRGHPRQVWUDGRQRV~OWLPRVDQRVTXH
R SURFHVVR GH QHXURJrQHVH QR 61 GR DGXOWR VRIUH IRUWH LQIOX
rQFLD GH XPD JUDQGH YDULHGDGH GH HVWtPXORV (P
DPHURQ HW DO PRVWUDUDP TXH D DWLYDomR GRV UHFHSWRUHV 1
PHWLO 'DVSDUWDWR 10'$
4. GLPLQXL D QHXURJrQHVH QD =6*
HQTXDQWR TXH R EORTXHLR GHVVHV UHFHSWRUHV SURSRUFLRQD XP
HIHLWR LQYHUVR 'HEDVVLR HW DO GHPRQVWUDUDP TXH D GHVQXWUL
omRSUpQDWDOSURGX]LGDSRUSULYDomRSURWpLFDDOWHUDVLJQLILFD
WLYDPHQWH R SHUILO GD QHXURJrQHVH SyVQDWDO QD UHJLmR GR JLUR
GHQWDGRHPDQLPDLVGHODERUDWyULRHTXHHVVHSURFHVVRSHUVLVWH
PHVPR FRP D UHDELOLWDomR QXWULFLRQDO DSyV R QDVFLPHQWR
(P .HPSHUPDQQ HW DO PRVWUDUDP DXPHQWR GD
,,,,QQQQWWWWUUUURRRRGGGGXXXXoooommmmRRRR
1R ILQDO GR VpFXOR ;,; H LQtFLR GR VpFXOR ;; .RHOOLNHU H
+LV HVWXGDQGR R SURFHVVR GH GHVHQYROYLPHQWR GR 6LVWHPD
1HUYRVR HQWUDO 61
5. HP VHUHV KXPDQRV H RXWURV PDPtIH
URV SRVWXODUDP TXH D HVWUXWXUD FHUHEUDO SHUPDQHFHULD IL[D
DSyV R QDVFLPHQWR /RJR HP VHJXLGD 5DPRQ DMDO GHV
FUHYHUDP´QR61GRVDGXOWRVDVYLDVQHXURQDLVVmRIL[DVH
LPXWiYHLV 7RGDV DV FpOXODV GHYHUmR PRUUHU H QmR RFRUUHUi
UHJHQHUDomR 7DOYH] QR IXWXUR D FLrQFLD PXGH HVWD OHLµ
(QWUHWDQWR QD SULPHLUD PHWDGH GR VpFXOR ;; DOJXQV SHVTXL
VDGRUHVVXJHULUDPDH[LVWrQFLDGHXPSURFHVVRPLWyWLFRFHUH
EUDO HP UDWRV DSyV R QDVFLPHQWR VHP DILUPDU FRP FODUH]D
VHWDLVFpOXODVHPGLYLVmRVHWUDQVIRUPDULDPHPQHXU{QLRVRX
HP FpOXODV GD JOLD
2VHVWXGRVVREUHQHXURJrQHVHWLYHUDPDOJXPSURJUHVVRDSyV
D LQWURGXomR GD WpFQLFD GH DXWRUDGLRJUDILD GH +@WLPLGLQD
D TXDO p LQFRUSRUDGD DR '1$ GDV FpOXODV HP GLYLVmR -RVHSK
$OWPDQ XWLOL]DQGR HVVD WpFQLFD UHODWRX D RFRUUrQFLD GH
QHXURJrQHVH HP YiULDV HVWUXWXUDV FHUHEUDLV GH UDWRV MRYHQV H
DGXOWRVFRPRQRJLURGHQWDGRQHRFyUWH[HEXOERROIDWyULR
1HVVHV WUDEDOKRV $OWPDQ DUJXPHQWDYD TXH HVVHV QRYRV
QHXU{QLRV HUDP ´PLFURQHXU{QLRVµ LVWR p FpOXODV JUDQXODUHV
RXHVWHODUHVFRPD[{QLRVFXUWRVRVTXDLVHVWDULDPHQYROYLGRV
FRP RV SURFHVVRV GH DSUHQGL]DJHP H PHPyULD RPR DV
WpFQLFDV GLVSRQtYHLV QD pSRFD QmR HUDP FDSD]HV GH GHPRQV
WUDU FRP SUHFLVmR VH HVVDV FpOXODV HUDP QHXU{QLRV SURSULD
PHQWHGLWRVRXFpOXODVGDJOLDRVUHVXOWDGRVGH$OWPDQIRUDP
LJQRUDGRV1RHQWDQWRFRPRVXUJLPHQWRGDPLFURVFRSLDHOH
WU{QLFD .DSODQ PRVWURX TXH DV FpOXODV GR JLUR GHQWDGR H GR
EXOERROIDWyULRGHUDWRVDGXOWRVTXHLQFRUSRUDUDP+@WLPLGLQD
H[LELDP FDUDFWHUtVWLFDV XOWUDHVWUXWXUDLV GH QHXU{QLRV
)LQDOPHQWH R DYDQoR QR HVWXGR GD QHXURJrQHVH RFRUUHX QRV
DQRVFRPRGHVHQYROYLPHQWRGRDQiORJRVLQWpWLFRGDWLPLGLQD
%UG8FURPR·GHR[LXULGLQD